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*  Ozarelix
... (developmental code names D-63153, SPI-153) is a peptide gonadotropin-releasing hormone antagonist (GnRH antagonist) ... induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of ... Gonadotropin-releasing hormone receptor § Antagonists List of investigational hormonal agents § GnRH/gonadotropins http:// ...
*  Carboxypeptidase E
CPE is involved in the biosynthesis of most neuropeptides and peptide hormones. The production of neuropeptides and peptide ... Carboxypeptidase E functions in the production of nearly all neuropeptides and peptide hormones. The enzyme acts as an ... because CPE is not a rate-limiting enzyme for the production of most neuropeptides and peptide hormones, it is not clear how ... although for many peptides the action of the proprotein convertases and CPE is sufficient to produce the bioactive peptide. ...
*  Gonadotropin-releasing hormone antagonist
... a hormone made by neurons in the hypothalamus) but that have an antagonistic effect. These GnRH antagonists are peptide ... rapidly reducing sex hormone levels without an initial surge. GnRH modulator Gonadotropin-releasing hormone agonist Van Poppel ... blocking the release of luteinising hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary. In men, the ... clinical use of agonists and antagonists of luteinizing-hormone-releasing hormone. Nat. Clin. Pract. Endocrinol. Metab.: 3: 157 ...
*  Peptide hormone
Peptide hormones or protein hormones are hormones whose molecules are peptides or proteins, respectively. The latter have ... Most hormones can be classified as either amino acid-based hormones (amine, peptide, or protein) or steroid hormones. The ... Peptide Hormone Secretion/Peptide Hormone Action: A Practical Approach, K. Siddle, J. C. Hutton, Oxford University Press, 1991 ... to act within their nuclei Like all peptides and proteins, peptide hormones and protein hormones are synthesized in cells from ...
*  Relaxin family peptide hormones
... in humans are represented by 7 members: three relaxin-like (RLN) and four insulin-like (INSL) ... The receptors for the RLN/INSL peptides are collectively called "Relaxin family peptide receptors (RXFPs)". There are two ... Peptides. 27 (11): 2535-46. doi:10.1016/j.peptides.2006.06.008. PMID 16920224. Mita, Masatoshi (25 July 2012). "Relaxin-like ... The number of peptides and their receptors is varied among vertebrates due to lineage specific gene loss and duplications For ...
*  Plant peptide hormone
... except for the removal of the N-terminal signal peptide. SCR/SP11 like other small peptide hormones binds to a membrane bound ... It was the first plant hormone proven to be a peptide. Systemin induces the production of protein defense compound called ... The peptides are 77 amino acids in length and possess an amino-terminal secretions signal. Like the CLE peptide family these ... Unlike other peptide hormones, no further post-translational processing occurs, ...
*  NCAA drug testing
... peptide hormones and analogues; anti-estrogens, and beta-2 agonists. Alcohol and beta blockers are also banned for rifle only. ...
*  Peptitergents
Kaiser, ET; Kézdy, FJ (20 January 1984). "Amphiphilic secondary structure: design of peptide hormones". Science. 223 (4633): ... Peptitergents (a portmanteau of peptide and detergent) are synthetic peptides designed to be lipophilic on one side and ... "Structure at 2.5 A of a designed peptide that maintains solubility of membrane proteins". Science. 262 (5134): 734-8. PMID ...
*  Anabolic steroid
The pharmacodynamics of AAS are unlike peptide hormones. Water-soluble peptide hormones cannot penetrate the fatty cell ... A more frequent schedule may be desirable in order to maintain a more constant level of hormone in the system. Injectable ... The pharmacodynamic action of AAS begin when the exogenous hormone penetrates the membrane of the target cell and binds to an ... Masculinizing hormone therapy for transgender men, other transmasculine people, and intersex people, by producing masculine ...
