Phosphatidylinositol-4-phosphate 3-kinase
In enzymology, a phosphatidylinositol-4-phosphate 3-kinase (EC 2.7.1.154) is an enzyme that catalyzes the chemical reaction ATP ... This enzyme participates in phosphatidylinositol signaling system. As of late 2007, 3 structures have been solved for this ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase. Other names in ... PC, Woscholski R, Parker PJ, Waterfield MD (2001). "Synthesis and function of 3-phosphorylated inositol lipids". Annu. Rev. ...
Phosphatidylinositol 3-kinase-related kinase
... are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks). The human PIKK ... Pfam PF02259 kinase domain (KD; PI3_PI4_kinase), PIKK- regulatory domain (PRD), and C-terminus FAT-C-terminal (FATC) domain ... Kinase Family PIKK at WikiKinome. Portal: Biology v t e (Articles with short description, Short description matches Wikidata, ...
1-phosphatidylinositol-3-phosphate 5-kinase
Other names in common use include type III PIP kinase, and phosphatidylinositol 3-phosphate 5-kinase. This enzyme participates ... In enzymology, a 1-phosphatidylinositol-3-phosphate 5-kinase (EC 2.7.1.150) is an enzyme that catalyzes the chemical reaction ... "The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae". ... in phosphatidylinositol signaling system and regulation of actin cytoskeleton. Cooke FT, Dove SK, McEwen RK, Painter G, Holmes ...
Phosphatidylinositol-4,5-bisphosphate 3-kinase
In enzymology, a phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153) is an enzyme that catalyzes the chemical ... Human genes encoding proteins with phosphatidylinositol-4,5-bisphosphate 3-kinase activity include: PIK3CA PIK3CB PIK3CD PIK3CG ... phosphatidylinositol signaling system, mtor signaling pathway, apoptosis, VEGF signaling pathway, focal adhesion, toll-like ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase. This ...
Phosphatidylinositol-4-phosphate 5-kinase
Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) Phosphatidylinositol-5-phosphate 4-kinase type-2 beta (PIP4K2B ... Phosphatidylinositol-4-phosphate 5-kinases (PIP5Ks, or PI4P5Ks) are a class of enzymes that phosphorylate phosphatidylinositol ... September 2010). "Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain ... Type I phosphatidylinositol-4-phosphate 5-kinase (PIP5KI) are further classified as PIP5Kα, PIP5Kβ and PIP5Kγ on the basis of ...
1-phosphatidylinositol-4-phosphate 5-kinase
PIP kinase, phosphatidylinositol 4-phosphate kinase, phosphatidylinositol-4-phosphate 5-kinase, and type I PIP kinase. This ... In enzymology, 1-phosphatidylinositol-4-phosphate 5-kinase (EC 2.7.1.68) is an enzyme that catalyzes the chemical reaction ATP ... Kai M, Salway JG, Hawthorne JN (1968). "The diphosphoinositide kinase of rat brain". Biochem. J. 106 (4): 791-801. doi:10.1042/ ... Other names in common use include diphosphoinositide kinase, ... "A new pathway for synthesis of phosphatidylinositol-4,5- ...
1-phosphatidylinositol 4-kinase
... phosphatidylinositol 4-kinase, phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. ... "Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate". Nature. 332 (6165): ... In enzymology, a 1-phosphatidylinositol 4-kinase (EC 2.7.1.67) is an enzyme that catalyzes the chemical reaction ATP + 1- ... Kai M, White GL, Hawthorne JN (1966). "The phosphatidylinositol kinase of rat brain". Biochem. J. 101 (2): 328-37. doi:10.1042/ ...
1-phosphatidylinositol-5-phosphate 4-kinase
In enzymology, a 1-phosphatidylinositol-5-phosphate 4-kinase (EC 2.7.1.149) is an enzyme that catalyzes the chemical reaction ... This enzyme is also called type II PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism ... Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". ... phosphatidylinositol signaling system, and regulation of actin cytoskeleton. ...
Phosphoinositide 3-kinase
"Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate". Nature. 332 (6165): ... Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM (1985). "Association of phosphatidylinositol kinase activity with ... Many of these mutations cause the kinase to be more active. It is the single most mutated kinase in glioblastoma, the most ... While in vitro, they have also been shown to convert phosphatidylinositol (PI) into phosphatidylinositol 3-phosphate (PI3P) and ...
