Dwivedi Y, Agrawal AK, Rizavi HS, Pandey GN (December 2002). "Antidepressants reduce phosphoinositide-specific phospholipase C ... and also antagonism of the 5-HT2A and α1-adrenergic receptors inhibits activation of intracellular phospholipase C (PLC), which ...
A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C- ... Gross BS, Melford SK, Watson SP (1999). "Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc ... The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic ... From OMIM as of March 24, 2020: Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield ...
The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate ... Oishi K, Takahashi M, Mukai H, Banno Y, Nakashima S, Kanaho Y, Nozawa Y, Ono Y (May 2001). "PKN regulates phospholipase D1 ... Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR (July 2000). "A 3-phosphoinositide-dependent protein kinase-1 ... Protein kinase N1 has been shown to interact with: AKAP9, Actinin, alpha 1, CCDC85B, NEFL, NEUROD2 Phosphoinositide-dependent ...
... an enzyme Phosphoinositide phospholipase C, an enzyme This disambiguation page lists articles associated with the title ...
"Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this ... Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. The class I ... October 2010). "Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction". Journal ... "Entrez Gene: PIK3CD phosphoinositide-3-kinase, catalytic, delta polypeptide". Harris SJ, Foster JG, Ward SG (November 2009). " ...
"Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this ... "Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide". Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, ... Visnjić D, Crljen V, Curić J, Batinić D, Volinia S, Banfić H (Oct 2002). "The activation of nuclear phosphoinositide 3-kinase ... The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling ...
1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation ... "Entrez Gene: PIK3C3 phosphoinositide-3-kinase, class 3". Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation ... 1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells ... It's a class III phosphoinositide 3-kinase. GRCh38: Ensembl release 89: ENSG00000078142 - Ensembl, May 2017 GRCm38: Ensembl ...
1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation ... "Entrez Gene: PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide". Lee C, Liu QH, Tomkowicz B, et al. (2004). " ... The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling ... 1998). "A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during ...
1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation ... Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have ... "Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide". Katada T, Kurosu H, Okada T, et al. (1999). " ... 2002). "Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase". Proc. Natl. Acad. Sci. U.S ...
1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation ... "Entrez Gene: PIK3C2A phosphoinositide-3-kinase, class 2, alpha polypeptide". Tiosano D, Baris HN, Chen A, Hitzert MM, Schueler ... 2000). "Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors". Mol. Cell ... Gaidarov I, Smith ME, Domin J, Keen JH (2001). "The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and ...
2005). "Role of phosphoinositide signaling in the control of insulin exocytosis". Molecular Endocrinology. 19 (12): 3097-3106. ... PtdIns(4,5)P2 is a substrate for hydrolysis by phospholipase C (PLC), a membrane-bound enzyme activated through protein ... Loss of inositol phospholipids and inhibition of secretion in permeabilized cells caused by a bacterial phospholipase C and ... The first evidence that indicated phosphoinositides(PIs) (especially PI(4,5)P2) are important during the exocytosis process was ...
PLCγ (Phosphoinositide Phospholipase C γ) hydrolyzes membrane phospholipids to form IP3 (Inositoltriphosphate) and DAG ( ... "Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize ... PKA leads to protein tyrosine phosphorylation.Phospholipase C (PLC) is involved in acrosome reaction. ZP3 is a glycoprotein ...
Characterized and Putative Isoforms of Inositol Phospholipid Kinase and Phosphoinositide-Specific Phospholipase C. Plant ... Analysis of intact phosphoinositides in biological samples. American Soc f Biochem and Mol Biol 2006; 47:1588-1596 Muller- ... Phosphatidylinositol phosphate kinases (PIPK) are kinases that phosphorylate the phosphoinositides PtdInsP and PtdInsP2 that ...
... is involved in the phosphoinositide and insulin signaling cascades. As mentioned, the C-terminal START domain of DLC1 is ... involved in phosphoinositide signaling: it is able to interact with phospholipase C-δ1 (PLC- δ1), thereby stimulating it to ... This region interacts with phospholipase C-δ1 (PLCδ1) and activates its ability to hydrolyze the membrane lipid ...
... digested by proteinase K and can be liberated from the cell surface in vitro by the enzyme phosphoinositide phospholipase C (PI ...
Characterized and Putative Isoforms of Inositol Phospholipid Kinase and Phosphoinositide-Specific Phospholipase C. ... Hydrolysis of phosphoinositides yield one mole of glycerol, two moles of fatty acids, one mole of inositol and one, two, or ... Phosphoinositides are regarded as the most acidic phospholipids. The specific fatty acids of PtdIns, and their conformation, ... The most common fatty acids of phosphoinositides are stearic acid in the SN1 position and arachidonic acid, in the SN2 position ...
