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*  PTPRN2
Specifically, phogrin was shown to act upon phosphatidylinositol 3-phosphate and Phosphatidylinositol 4,5-diphosphate, whereas ... Phosphorylated forms of phosphatidylinositol (PI) are called phosphoinositides and play important roles in lipid signaling, ... "The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion". J. ... 151 (5): 985-1002. doi:10.1083/jcb.151.5.985. PMC 2174349 . PMID 11086001. Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, ...
*  List of MeSH codes (D10)
... phosphatidylinositol phosphates MeSH D10.570.755.375.760.400.942.625.900 --- phosphatidylinositol 4,5-diphosphate MeSH D10.570. ... phosphatidylinositols MeSH D10.570.755.375.760.400.942.250 --- glycosylphosphatidylinositols MeSH D10.570.755.375.760.400. ... prosta-5,13-dienoic acid MeSH D10.251.355.255.550.100 --- prostaglandins a MeSH D10.251.355.255.550.150 --- prostaglandins b ... 12-hydroxy-5,8,10,14-eicosatetraenoic acid MeSH D10.251.355.255 --- eicosanoids MeSH D10.251.355.255.049 --- 5,8,11,14- ...
*  PI(4,5)P2 Cycle
Generated CDP-DAG then condensed to PI by phosphatidylinositol synthase. This PI is then phosphorylated to PI4P and back to ... Furthermore, CDP-diacylglycerol synthetase uses CTP to create cytidine diphosphate diacylglycerol from PA. ... Bankaitis, Vytas A.; Grabon, Aby (15 November 2011). "Phosphatidylinositol Synthase and Diacylglycerol Platforms Bust a Move". ... Christie, William (Bill) W. "Cytidine Diphosphate Diacylglycerol (CDP-DAG), phospholipid biosynthesis - composition and ...
*  List of EC numbers (EC 3)
... phosphatidylinositol-3-phosphatase EC 3.1.3.65: now with EC 3.1.3.64 EC 3.1.3.66: phosphatidylinositol-3,4-bisphosphate 4- ... diacylglycerol diphosphate phosphatase EC 3.1.3.82: D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase EC 3.1.3.83: ... diphosphate) 3'-diphosphatase EC 3.1.7.3: monoterpenyl-diphosphatase EC 3.1.7.4: sclareol cyclase EC 3.1.7.5: geranylgeranyl ... phosphatidylinositol deacylase EC 3.1.1.53: sialate O-acetylesterase EC 3.1.1.54: acetoxybutynylbithiophene deacetylase EC 3.1. ...
*  Kinase
The end result is a phosphatidylinositol-3-phosphate as well as adenosine diphosphate (ADP). The enzymes can also help to ... Phosphatidylinositol kinases phosphorylate phosphatidylinositol species, to create species such as phosphatidylinositol 3,4- ... and phosphatidylinositol 3-phosphate (PI3P). The kinases include phosphoinositide 3-kinase (PI3K), phosphatidylinositol-4- ... Nucleoside diphosphate kinase catalyzes production of thymidine triphosphate, dTTP, which is used in DNA synthesis. Because of ...
*  Chromosome 8 (human)
... phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 PROSC: proline synthetase co-transcribe bacterial ... member H FBXO16 encoding protein F-box protein 16 FDFT1 encoding protein Farnesyl-diphosphate farnesyltransferase 1 FGFR1: ... 439 (7074): 331-5. Bibcode:2006Natur.439..331N. doi:10.1038/nature04406. PMID 16421571. CS1 maint: Explicit use of et al. (link ... 5 (4): 345-54. doi:10.1089/109065701753617516. PMID 11960583. Nusbaum C; et al. (2006). "DNA sequence and analysis of human ...