*  Oxytocin
... (Oxt; /ˌɒksɪˈtoʊsɪn/) is a peptide hormone and neuropeptide. Oxytocin is normally produced by the paraventricular ... However, oxytocin neurons make other peptides, including corticotropin-releasing hormone and dynorphin, for example, that act ... especially for the first synthesis of a polypeptide hormone." Oxytocin and vasopressin are the only known hormones released by ... The oxytocin peptide is synthesized as an inactive precursor protein from the OXT gene. This precursor protein also includes ...
*  Lysine carboxypeptidase
Skidgel, R.A. (1988). "Basic carboxypeptidases: regulators of peptide hormone activity". Trends Pharmacol. Sci. 9: 301-303. doi ...
*  Carboxypeptidase M
Skidgel, R.A. (1988). "Basic carboxypeptidases: Regulators of peptide hormone activity". Trends Pharmacol. Sci. 9: 303-304. doi ... Purification and characterization of membrane-bound carboxypeptidase that cleaves peptide hormones". J. Biol. Chem. 264: 2236- ...
*  Vitamin C
This increases peptide hormone stability and activity. 4-hydroxyphenylpyruvate dioxygenase modulates tyrosine metabolism. The ... Peptidylglycine alpha-amidating monooxygenase amidates peptide hormones by removing the glyoxylate residue from their c- ... Ascorbic acid functions as a cofactor for enzymes involved in photosynthesis, synthesis of plant hormones, as an antioxidant ... Eipper BA, Stoffers DA, Mains RE (1992). "The biosynthesis of neuropeptides: peptide alpha-amidation". Annual Review of ...
*  Cell signaling
Re, R (October 1999). "The nature of intracrine peptide hormone action". Hypertension. 34 (4 Pt 1): 534-8. doi:10.1161/01.HYP. ... A number of transmembrane receptors for small molecules and peptide hormones, as well as intracellular receptors for steroid ... Endocrine signals are called hormones. Hormones are produced by endocrine cells and they travel through the blood to reach all ... The intracrine action of peptide hormones remains a subject of debate. Hydrogen sulfide is produced in small amounts by some ...
*  Somatostatin
... , also known as growth hormone-inhibiting hormone (GHIH) or by several other names, is a peptide hormone that ... Synonyms of somatostatin are as follows: growth hormone-inhibiting hormone (GHIH) growth hormone release-inhibiting hormone ( ... thus opposing the effects of growth hormone-releasing hormone (GHRH)) Inhibit the release of thyroid-stimulating hormone (TSH) ... Simonetti M, Di BC (February 2002). "Structural motifs in the maturation process of peptide hormones. The somatostatin ...
*  Intracrine
Examples of intracrine peptide hormones: There are several protein/peptide hormones that are also intracrines. Notable examples ... Several peptide/protein hormones or their isoforms also act inside the cell through different mechanisms. These peptide/protein ... depending on the origin of the hormone. The intracrine effect of some of the peptide/protein hormones are similar to their ... In contrast, peptide or protein hormones, in general, act as endocrines, autocrines, or paracrines by binding to their ...
*  Enteroglucagon
... is a peptide hormone derived from preproglucagon. It is a gastrointestinal hormone, secreted from mucosal cells ...
*  Proopiomelanocortin
POMC is cleaved to give rise to multiple peptide hormones. Each of these peptides is packaged in large dense-core vesicles that ... ACTH is a peptide hormone that regulates the secretion of glucocorticoids from the adrenal cortex. β-Endorphin and [Met] ... N-Terminal Peptide of Proopiomelanocortin (NPP, or pro-γ-MSH) α-Melanotropin (α-Melanocyte-Stimulating Hormone, or α-MSH) β- ... Adrenocorticotropic Hormone, or ACTH Corticotropin-like Intermediate Peptide (CLIP) β-Lipotropin (β-LPH) Gamma Lipotropin (γ- ...
*  Adipokinetic hormone
... (AKH) is a short peptide hormone that has been studied in insects. It is a lipid mobilising hormone and is ... This was the first instance where an insect peptide hormone had been identified. Later, after AKH was identified in cockroaches ... The hormone itself is part of a larger family, often referred to as red pigment concentrating hormones (RPCH) discovered in ... Adipokinetic activity of shrimp and locust peptide hormones in butterflies. General and Comparative Endocrinology, 1981. 43(2 ...
*  L-Ribonucleic acid aptamer
... a new substance class to efficiently inhibit peptide hormones". European Journal of Biochemistry. 271 (S1). doi:10.1111/j.1474- ... In the case of peptides and small proteins that are produced synthetically, an enantiomer is made using synthetic D-amino acids ... Like other aptamers, L-RNA aptamers are able to bind molecules such as peptides, proteins, and substances of low molecular ...
*  Dactylysin
"Characterization of the thermolysin-like cleavage of biologically active peptides by Xenopus laevis peptide hormone ... Carvalho, K.M.; Joudiou, C.; Boussetta, H.; Leseney, A.-M. & Cohen, P. (1992). "A peptide-hormone-inactivating endopeptidase in ... Dactylysin (EC 3.4.24.60, peptide hormone inactivating endopeptidase, PHIE) is an enzyme. This enzyme catalyses the following ... Shows a preference for hydrophobic doublets such as -Phe-Phe- and -Phe-Leu- in somatostatin-(1-14)-peptide and dynorphin A-(1-6 ...
*  G cell
The peptide hormone bombesin also stimulates gastrin from G cells. Gastrin-releasing peptide, as well as the presence of amino ... Gastrin-releasing peptide is released by the post-ganglionic fibers of the vagus nerve onto G cells during parasympathetic ...
*  KIAA0922
Mentlein R (July 1988). "Proline residues in the maturation and degradation of peptide hormones and neuropeptides". FEBS Lett. ... PREP has been found to be involved with the maturation and degradation of neuropeptides and peptide hormones. PREP and its ... PREP acts in the cytosol by cleaving peptide bonds on the C-terminus of short prolyl residues (approx. 30 amino acids long). ... The mature mRNA of certain transcript variants have a confirmed signal peptide region. although protein localization remains ...
*  Michel Chrétien
His research proposed that peptide hormones are produced from large precursor proteins. He was an Associate Member, ... In 1967, he opened a laboratory on polypeptide hormones at the Clinical Research Institute of Montreal (CRIM) where would ... In 2006, he was appointed Senior Scientist, Hormone, Growth and Development, Ottawa Health Research Institute. In 1986, he was ...
*  Secretin family
Glucagon/GIP/secretin/VIP hormones are a family of evolutionarily related peptide hormones that regulate activity of G-protein ... vasoactive intestinal peptide (VIP), prealbumin, peptide HI-27 and growth hormone releasing factor. ADCYAP1; GCG; GHRH; GIP; ... Pollock HG; Hamilton JW; Rouse JB; Ebner KE; Rawitch AB (1988). "Isolation of peptide hormones from the pancreas of the ... Glucagon is produced, like other peptide hormones, as part of a larger precursor (preproglucagon), which is cleaved to produce ...
*  TENM3
The peptide cleaved from the C terminal of Ten-m3, TCAP-3, stimulates the production of cAMP and the proliferation of neurons. ... Hormone Molecular Biology and Clinical Investigation. 24 (2): 83-90. doi:10.1515/hmbci-2015-0032. PMID 26485751. Zhou XH, ... The TCAP is the resulting peptide from cleaving a putative furin cleavage site found immediately on the N-terminal of TCAP. The ... Lovejoy DA, Pavlović T (November 2015). "Role of the teneurins, teneurin C-terminal associated peptides (TCAP) in reproduction ...
*  Glyceroneogenesis
Insulin is a peptide hormone which induces cells to intake glucose. In glyceroneogenesis, insulin down regulates the expression ... Norepinephrine is a neurotransmitter hormone which decreases the activity of PEPC-K when the cell is oriented in a cold ... However, when exposed to cold, a neurotransmitter hormone called norepinephrine will suppress the activity of PEPC-K. When the ... Glucocorticoid is a steroid hormone which is involved in the reciprocal regulation of glyceroneogenesis in liver and adipose ...