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*  Tetrahydrobiopterin deficiency
... is a rare metabolic disorder that increases the blood levels of phenylalanine. Phenylalanine is an amino acid obtained through ... As a result, phenylalanine from the diet builds up in the bloodstream and other tissues, potentially damaging nerve cells in ... High levels of phenylalanine are present from infancy in people with untreated tetrahydrobiopterin (THB, BH4) deficiency. The ... In most parts of the world, only 1% to 2% of all infants with high phenylalanine levels have this disorder. In Taiwan, about 30 ...
*  Phenylpropanoids metabolism
Phenylalanine ammonia-lyase (PAL, a.k.a. phenylalanine/tyrosine ammonia-lyase) is an enzyme responsible for the transformation ... phenylalanine, tyrosine, and tryptophan). In plants, the biosynthesis of all phenylpropanoids begins with the amino acids ... of L-phenylalanine or tyrosine into trans-cinnamic acid or p-coumaric acid respectively and ammonia. Trans-cinnamate 4- ...
*  3,4-Dihydroxystyrene
Phenylalanine hydroxylase Koizumi S; Matsushima Y; Nagatsu T; Iinuma H; Takeuchi T; Umezawa H (September 1984). "3,4- ... 3,4-Dihydroxystyrene (DHS) is a centrally-acting inhibitor of the enzyme phenylalanine hydroxylase (PH). It is likely that DHS ... dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases". ...
*  Hyperphenylalaninemia
Phenylalanine concentrations ([phe]) are routinely screened in newborns by the neonatal heel prick (Guthrie test), which takes ... A small subset of patients with hyperphenylalaninemia shows an appropriate reduction in plasma phenylalanine levels with ... phenylalanine + -emia = high [phe] in blood). The coloration of the skin, hair, and eyes is different in children with PKU. ... and a continued phenylalanine-restricted diet is now recommended. PKU or hyperphenylalaninemia may also occur in persons ...
*  Phenylalanine ammonia-lyase
... phenylalanine ammonium-lyase, PAL, and L-phenylalanine ammonia-lyase. Phenylalanine ammonia lyase is specific for L-Phe, and to ... Phenylalanine ammonia lyase (EC 4.3.1.24) is an enzyme that catalyzes a reaction converting L-phenylalanine to ammonia and ... phenylalanine ammonia-lyases), EC 4.3.1.25 (tyrosine ammonia-lyases), and EC 4.3.1.26 (phenylalanine/tyrosine ammonia-lyases). ... Phenylalanine ammonia lyase (PAL) is the first and committed step in the phenyl propanoid pathway and is therefore involved in ...
*  Protein metabolism
Cysteine Selenocysteine Glycine Proline Hydrophobic side chains Alanine Valine Isoleucine Leucine Methionine Phenylalanine ...
*  Phenylalanine hydroxylase
... is the rate-limiting enzyme of the metabolic pathway that degrades excess phenylalanine. Research on ... GeneReviews/NCBI/NIH/UW entry on Phenylalanine Hydroxylase Deficiency Locus-specific database of the human phenylalanine ... "Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylase". Archives of Biochemistry and ... "The structural basis of the recognition of phenylalanine and pterin cofactors by phenylalanine hydroxylase: implications for ...
*  Essential amino acid
The nine amino acids humans cannot synthesize are phenylalanine, valine, threonine, tryptophan, methionine, leucine, isoleucine ... phenylalanine, leucine, isoleucine, methionine, valine, and arginine, in addition to threonine. Rose's later work showed that ... phenylalanine and tyrosine. Likewise arginine, ornithine, and citrulline, which are interconvertible by the urea cycle, are ...
*  Phenylpyruvic acid
It is a product from the oxidative deamination of phenylalanine. It is prepared by condensation of benzaldehyde and glycine ...
*  Phenylalanine
DL-Phenylalanine is a mixture of D-phenylalanine and L-phenylalanine. The reputed analgesic activity of DL-phenylalanine may be ... A small amount of D-phenylalanine appears to be converted to L-phenylalanine. D-Phenylalanine is distributed to the various ... Lignan is derived from phenylalanine and from tyrosine. Phenylalanine is converted to cinnamic acid by the enzyme phenylalanine ... who must ingest phenylalanine or phenylalanine-containing proteins. The first description of phenylalanine was made in 1879, ...
