"Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein- ... coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase". ... Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly ... 1999). "Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)". Oncogene. 17 (24): 3157-67. doi ...
The protein encoded by this gene is a member of the MAP (mitogen-activated protein) kinase family. MAP kinases are also known ... "Characterization of the reversible phosphorylation and activation of ERK8". The Biochemical Journal. 394 (Pt 1): 365-73. doi: ... including cyclin-dependent kinase 2 (CDK2), mitogen-activated protein kinase 12 (MAPK12), and lactotransferrin (LTF), among ... Mitogen-activated protein kinase 15, also known as MAPK15, ERK7, or ERK8, is an enzyme that in humans is encoded by the MAPK15 ...
For example, one of the signal transduction pathways that are activated is called the mitogen-activated protein kinase (MAPK) ... This phosphorylation can generate a binding site for a different protein and thus induce protein-protein interaction. In this ... The MAPK protein is an enzyme, a protein kinase that can attach phosphate to target proteins such as the transcription factor ... The GPCR can then activate an associated G protein by exchanging the GDP bound to the G protein for a GTP. The G protein's α ...
"Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold ... thereby ensuring specific kinase phosphorylation. Additionally, some signaling proteins require multiple interactions for ... An example is the Ste5 scaffold in the mitogen-activated protein kinase (MAPK) pathway. Ste5 has been proposed to direct mating ... A-kinase anchor proteins (AKAPs), which target cyclic AMP-dependent protein kinase (PKA) to various sites in the cell. This ...
... a member of the mitogen-activated protein kinase (MAPK) family, through phosphorylation. Activation of p38 is necessary to ... causes an increase in phosphorylated p38 mitogen-activated protein kinase (MAPK) in microglia in the dorsal horn of the spinal ... "Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase". ... "Stress-Induced p38 Mitogen-Activated Protein Kinase Activation Mediates κ-Opioid-Dependent Dysphoria". J. Neurosci. 27 (43): ...
Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid ... "Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein ... This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with ... isoform 1-binding protein that negatively regulates RSK kinase activity". J. Biol. Chem. 278 (20): 18376-83. doi:10.1074/jbc. ...
... contains important regulatory peptide motifs including potential phosphorylation sites for mitogen-activated protein kinases( ... cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3 ... MAPKs), Erk-family MAP kinases, the Ca2+ /calmodulin-dependent protein kinase II (CamKII) and protein kinase C (PKC). Smad7 ... It interacts with activated TGF-β type I receptor therefore block the association, phosphorylation and activation of Smad2. By ...
"Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases". Mol. Cancer Res. 1 (7): 541-50. ... Roskoski R (2005). "Src kinase regulation by phosphorylation and dephosphorylation". Biochem. Biophys. Res. Commun. 331 (1): 1- ... The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling ... "Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase ...
... cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine ... "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. 94 ( ... "Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB ... "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): ...
2005). "Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation ... "Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins". Blood. ... Docking protein 2 is a protein that in humans is encoded by the DOK2 gene. The protein encoded by this gene is constitutively ... 2004). "Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase". Oncogene. 23 ( ...
c-Jun N-terminal kinase (JNK) signaling is part of the mitogen-activated protein kinase (MAPK) signaling pathway essential in ... "Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site". The Journal ... which activates the Ras G protein. Ras activates Raf (MAPKKK), which activates Mek (MAPKK), which activates Erk (MAPK). Erk can ... Nagalingam A, Arbiser JL, Bonner MY, Saxena NK, Sharma D (February 2012). "Honokiol activates AMP-activated protein kinase in ...
"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proceedings of the National ... "DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein". European Journal of ... InterPro signatures for protein family: IPR002418, IPR011598, IPR003327 The Myc Protein NCBI Human Myc protein Myc cancer gene ... Myc proteins are transcription factors that activate expression of many pro-proliferative genes through binding enhancer box ...
... kinase, which acts upstream of the stress-induced mitogen-activated protein kinase (MAPK) cascade. The encoded protein can ... "Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/ ... Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene. The protein encoded by this gene is ... The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this ...
... kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels". ... "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase ... Johnson GL, Lapadat R (Dec 2002). "Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases". ... "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proceedings of the National ...
"Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2". The Biochemical ... "Nuclear translocation of doublecortin-like protein kinase and phosphorylation of a transcription factor JDP2". Biochemical and ... Jun dimerization protein 2 (JUNDM2) is a protein that in humans is encoded by the JDP2 gene. The Jun dimerization protein is a ... Other proteins such as interferon regulatory factor-2-binding protein-1 (IRF2BP1). CCAAT/enhancer-binding protein gamma (C/EBPγ ...
... it was found that IRAK4 activity was necessary for activating signal pathways which lead to mitogen-activated protein kinases ( ... The protein also contains three auto-phosphorylation sites, each of which when mutated results in a decrease in the kinase ... IRAK4 is a threonine/serine protein kinase made up of 460 amino acids, which contains both a kinase domain and a death domain. ... TRAF6 can polyubiquitinate IKK-γ as well as itself, which recruits TGF-β activated kinase 1 (TAK1) in order to activate its ...
