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*  P-selectin
In quiescent platelet, P-selectin is located on the inner wall of α-granules. Platelet activation (through agonists such as ... The P-selectin then promotes platelet aggregation through platelet-fibrin and platelet-platelet binding. P-selectin attaches to ... at page 538 doi:10.1038/sj.bjp.0702328 Wang J, Li J, Liu Q (August 2005). "Association between platelet activation and ... Other names for P-selectin include CD62P, Granule Membrane Protein 140 (GMP-140), and Platelet Activation-Dependent Granule to ...
*  Multiple electrode aggregometry
TXA2 increases platelet aggregation, promotes degranulation and stimulates platelet activation. Inhibition of COX1, as with ... The P2Y1 receptor is required for ADP-induced platelet activation, but is not sufficient for a full platelet aggregation in ... cAMP inhibits platelet aggregation, and decreased amounts of cAMP in platelets lead to platelet aggregation. The PGE1 reagent ... Binding of fibrinogen to GPIIb/IIIa receptors leads to platelet-to-platelet bridges and results in platelet aggregation. ...
*  Thromboregulation
... plays as an agonist in platelet adhesion and its activation. The binding of platelets to the sub-endothelial collagen ... but platelet aggregation must grow exponentially to form a platelet thrombus and prevent blood loss. Platelet aggregation ... Thromboxane A2 (TX2) has a positive feedback in platelet activation. It is produced by the oxygenation of arachidonic acid by ... Brass, Lawrence (September 2003). "Thrombin and Platelet activation". Chest: Journal of the College of Chest Physicians. USA. ...
*  Beta-thromboglobulin
... is a protein that is stored in alpha-granules of platelets and released in large amounts after platelet activation. It is a ... Levels of Beta-Thromboglobulin is used to index platelet activation. It is measured by ELISA in blood plasma or urine, and ... Beta-Thromboglobulin also affects megakaryocyte maturation, and thus helps in regulating platelet production. ... Beta-thromboglobulin (β-thromboglobulin, also called Pro-Platelet basic protein) ...
*  Chemokine
Activation of G proteins, by chemokine receptors, causes the subsequent activation of an enzyme known as phospholipase C (PLC ... Platelet factor-4 superfamily or intercrines. Some chemokines are considered pro-inflammatory and can be induced during an ... Ligands of these receptors CCL2 and CCL5 play an important role in mast cell recruitment and activation in the lung.There is ... Furthermore, CXCR3 expression by T-cells is induced following T-cell activation and activated T-cells are attracted to sites of ...
*  Thrombin
As part of its activity in the coagulation cascade, thrombin also promotes platelet activation and aggregation via activation ... The activation of protein C is greatly enhanced following the binding of thrombin to thrombomodulin, an integral membrane ... The historic model of activation of serine proteases involves insertion of this newly formed N-terminus of the heavy chain into ... Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin ...
*  GP1BA
... and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. ... Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of ... "Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease". Proc. Natl ... Lopez JA, Chung DW, Fujikawa K, Hagen FS, Davie EW, Roth GJ (1988). "The alpha and beta chains of human platelet glycoprotein ...
*  G protein-coupled receptor
Brass LF (September 2003). "Thrombin and platelet activation". Chest. 124 (3 Suppl): 18S-25S. doi:10.1378/chest.124.3_suppl.18S ... Activation of adenylate cyclase ends when the G protein returns to the GDP-bound state. Adenylate cyclases (of which 9 membrane ... The eventual effect of all three types of agonist-induced activation is a change in the relative orientations of the TM helices ... This creates a conformational change in the receptor, causing activation of a G protein. Further effect depends on the type of ...
*  Platelet
Intracellular calcium concentration determines platelet activation status, as it is the second messenger that drives platelet ... Thrombin also promotes secondary fibrin-reinforcement of the platelet plug. Platelet activation in turn degranulates and ... Platelets secrete thromboxane A2, which acts on the platelet's own thromboxane receptors on the platelet surface (hence the so- ... Volume reduced platelets have a shelf life of only four hours. Platelets release platelet-derived growth factor (PDGF), a ...
