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*  P-selectin
... is expressed on the surface of both stimulated endothelial cell and activated platelet and helps cancer cells invade ... "Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and ... The P-selectin then promotes platelet aggregation through platelet-fibrin and platelet-platelet binding. P-selectin attaches to ... In quiescent platelet, P-selectin is located on the inner wall of α-granules. Platelet activation (through agonists such as ...
*  Multiple electrode aggregometry
Thrombin receptor activating peptide-6 (TRAP-6) activates platelets through the thrombin receptor protease activated receptor-1 ... Ristocetin forms complexes with von Willebrand Factor (vWF) that bind to the glycoprotein Ib (GP1b) receptors on platelets, ... cAMP inhibits platelet aggregation, and decreased amounts of cAMP in platelets lead to platelet aggregation. The PGE1 reagent ... Binding of fibrinogen to GPIIb/IIIa receptors leads to platelet-to-platelet bridges and results in platelet aggregation. ...
*  Thromboregulation
Platelet aggregation factors are the regulators that enhance the adhesion and stimulate the platelets to secrete its granules. ... Inositol 1,4,5-triphosphate causes an increase in Ca concentration and the release of diacylglycerol activates PKC. TPα ... PGE1 inhibits the secretion of factors that stimulate platelet aggregation by competitive inhibition. Kistrin is a protein ... Platelet aggregation plays a critical role in the genesis of a resulting thrombus. Adhesion should remain local, but platelet ...
*  Discovery and development of direct thrombin inhibitors
Thrombin also activates factor XIII that stabilizes the fibrin complex and therefore the clot and it stimulates platelets, ... which results from a platelet-activating immune response triggered by the interaction of heparin with platelet factor 4 (PF4). ... Furthermore, it activates factors V, VIII and XI, all by cleaving the sequences GlyGlyGlyValArg-GlyPro and PhePheSerAlaArg- ... When a blood vessel ruptures or gets injured, factor VII comes into contact with tissue factors which starts a process called ...
*  Heparin-induced thrombocytopenia
In HIT, the immune system forms antibodies against heparin when it is bound to a protein called platelet factor 4 (PF4). These ... HIT is caused by the formation of abnormal antibodies that activate platelets. If someone receiving heparin develops new or ... This test uses platelets and serum from the patient; the platelets are washed and mixed with serum and heparin. The sample is ... The tail of the antibody then binds to the FcγIIa receptor, a protein on the surface of the platelet. This results in platelet ...
*  Chemokine
Platelet factor-4 superfamily or intercrines. Some chemokines are considered pro-inflammatory and can be induced during an ... Certain inflammatory chemokines activate cells to initiate an immune response or promote wound healing. They are released by ... Furthermore, CXCR3 expression by T-cells is induced following T-cell activation and activated T-cells are attracted to sites of ... An example CXCL8 (IL-8) is chemoattractant for neutrophils and also activating their metabolic and degranulation. Proteins are ...
*  Thrombin
... activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is ... platelet activation and aggregation via activation of protease-activated receptors on the cell membrane of the platelet. ... Activated protein C inactivates factors Va and VIIIa. Binding of activated protein C to protein S leads to a modest increase in ... Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). The activity of factor ...
*  Platelet factor 4
Platelet-activating factor Platelet-derived growth factor GRCh38: Ensembl release 89: ENSG00000163737 - Ensembl, May 2017 ... Bikfalvi A, Gimenez-Gallego G (2004). "The control of angiogenesis and tumor invasion by platelet factor-4 and platelet factor- ... Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with ... Maurer AM, Zhou B, Han ZC (2007). "Roles of platelet factor 4 in hematopoiesis and angiogenesis". Growth Factors. 24 (4): 242- ...
*  P-selectin glycoprotein ligand-1
As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. ... Immune Factor Seen to Control T-Cell Checkpoints Involved in Spread of Cancers and Infections. June 2016 Furie B, Furie BC ( ... 2000). "P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions ... The organization of the SELPLG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which ...
*  Platelet-activating factor
Platelet Activating Factor) Platelet Activating Factor at the US National Library of Medicine Medical Subject Headings (MeSH). ... cytoplasmic platelet-activating factor acetylhydrolase 2, and platelet-activating factor acetylhydrolase 1b. Cations are one ... Platelet-activating factor receptor Platelet-derived growth factor Zimmerman GA, McIntyre TM, Prescott SM, Stafforini DM (May ... an enzyme that catabolizes platelet-activating factor. It is an important mediator of bronchoconstriction. It causes platelets ...
*  Platelet-activating factor receptor
The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF ... "Entrez Gene: PTAFR platelet-activating factor receptor". Correa-Costa M (Apr 2014). "Activation of platelet-activating factor ... Valone FH (1984). "Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl- ... 1995). "Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor". Nature. 377 ( ...
*  Platelet-activating factor acetyltransferase
In enzymology, a platelet-activating factor acetyltransferase (EC 2.3.1.149) is an enzyme that catalyzes the chemical reaction ... "A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acyl analogs of platelet-activating factor ( ...
*  Ether lipid
Platelet-activating factor (PAF) is an ether lipid which has an acetyl group instead of an acyl chain at the second position ( ... Ether lipids can also act directly in cell signaling, as the platelet-activating factor is an ether lipid signaling molecule ... Demopoulos C, Pinckard R, Hanahan D (10 October 1979). "Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl ...
*  Acyltransferase like 2
platelet-activating factor. ...
