Loading...
*  Protein primary structure
Finally, the peptide side chains can also be modified covalently, e.g., phosphorylation Aside from cleavage, phosphorylation is ... As with phosphorylation, sulfation adds a negative charge to a previously neutral site. prenylation and palmitoylation − C ( = ... The phosphorylated tyrosines are often used as "handles" by which proteins can bind to one another, whereas phosphorylation of ...
*  Protein kinase C
Phosphorylation of the hydrophobic motif is rendered unnecessary by the presence of a glutamic acid in place of a serine, which ... These phosphorylation events are essential for the activity of the enzyme, and 3-phosphoinositide-dependent protein kinase-1 ( ... This is contingent upon phosphorylation of the catalytic region, discussed below. The catalytic region or kinase core of the ... The conventional and novel PKCs have three phosphorylation sites, termed: the activation loop, the turn motif, and the ...
*  Phosphorylation
... mostly on protein phosphorylation). Phosphorylation of sugars is often the first stage in their catabolism. Phosphorylation ... Within a protein, phosphorylation can occur on several amino acids. Phosphorylation on serine is thought to be the most common ... Tyrosine phosphorylation is relatively rare but lies at the head of many protein phosphorylation signalling pathways (e.g. in ... While phosphorylation is performed by ATPs during preparatory steps, phosphorylation during payoff phase is maintained by ...
*  Oxidative phosphorylation
... (or OXPHOS in short) (UK /ɒkˈsɪd.ə.tɪv/, US /ˈɑːk.sɪˌdeɪ.tɪv/) is the metabolic pathway in which ... This phosphorylation reaction is an equilibrium, which can be shifted by altering the proton-motive force. In the absence of a ... The term oxidative phosphorylation was coined by Volodymyr Belitser (uk) in 1939. For another twenty years, the mechanism by ... Although oxidative phosphorylation is a vital part of metabolism, it produces reactive oxygen species such as superoxide and ...
*  Protein phosphorylation
Phosphorylation of the enzyme GSK-3 by AKT (Protein kinase B) as part of the insulin signaling pathway. Phosphorylation of Src ... Regulatory roles of phosphorylation include: Phosphorylation of Na+/K+-ATPase during the transport of sodium (Na+) and ... Protein phosphorylation is a reversible post-translational modification of proteins. In eukaryotes, protein phosphorylation ... Compared to the protein phosphorylation of prokaryotes, studies of protein phosphorylation in eukaryotes from yeast to human ...
*  Tyrosine phosphorylation
Regulation with tyrosine phosphorylation plays a very important role in gene regulation. Tyrosine phosphorylation can influence ... suggest that tyrosine phosphorylation may regulate synaptic transmission. The role of tyrosine phosphorylation in the ... Tyrosine phosphorylation is the addition of a phosphate (PO43−) group to the amino acid tyrosine on a protein. It is one of the ... leading to autophosphorylation and phosphorylation of several receptor substrates. Phosphorylation of selected tyrosine sites ...
*  Phosphorylation cascade
A phosphorylation cascade is a sequence of events where one enzyme phosphorylates another, causing a chain reaction leading to ... the phosphorylation of thousands of proteins. This can be seen in signal transduction of hormone messages. Freeman, Scott; et ...
*  Substrate-level phosphorylation
Unlike oxidative phosphorylation, oxidation and phosphorylation are not coupled in the process of substrate-level ... Most ATP is generated by oxidative phosphorylation in aerobic or anaerobic respiration while substrate-level phosphorylation ... producing 3-phosphoglycerate and ATP through a substrate-level phosphorylation. The second substrate-level phosphorylation ... Substrate-level phosphorylation is a metabolic reaction that results in the formation of ATP or GTP by the direct transfer of a ...
*  EHD3
Phosphorylation. It consists of the addition of a phosphate group (HPO3). In EHD3, there are two serine phosphorylations; one ... Apart from an EF-hand domain, it can also include tyrosine phosphorylation sites and coiled coils. This domain is often related ...
*  Glycolysis
Furthermore, the second phosphorylation event is necessary to allow the formation of two charged groups (rather than only one) ... The phosphorylation and dephosphorylation of these enzymes (ultimately in response to the glucose level in the blood) is the ... A final substrate-level phosphorylation now forms a molecule of pyruvate and a molecule of ATP by means of the enzyme pyruvate ... This step, one of the two substrate-level phosphorylation steps, requires ADP; thus, when the cell has plenty of ATP (and ...
*  Diffusion limited enzyme
Berg, Jeremy M.; Tymoczko, J. L.; Stryer, L. (2006). "Oxidative phosphorylation". Biochemistry. 5: 491-526. Alberty, Robert A ...
