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*  Protein primary structure
glycosyl phosphatidylinositol (GPI) attachment Glycosyl phosphatidylinositol is a large, hydrophobic phospholipid prosthetic ... A phosphate group can be attached to the sidechain hydroxyl group of serine, threonine and tyrosine residues, adding a negative ... Arginine residues interact with the nucleic acid phosphate backbone and commonly form hydrogen bonds with the base residues, ... thence to sundry sugars and finally to the phosphatidylinositol lipid moiety. Finally, the peptide side chains can also be ...
*  Phosphatidylinositol phosphate
... may refer to: Phosphatidylinositol 3-phosphate, also known as PI(3)P Phosphatidylinositol 4- ... phosphate, also known as PI(4)P Phosphatidylinositol 5-phosphate, also known as PI(5)P. ...
*  Phosphatidylinositol phosphate kinases
... (PIPK) are kinases that phosphorylate the phosphoinositides PtdInsP and PtdInsP2 that ... The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell 2000 5:1-11. ... Phosphatidylinositol phosphate kinases, a multifaceted family of signalling enzymes. J Biol Chem 1999; 274:9907-9910 Kunz J, ... are derivatives of phosphatidylinositol (PtdIns). It has been found that PtdIns is only phosphorylated on three (3,4,5) of its ...
*  Phosphatidylinositol 4-phosphate
Phosphatidylinositol 3-phosphate Phosphatidylinositol 5-phosphate Phosphatidylinositol (3,4,5)-trisphosphate Godi A et al., ... Phosphatidylinositol 4-phosphate (PtdIns4P, PI-4-P, PI4P, or PIP) is a precursor of phosphatidylinositol (4,5)-bisphosphate. ... "Lipid Membrane Curvature Induced by Distearoyl Phosphatidylinositol 4-Phosphate". Soft Matter. 8: 3090-3093. doi:10.1039/ ... "Pressure-dependent inverse bicontinuous cubic phase formation in a phosphatidylinositol 4-phosphate/phosphatidylcholine system ...
*  Phosphatidylinositol 5-phosphate
Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and ... Phosphatidylinositol 4-phosphate and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate). Notably, steady-state PtdIns5P ... Phosphatidylinositol 5-phosphate is one of the 7 known cellular phosphoinositides with less understood functions. It is ... Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. J ...
*  Phosphatidylinositol 3-phosphate
... (PtdIns3P or PI3P) is a phospholipid found in cell membranes that helps to recruit a range of ... D J Gillooly; A Simonsen; H Stenmark (April 15, 2001). "Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain ... It is the product of both the class II and III phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol. ...
*  Phosphatidylinositol-4-phosphate 3-kinase
In enzymology, a phosphatidylinositol-4-phosphate 3-kinase (EC 2.7.1.154) is an enzyme that catalyzes the chemical reaction ATP ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase. Other names in ... This enzyme participates in phosphatidylinositol signaling system. As of late 2007, 3 structures have been solved for this ... the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 4-phosphate, whereas its two products are ADP and ...
*  1-phosphatidylinositol-4-phosphate 5-kinase
... phosphatidylinositol 4-phosphate kinase, phosphatidylinositol-4-phosphate 5-kinase, and type I PIP kinase. This enzyme ... In enzymology, 1-phosphatidylinositol-4-phosphate 5-kinase (EC 2.7.1.68) is an enzyme that catalyzes the chemical reaction ATP ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase. Other names in ... participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of ...
*  1-phosphatidylinositol-5-phosphate 4-kinase
In enzymology, a 1-phosphatidylinositol-5-phosphate 4-kinase (EC 2.7.1.149) is an enzyme that catalyzes the chemical reaction ... This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase. This enzyme is ... Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". ...
*  1-phosphatidylinositol-3-phosphate 5-kinase
... and phosphatidylinositol 3-phosphate 5-kinase. This enzyme participates in phosphatidylinositol signaling system and regulation ... In enzymology, a 1-phosphatidylinositol-3-phosphate 5-kinase (EC 2.7.1.150) is an enzyme that catalyzes the chemical reaction ... "The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae". Curr ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase. Other names in ...
*  Phosphatidylinositol-4-phosphate 5- kinases (PIP5K) in neuronal development
"Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain". The Journal of ... November 1999). "Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in ... Phosphatidylinositol 4-Phosphate-5 kinase (PI4P5K) or PIP5K or PI5K family regulates diverse cellular processes such as G ... Both Type I and Type II phosphatidylinositol-4-phosphate 5-kinase (PIP5KI) are further classified as PIP5Kα, PIP5Kβ and PIP5Kγ ...
*  Phytase
Conway SJ, Miller GJ (2007). "Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives". Nat Prod ... The organic phosphate found in phytic acid is largely unavailable to the animals that consume it, but the inorganic phosphate ... phenyl phosphate, fructose 1,6-bisphosphate, glucose 6-phosphate, glycerophosphate and 3-phosphoglycerate. Only a few phytases ... Phytases hydrolyze phosphates from phytic acid in a stepwise manner, yielding products that again become substrates for further ...