*  PAFAH2
Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2 gene. It is one ... "Entrez Gene: PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa". Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM ... This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes ... Min JH, Wilder C, Aoki J, Arai H, Inoue K, Paul L, Gelb MH (Apr 2001). "Platelet-activating factor acetylhydrolases: broad ...
*  PAFAH1B1
Platelet-activating factor acetylhydrolase IB subunit alpha is an enzyme that in humans is encoded by the PAFAH1B1 gene. The ... "Entrez Gene: PAFAH1B1 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa". Kardon JR, Vale RD (Dec ... platelet-activating factor PAFAH1B2 PAFAH1B3 GRCh38: Ensembl release 89: ENSG00000007168 - Ensembl, May 2017 GRCm38: Ensembl ... Sapir T, Elbaum M, Reiner O (Dec 1997). "Reduction of microtubule catastrophe events by LIS1, platelet-activating factor ...
*  Lipoprotein-associated phospholipase A2
T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary ... "A mutation in plasma platelet-activating factor acetylhydrolase (Val279-->Phe) is a genetic risk factor for stroke". Stroke: A ... "A mutation in plasma platelet-activating factor acetylhydrolase (Val279Phe) is a genetic risk factor for cerebral hemorrhage ... Lp-PLA2 is platelet-activating factor (PAF) acetylhydrolase (EC 3.1.1.47), a secreted enzyme that catalyzes the degradation of ...
*  Icos
PAF-AH inactivates platelet-activating factor, a phospholipid that plays a role in the inflammation seen in sepsis. The enzyme ... Pafase is the recombinant form of platelet-activating factor acetylhydrolase (PAF-AH, also known as lipoprotein-associated ... April 6, 1995). "Anti-inflammatory properties of a platelet-activating factor acetylhydrolase". Nature. 374 (6522): 549-53. ... Stafforini DM (February 2009). "Biology of Platelet-activating Factor Acetylhydrolase (PAF-AH, Lipoprotein Associated ...
*  Phosphorylcholine
... is part of platelet-activating factor; the phospholipid phosphatidylcholine as well as sphingomyelin, the ...
*  GPR135
"The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel ...
*  Retrograde signaling
Kato K, Clark G, Bazan N, Zorumski C (1994). "Platelet-activating factor as a potential retrograde messenger in CA1 hippocampal ... Kato K, Zorumski C (1996). "Platelet-activating factor as a potential retrograde messenger". J Lipid Mediat Cell Signal. 14 (1- ... platelet-activating factor, arachidonic acid, and nitric oxide. Nitric oxide has received a great deal of attention in the past ... pairing the other factor(s) with the retrograde signal should mimic the phenomenon The most prevalent endogenous retrograde ...
*  Thromboxane receptor
Farooque SP, Arm JP, Lee TH (2008). "Lipid Mediators: Leukotrienes, Prostanoids, Lipoxins, and Platelet-Activating Factor". In ... Several synthetic compounds bind to, but do not activate, TP and thereby inhibit its activation by activating ligands. These ... activating cell signal pathways, and/or platelet functional responses not only to TP agonists but also to agents that stimulate ... "G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets". Proc. Natl. Acad. Sci ...
*  PAF acetylhydrolase
Lipoprotein-associated phospholipase A2 Platelet-activating factor acetylhydrolase 2, cytoplasmic Platelet-activating factor ... PAF acetylhydrolase is an enzyme that catabolizes platelet-activating factor. There are multiple enzymes with this function: ...
*  RGS4
Richardson RM, Marjoram RJ, Barr AJ, Snyderman R (2001). "RGS4 inhibits platelet-activating factor receptor phosphorylation and ... Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha ... Regulator of G protein signalling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) ... Thaminy S, Auerbach D, Arnoldo A, Stagljar I (2003). "Identification of novel ErbB3-interacting factors using the split- ...
*  Arachidonate 5-lipoxygenase
... platelet-activating factor, to stimulate and otherwise activate eosinophils. ALOX5 contributes to non-allergic reactions of the ... Rossi AG, O'Flaherty JT (1991). "Bioactions of 5-hydroxyicosatetraenoate and its interaction with platelet-activating factor". ... This chemotactic factor stimulation concurrently causes the activation of mitogen-activated protein kinases (MAPK) which in ... and possibly also weaker chemotactic factor, 5S-HETE, which serve to attract and otherwise activate inflammation-inducing cells ...
*  Proto-oncogene tyrosine-protein kinase Src
Most studies have looked at the receptor tyrosine kinases and examples of these are platelet derived growth factor receptor ( ... PDGFR) pathway and epidermal growth factor receptor (EGFR). When src is activated, it promotes survival, angiogenesis, ... EGFR activates c-Src while EGF also increases the activity of c-Src. In addition, overexpression of c-Src increases the ... Zan L, Zhang X, Xi Y, Wu H, Song Y, Teng G, Li H, Qi J, Wang J (2013). "Src regulates angiogenic factors and vascular ...
*  5-oxo-eicosatetraenoic acid
The interactions of 5-oxo-ETE with these mediators of allergy (e.g. platelet-activating factor, interleukin 5) in eosinophils ... 5-Oxo-ETE and another potential mediator of human allergic reactions, platelet-activating factor, act in synergy in stimulating ... and production of mediators such as various arachidonic acid metabolites and platelet-activating factor in human eosinophils, ... "Bioactions of 5-hydroxyicosatetraenoate and its interaction with platelet-activating factor". Lipids. 26 (12): 1184-8. doi: ...