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*  Phosphotyrosine-binding domain
In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine. The phosphotyrosine- ... The phosphotyrosine-binding domain of insulin receptor substrate-1 is not related to the phosphotyrosine-binding domain of ... Two arginines in this domain are responsible for hydrogen bonding phosphotyrosine residues on an Ac-LYASSNPApY-NH2 peptide in ... Insulin receptor substrate-1 proteins contain both a pleckstrin homology domain and a phosphotyrosine binding (PTB) domain. The ...
*  Parvularia atlantis
"Earliest Holozoan expansion of phosphotyrosine signaling". Molecular Biology and Evolution. 31 (3): 517-528. doi:10.1093/molbev ...
*  LNX1
Dho SE, Jacob S, Wolting CD, French MB, Rohrschneider LR, McGlade CJ (Apr 1998). "The mammalian numb phosphotyrosine-binding ...
*  NUMB (gene)
Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain". J. Biol. Chem. 274 (46 ... 1998). "The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a ... 2003). "Integrin β cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity ... was found to selectively tag the membrane Notch1 receptor for ubiquitination through the interaction of its Phosphotyrosine- ...
*  Tyrosine
Phosphotyrosine can be detected through specific antibodies. Tyrosine residues may also be modified by the addition of a ... In its phosphorylated form, tyrosine is called phosphotyrosine. Tyrosine phosphorylation is considered to be one of the key ... Tyrosine sulfation is catalyzed by tyrosylprotein sulfotransferase (TPST). Like the phosphotyrosine antibodies mentioned above ...
*  Giulio Superti-Furga
2002; 108:247-259, doi:10.1016/S0092-8674(02)00623-2. Hantschel, O. et al.: A Myristoyl / Phosphotyrosine Switch Regulates c- ...
*  Adapter molecule crk
9614078 Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1 ... "Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity". Proc Natl Acad ... recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 ...
*  Lewis C. Cantley
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC (March 2008). "Pyruvate kinase M2 is a phosphotyrosine-binding ... and that the SH2 domain of p85 specifically recognized phosphotyrosines on growth factor receptors or adaptor proteins via the ...
*  Piers Nash
2007). "High-Throughput Phosphotyrosine Profiling Using SH2 Domains". Molecular Cell. 26 (6): 899-915. doi:10.1016/j.molcel. ... Liu, Bernard A.; Engelmann, Brett W.; Nash, Piers D. (2012). "The language of SH2 domain interactions defines phosphotyrosine- ... Liu, B. A.; Nash, P. D. (2012). "Evolution of SH2 domains and phosphotyrosine signalling networks". Philosophical Transactions ... "The SH2 Domain-Containing Proteins in 21 Species Establish the Provenance and Scope of Phosphotyrosine Signaling in Eukaryotes ...
*  HER2/neu
Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Molecular Systems Biology ...
*  QSER1
Eight are phosphoserines, one phosphotyrosine, and three phosphothreonines. Three of these sites have been shown to be ...
*  STAT5A
Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1 (1): ...
*  Epidermal growth factor receptor
Sakaguchi K, Okabayashi Y, Kido Y, Kimura S, Matsumura Y, Inushima K, Kasuga M (April 1998). "Shc phosphotyrosine-binding ... Keilhack H, Tenev T, Nyakatura E, Godovac-Zimmermann J, Nielsen L, Seedorf K, Böhmer FD (September 1998). "Phosphotyrosine 1173 ... Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Molecular Systems Biology ... and signaling by several other proteins that associate with the phosphorylated tyrosines through their own phosphotyrosine- ...
*  PKM2
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC (Mar 2008). "Pyruvate kinase M2 is a phosphotyrosine-binding protein ...
*  PTPN11
"Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human ... This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the ... Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1 (1): ... "The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp". J. Biol. Chem. 268 (16): ...
*  MAPK/ERK pathway
Docking proteins such as GRB2 contain an SH2 domain that binds to the phosphotyrosine residues of the activated receptor. GRB2 ... Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Molecular Systems Biology ...
*  PTPN5
Nguyen TH, Liu J, Lombroso PJ (Jul 2002). "Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420". The ... Nguyen TH, Liu J, Lombroso PJ (Jul 2002). "Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420". The ...
*  N-acetyl-D-glucosamine kinase
Maguire PB, Wynne KJ, Harney DF, O'Donoghue NM, Stephens G, Fitzgerald DJ (Jun 2002). "Identification of the phosphotyrosine ...
*  Src family kinase
"Global impact of oncogenic Src on a phosphotyrosine proteome". Journal of Proteome Research. 7 (8): 3447-60. doi:10.1021/ ...
*  CD61
"The phosphotyrosine binding-like domain of talin activates integrins". J. Biol. Chem. United States. 277 (24): 21749-58. doi: ...
*  TLN1
Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH (Jun 2002). "The phosphotyrosine binding- ...
*  Talin protein
Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH (2002). "The phosphotyrosine binding-like ...
*  DAPP1
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the ... "Entrez Gene: DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides". Bonaldo MF, Lennon G, Soares MB (1997). " ... 2001). "Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by ... tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines". J. ...
*  Type I topoisomerase
Type IB enzymes form a covalent 3'-phosphotyrosine intermediate. Type 1C topoisomerases form a covalent 3'-phosphotyrosine ... The enzyme first wraps around DNA and creates a single, 3' phosphotyrosine intermediate. The 5' end is then free to rotate, ... They both form a 5' phosphotyrosine intermediate, and require a divalent metal ion to perform its work. Unlike type II ... All topoisomerases form a phosphotyrosine intermediate between the catalytic tyrosine of the enzyme and the scissile phosphoryl ...
*  Paracrine signalling
The resulting phosphotyrosines attract STAT proteins. The STAT proteins dimerize and enter the nucleus to act as transcription ...