*  Neomycin
... exhibits a high binding affinity for phosphatidylinositol 4,5-bisphosphate (PIP2), which is a phospholipid component ... "Binding of Neomycin to Phosphatidylinositol 4,5-Biphosphate (PIP 2)." BBA − Biomembranes 979.1 (1989): 105-12. CrossRef. Web. ... 28 (5 Pt 1): 934-9. doi:10.1172/JCI102182. PMC 438928 . PMID 16695766. Hellman, L. M. "Neomycin, a New Antibiotic Active ... Page 4).: John Wiley and Sons Ltd. pp. 508, 510, 511. ISBN 978-0-470-74168-9. Kudo, Fumitaka; Yamamoto, Yasuhito; Yokoyama, ...
*  Walker motifs
... signaling Cyclin-dependent kinase G protein-coupled receptor Nucleoside-diphosphate kinase Phosphatase Phosphatidylinositol ... Walker et al reported the consensus sequence of this motif to be [RK]-x(4)-G-x(4)-LhhhhD, where R, K, G, L and D denote ... 15 (11): 430-4. doi:10.1016/0968-0004(90)90281-f. PMID 2126155. Zhang M, Stauffacher CV, Lin D, Van Etten RL (August 1998). " ... 580 (4): 1049-55. doi:10.1016/j.febslet.2005.12.051. PMID 16412422. Koonin EV (June 1993). "A common set of conserved motifs in ...
*  Bisphosphate
... phosphate Phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153), an enzyme that catalyzes the chemical reaction ATP + 1 ... 6-diphosphate), abbreviated Fru-2,6-P2, a metabolite which allosterically affects the activity of the enzymes ... phosphate Phosphatidylinositol (3,4)-bisphosphate (PtdIns(3,4)P2), a minor phospholipid component of cell membranes, yet an ... a minor phospholipid component of cell membranes Phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66), an enzyme ...
*  List of EC numbers (EC 2)
... chrysanthemyl diphosphate synthase EC 2.5.1.68: (2Z,6E)-farnesyl diphosphate synthase EC 2.5.1.69: lavandulyl diphosphate ... phosphatidylinositol 3-kinase EC 2.7.1.138: ceramide kinase EC 2.7.1.139: now with EC 2.7.1.134 EC 2.7.1.140: inositol- ... farnesyl-diphosphate specific) EC 2.5.1.84: all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) EC 2.5. ... farnesyl diphosphate specific) EC 2.5.1.88: trans,polycis-polyprenyl diphosphate synthase ((2Z,6E)-farnesyl diphosphate ...
*  Housekeeping gene
Nucleoside diphosphate kinase NONO P4HB PRDX1 peroxiredoxin (reduces peroxides) PTMA Prothymosin RPA2 Binds DNA during ... GNAI2 HAX1 associated with tyrosine kinases ILK Integrin linked kinase MAPKAPK2 MAP2K2 MAP3K11 PITPNM Phosphatidylinositol ... 23 (4): 387-388. doi:10.1038/70487. PMID 10581018. Hsiao LL, Dangond F, Yoshida T, Hong R, Jensen RV, Misra J, Dillon W, Lee KF ... ATF1 NM_005171 ATF2 NM_001880 ATF4 Activating transcription factor 4 NM_001675 ATF6 NM_007348 ATF7 NM_001206682 ATF7IP NM_ ...
*  COL4A3BP
"Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi". Cell. 114 (3): 299-310. ... 17 (3): 320-5. PMID 16970251. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, ... 14 (4): 434-47. doi:10.1016/S0955-0674(02)00357-5. PMID 12383794. Levine TP, Munro S (Apr 2002). "Targeting of Golgi-specific ... The isomers of PIPs are distributed to various organelles: PI-4,5-diphosphate goes to the plasma membrane, PI-3-monophosphate ...
*  Dock180
In their resting state G proteins are bound to Guanosine diphosphate (GDP) and their activation requires the dissociation of ... "The CDM Superfamily Protein MBC Directs Myoblast Fusion through a Mechanism That Requires Phosphatidylinositol 3,4,5- ... 15 (4): 371-77. doi:10.1016/j.cub.2005.01.050. PMID 15723800. Makino Y, Tsuda M, Ichihara S, et al. (March 2006). "Elmo1 ... 16 (4): 1770-6. PMC 231163 . PMID 8657152. Nishihara H, Kobayashi S, Hashimoto Y, Ohba F, Mochizuki N, Kurata T, Nagashima K, ...