*  Andrew Bruce Holmes
"Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes". Organic & Biomolecular Chemistry. 8 (1 ...
*  TLN1
Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA (Nov 2002). "Type I gamma phosphatidylinositol phosphate kinase ... "Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin". Nature. 420 ( ...
*  TLN2
Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA (Nov 2002). "Type I gamma phosphatidylinositol phosphate kinase ... "Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin". Nature. 420 ( ... the major phosphatidylinositol 4,5-bisphosphate-synthesizing enzyme of the brain. In patients with temporal lobe epilepsy, ... coordinating phosphatidylinositol synthesis, and modulating actin dynamics through interactions with PIP kinase type 1γ, ...
*  PIP5K1C
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma is an enzyme that in humans is encoded by the PIP5K1C gene. This gene ... 2007). "Type Igamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct ... "Entrez Gene: PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma". "Salmonella infection data for Pip5k1c". ... 2006). "Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis". J. Biol. ...
*  PIP5K1A
Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene. GRCh38: ... "Entrez Gene: PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha". Honda A, Nogami M, Yokozeki T, et al. (1999). " ... 2000). "Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible ... Xie Y, Zhu L, Zhao G (Jun 2000). "Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome ...
*  Phosphatidylinositol 4,5-bisphosphate
PIP2 is formed primarily by the type I phosphatidylinositol 4-phosphate 5-kinases from PI(4)P. In metazoans, PIP2 can also be ... "Exploring phosphatidylinositol 5-phosphate 4-kinase function". Adv Biol Regul. 57: 193-202. doi:10.1016/j.jbior.2014.09.007. ... 2005). "Phosphatidylinositol phosphate kinase type Iγ regulates dynamics of large dense-core vesicle fusion". PNAS. 102: 5204- ... Phosphatidylinositol 4,5-bisphosphate or PtdIns(4,5)P2, also known simply as PIP2 or PI(4,5)P2, is a minor phospholipid ...
*  PIP4K2B
Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene. The protein ... "Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta". Niiro H, Clark EA (2003). "Branches of the B ... This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show ... 2007). "Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear ...
*  SNAP91
"ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma ...
*  PI(4,5)P2 Cycle
... and caspase inactivation of phosphatidylinositol phosphate 5-kinases". The Journal of Biological Chemistry. 276 (3): 1865-1872 ... Generated CDP-DAG then condensed to PI by phosphatidylinositol synthase. This PI is then phosphorylated to PI4P and back to ... Bankaitis, Vytas A.; Grabon, Aby (15 November 2011). "Phosphatidylinositol Synthase and Diacylglycerol Platforms Bust a Move". ... "CDP-Diacylglycerol Synthetase Coordinates Cell Growth and Fat Storage through Phosphatidylinositol Metabolism and the Insulin ...
*  PIK3C2A
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide is an enzyme that in humans is encoded by the ... A source of phosphatidylinositol 3-phosphate". J. Biol. Chem. 273 (23): 14081-14084. doi:10.1074/jbc.273.23.14081. PMID 9603905 ... Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a ... 1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat ...
*  PIKFYVE
Sbrissa D, Ikonomov OC, Deeb R, Shisheva A (2002). "Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is ... PIKfyve activity is responsible for the production of both PtdIns(3,5)P2 and phosphatidylinositol 5-phosphate (PtdIns5P). ... Sbrissa D, Ikonomov OC, Deeb R, Shisheva A (December 2002). "Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve ... Cabezas A, Pattni K, Stenmark H (April 2006). "Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate ...
*  PIP4K2A
"Entrez Gene: PIP5K2A phosphatidylinositol-4-phosphate 5-kinase, type II, alpha". Xu H, Yang W, Perez-Andreu V, Devidas M, Fan Y ... Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha is an enzyme that in humans is encoded by the PIP4K2A gene. ... This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. Through genome wide association studies (GWAS), ... Loijens JC, Boronenkov IV, Parker GJ, Anderson RA (1996). "The phosphatidylinositol 4-phosphate 5-kinase family". Advances in ...
*  Inositol
... and its various phosphates, the phosphatidylinositol phosphate (PIP) lipids. Inositol or its phosphates and associated lipids ... First, G-6-P is isomerised by an inositol-3-phosphate synthase enzyme (for example, ISYNA1) to myo-inositol 1-phosphate, which ... Inositol, phosphatidylinositol and some of their mono- and polyphosphates function as secondary messengers in a number of ... Myo-inositol (free of phosphate) was once considered a member of the vitamin B complex, called Vitamin B8 in this context. ...
*  ENTH domain
The lipid ligand is coordinated by residues from surrounding alpha-helices and all three phosphates are multiply coordinated. ... In particular, epsin-1 shows specificity for the membrane glycophospholipid phosphatidylinositol-4,5-bisphosphate, however not ...
*  HGS (gene)
"Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells". EMBO J. 19 (17): 4577-88. doi:10.1093/emboj/ ...