Kinase
Phosphatidylinositol kinases phosphorylate phosphatidylinositol species, to create species such as phosphatidylinositol 3,4- ... Kinases are classified into broad groups by the substrate they act upon: protein kinases, lipid kinases, carbohydrate kinases. ... The protein kinases make up the majority of all kinases and are widely studied. These kinases, in conjunction with phosphatases ... kinase G protein-coupled receptor Nucleoside-diphosphate kinase Phosphatase Phosphatidylinositol phosphate kinases Phospholipid ...
Phosphoinositide 3-kinase inhibitor
January 2015). "First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K ... Sabbah DA, Hajjo R, Bardaweel SK, Zhong HA (October 2021). "Phosphatidylinositol 3-kinase (PI3K) inhibitors: a recent update on ... Umbralisib (trade name Ukoniq; codenamed TGR-1202, Rp-5264; PIK3CD and casein kinase CSNK1E inhibitor): FDA-approved in ... Ito K, Caramori G, Adcock IM (April 2007). "Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory ...
PI4KB
... phosphatidylinositol 4-kinase beta (PI4KB) phosphatidylinositol 4-kinase 2-alpha (PI4K2A) phosphatidylinositol 4-kinase 2-beta ... Phosphatidylinositol 4-kinases are evolutionary conserved among eukaryotes and include four human isoforms phosphatidylinositol ... This gene encodes a phosphatidylinositol 4-kinase which catalyzes phosphorylation of phosphatidylinositol at the D-4 position, ... "Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the ...
PASLI disease
... is caused by gain-of-function mutations in the gene PIK3CD, which stands for phosphatidylinositol 3-kinase, ... Specific p110δ mutants cause stronger binding to membranes and relieve inhibition of the kinase by regulatory proteins. These ... "OMIM: PHOSPHATIDYLINOSITOL 3-KINASE, CATALYTIC, DELTA; PIK3CD". OMIM. Johns Hopkins University. Retrieved December 8, 2018. ... and a kinase domain. Mutations have been identified in multiple domains, although there seems to be a recurrent transition ...
Class III PI 3-kinase
In vivo Vps34 can phosphorylate only phosphatidylinositol to form phosphatidylinositol (3)-phosphate (PtdIns(3)P). Vps34 was ... Vps34 has been shown to interact with Vps15 (PIK3R4, p150), a protein kinase. Vps15 can activate the lipid kinase activity of ... Vps34 is more accurately described as a phosphatidylinositol 3-kinase. ... Class III PI 3-kinase is a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain ...
Interleukin 1 receptor, type I
"Entrez Gene: IL1R1 interleukin 1 receptor, type I". Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3- ... kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 ... Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to ... Reddy SA, Huang JH, Liao WS (1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the ...
Inositol-tetrakisphosphate 5-kinase
This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. Shears SB (1989). "The ... In enzymology, an inositol-tetrakisphosphate 5-kinase (EC 2.7.1.140) is an enzyme that catalyzes the chemical reaction ATP + 1D ... This enzyme is also called 1D-myo-inositol-tetrakisphosphate 5-kinase. ... 5-kinases". J. Biol. Chem. 277 (45): 42711-8. doi:10.1074/jbc.M209112200. PMID 12226109. Portal: Biology v t e (EC 2.7.1, ...
P70-S6 Kinase 1
... and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase". Nature. 370 (6484): 71-75. Bibcode: ... It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway ... Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein ... "Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and ...
Ceramide kinase
... has also been demonstrated to regulate localization and level of phosphatidylinositol 4,5-bisphosphate (PIP2) ... Sugiura M, Kono K, Liu H, Shimizugawa T, Minekura H, Spiegel S, Kohama T (June 2002). "Ceramide kinase, a novel lipid kinase. ... Bajjalieh SM, Martin TF, Floor E (August 1989). "Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co- ... "Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction". Proc. Natl. Acad. ...
PIK3R2
"Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". The Journal of ... Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene. A recent study ... June 1997). "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking- ... April 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 ...
Ataxia telangiectasia and Rad3 related
It is a large kinase of about 301.66 kDa. ATR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. ATR ... kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment ... Serine/threonine-protein kinase ATR, also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein ... Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J (April 2005). "Rheb binds and regulates the mTOR kinase". Current Biology. 15 ...