*  List of EC numbers (EC 4)
... farnesyl diphosphate cyclizing) EC 4.2.3.51: beta-phellandrene synthase (neryl-diphosphate-cyclizing) EC 4.2.3.52: (4S)-beta- ... phosphatidylinositol diacylglycerol-lyase EC 4.6.1.14: glycosylphosphatidylinositol diacylglycerol-lyase EC 4.6.1.15: FAD-AMP ... farnesyl diphosphate cyclizing) EC 4.2.3.54: (-)-endo-alpha-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing) EC ... copal-8-ol diphosphate hydratase EC 4.2.1.134: very-long-chain (3R)-3-hydroxyacyl-(acyl-carrier protein) dehydratase EC 4.2. ...
*  List of MeSH codes (D08)
1-phosphatidylinositol 3-kinase MeSH D08.811.913.696.620.550 --- 1-phosphatidylinositol 4-kinase MeSH D08.811.913.696.620.650 ... ribonucleoside diphosphate reductase MeSH D08.811.682.830.249 --- electron transport complex ii MeSH D08.811.682.830.249.500 ... phosphatidylinositol diacylglycerol-lyase MeSH D08.811.277.352.640.700.700.750 --- phospholipase c gamma MeSH D08.811.277.352. ... nucleoside-diphosphate kinase MeSH D08.811.913.696.650.575 --- nucleoside-phosphate kinase MeSH D08.811.913.696.900 --- ...
*  Cell surface receptor
In response to receptor activation, the α subunit releases bound guanosine diphosphate (GDP), which is displaced by guanosine ... the cAMP signaling pathway and the phosphatidylinositol signaling pathway. Both are mediated via G protein activation. The G- ... 7 (4): 210-214. doi:10.1159/000106881. PMID 8835885. Wang R.; Gao Y.; Lai L. (2000). "LigBuilder: A Multi-Purpose Program for ... 4 (8): 649-663. doi:10.1038/nrd1799. PMID 16056391. Jorgensen W.L. (2004). "The Many Roles of Computation in Drug Discovery". ...
*  G protein-coupled receptor
The lipase hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into two second messengers: inositol 1,4,5-trisphosphate ( ... that is rendered inactive when reversibly bound to Guanosine diphosphate (GDP) (or, alternatively, no guanine nucleotide) but ... In the phosphatidylinositol signal pathway, the extracellular signal molecule binds with the G-protein receptor (Gq) on the ... the cAMP signal pathway and the phosphatidylinositol signal pathway. When a ligand binds to the GPCR it causes a conformational ...
*  RhoG
Yamaki N, Negishi M, Katoh H (August 2007). "RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism ... Guanosine diphosphate). Three classes of protein interact with RhoG to regulate GTP/GDP loading. The first are known as Guanine ... 113 (Pt 4): 729-39. PMID 10652265. Bellanger JM, Lazaro JB, Diriong S, Fernandez A, Lamb N, Debant A (January 1998). "The two ... 4 (8): 574-82. doi:10.1038/ncb824. PMID 12134158. Lu M, Kinchen JM, Rossman KL, Grimsley C, deBakker C, Brugnera E, Tosello- ...
*  DNA repair
PARP1 synthesizes polymeric adenosine diphosphate ribose (poly (ADP-ribose) or PAR) chains on itself. Next the chromatin ... Checkpoint Proteins can be separated into four groups: phosphatidylinositol 3-kinase (PI3K)-like protein kinase, proliferating ... 24 (4): 849-60. doi:10.1038/sj.emboj.7600563. PMC 549622 . PMID 15692565. Wang H, Perrault AR, Takeda Y, Qin W, Wang H, Iliakis ... 5 (5): 503-9. doi:10.1038/sj.embor.7400127. PMC 1299048 . PMID 15105825. De Boer, J; Andressoo, JO; De Wit, J; Huijmans, J; ...