Phosphatidylinositol 3-phosphate, a common endosomal lipid, binds to this FYVE domain resulting in the recruitment of ESCRT-0 ... Vps27 binds to phosphatidylinositol 3-phosphate, an endosomal lipid, which then recruits the entire complex to an endosome. ... Vps36 contains a GLUE domain that binds phosphatidylinositol 3-phosphate and Vps28 of ESCRT-I. Two zinc finger domains are ...

"Enhanced resistance in Theobroma cacao against oomycete and fungal pathogens by secretion of phosphatidylinositol-3-phosphate- ...

A component of the lipid bilayer, phosphatidyl inositol phosphate (PIP) can be phosphorylated to form PIP2 and PIP3. In some ...

Brice SE, Alford CW, Cowart LA (March 2009). "Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate ... been shown between complex sphingolipid synthesis and cycling of phosphatidylinositol 4-phosphate by the phosphatidylinositol ... This forms ethanolamine phosphate and hexadecenal. Sphingolipids are commonly believed to protect the cell surface against ... Bandhuvula P, Saba JD (May 2007). "Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren". Trends in ...

... is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and ... phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associated with ...

2005). "Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases". J. Biol. ... Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes". Biochem. J. 284 (Pt 1): ... Phosphatidylinositol 4-kinase alpha is an enzyme that in humans is encoded by the PI4KA gene. This gene encodes a 1- ... phosphatidylinositol 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5- ...

August 2003). "Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi". Cell. 114 ... phosphatidylinositol 4-kinase beta (PI4KB) phosphatidylinositol 4-kinase 2-alpha (PI4K2A) phosphatidylinositol 4-kinase 2-beta ... Phosphatidylinositol 4-kinases are evolutionary conserved among eukaryotes and include four human isoforms phosphatidylinositol ... This gene encodes a phosphatidylinositol 4-kinase which catalyzes phosphorylation of phosphatidylinositol at the D-4 position, ...

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the ... Cook JA, August A, Henderson AJ (Jul 2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by ... "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25 ... "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol- ...

Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate ( ...

... phosphatidylinositol 3-phosphate". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8910-5. Bibcode:2000PNAS...97.8910T. doi:10.1073/pnas ...

... and caspase inactivation of phosphatidylinositol phosphate 5-kinases". The Journal of Biological Chemistry. 276 (3): 1865-1872 ... Generated CDP-DAG then condensed to PI by phosphatidylinositol synthase. This PI is then phosphorylated to PI4P and back to ... Bankaitis, Vytas A.; Grabon, Aby (15 November 2011). "Phosphatidylinositol Synthase and Diacylglycerol Platforms Bust a Move". ... "CDP-Diacylglycerol Synthetase Coordinates Cell Growth and Fat Storage through Phosphatidylinositol Metabolism and the Insulin ...

... is involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the ... Zhang X, Majerus PW (April 1998). "Phosphatidylinositol signalling reactions". Seminars in Cell & Developmental Biology. 9 (2 ... "The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol". ... inositol ring from inositol 3,4-bisphosphate and phosphate groups from phosphotyrosines. There is limited data to suggest that ...

Within the FYVE domain there are Zinc finger binding sites that interact with phosphatidylinositol-3-phosphate, to bring target ...

... of bovine brain acting on phosphatidylinositol". Can. J. Biochem. 60 (2): 108-17. doi:10.1139/o82-015. PMID 7083039. Portal: ... sn-3-glycerol phosphate:1->2' galactosyltransferase, floridoside phosphate synthetase, and floridoside phosphate synthase. Gray ... Other names in common use include floridoside-phosphate synthase, UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl ... sn-glycerol 3-phosphate Thus, the two substrates of this enzyme are UDP-galactose and sn-glycerol 3-phosphate, whereas its two ...

