Phosphatidylinositol
P Phosphatidylinositol 5-phosphate, also known as PtdIns5P or PI(5)P Phosphatidylinositol bisphosphates: Phosphatidylinositol 3 ... The phosphatidylinositol can be phosphorylated to form phosphatidylinositol phosphate (PI-4-P, referred to as PIP in close ... The synthesis of phosphatidylinositol in the laboratory is catalyzed by phosphatidylinositol synthase and involves CDP- ... Membrane lipids Phosphatidyl-inositol Inositol Glycerol Wikimedia Commons has media related to Phosphatidylinositol. ...
Phosphatidylinositol deacylase
The enzyme phosphatidylinositol deacylase (EC 3.1.1.52) catalyzes the reaction 1-phosphatidyl-D-myo-inositol + H2O ⇌ {\ ... Other names in common use include phosphatidylinositol phospholipase A2, and phospholipase A2. Gray NC, Strickland KP (1982). " ... of bovine brain acting on phosphatidylinositol". Can. J. Biochem. 60 (2): 108-17. doi:10.1139/o82-015. PMID 7083039. Gray NC, ...
Phosphatidylinositol phosphate
... may refer to: Phosphatidylinositol 3-phosphate, also known as PI(3)P Phosphatidylinositol 4- ... phosphate, also known as PI(4)P Phosphatidylinositol 5-phosphate, also known as PI(5)P This disambiguation page lists articles ... associated with the title Phosphatidylinositol phosphate. If an internal link led you here, you may wish to change the link to ...
Phosphatidylinositol N-acetylglucosaminyltransferase
In enzymology, a phosphatidylinositol N-acetylglucosaminyltransferase (EC 2.4.1.198) is an enzyme that catalyzes the chemical ... Other names in common use include UDP-N-acetyl-D-glucosamine:phosphatidylinositol, N-acetyl-D-glucosaminyltransferase, uridine ... the two substrates of this enzyme are UDP-N-acetylglucosamine and phosphatidylinositol, whereas its two products are UDP and N- ... "Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of ...
Phosphatidylinositol diacylglycerol-lyase
... phosphatidylinositol phospholipase C, 1-phosphatidylinositol phosphodiesterase, 1-phosphatidyl-D-myo-inositol ... The enzyme phosphatidylinositol diacylglycerol-lyase (EC 4.6.1.13) catalyzes the following reaction: 1-phosphatidyl-1D-myo- ... Michell RH, Allan D (1975). "Inositol cyclis phosphate as a product of phosphatidylinositol breakdown by phospholipase C ( ... Low MG, Finean JB (1977). "Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C". ...
Phosphatidylinositol-3-phosphatase
The enzyme phosphatidylinositol-3-phosphatase (EC 3.1.3.64) catalyzes the reaction 1-phosphatidyl-1D-myo-inositol 3-phosphate ... Lips DL, Majerus PW (1989). "The discovery of a 3-phosphomonoesterase that hydrolyzes phosphatidylinositol 3-phosphate in NIH ... This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. As of late 2007, two ... "Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3- ...
Phosphatidylinositol a-mannosyltransferase
In enzymology, a phosphatidylinositol alpha-mannosyltransferase (EC 2.4.1.57) is an enzyme that catalyzes the chemical reaction ... guanosine diphosphomannose-phosphatidyl-inositol, alpha-mannosyltransferase, and phosphatidyl-myo-inositol alpha- ...
Phosphatidylinositol transfer protein
... , alpha (PITPNA) Phosphatidylinositol transfer protein, beta (PITPNB) Phosphatidylinositol ... Phosphatidylinositol transfer protein (PITP) or priming in exocytosis protein 3 (PEP3) is a ubiquitous cytosolic domain ... Hay JC, Martin TF (December 1993). "Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca(2+)- ... Hsuan J, Cockcroft S (2001). "The PITP family of phosphatidylinositol transfer proteins". Genome Biol. 2 (9): REVIEWS3011. doi: ...
Phosphatidylinositol 3-phosphate
... (PtdIns3P) is a phospholipid found in cell membranes that helps to recruit a range of proteins ... Phosphatidylinositol 3-phosphate-binding protein 2 Gillooly DJ, Simonsen A, Stenmark H (April 2001). "Cellular functions of ... It is the product of both the class II and III phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol. ... Stenmark H, Aasland R, Driscoll PC (February 2002). "The phosphatidylinositol 3-phosphate-binding FYVE finger". FEBS Letters. ...
