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*  Protein kinase C
It is presumed that this is achieved by the production of diacylglycerol from phosphatidylinositol by a phospholipase; fatty ... Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in ... The consensus sequence of protein kinase C enzymes is similar to that of protein kinase A, since it contains basic amino acids ... Serine/threonine-specific protein kinase Signal transduction Yasutomi Nishizuka, discovered protein kinase C Wilson CH, Ali ES ...
*  Phosphatidylinositol 3-kinase-related kinase
... are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks). The human PIKK ... Pfam PF02259 kinase domain (KD; PI3_PI4_kinase), PIKK- regulatory domain (PRD), and C-terminus FAT-C-terminal (FATC) domain ... Kinase Family PIKK at WikiKinome. Molecular and Cellular Biology portal. ...
*  Phosphatidylinositol-4-phosphate 3-kinase
In enzymology, a phosphatidylinositol-4-phosphate 3-kinase (EC 2.7.1.154) is an enzyme that catalyzes the chemical reaction ATP ... This enzyme participates in phosphatidylinositol signaling system. As of late 2007, 3 structures have been solved for this ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase. Other names in ... PC, Woscholski R, Parker PJ, Waterfield MD (2001). "Synthesis and function of 3-phosphorylated inositol lipids". Annu. Rev. ...
*  1-phosphatidylinositol-3-phosphate 5-kinase
Other names in common use include type III PIP kinase, and phosphatidylinositol 3-phosphate 5-kinase. This enzyme participates ... In enzymology, a 1-phosphatidylinositol-3-phosphate 5-kinase (EC 2.7.1.150) is an enzyme that catalyzes the chemical reaction ... "The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae". Curr ... in phosphatidylinositol signaling system and regulation of actin cytoskeleton. RH, Parker PJ; Dove, SK; McEwen, RK; Painter, G ...
*  Phosphatidylinositol-4,5-bisphosphate 3-kinase
In enzymology, a phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153) is an enzyme that catalyzes the chemical ... Human genes encoding proteins with phosphatidylinositol-4,5-bisphosphate 3-kinase activity include: PIK3CA PIK3CB PIK3CD PIK3CG ... phosphatidylinositol signaling system, mtor signaling pathway, apoptosis, VEGF signaling pathway, focal adhesion, toll-like ... The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase. This ...
*  Interleukin 1 receptor, type I
Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to ... Reddy SA, Huang JH, Liao WS (1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the ... "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement ...
*  PASLI disease
"OMIM: PHOSPHATIDYLINOSITOL 3-KINASE, CATALYTIC, DELTA; PIK3CD". Retrieved 2014. Check date values in: ,access-date= (help) Seki ... Specific p110δ mutants cause stronger binding to membranes and relieve inhibition of the kinase by regulatory proteins. These ... PASLI disease is caused by gain-of-function mutations in the gene PIK3CD, which stands for phosphatidylinositol 3-kinase, ... and a kinase domain. Mutations have been identified in multiple domains, although there seems to be a recurrent transition ...
*  PIK3R2
"Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". The Journal of ... Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene. PIK3R2 has ... August A, Dupont B (May 1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase". International Immunology ... a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene. 7 (4): 789-93. PMID 1314371. "Entrez Gene: ...
*  PIK3R5
Metjian A, Roll RL, Ma AD, Abrams CS (1999). "Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A ... Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene. PIK3R5 has been shown ... 2005). "p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma". Curr. Biol. 15 ... "Entrez Gene: PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5, p101". Johnson C, Marriott SJ, Levy LS (2007). " ...
*  Neuroblastoma RAS viral oncogene homolog
1995). "The activation of phosphatidylinositol 3-kinase by Ras". Curr. Biol. 4 (9): 798-806. doi:10.1016/S0960-9822(00)00177-9 ... 48 (4): 950-3. PMID 3276402. Hirai H, Kobayashi Y, Mano H, et al. (1987). "A point mutation at codon 13 of the N-ras oncogene ... 5 (3): 582-5. PMC 366752 . PMID 3887133. Brown R, Marshall CJ, Pennie SG, Hall A (1984). "Mechanism of activation of an N-ras ... 299 (5879): 171-3. doi:10.1038/299171a0. PMID 6287287. Shimizu K, Goldfarb M, Perucho M, Wigler M (January 1983). "Isolation ...
*  Transformation/transcription domain-associated protein
TRRAP belongs to the phosphatidylinositol 3-kinase-related kinase protein family. TRRAP is an adapter protein, which is found ... 4 (3): 383-7. doi:10.4161/cc.4.3.1546. PMID 15711126. Murr R, Vaissière T, Sawan C, Shukla V, Herceg Z (2007). "Orchestration ... 3 (2): 217-23. doi:10.1002/pmic.200390030. PMID 12601814. Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (2003). "c-Myc ... 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. ...
*  IRS2
The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an ... Izuhara K, Harada N (1997). "Interleukin-4 activates two distinct pathways of phosphatidylinositol-3 kinase in the same cells ... Potential role of JAK kinases". J. Biol. Chem. 270 (48): 28527-30. doi:10.1074/jbc.270.48.28527. PMID 7499365. Patti ME, Sun XJ ... and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. ...
*  RhoG
Yamaki N, Negishi M, Katoh H (August 2007). "RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism ... Phospholipase D1 and the MAP Kinase activator MLK3. RhoG has been shown to interact with KTN1. GRCh38: Ensembl release 89: ... 22 (3): 330-42. doi:10.1038/sj.onc.1206116. PMID 12545154. Katoh H, Yasui H, Yamaguchi Y, Aoki J, Fujita H, Mori K, Negishi M ( ... Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B (November 1996). "RhoGDI-3 is a new GDP ...
*  Proteases in angiogenesis
2005). "Distinct roles of the receptor tyrosine kinases Tie1 and Tie2 in blood vessel formation". Cell. 123 (2): 291-304. doi: ... Kumar, P; Amin, MA; Harlow, LA; Polverini, PJ; Koch, AE (2003). "Src and phosphatidylinositol 3-kinase mediate soluble E- ... 1995). "Distinct roles of the receptor tyrosine kinases Tie1 and Tie2 in blood vessel formation". Nature. 376 (6535): 70-74. ... and modulate the activity of focal adhesion kinase (FAK). Endostatin is a 20 kDa fragment of collagen XVIII. The major role of ...
*  AKT1
"Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and ... It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a ... Chan TO, Rittenhouse SE, Tsichlis PN (2000). "AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by ... "Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation ...
*  Ataxia telangiectasia and Rad3 related
... kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment ... ATR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. ATR is activated in response to single strand ... Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein ... Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J (Apr 2005). "Rheb binds and regulates the mTOR kinase". Current Biology. 15 ( ...
*  BECN1
Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T (Apr 2001). "Beclin-phosphatidylinositol 3-kinase complex functions at the trans- ... "Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1". The Journal of ... "Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex ... 3 (6): 561-8. doi:10.4161/auto.4713. PMID 17643073. Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N (Aug 2002). "A ...
*  PDK4
It codes for an isozyme of pyruvate dehydrogenase kinase. This gene is a member of the PDK/BCKDK protein kinase family and ... This is done through a proposed phosphatidylinositol 3-kinase-dependent pathway. In fact, even when cells are exposed to ... Kwon HS, Huang B, Unterman TG, Harris RA (Apr 2004). "Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 ... Pyruvate dehydrogenase lipoamide kinase isozyme 4, mitochondrial is an enzyme that in humans is encoded by the PDK4 gene. ...
*  Phosphoinositide 3-kinase inhibitor
Copanlisib (Inhibitor of phosphatidylinositol-3-kinase, predominantly against PI3K-α and PI3K-δ) FDA approved in September 2017 ... "Semafore's PI3 Kinase Inhibitor SF1126 Is A Vascular Targeted Conjugate In Phase I Clinical Trials In Solid Tumors And Multiple ... "First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in ... Clinical trial number NCT00974584 for "A Study of the Safety and Pharmacology of PI3-Kinase Inhibitor GDC-0941 in Combination ...
*  SMG1
"Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein". J ... Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene. SMG1 belongs to the ... The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 ... Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT (1998). "Localization of atypical protein kinase C isoforms into ...
*  DDIT4
... acts as a negative regulator of mTOR, a serine/threonine kinase that regulates a variety of cellular functions such as ... "REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase". Oncogene. 24 (7): 1138-49. ... 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614. Kim JR, Lee SR, Chung HJ, Kim S, Baek SH, Kim JH, ... 11 (3): 422-35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166. Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, ...
*  HNRPU
Sidorenko SP, Law CL, Chandran KA, Clark EA (1995). "Human spleen tyrosine kinase p72Syk associates with the Src-family kinase ... "Thymocyte activation induces the association of phosphatidylinositol 3-kinase and pp120 with CD5". Eur. J. Immunol. 27 (3): 679 ... Jordan P, Heid H, Kinzel V, Kübler D (1995). "Major cell surface-located protein substrates of an ecto-protein kinase are ... 425 (3): 401-6. doi:10.1016/S0014-5793(98)00269-5. PMID 9563502. Matsui M, Breau WC, Iwasaki S, Hagiwara S, Tamai Y, Mori C, ...
*  DNA-PKcs
"DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene ... "Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit". J. Biol. Chem. 272 ( ... "Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex". J. ... DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that in humans is encoded by the gene ...
*  GAB2
CT10 regulator of kinase (Crk) is also known as the breast cancer anti-oestrogen resistance protein. It plays a role in both ... Boudot C, Kadri Z, Petitfrère E, Lambert E, Chrétien S, Mayeux P, Haye B, Billat C (October 2002). "Phosphatidylinositol 3- ... This leads to the activation of c-Jun N-terminal kinase(JNK) as part of the JNK signaling pathway. Upon stimulation by growth ... It mediates the interaction between receptor tyrosine kinases (RTKs) and non-RTK receptors serving as the gateway into the cell ...
*  Cyclin D/Cdk4
Kato JY, Matsuoka M, Strom DK, Sherr CJ (1994). "Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase". ... Phosphatidylinositol 3 kinase phosphorylates p27 (or p16 or p21) and SCF/Skp1. The phosphorylation of p27 inhibits p27's ... a serine-threonine kinase. This complex is one of many cyclin/cyclin-dependent kinase complexes that are the "hearts of the ... These receptor tyrosine kinases in turn phosphorylate and activate many other proteins, including Fos/Jun/Myc and ...
*  Interferon
Antiviral and antiproliferative effects specific to type I IFNs result from p38 MAP kinase signaling. The phosphatidylinositol ... Type I IFNs further activate p38 mitogen-activated protein kinase (MAP kinase) to induce gene transcription. ... Production of protein kinase R, for example, can be disrupted in cells infected with JEV Some viruses escape the anti-viral ... In response to interferon, cells produce large amounts of an enzyme known as protein kinase R (PKR). This enzyme phosphorylates ...
*  P110α
"Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta". The Journal of Biological Chemistry ... The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (the HUGO-approved official symbol = PIK3CA; HGNC ... Li W, Han M, Guan KL (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex ... Prasad KV, Kapeller R, Janssen O, Repke H, Duke-Cohan JS, Cantley LC, Rudd CE (December 1993). "Phosphatidylinositol (PI) 3- ...