Perforin-1
... is a protein that in humans is encoded by the PRF1 gene and the Prf1 gene in mice. Perforin is a pore forming ... perforin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Perforin-1 at NLM Genetics Home Reference ( ... "Entrez Gene: PRF1 perforin 1 (pore forming protein)". Osińska, Iwona et al. "Perforin: an important player in immune response ... which works as a chaperone protein to prevent perforin from degrading. Perforin then binds to the target cell's plasma membrane ...
Severe cutaneous adverse reactions
... and perforin); and two cytokines that stimulate the proliferation and activation of natural killer and T cells (viz., ...
MACPF
Perforin is released by cytotoxic T cells and lyses virally infected and transformed cells. In addition, perforin permits ... Perforin functions via two distinct mechanisms. Firstly, like C9, high concentrations of perforin can form pores that lyse ... 2007). "Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and ... Secondly, perforin permits delivery of the cytotoxic granzymes A and B into target cells. Once delivered, granzymes are able to ...
Granzyme B
Perforin has a radius of 5.5 nm and granzyme B has a stokes radius of 2.5 nm and can therefore pass through the perforin pore ... It is secreted by these cells along with the pore forming protein perforin to mediate apoptosis in target cells. Granzyme B has ... Granzyme B release with perforin from CD8+ T cells can cause heart and kidney transplant rejection through killing of ... Granzyme B is released with perforin which inserts into a target cell's plasma membrane forming a pore. ...
Hemophagocytic lymphohistiocytosis
April 2013). "Human perforin mutations and susceptibility to multiple primary cancers". Oncoimmunology. 2 (4): e24185. doi: ... Perforin) FHL3: UNC13D (Munc13-4) FHL4: STX11 (Syntaxin 11) FHL5: STXBP2 (Syntaxin binding protein 2)/UNC18-2 Nearly half of ...
Innate immune system
Ma LL, Wang CL, Neely GG, Epelman S, Krensky AM, Mody CH (September 2004). "NK cells use perforin rather than granulysin for ...
Tissue-resident memory T cell
TRM cells positive for this marker produce perforin and IFNɤ. On the other side, TRM without CD49a expression produce IL-17. ... granzyme B and perforin. However, malignant cells can avoid this elimination by various mechanisms such as the loss of MHC I ...
ITGAE
Tilburgs T, Scherjon SA, Roelen DL, Claas FH (2009). "Decidual CD8+CD28- T cells express CD103 but not perforin". Hum. Immunol ...
Stonustoxin
... (SNTX) is an extremely potent cytolytic toxin of the perforin-like superfamily. It is mainly found in stonefish ( ... "Stonefish toxin defines an ancient branch of the perforin-like superfamily". Proceedings of the National Academy of Sciences of ...
Complement component 9
The overall complex belongs to MAC/perforin-like (MACPF)/CDC superfamily. Pore formation involves binding the C9 molecules to ...
Large granular lymphocytic leukemia
Immunohistochemistry for perforin, TIA-1, and granzyme B are usually positive. Clonal rearrangements of the T-cell receptor ( ... seen in this disease are large in size with azurophilic granules that contains proteins involved in cell lysis such as perforin ...
Granzyme
Perforin's role in protecting the body against lymphoma was emphasized when scientists discovered that p53 did not have as big ... Perforin and granzymes have been found to have a directly related ability to protect the body against the formation of ... In NK cells and T cells, granzymes are packaged in cytotoxic granules along with perforin. Granzymes can also be detected in ... As many of these cell types either do not express perforin or do not form immunological synapses, granzyme B is released ...
Cellular senescence
The senescent cells are killed using perforin pore-forming cytolytic protein. CD8+ cytotoxic T-lymphocytes also use NKG2D ...
Abdominal aortic aneurysm
"Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm". Am. J. Pathol. 176 (2): 1038- ... "Perforin-Independent Extracellular Granzyme B Activity Contributes to Abdominal Aortic Aneurysm". The American Journal of ...
CD4+ T cells and antitumor immunity
2001) Perforin is a protein produced by CD8+ T cells, which plays a central role in the cytotoxic killing mechanisms by ... Perforin and interferon-γ activities independently control tumor initiation, growth, and metastasis. Blood 97, pp. 192-197. ... Perforin deficient mice were also shown to have a reduced ability to ward off MCA induced cancers, suggesting an important role ...
Centre d'immunologie de Marseille-Luminy
Kägi, D; Vignaux, F; Ledermann, B; Burki, K; Depraetere, V; Nagata, S; Hengartner, H; Golstein, P (1994). "Fas and perforin ... and the demonstration of their playing a role in the perforin-granzyme-based mechanism of T-cell-mediated cytotoxicity, and to ...
CCL4
Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta. CCL4 is produced by: neutrophils, monocytes, B cells, T ... Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (July 2001). "Perforin-low memory CD8+ cells are ...
GZMM
2004). "Granzyme M mediates a novel form of perforin-dependent cell death". J. Biol. Chem. 279 (21): 22236-42. doi:10.1074/jbc. ...
Peter J. Peters
... containing both perforin and granzymes". Journal of Experimental Medicine. 173 (5): 1099-1109. doi:10.1084/jem.173.5.1099. ISSN ...
IFN1@
2007). "Influence of HLA-DR2 on perforin-positive cells in pulmonary tuberculosis". International Journal of Immunogenetics. 34 ...
Calreticulin
... has been shown to interact with Perforin and NK2 homeobox 1. GRCh38: Ensembl release 89: ENSG00000179218 - Ensembl ... "Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules". ...
Suberites domuncula
... have the ability to produce a perforin-like antibacterial protein. "Suberites domuncula". Integrated ...
Veto cells
Chrobak, P; Gress, RE (15 March 2001). "Veto activity of activated bone marrow does not require perforin and Fas ligand". ... a novel role for perforin, granzyme A, TREM-1, and TLR7". Blood. 120 (8): 1647-57. doi:10.1182/blood-2012-02-410803. PMID ... on the target cell by CD8 on the veto cell and killing can then be mediated via either the Fas/FASL pathway or the Perforin ...
Immunological synapse
Immunosenescence
Yang OO, Lin H, Dagarag M, Ng HL, Effros RB, Uittenbogaart CH (February 2005). "Decreased perforin and granzyme B expression in ... granzyme B or perforin impaired proliferation in response to antigenic stimulation accumulation and clonal expansion of memory ...
CBR1
"Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes". The Journal of Biological ...
Natural killer cell
Upon release in close proximity to a cell slated for killing, perforin forms pores in the cell membrane of the target cell, ... NK cells are cytotoxic; small granules in their cytoplasm contain proteins such as perforin and proteases known as granzymes. ... Natural killer cells can use NKG2D receptors to detect senescent cells, and kill those cells using perforin pore-forming ... despite containing perforin. Lack of cytotoxicity in vivo may be due to the presence of ligands for their inhibitory receptors ...
Perivitellin-2
As a perforin, PV2s are able to disrupt intestinal cells altering the plasma membrane conductance and to form large pores in ... PV2s have both lectin and perforin activities, associated to the two subunits of their particular structures. As a lectin, PV2s ... An interesting issue with these perivitellins is that the combination of two immune proteins (lectin and perforin) gave rise to ... disulfide-linked to a pore-forming protein of the Membrane Attack Complex and Perforin (MACPF) family (toxic unit). Like most ...
Immunodeficiency
Presence of multiple uncleared viral infections due to lack of perforin are thought to be responsible. In addition to chronic ...
Cytotoxic T cell
Through the action of perforin, granzymes enter the cytoplasm of the target cell and their serine protease function triggers ... When exposed to infected/dysfunctional somatic cells, TC cells release the cytotoxins perforin, granzymes, and granulysin. ... TC cells are resistant to the effects of their perforin and granzyme cytotoxins. A second way to induce apoptosis is via cell- ... perforins, granzymes...), and interact with other cells, such as epithelial cells, monocytes, dendritic cells, neutrophils and ...