Phosphatidylinositol 4-phosphate
Phosphatidylinositol 3-phosphate Phosphatidylinositol 5-phosphate Phosphatidylinositol (3,4,5)-trisphosphate Godi A et al., ... Phosphatidylinositol-4-phosphate (PtdIns4P, PI-4-P, PI4P, or PIP) is a precursor of phosphatidylinositol (4,5)-bisphosphate. ... "Lipid Membrane Curvature Induced by Distearoyl Phosphatidylinositol 4-Phosphate". Soft Matter. 8 (11): 3090-3093. doi:10.1039/ ... "Pressure-dependent inverse bicontinuous cubic phase formation in a phosphatidylinositol 4-phosphate/phosphatidylcholine system ...
Phosphatidylinositol 5-phosphate
Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and ... Phosphatidylinositol 4-phosphate and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate). Notably, steady-state PtdIns5P ... Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. Proc Natl Acad Sci U S A. 2007 ... Phosphatidylinositol 5-phosphate is one of the 7 known cellular phosphoinositides with less understood functions. It is ...
Phosphatidylinositol phosphate kinases
Phosphatidylinositol-4-phosphate 3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase Phosphatidylinositol-4-phosphate 5- ... Phosphatidylinositol phosphate kinases (PIPK) are kinases that phosphorylate the phosphoinositides PtdInsP and PtdInsP2 that ... The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell 2000 5:1-11 v t e ( ... Phosphatidylinositol phosphate kinases, a multifaceted family of signalling enzymes. J Biol Chem 1999; 274:9907-9910 Kunz J, ...
Phosphatidylinositol 3,4-bisphosphate
Phosphatidylinositol (3,4)-bisphosphate (PtdIns(3,4)P2) is a minor phospholipid component of cell membranes, yet an important ... A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in ... Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate. Nature. (2013) 499:233-7. 10.1038/nature12360 ... Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate. Nature. (2013) 499:233-7. 10.1038/nature12360 ...
Phosphatidylinositol 4,5-bisphosphate
... or PtdIns(4,5)P2, also known simply as PIP2 or PI(4,5)P2, is a minor phospholipid ... PIP2 is formed primarily by the type I phosphatidylinositol 4-phosphate 5-kinases from PI(4)P. In metazoans, PIP2 can also be ... 2005). "Phosphatidylinositol phosphate kinase type Iγ regulates dynamics of large dense-core vesicle fusion". PNAS. 102 (14): ... 2005). "Plasmalemmal phosphatidylinositol-4, 5-bisphosphate level regulates the releasable vesicle pool size in chromaffin ...
Phosphatidylinositol transfer protein, alpha
Phosphatidylinositol transfer protein alpha isoform is a protein that in humans is encoded by the PITPNA gene. ... Phosphatidylinositol transfer proteins are a diverse set of cytosolic phospholipid transfer proteins that are distinguished by ... "Entrez Gene: PITPNA phosphatidylinositol transfer protein, alpha". Wirtz KW (1991). "Phospholipid transfer proteins". Annu. Rev ... Hay JC, Martin TF (Jan 1994). "Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca(2+)-activated ...
Phosphatidylinositol 3,5-bisphosphate
... defines a novel PI 3-kinase pathway in resting mouse fibroblasts. Biochem J. 1997 May 1; ... Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is one of the seven phosphoinositides found in eukaryotic cell membranes ... PMID 20035756 phosphatidylinositol+3,5-bisphosphate at the U.S. National Library of Medicine Medical Subject Headings (MeSH) ( ... The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J Cell Sci. ...
1-phosphatidylinositol 4-kinase
... phosphatidylinositol 4-kinase, phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. ... In enzymology, a 1-phosphatidylinositol 4-kinase (EC 2.7.1.67) is an enzyme that catalyzes the chemical reaction ATP + 1- ... Kai M, White GL, Hawthorne JN (1966). "The phosphatidylinositol kinase of rat brain". Biochem. J. 101 (2): 328-37. doi:10.1042/ ... Whitman M, Downes CP, Keeler M, Keller T, Cantley L (1988). "Type I phosphatidylinositol kinase makes a novel inositol ...
Phosphatidylinositol transfer protein, cytoplasmic 1
... is a protein that in humans is encoded by the PITPNC1 gene. This gene ... "Entrez Gene: Phosphatidylinositol transfer protein, cytoplasmic 1". Retrieved 2017-12-27. Garner K, Li M, Ugwuanya N, Cockcroft ... Garner K, Hunt AN, Koster G, Somerharju P, Groves E, Li M, Raghu P, Holic R, Cockcroft S (2012). "Phosphatidylinositol transfer ... S (2011). "The phosphatidylinositol transfer protein RdgBβ binds 14-3-3 via its unstructured C-terminus, whereas its lipid- ...
Phosphatidylinositol-4-phosphate 3-kinase
In enzymology, a phosphatidylinositol-4-phosphate 3-kinase (EC 2.7.1.154) is an enzyme that catalyzes the chemical reaction ATP ... This enzyme participates in phosphatidylinositol signaling system. As of late 2007, 3 structures have been solved for this ...
Phosphatidylinositol (3,4,5)-trisphosphate
... (PtdIns(3,4,5)P3), abbreviated PIP3, is the product of the class I phosphoinositide ... Whitman M, Downes CP, Keeler M, Keller T, Cantley L (April 1988). "Type I phosphatidylinositol kinase makes a novel inositol ... phosphatidylinositol 3,4,5 trisphosphate (PIP3) occurs naturally in human neutrophils with levels that increased rapidly ... position of the inositol ring resulting in the formation of phosphatidylinositol-3-phosphate (PI3P). Working independently, ...
Phosphatidylinositol-4-phosphate 5-kinase
... s (PIP5Ks, or PI4P5Ks) are a class of enzymes that phosphorylate phosphatidylinositol ... Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) Phosphatidylinositol-5-phosphate 4-kinase type-2 beta (PIP4K2B ... September 2010). "Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain ... Type I phosphatidylinositol-4-phosphate 5-kinase (PIP5KI) are further classified as PIP5Kα, PIP5Kβ and PIP5Kγ on the basis of ...
Phosphatidylinositol 3-kinase-related kinase
... s (PIKKs) are a family of Ser/Thr-protein kinases with sequence similarity to ... phosphatidylinositol-3 kinases (PI3Ks). The human PIKK family includes six members: PIKKs proteins contain the following four ...
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase
... (EC 3.1.3.78, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, ... Phosphatidylinositol-4,5-bisphosphate+4-phosphatase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) ... Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW (October 2007). "Type I phosphatidylinositol-4,5-bisphosphate 4- ... phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, type I PtdIns-4,5-P2 4-Ptase, type II PtdIns-4,5-P2 4-Ptase, IpgD, ...
Phosphatidylinositol-3,4-bisphosphate 4-phosphatase
The enzyme phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) that catalyzes the reaction 1-phosphatidyl-myo- ... This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. Howell S, Barnaby RJ, Rowe ...
1-phosphatidylinositol-4-phosphate 5-kinase
In enzymology, 1-phosphatidylinositol-4-phosphate 5-kinase (EC 2.7.1.68) is an enzyme that catalyzes the chemical reaction ATP ... Other names in common use include diphosphoinositide kinase, PIP kinase, phosphatidylinositol 4-phosphate kinase, ... This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and ... "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192-6. Bibcode:1997Natur.390..192R. ...
1-phosphatidylinositol-3-phosphate 5-kinase
In enzymology, a 1-phosphatidylinositol-3-phosphate 5-kinase (EC 2.7.1.150) is an enzyme that catalyzes the chemical reaction ... Other names in common use include type III PIP kinase, and phosphatidylinositol 3-phosphate 5-kinase. This enzyme participates ... "The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae". ... in phosphatidylinositol signaling system and regulation of actin cytoskeleton. Cooke FT, Dove SK, McEwen RK, Painter G, Holmes ...
Phosphatidylinositol-4,5-bisphosphate 3-kinase
In enzymology, a phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153) is an enzyme that catalyzes the chemical ... Human genes encoding proteins with phosphatidylinositol-4,5-bisphosphate 3-kinase activity include: PIK3CA PIK3CB PIK3CD PIK3CG ... phosphatidylinositol signaling system, mtor signaling pathway, apoptosis, VEGF signaling pathway, focal adhesion, toll-like ...
1-phosphatidylinositol-5-phosphate 4-kinase
In enzymology, a 1-phosphatidylinositol-5-phosphate 4-kinase (EC 2.7.1.149) is an enzyme that catalyzes the chemical reaction ... Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". ... This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and ...
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
The enzyme phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (EC 3.1.3.67) catalyzes the chemical reaction 1-phosphatidyl- ... Kabuyama Y, Nakatsu N, Homma Y, Fukui Y (1996). "Purification and characterization of the phosphatidylinositol-3,4,5- ... Other names in common use include PTEN,[citation needed] MMAC1, and phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase ... phosphatidylinositol 3,4,5-trisphosphate". J. Biol. Chem. 273 (22): 13375-8. doi:10.1074/jbc.273.22.13375. PMID 9593664. Portal ...
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
... (EC 3.1.3.86, SHIP, p150Ship) is an enzyme with systematic name 1- ... Phosphatidylinositol-3,4,5-trisphosphate+5-phosphatase at the U.S. National Library of Medicine Medical Subject Headings (MeSH ... "The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol ... 5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase". Biochemical and Biophysical Research ...