TIM-4 serves as a ligand for TIM-1 but also as a receptor for phosphatidylserine. Its phosphatidylserine binding however does ... Moreover recognition of phosphatidylserine also helps to control adaptive immune system by clearing phosphatidylserine ... Wong K, Valdez PA, Tan C, Yeh S, Hongo JA, Ouyang W (May 2010). "Phosphatidylserine receptor Tim-4 is essential for the ... Its phosphatidylserine binding properties also play an important role in removal of apoptotic cells. ...
Raetz CR, Kennedy EP (1974). "Partial purification and properties of phosphatidylserine synthetase from Escherichia coli". J. ... Other names in common use include phosphatidylserine synthase, CDPdiglyceride-serine O-phosphatidyltransferase, PS synthase, ... Larson TJ, Dowhan W (1976). "Ribosomal-associated phosphatidylserine synthetase from Escherichia coli: purification by ... cytidine 5'-diphospho-1,2-diacyl-sn-glycerol, (CDPdiglyceride):L-serine O-phosphatidyltransferase, phosphatidylserine ...
"Livedo Vasculopathy Associated with IgM Anti-phosphatidylserine-prothrombin Complex Antibody". Acta Dermato Venereologica. 90 ( ...
aminophospholipids, phosphatidylserine, and phosphatidylethanolamine are specifically sequestered in the inner leaflet of the ... subsequent phosphatidylserine exposure, and a transient phospholipidic imbalance between the external leaflet at the expense of ... Uptake of endothelial micoparticles is Annexin I/Phosphatidylserine receptor dependant. Microparticles are derived from many ... "Endothelial Microparticle Uptake in Target Cells Is Annexin I/Phosphatidylserine Receptor Dependent and Prevents Apoptosis". ...
However, phosphatidylserine is made in the endoplasmic reticulum. Because of this, the transport of phosphatidylserine from the ... Phosphatidylserine decarboxylase is the enzyme that is used to decarboxylate phosphatidylserine in the first pathway. The ... Phosphatidylethanolamine is also thought to play a role in blood clotting, as it works with phosphatidylserine to increase the ... Phosphatidylserine and phosphatidylethanolamine in mammalian cells: Two metabolically related aminophospholipids". The Journal ...
... A-V can form 2-dimensional networks when bound to the phosphatidylserine unit of the membrane. Annexin A-V is effective ... Alternatively, annexins A-I and A-II bind phosphatidylserine and phosphatidylcholine units in the cell membrane, and are often ... "Cell surface-expressed phosphatidylserine and annexin A5 open a novel portal of cell entry". J. Biol. Chem. 279 (50): 52623-9. ... functions of phosphatidylserine-binding and two-dimensional crystallization". Biochim. Biophys. Acta. 1783 (6): 953-63. doi: ...
These include prohibitin, phosphatidylserine, glycosaminoglycans and ATP synthase β subunit. Replication occurs within the ...
Kolb S, Vranckx R, Huisse MG, Michel JB, Meilhac O (July 2007). "The phosphatidylserine receptor mediates phagocytosis by ... If the cell is unable to signal to the reticuloendothelial phagocytes by externalizing phosphatidylserine, it is likely to lyse ...
Healthy cells do not expose phosphatidylserine on their surface, whereas dead, dying, infected, injured and some activated ... Currently known eat-me signals include: phosphatidylserine, oxidized phospholipids, sugar residues (such as galactose), ... The most well characterised eat-me signal is the phospholipid phosphatidylserine. ... cells expose phosphatidylserine on their surface in order to induce phagocytes to phagocytose them. Most glycoproteins and ...
... scramblases and transfer proteins in phosphatidylserine subcellular distribution". Traffic. 16 (1): 35-47. doi:10.1111/tra. ...
... annexin I is externalized in the same locations as phosphatidylserine and helps with clustering phagocytic phosphatidylserine ... Consequently, the phosphatidylserine content in the outer leaflet of the membrane is quickly increased. It is then recognized ... The phosphatidylserine molecules can also be oxidized and contribute to the induction of engulfment. Some molecules naturally ... On a viable cell, phosphatidylserine is only present in the inner layer of the cell membrane - this is maintained by ...
Phosphatidylserine is the most abundant anionic phospholipid in the cell's plasma membrane, and is usually positioned ... As such, targeting external phosphatidylserine may be a strategy for novel broad-spectrum anti-viral therapies. Bavituximab is ... Soares MM, King SW, Thorpe PE (December 2008). "Targeting inside-out phosphatidylserine as a therapeutic strategy for viral ... Bavituximab (PGN401) is a human-mouse chimeric monoclonal antibody against phosphatidylserine, which is a component of cell ...
Membrane phosphatidylserine distribution as a non-apoptotic signaling mechanism in lymphocytes'. Salmond, R.J., Huyer, G., ...
Wheeler, K. P.; Whittam, R. (1 April 1970). "The involvement of phosphatidylserine in adenosine triphosphatase activity of the ...
p. 4. ISBN 978-0-19-530106-9. Baumeister J, Barthel T, Geiss KR, Weiss M (2008). "Influence of phosphatidylserine on cognitive ...
As receptors for phosphatidylserine, TIM proteins bind many families of viruses [filovirus, flavivirus, New World arenavirus ... "The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry". Cell Host Microbe. 12 (4): 544-557. doi: ... "TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells". Immunity. 27 (6): 927-940. doi: ... modulating the phagocytosis of apoptotic cells by interacting with phosphatidylserine (PS) exposed on apoptotic cell surface. ...
The flavivirus lipid membrane has been found to contain cholesterol and phosphatidylserine, but other elements of the membrane ... "The TIM and TAM Families of Phosphatidylserine Receptors Mediate Dengue Virus Entry". Cell Host & Microbe. 12 (4): 544-557. doi ...
... phosphatidyl serine, and inositol). Folch was the first to have elucidated the structure of phosphatidyl serine. Furthermore, ...
While the BV envelope consists of phosphatidylserine, ODV contains phosphatidylcholine and phosphatidylethanolamine.[citation ...
These require Ca2+, DAG, and a phospholipid such as phosphatidylserine for activation. Novel (n)PKCs include the δ, ε, η, and θ ... require phosphatidyl serine) PKC-ι (PRKCI) PKC-ζ (PRKCZ) related PKD PKD1 (PRKD1) PKD2 (PRKD2) PKD3 (PRKD3) related PKN PK-N1 ( ...
"ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes". Nature Immunology. 12 ( ...
PECAM-1 and phosphatidylserine on the cell surface are involved in this process. Neutrophils undergo a process called ...
... phosphatidylserine, and phosphatidic acid. They are often abbreviated to PC, PI, PE, PS and PA, respectively. Purified ... phosphatidylserine, and phosphatidic acid. Lecithin was first isolated in 1845 by the French chemist and pharmacist Théodore ... other phosphatides including phosphatidylserine 5% free carbohydrates 2-5% sterols 1% moisture Lecithin is used for ...
December 2004). "Cell surface-expressed phosphatidylserine and annexin A5 open a portal of cell entry". J. Biol. Chem. 279 (50 ... The annexin a5 protein binds to apoptotic cells in a calcium-dependent manner using phosphatidylserine-containing membrane ... phosphatidylserine) on the cell surface. In normal cells, the negative phospholipids reside on the inner side of the cellular ... a review on an apoptosis detection system based on phosphatidylserine exposure". Cytometry. 31 (1): 1-9. doi:10.1002/(sici)1097 ...
A classic feature of apoptotic cells is the cell-surface exposure of phosphatidylserine (PtdSer) as an 'eat me' signal for ... "Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells". Science. 341 (6144): 403-406. Bibcode: ... "Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization". Nature ...
Prinz, William A.; Choudhary, Vineet; Liu, Li-Ka; Lahiri, Sujoy; Kannan, Muthukumar (2017-03-01). "Phosphatidylserine synthesis ... Phosphatidylserine (DOPS) PEG phospholipid (mPEG-phospholipid, polyglycerin-phospholipid, functionalized-phospholipid, terminal ... Phosphatidylserine (PS) Phosphoinositides: Phosphatidylinositol (PI) Phosphatidylinositol phosphate (PIP) Phosphatidylinositol ...
"Transport of Phosphatidylserine from the Endoplasmic Reticulum to the Site of Phosphatidylserine Decarboxylase2 in Yeast: ... Kannan, Muthukumar; Lahiri, Sujoy; Liu, Li-Ka; Choudhary, Vineet; Prinz, William A. (March 2017). "Phosphatidylserine synthesis ... Phosphatidylserine Transport to the Locus of Psd2p". Traffic. 16 (2): 123-134. doi:10.1111/tra.12236. PMID 25355612. S2CID ...
Associated with extracellular phosphatidylserine exposure, membrane blebbing, with no release of cytochrome c. Annmarie ... Apoptotic events such as membrane blebbing, phosphatidylserine flips (exposure to extracellular space), mitochondrial swelling ...
"Snake cytotoxins bind to membranes via interactions with phosphatidylserine head groups of lipids". PLOS ONE. 6 (4): e19064. ...
Phosphatidylserine lipids are known to be involved in signaling for the phagocytosis of apoptotic cells or pieces of cells. ... After this occurs, other cells recognize the phosphatidylserines and phagocytosize the cells or cell fragments exposing them. ... and phosphatidylserine (PS or GPSer). In addition to serving as a primary component of cellular membranes and binding sites for ...