Signaling pathways activated by HER2 include: mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K/Akt) ... phospholipase C γ protein kinase C (PKC) Signal transducer and activator of transcription (STAT) In summary, signaling through ... "Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma". The EMBO Journal. 10 (8): ... "Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas". Proceedings of ...
Phospholipase C (PLC) which when activated is responsible for forming Inositol trisphosphate (IP3) and diacylglycerol secondary ... Phosphoinositide 3-kinase which when activated is responsible for forming phosphatidylinositol 3-phosphate, ...
... phosphoinositide phospholipase C EC 3.1.4.12: sphingomyelin phosphodiesterase EC 3.1.4.13: serine-ethanolaminephosphate ... EC 3.1.1.1: carboxylesterase EC 3.1.1.2: arylesterase EC 3.1.1.3: triacylglycerol lipase EC 3.1.1.4: phospholipase A2 EC 3.1. ... phospholipase D EC 3.1.4.5: Now EC 3.1.21.1, deoxyribonuclease I EC 3.1.4.6: Now EC 3.1.22.1, deoxyribonuclease II EC 3.1.4.7: ... phospholipase A1 EC 3.1.1.33: 6-acetylglucose deacetylase EC 3.1.1.34: lipoprotein lipase EC 3.1.1.35: dihydrocoumarin ...
... a seven-transmembrane G-protein-coupled receptor that stimulates the beta isoform of Phosphoinositide phospholipase C, which ...
... investigating molecular mechanisms of signal transduction in the Phospholipase C (PLC) and Phosphoinositide 3-kinase (PI3 ...
It also binds with a high affinity to the membranes of atrial and brain to induce hydrolysis of phosphoinositides in these ... which seems to activate type C and D phospholipases. However, distinct and widespread subtypes of glycosylated receptors are ... Above characteristics suggest that sarafotoxins (and endothelins) use the phosphoinositide signal transduction pathway via ... phosphoinositide hydrolysis in rat heart and brain". Science. 242 (4876): 268-70. Bibcode:1988Sci...242..268K. doi:10.1126/ ...
Alphafold structure of Nir1) The PITPNM family of proteins has been shown to participate in the phosphoinositide cycle. Lipids ... 5-bisphosphate-phospholipase C resynthesis cycle: PITPs bridge the ER-PM gap". Biochemical Journal. 473 (23): 4289-4310. doi: ... Balla, Tamas (July 2013). "Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation". Physiological Reviews. 93 (3 ... "Phosphorylation of human phospholipase A1 DDHD1 at newly identified phosphosites affects its subcellular localization". Journal ...
PIP2 and other phosphoinositides are important modifiers of cytoskeletal dynamics and membrane transport and can traffic PLD to ... Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase ... Mammalian cells encode two isoforms of phospholipase D: PLD1 and PLD2. Phospholipase D is an important player in many ... Phosphatidyl choline Phosphatidate Choline Phospholipase cleavage sites Jenkins GM, Frohman MA (October 2005). "Phospholipase D ...
Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH (2002). "Phospholipase C gamma 1 is a ... phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton". J. Biol. Chem. ...
"Entrez Gene: PLCD1 phospholipase C, delta 1". Yagisawa H (2006). "Nucleocytoplasmic shuttling of phospholipase C-delta1: a link ... immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide ... 1998). "Phospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effector". Biochem. J. 331 (1): 283 ... Ishikawa S, Takahashi T, Ogawa M, Nakamura Y (Nov 1997). "Genomic structure of the human PLCD1 (phospholipase C delta 1) locus ...
Phosphoinositides (PIP, PIP2, and PIP3) are molecules that have been shown to affect neuronal polarity. A gene (ttx-7) was ... The egl-8 gene encodes a homolog of phospholipase Cβ (PLCβ), an enzyme that cleaves PIP2. When ttx-7 mutants also had a mutant ...
"Asp49 phospholipase A(2)-elaidoylamide complex: a new mode of inhibition". Biochem. Biophys. Res. Commun. 319 (4): 1314-21. doi ... "Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit". ...
Phospholipase C gamma (PLCγ) becomes phosphorylated once bound to LAT, and is then used to catalyze phosphatidylinositol ... The tyrosine kinase FYN phosphorylates Grb2-associated-binding protein 2 (Gab2), which binds to phosphoinositide 3-kinase, ... including phospholipase Cγ1 and the receptor βγ2 complex, in RBL-2H3 rat basophilic leukemia cells". Molecular and Cellular ...
Perez-Villar JJ, Kanner SB (1999). "Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 ... with the p85 subunit of phosphoinositide 3-kinase". FEBS Lett. 575 (1-3): 35-40. doi:10.1016/j.febslet.2004.07.090. PMID ... Perez-Villar JJ, Kanner SB (2000). "Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 ...