*  P2RY1
In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in ... Jin J, Daniel JL, Kunapuli SP (January 1998). "Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor ... play a role in controlling shape change in human platelets". Platelets. 14 (1): 15-20. doi:10.1080/0953710021000062914. PMID ... Aktas B, Hönig-Liedl P, Walter U, Geiger J (August 2002). "Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP- ...
*  Pathophysiology of multiple sclerosis
"Evidence of platelet activation in multiple sclerosis". J Neuroinflammation. 5 (1): 27. doi:10.1186/1742-2094-5-27. PMC 2474601 ... Platelets are known to have abnormal high levels. MS patients are also known to be CD46 defective, and this leads to ... Activation of macrophages and lymphocytes and their migration across the barrier may result in direct attacks on myelin sheaths ... Further activation of cytokines is also induced by macrophage and lymphocyte activity, promoting inflammatory activity as well ...
*  Prostacyclin
This activation, in turn, signals adenylyl cyclase to produce cAMP. cAMP goes on to inhibit any undue platelet activation (in ... It inhibits platelet activation and is also an effective vasodilator. When used as a drug, it is also known as epoprostenol. ... leading to platelet activation and subsequent coagulation). PGI2 also binds to endothelial prostacyclin receptors and in the ... It does this by inhibiting platelet activation. It is also an effective vasodilator. Prostacyclin's interactions in contrast to ...
*  Coagulation factor II receptor
Initial localization and subsequent redistribution during platelet activation". The Journal of Biological Chemistry. 272 (9): ... Proteolytic cleavage leads to the activation of the receptor. PAR-1 has multifaceted effects and plays a key role in mediating ... Molino M, Bainton DF, Hoxie JA, Coughlin SR, Brass LF (Feb 1997). "Thrombin receptors on human platelets. ... "G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets". Proceedings of the ...
*  Nitinol biocompatibility
It has been suggested that fibrinogen may cause platelet activation due to a breakdown of the protein structure as it interacts ... Albumin on the other hand, inhibits platelet activation. This implies that there are two mechanisms which can help lower ... In vitro tests use indicators of thrombosis, such as platelet, Tyrosine aminotransferase, and β-TG levels. Surface treatments ...
*  GNA13
Offermanns S, Hu YH, Simon MI (Oct 1996). "Galpha12 and galpha13 are phosphorylated during platelet activation". The Journal of ... Shi CS, Sinnarajah S, Cho H, Kozasa T, Kehrl JH (Aug 2000). "G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha ... Jin S, Exton JH (Nov 2000). "Activation of RhoA by association of Galpha(13) with Dbl". Biochemical and Biophysical Research ... Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA (Aug 2000). "Conformational activation of ...
*  CASS4
... signaling may contribute to platelet activation and aggregation. A PKA/PKG phosphorylation site has been identified in ... Zimman A, Titz B, Komisopoulou E, Biswas S, Graeber TG, Podrez EA (2014). "Phosphoproteomic analysis of platelets activated by ... Pugacheva EN, Golemis EA (October 2005). "The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and ... Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA (June 2007). "HEF1-dependent Aurora A activation induces ...
*  F2RL3
2003). "Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP". J. Thromb. Haemost. 1 (4): 798-804. doi: ... 1999). "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin". J. Clin. Invest. 103 (6): 879- ... 1998). "A dual thrombin receptor system for platelet activation". Nature. 394 (6694): 690-4. doi:10.1038/29325. PMID 9716134. ... Covic L, Singh C, Smith H, Kuliopulos A (2003). "Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates ...
*  CD63
It may function as a blood platelet activation marker. Deficiency of this protein is associated with HermanskyPudlak syndrome. ... 1993). "The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears ... The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and ... The test is commonly designated as basophil activation test (BAT). Initially, deletion and point mutants were used to ...