PIK3R5
Metjian A, Roll RL, Ma AD, Abrams CS (1999). "Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A ... Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene. PIK3R5 has been shown ... 2005). "p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma". Curr. Biol. 15 ... "Entrez Gene: PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5, p101". Johnson C, Marriott SJ, Levy LS (2007). " ...
Neuroblastoma RAS viral oncogene homolog
1995). "The activation of phosphatidylinositol 3-kinase by Ras". Curr. Biol. 4 (9): 798-806. doi:10.1016/S0960-9822(00)00177-9 ... 48 (4): 950-3. PMID 3276402. Hirai H, Kobayashi Y, Mano H, et al. (1987). "A point mutation at codon 13 of the N-ras oncogene ... 5 (3): 582-5. doi:10.1128/mcb.5.3.582. PMC 366752. PMID 3887133. Brown R, Marshall CJ, Pennie SG, Hall A (1984). "Mechanism of ... 299 (5879): 171-3. Bibcode:1982Natur.299..171M. doi:10.1038/299171a0. PMID 6287287. S2CID 4342747. Shimizu K, Goldfarb M, ...
Protein kinase B
In the case of the PH domain of the Akt proteins, it binds either PIP3 (phosphatidylinositol (3,4,5)-trisphosphate, PtdIns(3,4, ... including integrin-linked kinase (ILK) and mitogen-activated protein kinase-activated protein kinase-2 (MAPKAPK2) can also ... Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases ... Glycogen synthase kinase 3 (GSK-3) could be inhibited upon phosphorylation by Akt, which results in increase of glycogen ...
Bruton's tyrosine kinase
Btk contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces Btk to ... Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is ... "Bruton's tyrosine kinase (Btk) associates with protein kinase C mu". FEBS Letters. 461 (1-2): 68-72. doi:10.1016/S0014-5793(99) ... Bruton's tyrosine kinase has been shown to interact with: ARID3A BLNK (SLP-65), CAV1, GNAQ, GTF2I, PLCG2, PRKD1, and SH3BP5. ...
PIK3R4
... also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 ... Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex". J. Biol. Chem. 272 (4): ... an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. ... J. 417 (3): 747-55. doi:10.1042/BJ20081865. PMC 2652830. PMID 18957027. Portal: Biology v t e (Articles with short description ...
Estrogen receptor alpha
March 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates ... Interaction of estrogen receptor alpha with phosphatidylinositol 3-OH kinase". Steroids. 67 (12): 935-939. doi:10.1016/S0039- ... Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor". Cell Stress & Chaperones. 1 (4 ... monophosphate-dependent protein kinase". Endocrinology. 149 (9): 4336-4345. doi:10.1210/en.2008-0037. PMID 18499756. Wong CW, ...
IRS2
The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an ... Izuhara K, Harada N (1997). "Interleukin-4 activates two distinct pathways of phosphatidylinositol-3 kinase in the same cells ... Potential role of JAK kinases". J. Biol. Chem. 270 (48): 28527-30. doi:10.1074/jbc.270.48.28527. PMID 7499365. Patti ME, Sun XJ ... and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. ...
RhoG
Yamaki N, Negishi M, Katoh H (August 2007). "RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism ... Phospholipase D1 and the MAP Kinase activator MLK3. RhoG has been shown to interact with KTN1. GRCh38: Ensembl release 89: ... 22 (3): 330-42. doi:10.1038/sj.onc.1206116. PMID 12545154. Katoh H, Yasui H, Yamaguchi Y, Aoki J, Fujita H, Mori K, Negishi M ( ... Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B (November 1996). "RhoGDI-3 is a new GDP ...
Proteases in angiogenesis
2005). "Distinct roles of the receptor tyrosine kinases Tie1 and Tie2 in blood vessel formation". Cell. 123 (2): 291-304. doi: ... Kumar, P; Amin, MA; Harlow, LA; Polverini, PJ; Koch, AE (2003). "Src and phosphatidylinositol 3-kinase mediate soluble E- ... 1995). "Distinct roles of the receptor tyrosine kinases Tie1 and Tie2 in blood vessel formation". Nature. 376 (6535): 70-74. ... and modulate the activity of focal adhesion kinase (FAK). Endostatin is a 20 kDa fragment of collagen XVIII. The major role of ...
AKT1
"Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and ... It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a ... Chan TO, Rittenhouse SE, Tsichlis PN (2000). "AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by ... "Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation ...