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*  PRDX5
... sequence identity with typical 2-Cys and 1-Cys peroxiredoxins. The divergent amino acid sequence of this atypical peroxiredoxin ... human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III ... The typical peroxiredoxin is composed of a thioredoxin domain and a C-terminal, whereas PRDX5 has an N-terminal domain and a ... Peroxiredoxin-5 (PRDX5), mitochondrial is a protein that in humans is encoded by the PRDX5 gene, located on chromosome 11. This ...
*  PRDX3
Chang TS, Cho CS, Park S, Yu S, Kang SW, Rhee SG (2004). "Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates ... "Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas". Anticancer Res. 22 ( ... "Entrez Gene: PRDX3 peroxiredoxin 3". Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T (Jan 2003). "Mixed lineage kinase LZK and ... It is a member of the peroxiredoxin family of antioxidant enzymes. This gene encodes a protein with antioxidant function and is ...
*  RPS6KC1
2005). "RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains". Mol. Cells. 19 ( ... yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III ... 61 (3): 314-8. doi:10.1006/geno.1999.5963. PMID 10552933. "Entrez Gene: RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide ... 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. Molecular and Cellular Biology portal. ...
*  Peroxiredoxin
The recycling of the sulfenic acid back to a thiol is what distinguishes the three enzyme classes. 2-Cys peroxiredoxins are ... Peroxiredoxins are proposed to play a role in cell signaling by regulating H2O2 levels. Plant 2-Cys peroxiredoxins are post- ... Peroxiredoxin 1 knockout mice have a 15% reduction in lifespan. Peroxiredoxin 6 knockout mice are viable and do not display ... PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family". Nucleic Acids ...
*  TXN2
Zhang H, Go YM, Jones DP (Sep 2007). "Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with ... 443 (3): 821-7. doi:10.1016/j.bbrc.2013.12.050. PMID 24342608. Wang Z, Zhang H, Li XF, Le XC (2007). "Study of interactions ... Two mRNA transcripts of the TXN2 gene differ by ~330 bp in the length of the 3′-untranslated region, and both are believed to ...
*  Iodothyronine deiodinase
In most vertebrates, there are three types of enzymes that can deiodinate thyroid hormones: Deiodinase 1 both activates T4 to ... "Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic ... phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pups". Toxicol. Sci. 107 (1): 27 ... The three deiodinase enzymes share certain structural features in common although their sequence identity is lower than 50%. ...
*  Peroxiredoxin 2
Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene. This gene encodes a member of the peroxiredoxin ... "Entrez Gene: PRDX2 peroxiredoxin 2". Yao Y, Taylor M, Davey F, RenY, Aiton J , Coote P, Chen X, Yan SD & Gunn-Moore FJ. (2007 ... 2001). "Overexpression of peroxiredoxin in human breast cancer". Anticancer Res. 21 (3B): 2085-90. PMID 11497302. Kim SH, ... Evidence for in vivo overoxidation of peroxiredoxins at their active site". J. Biol. Chem. 277 (22): 19396-401. doi:10.1074/jbc ...
*  Peroxiredoxin 1
Three transcript variants encoding the same protein have been identified for this gene. Peroxiredoxin 1 has been shown to ... Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene. This gene encodes a member of the peroxiredoxin ... Peroxiredoxin 1 and peroxiredoxin 2 have been shown to be released by some cells when stimulated by LPS or TNF-alpha. The ... The expression patterns of peroxiredoxin 1 along with peroxiredoxin 4 are involved in human lung cancer malignancy. It has also ...
*  Sulfiredoxin
... peroxiredoxin-(S-hydroxycysteine)-forming]. Other names in common use include Srx1, sulphiredoxin, and peroxiredoxin-(S-hydroxy ... In enzymology, a sulfiredoxin (EC 1.8.98.2) is an enzyme that catalyzes the chemical reaction peroxiredoxin-(S-hydroxy-S- ... This enzyme is involved in antioxidant metabolism by re-activating peroxiredoxins, which are a group of peroxidases, when these ... The systematic name of this enzyme class is peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; ...
*  Epoxide hydrolase 3
Furuta J, Nobeyama Y, Umebayashi Y, Otsuka F, Kikuchi K, Ushijima T (June 2006). "Silencing of Peroxiredoxin 2 and aberrant ... The former three EH's differ in subcellular location, tissue expression patterns, substrate preferences, and thereby functions ... Epoxide hydrolase 3 (ABHD9, EH3, EPHX3), encoded by the EPHX3 gene, is the third defined isozyme in a set of epoxide hydrolase ...
*  Deiodinase
They are selenocysteine-dependent membrane proteins with a catalytic domain resembling Peroxiredoxins (Prx). Three related ... "Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic ... isoforms, deiodinase type I, II, and III, contribute to activation and inactivation of the initially released hormone precursor ...
*  NFE2L2
Neumann CA, Cao J, Manevich Y (Dec 2009). "Peroxiredoxin 1 and its role in cell signaling" (PDF). Cell Cycle. 8 (24): 4072-8. ... Sulfiredoxin 1 (SRXN1) and Thioredoxin reductase 1 (TXNRD1) support the reduction and recovery of peroxiredoxins, proteins ... 185 (3): 180-6. doi:10.1016/j.toxlet.2008.12.014. PMC 2676710 . PMID 19150646. Zhang Y, Gordon GB (Jul 2004). "A strategy for ... 230 (3): 383-9. doi:10.1016/j.taap.2008.03.003. PMC 2610481 . PMID 18417180. Patel R, Maru G (Jun 2008). "Polymeric black tea ...
*  PRDX4
Peroxiredoxin-4 is a protein that in humans is encoded by the PRDX4 gene. It is a member of the peroxiredoxin family of ... "Entrez Gene: PRDX4 peroxiredoxin 4". Sasagawa I, Matsuki S, Suzuki Y, Iuchi Y, Tohya K, Kimura M, Nakada T, Fujii J (2001). " ... Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of ... The protein encoded by this gene is an antioxidant enzyme of the peroxiredoxin family. The protein is localized to the ...
*  Pathology of multiple sclerosis
The meninges are three layers that protect the brain and the spinal cord. They are called (from the outside to the inside) the ... Holley JE, Newcombe J, Winyard PG, Gutowski NJ (2007). "Peroxiredoxin V in multiple sclerosis lesions: predominant expression ... The other patterns (III and IV) were highly suggestive of a primary oligodendrocyte dystrophy, reminiscent of virus- or toxin- ... Jarius S, König FB, Metz I, Ruprecht K, Paul F, Brück W, Wildemann B (29 Aug 2017). "Pattern II and pattern III MS are entities ...
*  PRDX6
Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene. It is a member of the peroxiredoxin family of ... III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". ... Manevich Y, Fisher AB (2005). "Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid ... 2000). "1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities". J. Biol. Chem ...
*  Thiol oxidoreductase
For example, thioredoxin reductase provides reducing equivalents to thioredoxin, which in turn reduces peroxiredoxin. Fomenko, ... and peroxiredoxin. They are involved in various processes, such as sulfur metabolism, DNA synthesis and repair, signaling, ...
*  Enzyme kinetics
Cleland, W.W. "The kinetics of enzyme-catalyzed reactions with two or more substrates or products: III. Prediction of Initial ... Akerman SE, Müller S (2003). "2-Cys peroxiredoxin PfTrx-Px1 is involved in the antioxidant defence of Plasmodium falciparum". ... Enzyme studies III: About the measurement and significance of the hydrogen ion concentration in enzymatic processes]. Biochem. ... One could also consider the less simple case E + S ⇌ k − 1 k 1 ES → k 2 EI → k 3 E + P {\displaystyle {\ce {{E}+{S}<=>[k_{1}][k ...
*  Selenium
Three days later, a pharmacy released a statement explaining that the horses had received an incorrect dose of one of the ... where selenoprotein peroxiredoxins protect bacterial and eukaryotic cells against oxidative damage. Selenoprotein families of ... From about three billion years ago, prokaryotic selenoprotein families drive the evolution of selenocysteine, an amino acid. ... III) selenate. Iodides of selenium are not well known. The only stable chloride is selenium monochloride (Se2Cl2), which might ...
*  STH (gene)
... interacts with peroxiredoxin 6". J Biol Chem. 280 (47): 39268-72. doi:10.1074/jbc.M506116200. PMID 16186110. "Entrez Gene: STH ... 16 (3): 132-5. doi:10.1159/000071000. PMID 12826738. de Silva R, Hope A, Pittman A, et al. (2004). "Strong association of the ... 377 (6547 Suppl): 3-174. PMID 7566098. Cook L, Brayne CE, Easton D, et al. (2002). "No evidence for an association between ... 348 (3): 163-6. doi:10.1016/S0304-3940(03)00788-2. PMID 12932819. Johansson A, Zetterberg H, Håkansson A, et al. (2006). "TAU ...
*  Reactive oxygen species
Then through a three-step chain reaction, water is sequentially converted to hydroxyl radical (•OH), hydrogen peroxide (H2O2), ... Peroxiredoxins also degrade H2O2, within the mitochondria, cytosol, and nucleus. 2 H2O2 → 2 H2O + O2 (catalase) 2GSH + H2O2 → ... This induction of ROS led to the induction of type III interferon and the induction of an antiviral state, limiting viral ... In mammals and most chordates, three forms of superoxide dismutase are present. SOD1 is located primarily in the cytoplasm, ...
*  PotC RNA motif
... untranslated regions of genes predicted to encode either membrane transport proteins or peroxiredoxins. Therefore, it was ... 11 (3): R31. doi:10.1186/gb-2010-11-3-r31. PMC 2864571 . PMID 20230605. Page for potC RNA at Rfam. ...
*  Circadian clock
They consist of three major components: a central biochemical oscillator with a period of about 24 hours that keeps time; a ... Cho CS, Yoon HJ, Kim JY, Woo HA, Rhee SG (Aug 2014). "Circadian rhythm of hyperoxidized peroxiredoxin II is determined by ... This group discovered circadian rhythms in redox proteins (peroxiredoxins) in cells that lacked a nucleus - human red blood ... More importantly, redox oscillations as demonstrated by peroxiredoxin rhythms have now been seen in multiple distant kingdoms ...
*  SESN2
2004). "Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD". Science. 304 (5670): 596-600. ... 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614. Wiemann S, Weil B, Wellenreuther R, et al. (2001 ...
*  SRXN1
2005). "Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins". J. Biol. Chem. 280 (5): 3125- ... 2006). "Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin ... 2005). "Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of ... 2005). "Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin". Biochemistry. 44 (24): ...
*  Glutaredoxin
Moreover, GRX act in antioxidant defence by reducing dehydroascorbate, peroxiredoxins, and methionine sulfoxide reductase. ... CC-type and 3 groups with additional domain of unknown function. The CC-type GRXs are only found in higher plants. In ...
*  Circadian rhythm
While it was previously hypothesised that these three genes model a negative feedback loop in which over-expressed CCA1 and LHY ... "Peroxiredoxins are conserved markers of circadian rhythms". Nature. 485 (7399): 459-464. Bibcode:2012Natur.485..459E. doi: ... To be called circadian, a biological rhythm must meet these three general criteria: The rhythm has an endogenous free-running ... Recent studies instead highlight the importance of co-evolution of redox proteins with circadian oscillators in all three ...