Hurd TW, Culbert AA, Webster KJ, Tavaré JM (December 2002). "Dual role for mitogen-activated protein kinase (Erk) in insulin- ... Psychostimulants] increase cAMP levels in striatum, which activates protein kinase A (PKA) and leads to phosphorylation of its ... Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 ... Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW (June 2000). "Activating protein-1, nuclear ...
"Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase". Science. 270 (5241): 1491-4. ... Through the receptor tyrosine kinases, signals are sent to the nucleus through the mitogen-activated protein kinase (MAPK/ERK) ... Glycogen synthase kinase-3 (GSK)-3β inhibits transcription by nuclear ER by inhibiting phosphorylation of serine 118 of nuclear ... Estrogen receptors (ERs) are a group of proteins found inside cells. They are receptors that are activated by the hormone ...
Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by ... and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, ... virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human ... "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): ...
... cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase ... a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase ... Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated ... Zhao Y, Bjorbaek C, Moller DE (1997). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases ...
The kinases involved are cyclin A-CDK2 at either SP190 or SP354, p38 mitogen-activated protein (MAP) kinase at SP692 in ... The function of TBX3 is also regulated by phosphorylation by the p38-MAPK, AKT3 and cyclin A/CDK2 and by protein co-factors, ... While there are 29 predicted phosphorylation sites in the TBX3 protein only the SP190, SP692 and S720 have been fully ... TBX3 can activate and/or repress its target genes by binding a T-element, or half T-element sites. Indeed, Tbx3 binds highly ...
The latest functions as an activator of mitogen-activated protein kinases. Another function derived from integrin binding is ... The fact this region contains some phosphorylation sites suggests L1 may be subject to regulation by kinases. L1CAM protein ... L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene. This protein, ... This position allows the protein to activate chemical signals which spread through the neurone. There are a wide variety of ...
... activation of STAT3 may occur via phosphorylation of serine 727 by Mitogen-activated protein kinases (MAPK) and through c-src ... Specifically, STAT3 becomes activated after phosphorylation of tyrosine 705 in response to such ligands as interferons, ... It is a member of the STAT protein family. STAT3 is a member of the STAT protein family. In response to cytokines and growth ... 1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells". Molecular and Cellular ...
PKR also activates several mitogen-activated protein kinases (MAPK) to lead to inflammation. To balance the effects of ... PKR can also be activated by the protein PACT via phosphorylation of S287 on its M3 domain. The promoter region of PKR has ... Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein ... September 2012). "Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis ...
... is activated by phosphorylation by casein kinase 1ε and inhibited by phosphorylation by MAPK. Phosphorylation by CK2α regulates ... Sanada K, Okano T, Fukada Y (January 2002). "Mitogen-activated protein kinase phosphorylates and negatively regulates basic ... is modulated in the cytoplasm by phosphorylation of PER proteins by casein kinase 1ε or δ (CK1 ε or CK1 δ), targeting these ... The protein encoded by the BMAL1 gene in mammals binds with a second bHLH-PAS protein via the PAS domain, CLOCK (or its paralog ...
This process includes mitogen-activated protein kinases and binding of the MEF2 transcription factor within the promoter region ... Also, phospholamban phosphorylation is increased in myostatin-knockout mice, leading to an increase in Ca2+ release into the ... may also be hindered by myostatin-regulated inhibition of protein kinase p38 and the serine-threonine protein kinase Akt, which ... Myostatin is produced as promyostatin, a precursor protein kept inactive by the latent TGF-β binding protein 3 (LTBP3). ...
... in cAMP concentration by inhibition of adenylyl cyclase and a rise in the concentration of mitogen-activated protein kinase ( ... This inhibition of cAMP is followed by phosphorylation and subsequent activation of not only a suite of MAP kinases (p38/p42/ ... through Gi/o-mediated inhibition of adenylyl cyclase and protein kinase A. Direct effects of CB1 receptors on membrane ... showed an increase in the expression of transcripts encoding myelin basic protein, endoplasmic proteins, cytochrome oxidase, ...
"Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1". FEBS Lett. 474 (2-3): 141 ... Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the TAB1 gene ... "Entrez Gene: MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1". "TAB1 (human)". www.phosphosite ... Kishimoto K, Matsumoto K, Ninomiya-Tsuji J (2000). "TAK1 mitogen-activated protein kinase kinase kinase is activated by ...
This protein then begins a phosphorylation cascade, culminating in the activation of mitogen-activated protein kinase (MAPK), ... Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations". Protein kinase phosphorylation ... This indirectly activates a protein kinase, PKB (Akt), via phosphorylation. PKB then phosphorylates several target proteins, ... which then activates several other kinases - most notably protein kinase B, (PKB, also known as Akt). PKB triggers the ...
"Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and ... "Entrez Gene: MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2". Sousa AM, Liu T, Guevara O, Stevens J, ... "LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils". The Journal ... "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase ...
... has been shown to interact with: CNOT7, MAPK1 MARCKS, Mitogen-activated protein kinase 9, and RPS6KA1. GRCh38: Ensembl ... The protein undergoes phosphorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein ... Protein Tob1 is a protein that in humans is encoded by the TOB1 gene. This gene encodes a member of the tob/btg1 family of anti ... This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers ...