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*  Vaccine-preventable diseases
Four diseases were responsible for 98% of vaccine-preventable deaths: measles, Haemophilus influenzae serotype b, pertussis, ... Vaccine-preventable deaths are usually caused by a failure to obtain the vaccine in a timely manner. This may be due to ... If a vaccine-preventable disease is uncommon in a country, then residents of that country are unlikely to receive a vaccine ... A vaccine-preventable disease is an infectious disease for which an effective preventive vaccine exists. If a person acquires a ...
*  Pertussis toxin
Cherry JD (March 2007). "Historical Perspective on Pertussis and Use of Vaccines to Prevent It". Microbe Magazine. Parton R ( ... Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping ... Carbonetti NH (2010). "Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell ... pertussis. Rats infected with B. parapertussis or a PT-deficient mutant of B. pertussis did not show this symptom; neither of ...
*  Pertussis vaccine
... is a vaccine that protects against pertussis. There are two main types: whole-cell vaccines and acellular ... Pertussis vaccine is usually administered as a component of the diphtheria-tetanus-pertussis (DTP) vaccines. There are several ... pertussis vaccine, however the efficacy of the acellular vaccine declines faster than the whole-cell vaccine. Between 10 and 50 ... These (Tdap) vaccines contain reduced amounts of pertussis antigens compared to DTaP vaccines. Both WHO and the CDC found that ...
*  National Vaccine Information Center
The CDC now recommends the newer acellular pertussis vaccines (DTaP and Tdap), and whole cell pertussis vaccines are no longer ... "Pertussis Vaccination: Use of Acellular Pertussis Vaccines Among Infants and Young Children Recommendations of the Advisory ... "Adverse Effects of Pertussis and Rubella Vaccines". Washington, DC: The National Academies Press. p. 324. ISBN 978-0309103688. ... "Diphtheria, Tetanus, and Pertussis Vaccine Recommendations". CDC. U.S. Department of Health & Human Services. " ...
*  Pearl Kendrick
When the pertussis vaccine was in the primary phase of development, the American-made vaccine was very effective, while the ... Pediatric Research - Childhood Vaccine Development: An Overview "Pearl Kendrick, Grace Eldering,and the Pertussis Vaccine" (PDF ... and the eventual inoculation of children with the pertussis vaccine. The vaccine was a success. Michigan started distributing ... Shapiro-Shapin, Carolyn G. (August 2010). "Pearl Kendrick, Grace Eldering, and the Pertussis Vaccine". Emerging Infectious ...
*  Grace Eldering
The development of the vaccine for pertussis also included the first "large-scale controlled clinical trial for pertussis ... Marks, H. M. "The Kendrick-Eldering-(Frost) Pertussis Vaccine Field Trial". The James Lind Library. Journal of the Royal ... Carolyn G. Shapiro-Shapin (August 2010). "Pearl Kendrick, Grace Eldering, and the Pertussis Vaccine". Emerging Infectious ... Many senior figures at this meeting did not want to endorse the vaccine they created because they felt it was not adequately ...
*  SynCo Bio Partners
Eurocetus B.V. becomes Chiron B.V. •1996 - Facility licensed for commercial production of Pertussis vaccine. •1997 - Facility ... 2005 - Expansion of GMP facilities to allow production of a wider range of protein, vaccine and live biotherapeutic products. • ... MCA and Italian Health Branch for Meningitis C polysaccharide and CRM197 carrier protein for conjugated vaccine Menjugate. • ...
*  Rino Rappuoli
... and pneumococcus vaccines; an acellular pertussis vaccine containing a genetically detoxified pertussis toxin; the first ... conjugate vaccine against meningococcal-C disease and the first recombinant bacterial vaccine against pertussis. Currently,[ ... Rappuoli joined Chiron as head of European vaccines research in 1992 with the acquisition of Italian vaccines company Sclavo ... Rappuoli, was previously the Global Head of Vaccines Research for Novartis Vaccines & Diagnostics (Siena, Italy) Since 2015, Dr ...
*  Exotoxin
... diphtheria and monocomponent acellular pertussis (TdaP) vaccine in comparison to a tetanus and diphtheria (Td) vaccine when ... Additionally, pertussis persists endemically and is one of the most common causes of vaccine-preventable deaths. As exotoxins ... DPT vaccine protects against pertussis, tetanus and diphtheria infections, caused by the exotoxin-producing Bordetella ... A widely used toxoid vaccine is the DPT vaccine, which is usually administered in multiple doses throughout childhood with ...
*  AB5 toxin
Guiso N. 2009.Bordetella pertussis and pertussis vaccines. Clin. Infect. Dis. 49:1565-1569 Faruque, S. M.; Chowdhury, N; Khan, ... Pertussis toxin is secreted by the gram-negative bacterium, Bordetella pertussis. Whooping cough is very contagious and cases ... The pertussis toxin does not have a specific receptor, and binds to sialylated glycoproteins. After endocytosis, pertussis ... Carbonetti, N. H. (2010). "Pertussis toxin and adenylate cyclase toxin: Key virulence factors of Bordetella pertussis and cell ...
*  Pertactin
Bordetella pertussis and is used for the vaccine production as one of the important components of acellular pertussis vaccine. ... "Acellular pertussis vaccines and the role of pertactin and fimbriae". Expert Rev Vaccines. 6 (1): 47-56. doi:10.1586/14760584.6 ... Emsley, P.; Charles, I. G.; Fairweather, N. F.; Isaacs, N. W. (1996). "Structure of Bordetella pertussis virulence factor P.69 ... Emsley P, Charles IG, Fairweather NF, Isaacs NW (May 1996). "Structure of Bordetella pertussis virulence factor P.69 pertactin ...
*  Antitoxin
Tetanus toxoid is commonly given in combination with diphtheria toxoid acellular pertussis vaccine. The vaccine provides a ...
*  Peter Openshaw (physician)
"Attenuated Bordetella Pertussis Vaccine Protects against RSV Disease via an IL-17-dependent Mechanism". Am J Respir Crit Care ... Guvenel, AK; Chiu, C; Openshaw, PJ (2014). "Current concepts and progress in RSV vaccine development". Expert Rev Vaccines. 13 ... He has worked on protective and harmful immunological reactions to viruses, inflammatory lung disease and vaccine development ... Loebbermann, J; Thornton, H; Johansson, C; Openshaw, PJM (2013). "Defective immunoregulation in vaccine-augmented viral lung ...
*  Tetanus vaccine
The lowercase d and p denote lower strengths of diphtheria and pertussis vaccines. The tetanus vaccine was developed in 1924 ... and pertussis vaccine, and DT and Td which contain diphtheria and tetanus vaccine. DTaP and DT are given to children less than ... Two new vaccines were launched in 1992. These combined tetanus and diphtheria with acellular pertussis (TDaP or DTaP) which ... DTP (which is the combined vaccine for diphtheria, tetanus, and pertussis) was first used in 1948 and was continued until 1991 ...
*  Abusive head trauma
Institute of Medicine (IOM) (1991). "Chapter 6) Evidence Concerning Pertussis Vaccines and Other Illnesses and Conditions -- ... Adverse Effects of Pertussis and Rubella Vaccines. The National Academies Press. p. 165. ISBN 0-309-04499-5. Lee RV (1983). " ...
*  Diphtheria
... vaccine is usually combined at least with tetanus vaccine (Td) and often with pertussis (DTP, DTaP, TdaP) vaccines, ... Three or four doses, given along with tetanus vaccine and pertussis vaccine, are recommended during childhood. Further doses of ... "Disease and Vaccines". historyofvaccines.orgHistory of Vaccines. Archived from the original on 1 July 2014. Retrieved 28 ... Quinvaxem is a widely administered pentavalent vaccine, which is a combination of five vaccines in one that protect babies from ...
*  Pertussis
The pertussis vaccine became available in the 1940s. Play media Play media The classic symptoms of pertussis are a paroxysmal ... The vaccine saved an estimated half a million lives in 2002. The multicomponent acellular pertussis vaccine is 71-85% effective ... Both WHO and the CDC found that the acellular pertussis vaccines were effective at prevention of the disease, but had a limited ... Prevention is mainly by vaccination with the pertussis vaccine. Initial immunization is recommended between six and eight weeks ...