*  Phenylalanine dehydrogenase
In enzymology, a phenylalanine dehydrogenase (EC 1.4.1.20) is an enzyme that catalyzes the chemical reaction L-phenylalanine + ... This enzyme participates in phenylalanine metabolism and phenylalanine, tyrosine and tryptophan biosynthesis. As of late 2007, ... Asano Y, Nakazawa A, Endo K, Hibino Y, Ohmori M, Numao N, Kondo K (1987). "Phenylalanine dehydrogenase of Bacillus badius. ... The systematic name of this enzyme class is L-phenylalanine:NAD+ oxidoreductase (deaminating). Other names in common use ...
*  Phenylalanine decarboxylase
In enzymology, a phenylalanine decarboxylase (EC 4.1.1.53) is an enzyme that catalyzes the chemical reaction L-phenylalanine ... and L-phenylalanine carboxy-lyase. This enzyme participates in phenylalanine metabolism. It employs one cofactor, pyridoxal ... The systematic name of this enzyme class is L-phenylalanine carboxy-lyase (phenylethylamine-forming). Other names in common use ... L-phenylalanine, and two products, phenylethylamine and CO2. This enzyme belongs to the family of lyases, specifically the ...
*  Phenylalanine adenylyltransferase
N-adenylyl-L-phenylalanine Thus, the two substrates of this enzyme are ATP and L-phenylalanine, whereas its two products are ... L-phenylalanine adenylyltransferase. This enzyme is also called L-phenylalanine adenylyltransferase. Lerbs W, Luckner M (1985 ... In enzymology, a phenylalanine adenylyltransferase (EC 2.7.7.54) is an enzyme that catalyzes the chemical reaction ATP + L- ... diphosphate and N-adenylyl-L-phenylalanine. This enzyme belongs to the family of transferases, specifically those transferring ...
*  Phenylalanine N-acetyltransferase
This enzyme is also called acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase. This enzyme participates in phenylalanine ... N-acetyl-L-phenylalanine Thus, the two substrates of this enzyme are acetyl-CoA and L-phenylalanine, whereas its two products ... In enzymology, a phenylalanine N-acetyltransferase (EC 2.3.1.53) is an enzyme that catalyzes the chemical reaction acetyl-CoA ... The systematic name of this enzyme class is acetyl-CoA:L-phenylalanine N-acetyltransferase. ...
*  Phenylalanine(histidine) transaminase
Other names in common use include phenylalanine (histidine) aminotransferase, phenylalanine(histidine):pyruvate ... In enzymology, a phenylalanine(histidine) transaminase (EC 2.6.1.58) is an enzyme that catalyzes the chemical reaction L- ... Minatogawa Y, Noguchi T, Kido R (1977). "Species distribution and properties of hepatic phenylalanine (histidine):pyruvate ... The systematic name of this enzyme class is L-phenylalanine:pyruvate aminotransferase. ...
*  Phenylalanine 2-monooxygenase
In enzymology, a phenylalanine 2-monooxygenase (EC 1.13.12.9) is an enzyme that catalyzes the chemical reaction L-phenylalanine ... Koyama H (1984). "A simple and rapid enzymatic determination of L-phenylalanine with a novel L-phenylalanine oxidase ( ... and phenylalanine (deaminating, decarboxylating)oxidase. This enzyme participates in phenylalanine metabolism. Koyama H ( ... Koyama H (August 1984). "Oxidation and oxygenation of L-amino acids catalyzed by a L-phenylalanine oxidase (deaminating and ...
*  Phenylalanine-tRNA ligase
This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and aminoacyl-tRNA biosynthesis. Phenylalanine- ... In enzymology, a phenylalanine-tRNA ligase (EC 6.1.1.20) is an enzyme that catalyzes the chemical reaction ATP + L- ... The systematic name of this enzyme class is L-phenylalanine:tRNAPhe ligase (AMP-forming). Other names in common use include ... L-phenylalanine, and tRNAPhe, whereas its 3 products are AMP, diphosphate, and L-phenylalanyl-tRNAPhe. This enzyme belongs to ...