... and its various phosphates, the phosphatidylinositol phosphate (PIP) lipids. Inositol or its phosphates and associated lipids ... myo-Inositol is synthesized from glucose 6-phosphate (G6P) in two steps. First, G6P is isomerised by an inositol-3-phosphate ... Inositol, phosphatidylinositol and some of their mono- and polyphosphates function as secondary messengers in a number of ... myo-Inositol (free of phosphate) was once considered a member of the vitamin B complex, called Vitamin B8 in this context. ...

The process is believed to be mediated by lysobiphosphatidic acid (LBPA), phosphatidylinositol-3-phosphate, Alix, and an ...

endosome Phosphatidylinositol 3-phosphate FYVE domain GRCh38: Ensembl release 89: ENSG00000102189 - Ensembl, May 2017 GRCm38: ... EEA1 binds directly to the phospholipid phosphatidylinositol 3-phosphate through its C-terminal FYVE domain and forms a ...

Its GRAM domain tethers it to the plasma membrane where it can bind phosphatidylinositol phosphate in areas enriched for it. ...

It dephosphorylates the D-5 position phosphate from phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and Phosphatidylinositol ...

The strongest phospholipid bonding the protein does is with phosphatidylinositol 4-phosphate, phosphatidylinositol 3,5- ... biphosphate and phosphatidylinositol 5-phosphate. GLUT1 5 is a protein that is recycled via the process of endosome-to-plasma ...

The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate ... and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly ...

Phosphatidyl inositol phosphates (PIPs), one of the most important lipid signaling molecules, is found to differ as the ... The mannose 6-phosphate receptor carries ligands from the Golgi destined for the lysosome by a similar mechanism. There are ... Markers include RAB7, RAB9, and mannose 6-phosphate receptors. In addition to this, the late endosomal membrane (and ... Molecules that follow these pathways include the mannose-6-phosphate receptors that carry lysosomal hydrolases to the endocytic ...

... when they discovered that radioactive 32P phosphate was incorporated into the phosphatidylinositol of pancreas slices when ... Phosphates at the 4th and 5th positions interact more extensively than the phosphate at the 1st position and the hydroxyl group ... see phosphoric acids and phosphates). This bond involves combining a hydroxyl group from the inositol ring and a free phosphate ... The pH of the solution, and thus the form of the phosphate group determines its ability to bind to other molecules. The binding ...

It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the ...

... and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. MTMR9 has been shown to ...

Once active, VPS34 phosphorylates the lipid phosphatidylinositol to generate phosphatidylinositol 3-phosphate (PtdIns(3)P) on ... Atg14L and the class III phosphatidylinositol 3-phosphate kinase (PI(3)K) Vps34. The active ULK and Beclin-1 complexes re- ... Beclin1 is generally required for phosphatidylinositol 3- phosphate production and as such it affects numerous lysosomal and ... Itakura E, Kishi C, Inoue K, Mizushima N (December 2008). "Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes ...

... regulates TRPV6 expression by enhancing phosphatidylinositol-3-phosphate-5-kinase PIKfyve (PIP5K3). This kinase is critical for ... TRPV6 channel activity is regulated by the intracellular level of phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) and ... Cao C, Zakharian E, Borbiro I, Rohacs T (February 2013). "Interplay between calmodulin and phosphatidylinositol 4,5- ...

1999). "Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle ...

Subrahmanyam G, Rudd CE, Schneider H (January 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 ... kinase, a key component in pathways of inositol phosphate turnover". European Journal of Immunology. 33 (1): 46-52. doi:10.1002 ... Lee DM, Patel DD, Pendergast AM, Haynes BF (August 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: ... "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". International Immunology. 8 (8 ...

"Ci-VSP is a depolarization-activated phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-3,4,5-trisphosphate 5'- ... Activity against the 3-phosphate of PI(3,4)P2 has also been demonstrated; this activity seems to become apparent at high ... The phosphatase domain in VSPs is highly homologous to the tumor suppressor PTEN, and acts to remove phosphate groups from ... Phospholipids such as inositol phosphates are signaling molecules which exert different effects depending on the pattern in ...