*  F2RL2
1999). "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin". J. Clin. Invest. 103 (6): 879- ... 1998). "A dual thrombin receptor system for platelet activation". Nature. 394 (6694): 690-4. doi:10.1038/29325. PMID 9716134. ... 2001). "Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets". ... F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is ...
*  P2Y12
"Central role of the P2Y12 receptor in platelet activation". The Journal of Clinical Investigation. 113 (3): 340-5. doi:10.1172/ ... In the field of purinergic signaling, the P2Y12 protein is found mainly but not exclusively on the surface of blood platelets, ... The P2Y12 receptor is involved in platelet aggregation and is thus a biological target for the treatment of thromboembolisms ... Murugappa S, Kunapuli SP (2006). "The role of ADP receptors in platelet function". Frontiers in Bioscience. 11 (1): 1977-86. ...
*  Reactive oxygen species
"Hydrogen peroxide is involved in collagen-induced platelet activation". Blood. 91 (2): 484-90. PMID 9427701. Guzik TJ, Korbut R ... In particular, platelets involved in wound repair and blood homeostasis release ROS to recruit additional platelets to sites of ... H oxidase-dependent platelet superoxide anion release increases platelet recruitment". Blood. 100 (3): 917-24. doi:10.1182/ ... On the other hand, a high level of ROS can suppress tumor growth through the sustained activation of cell-cycle inhibitor and ...
*  Serum amyloid A1
... inhibits platelet activation". The Journal of Laboratory and Clinical Medicine. 116 (2): 180-6. PMID 1697614. Steinkasserer A, ... The P2X7 purinergic receptor is another receptor used by SAA1 for a number of cellular functions including the activation of ... mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases". The Journal of ...
*  Tissue plasminogen activator
Wang J, Li J, Liu Q (August 2005). "Association between platelet activation and fibrinolysis in acute stroke patients". ... Wang J, Li J, Liu Q (August 2005). "Association between platelet activation and fibrinolysis in acute stroke patients". ...
*  Plasminogen activator inhibitor-1
Wang J, Li J, Liu Q (August 2005). "Association between platelet activation and fibrinolysis in acute stroke patients". ... a result of arterial hypertension and activation of the renin-angiotensin system. Annonacinone is a naturally occurring PAI-1 ...
*  Coagulation
cAMP inhibits platelet activation by decreasing cytosolic levels of calcium and, by doing so, inhibits the release of granules ... Five mechanisms keep platelet activation and the coagulation cascade in check. Abnormalities can lead to an increased tendency ... This binding helps mediate the activation of platelets and formation of primary hemostasis. Bernard-Soulier syndrome is a ... Binding of collagen to glycoprotein VI triggers a signaling cascade that results in activation of platelet integrins. Activated ...
*  Prostaglandin-endoperoxide synthase 2
It sticks platelets together and promotes clotting; inhibiting this helps prevent heart disease. On the other hand, PTGS2 (COX- ... Minghetti L, Pocchiari M (2007). "Cyclooxygenase-2, prostaglandin E2, and microglial activation in prion diseases". Int. Rev. ... Prostacyclin relaxes or unsticks platelets, so selective COX-2 inhibitors (coxibs) increase risk of cardiovascular events due ...
*  ITGA2B
Ma YQ, Qin J, Plow EF (2007). "Platelet integrin alpha(IIb)beta(3): activation mechanisms". J. Thromb. Haemost. 5 (7): 1345-52 ... functionally regulates platelet activation". J. Biol. Chem. United States. 279 (26): 27286-93. doi:10.1074/jbc.M402159200. ISSN ... Bennett JS (2001). "Platelet-fibrinogen interactions". Ann. N. Y. Acad. Sci. 936: 340-54. doi:10.1111/j.1749-6632.2001.tb03521. ... Naik UP, Parise LV (1997). "Structure and function of platelet alpha IIb beta 3". Curr. Opin. Hematol. 4 (5): 317-22. PMID ...