*  Phenylalanine N-monooxygenase
... (EC 1.14.13.124, phenylalanine N-hydroxylase, CYP79A2) is an enzyme with systematic name L- ... N-hydroxy-L-phenylalanine + O2 + NADPH + H+ ⇌ {\displaystyle \rightleftharpoons } N,N-dihydroxy-L-phenylalanine + NADP+ + H2O ( ... L-phenylalanine + O2 + NADPH + H+ ⇌ {\displaystyle \rightleftharpoons } N-hydroxy-L-phenylalanine + NADP+ + H2O: (1b) ... 1c) N,N-dihydroxy-L-phenylalanine ⇌ {\displaystyle \rightleftharpoons } (E)-phenylacetaldoxime + CO2 + H2O Phenylalanine N- ...
*  Phenylalanine (data page)
a EINECS number 200-568-1 (phenylalanine) ^a CID 994 from PubChem (phenylalanine) ^a CID 71567 from PubChem (D-phenylalanine) ^ ...
*  Phenylalanine/tyrosine ammonia-lyase
... (EC 4.3.1.25, PTAL, bifunctional PAL) is an enzyme with systematic name L-phenylalanine(or ... Phenylalanine/tyrosine ammonia-lyase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... Rösler, J.; Krekel, F.; Amrhein, N.; Schmid, J. (1997). "Maize phenylalanine ammonia-lyase has tyrosine ammonia-lyase activity ... This enzyme catalyses the following chemical reaction (1) L-phenylalanine ⇌ {\displaystyle \rightleftharpoons } trans-cinnamate ...
*  N-Formylmethionine-leucyl-phenylalanine
N-Formylmethionyl-leucyl-phenylalanine (FMLP) or N-formyl-met-leu-phe) is a N-formylated tripeptide and sometimes simply ... N-Formylmethionine Leucyl-Phenylalanine at the US National Library of Medicine Medical Subject Headings (MeSH). ... n-formylmethionine leucyl-phenylalanine, Cancerweb Panaro MA, Mitolo V (Aug 1999). "Cellular responses to FMLP challenging: a ...
*  Phenylalanine racemase (ATP-hydrolysing)
The enzyme phenylalanine racemase (EC 5.1.1.11, phenylalanine racemase, phenylalanine racemase (adenosine triphosphate- ... phenylalanine racemase phenylalanine racemase (adenosine triphosphate-hydrolysing) gramicidin S synthetase I Phenylalanine ... Phenylalanine Racemase Phenylketonuria Takahashi H, Sato E, Kurahashi K (1971). "Racemization of phenylalanine by adenosine ... Phenylalanine Pyridoxal-phosphate (active form of vitamin B6) Problems in the digestion of phenylalanine (phe) to tyrosine (tyr ...
*  6,7-dihydropteridine reductase
Kaufman S (1962). "Phenylalanine hydroxylase". Methods Enzymol. 5: 809-816. doi:10.1016/s0076-6879(62)05317-3. Lind KE ( ...
*  Arogenate dehydratase
2008). "Mutation of a rice gene encoding a phenylalanine biosynthetic enzyme results in accumulation of phenylalanine and ... The 2,5-cyclohexene ring becomes a phenyl ring, and L-phenylalanine is formed. Certain forms of ADT have been shown to exhibit ... The systematic name of this enzyme class is L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming). Other names in ... Arogenate dehydratase (ADT) (EC 4.2.1.91) is an enzyme that catalyzes the chemical reaction L-arogenate → L-phenylalanine + H2O ...
*  Newborn screening
Robert Guthrie developed a simple method using a bacterial inhibition assay that could detect high levels of phenylalanine in ... Mitchell, J. J.; Trakadis, Y. J.; Scriver, C. R. (2011). "Phenylalanine hydroxylase deficiency". Genetics in Medicine. 13 (8): ... a metabolic condition in which the inability to degrade the essential amino acid phenylalanine can cause irreversible mental ...