*  Children's Hospital of Philadelphia
Whooping cough (pertussis) vaccine was first developed. The first formal allocation of funds to research was recorded in 1937. ... and vaccine development. The Children's Hospital of Philadelphia is in Philadelphia's University City neighborhood, and since ...
*  GlaxoSmithKline
... its diphtheria/tetanus/pertussis vaccine Infanrix and its hepatitis B vaccine; the epilepsy drug Lamictal, and the ... April 2013). "Malaria vaccine R&D in the Decade of Vaccines: breakthroughs, challenges and opportunities". Vaccine. 31 ( ... doi:10.1016/j.vaccine.2013.02.040. PMID 23598488. "Malaria vaccine candidate reduces disease over 18 months of follow-up in ... Known as RTS,S, the vaccine was developed as a joint project with the PATH vaccines initiative and the Bill and Melinda Gates ...
*  Rachel Schneerson
"New NICHD-Sponsored Pertussis Vaccine Approved". "First Typhoid Vaccine to Protect Children Proven Effective by NICHD ... Their efforts led to the development and licensing of vaccines against pertussis (whooping cough), typhoid, Staphylococcus ... Rachel Schneerson is best known for her work on the vaccine for Haemophilus influenza type B, or Hib. Prior to the vaccine's ... After the success of the Hib vaccine, Schneerson and Robbins continued their work on single antigens and conjugate vaccines. ...
*  DTPa
... is the acronym for the triple antigen, combined diphtheria - tetanus - acellular pertussis vaccine administered to ... tetanus and acellular pertussis-containing vaccines. The acronym dTpa is used for formulations that contain substantially ... dTpa vaccines are usually used in adolescents and adults." DTPa Child and Adult formulations of the vaccine. ... lesser amounts of diphtheria toxoid and pertussis antigens than child (DTPa-containing) formulations; ...
*  Bordetella pertussis
Pertussis vaccine is part of the diphtheria, tetanus, and acellular pertussis (DTaP) immunization. The paroxysmal cough ... Warfel JM, Merkel TJ (2014). "The baboon model of pertussis: effective use and lessons for pertussis vaccines". Expert Review ... pertussis. The complete B. pertussis genome of 4,086,186 base pairs was published in 2003. Pertussis is an infection of the ... "Pertussis". Immunization, Vaccines and Biologicals. World Health Organisation. Finger, Horst; von Koenig, C.H.W. (1996). "Ch. ...
*  Augusta University
... co-developer of the pertussis vaccine Michael T. Dugan, n accounting academic, currently serving as Professor of Accounting at ...
*  Vaccine
... toxoids and pertussis (P) vaccine. Lower-case 'd' and 'p' denote reduced doses of diphtheria and pertussis used in the ... Examples include the polio vaccine, hepatitis A vaccine, rabies vaccine and some influenza vaccines.[citation needed] Some ... The first DIVA vaccines (formerly termed marker vaccines and since 1999 coined as DIVA vaccines) and companion diagnostic tests ... whole cell pertussis vaccine was used as an adjuvant for anthrax vaccine. This produces a more rapid immune response than ...
*  LAG3
... as potential serological markers of T helper-type cytokine response induced by acellular pertussis vaccine". International ... LAG could be used as a biomarker to assess the induction of Th-type responses in recipients of acellular pertussis vaccines. In ... In 1999 Triebel showed that LAG-3 could be used as a cancer vaccine, through cancer cell lines transfected with LAG-3. In 2001 ... April 2007 scientists working at Edward Jenner Institute for Vaccine Research in the UK demonstrated that LAG-3 participates in ...
*  Diseases of poverty
These include measles, pertussis and polio. Three other diseases, measles, pneumonia, and diarrheal diseases, are also closely ... Malaria vaccines are an area of intensive research. Intestinal parasites are extremely prevalent in tropical areas. These ... Borkow G, Bentwich Z (May 2002). "Host background immunity and human immunodeficiency virus protective vaccines, a major ... consideration for vaccine efficacy in Africa and in developing countries". Clin. Diagn. Lab. Immunol. 9 (3): 505-7. doi:10.1128 ...
*  1926 in science
First vaccine for Pertussis. American biogerontologist Raymond Pearl publishes his book Alcohol and Longevity demonstrating ...