*  Adenosine diphosphate
The biosynthesis of ATP is achieved throughout processes such as substrate-level phosphorylation, oxidative phosphorylation, ... "Oxidative phosphorylation". W H Freeman, 2002. Retrieved 4 April 2013. Medh, J. D. "Electron Transport Chain (Overview)" (PDF ... It is this energy coupling and phosphorylation of ADP to ATP that gives the electron transport chain the name oxidative ... Oxidative phosphorylation produces 26 of the 30 equivalents of ATP generated in cellular respiration by transferring electrons ...
*  Uncharacterized LOC644249 gene
A total of 13 likely phosphorylation sites were predicted: Ser: 5 Thr: 6 Tyr: 2 The main concentration of the phosphorylation ...
*  Insulin receptor
Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF (January 2002). "Phosphorylation of Ser307 in insulin receptor ... This protein then begins a phosphorylation cascade, culminating in the activation of mitogen-activated protein kinase (MAPK), ... Pearson RB, Kemp BE (1991). "Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations". ... Benaim G, Villalobo A (August 2002). "Phosphorylation of calmodulin. Functional implications". European Journal of Biochemistry ...
*  Estrogen receptor alpha
Lannigan DA (2003). "Estrogen receptor phosphorylation". Steroids. 68 (1): 1-9. doi:10.1016/S0039-128X(02)00110-1. PMID ... "Formation of an hERα-COUP-TFI complex enhances hERα AF-1 through Ser118 phosphorylation by MAPK". EMBO J. 21 (13): 3443-53. doi ... "Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and ...
*  Electrochemical gradient
Utilizing one full oxygen in oxidative phosphorylation requires the transfer of four electrons. The oxygen will then consume ... This potential energy is used for the synthesis of ATP by oxidative phosphorylation or photophosphorylation, respectively. An ... Electrochemical gradients also play a role in establishing proton gradients in oxidative phosphorylation in mitochondria.The ... ISBN 978-1-4292-3414-6. Nath, Sunil; Villadsen, John (2015-03-01). "Oxidative phosphorylation revisited". Biotechnology and ...
*  Epidermal growth factor receptor
Hashimoto Y, Katayama H, Kiyokawa E, Ota S, Kurata T, Gotoh N, Otsuka N, Shibata M, Matsuda M (July 1998). "Phosphorylation of ... Takahashi K, Suzuki K, Tsukatani Y (July 1997). "Induction of tyrosine phosphorylation and association of beta-catenin with EGF ... Olive DM (October 2004). "Quantitative methods for the analysis of protein phosphorylation in drug development". Expert Review ... There are several quantitative methods available that use protein phosphorylation detection to identify EGFR family inhibitors ...
*  Atherton-Todd reaction
Studies on phosphorylation. Part II. The reaction of dialkyl phosphites with polyhalogen compounds in presence of bases. A new ... method for the phosphorylation of amines" (in German), Journal of the Chemical Society (Resumed): pp. 660-663, doi:10.1039/ ...
*  Bernhard Kadenbach
The dissertation was entitled "The influence of thyroidhormones in vivo on oxidative phosphorylation and enzyme activities in ... 1800, 205-212 (2010). B. Kadenbach (ed.): Mitochondrial Oxidative Phosphorylation. Nuclear-Encodes Genes, Enzyme Regulation, ... New extension of the Mitchell Theory for oxidative phosphorylation in mitochondria of living organisms, Biochim. Biophys. Acta ...
*  CALM2
Minakami R, Jinnai N, Sugiyama H (1997). "Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype ... Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications". Eur. J. Biochem. 269 (15): 3619-31. doi ... interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein ...
*  Pancreatic polypeptide receptor 1
Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR (May 2000). "PKA phosphorylation dissociates ... Benaim G, Villalobo A (Aug 2002). "Phosphorylation of calmodulin. Functional implications". European Journal of Biochemistry / ...
*  CALM3
Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications". Eur. J. Biochem. 269 (15): 3619-31. doi ... interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein ...
*  Calmodulin 1
Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications". Eur. J. Biochem. 269 (15): 3619-31. doi ...
*  Diphosphomevalonate decarboxylase
First, phosphorylation occurs. This creates a reactive intermediate, which in the second stage undergoes concerted ... diphosphate decarboxylase probably evolved from a common ancestor since they have a similar fold and catalyze phosphorylation ...
*  Tyrosine-protein kinase CSK
CSK acts by suppressing the activity of the Src family of protein kinases by phosphorylation of Src family members at a ... Y184F - Abolishes phosphorylation. Y304F - Decreases activity by two-thirds and alters conformation. S364A - Strong decrease of ... Upon phosphorylation by other kinases, Src-family members engage in intramolecular interactions between the phosphotyrosine ... "Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure". The ...