... peptide fragments". Peptides. 28 (10): 1945-53. doi:10.1016/j.peptides.2007.07.022. PMID 17766010. S2CID 40284900. cocaine-+and ... "The activity of CART peptide fragments". Peptides. 27 (8): 1926-33. doi:10.1016/j.peptides.2005.10.025. PMID 16730858. S2CID ... Peptides. 27 (6): 1328-34. doi:10.1016/j.peptides.2005.10.016. PMID 16309793. S2CID 27440114. Wierup N, Kuhar M, Nilsson BO, ... The peptide is found in several areas, among them the ventral tegmental area (VTA) of the brain. When CART was injected into ...
... fragment-based discovery; structural bioinformatics; molecular mechanics and dynamics; peptide modeling; structural biology; ... Main application areas in MOE include structure-based design, fragment-based design, ligand-based design, pharmacophore ... Erlanson, Daniel A.; McDowell, Robert S.; O'Brien, Tom (2004). "Fragment-Based Drug Discovery". Journal of Medicinal Chemistry ...
Another method is fragment condensation, in which peptide fragments are coupled. Although the former can elongate the peptide ... Fragment condensation is better than stepwise elongation for synthesizing sophisticated long peptides, but its use must be ... Chemical peptide synthesis most commonly starts at the carboxyl end of the peptide (C-terminus), and proceeds toward the amino- ... Nyfeler R (7 November 1994). Peptide synthesis via fragment condensation. Methods in Molecular Biology. Vol. 35. New Jersey: ...
These range from small oxyanions to large peptide fragments. Other MFS transporters are notable for a lack of selectivity, ... "Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT". Proceedings of the National ...
B 46, 6700 Huang, Lulu; Massa, Lou; Karle, Jerome (2005). "Kernel energy method illustrated with peptides". International ... Effective fragment molecular orbital (EFMO) method combines some features of the effective fragment potentials (EFP) and FMO. A ... Alternatively, configuration analysis for fragment interaction (CAFI) and fragment interaction analysis based on local MP2 ( ... The fragment molecular orbital method (FMO) is a computational method that can be used to calculate very large molecular ...
The N-terminal peptide/fragment of proopiomelanocortin (NPP; N-POMC), also known as pro-γ-MSH, is a naturally occurring, ... Proopiomelanocortin (POMC) Bicknell AB (May 2016). "60 YEARS OF POMC: N-terminal POMC peptides and adrenal growth". Journal of ...
Three different types of backbone bonds can be broken to form peptide fragments: alkyl carbonyl (CHR-CO), peptide amide bond ( ... For example, a precursor peptide with a molecular weight of 774 has 21,909,046 possible peptides. Even though it is done in the ... In mass spectrometry, de novo peptide sequencing is the method in which a peptide amino acid sequence is determined from tandem ... Given previously predicted partial peptide sequence, neural-network-based de novo peptide sequencing models will repeatedly ...
Dyson HJ, Sayre JR, Merutka G, Shin HC, Lerner RA, Wright PE (August 1992). "Folding of peptide fragments comprising the ... Since the peptide bonds themselves are polar they are neutralised by hydrogen bonding with each other when in the hydrophobic ... Zehfus MH (June 1997). "Identification of compact, hydrophobically stabilized domains and modules containing multiple peptide ...
Some HLAs bind pathogenic peptide fragments with very high affinity. This in essence "supercharges" their immune system in ... Thus any alteration to the HLA that induces decreased binding to a certain peptide or increased binding to a certain peptide, ... If HLAs bind none of the peptides produced by a pathogen, then there is no way for the immune system to tell that a cell is ... This is a significant decrease and is almost certainly a result of the abnormally efficient binding of HLA-A*02 to peptides ...
... and fragmented in a mass spectrometer; the mass spectra corresponding to the fragments of peptide precursor is recorded. Tandem ... A peptide spectral library is a curated, annotated and non-redundant collection/database of LC-MS/MS peptide spectra. One ... neutral losses from fragments and various additional specific fragments, the process of spectra searching will be more specific ... which will continuously expand the coverage of peptide spectral library. For a peptide spectra library, to reach a maximal ...
... is then continually fragmented into different peptides, including α-endorphin, β-endorphin, and γ-endorphin. Peptide convertase ... FELDBERG, W.; SMYTH, D.G. (July 1977). "C-Fragment of Lipotropin-An Endogenous Potent Analgesic Peptide". British Journal of ... McLaughlin, Patricia J.; Zagon, Ian S. (2013), "POMC-Derived Opioid Peptides", Handbook of Biologically Active Peptides, ... which is not a peptide. Opioid peptides are classified based on their precursor propeptide: all endorphins are synthesized from ...
In mass spectrometry analysis, proteins/peptides are fragmented. Then, peptides are ionized through either electrospray ... a mass analyzer generates information-rich ion mass spectra from fragmented peptides. Four types of mass analyzers include ion ...
The Fc fragment is digested into small peptides. Fab fragments are generated by cleavage of IgG with papain instead of pepsin. ... Fab fragments and an intact Fc fragment. The fragments can be purified by gel filtration, ion exchange, or affinity ... Use of F(ab')2 or Fab fragments ensures that the antibodies are binding to the antigen and not Fc receptors. These fragments ... To produce an F(ab')2 fragment, IgG is digested with pepsin, which cleaves the heavy chains near the hinge region. One or more ...
"Effects of cell-permeating peptide binding on the distribution of 125I-labeled Fab fragment in rats". Bioconjugate Chemistry. ... These features are important for new peptide design. Helical β-peptides mimic antimicrobial activities of host defense peptides ... "A Noncovalent Peptide-Based Strategy for Peptide and Short Interfering RNA Delivery". Handbook of Cell-Penetrating Peptides, ... Cell-penetrating peptides (CPPs) are short peptides that facilitate cellular intake and uptake of molecules ranging from ...
Dwulet FE, Putnam FW (Feb 1981). "Complete amino acid sequence of a 50,000-dalton fragment of human ceruloplasmin". Proceedings ... I. Amino acid sequence of the cyanogen bromide peptides". The Journal of Biological Chemistry. 255 (7): 2878-85. doi:10.1016/ ... Kingston IB, Kingston BL, Putnam FW (Apr 1980). "Primary structure of a histidine-rich proteolytic fragment of human ...
Renin is a circulating enzyme that acts on a circulating peptide, angiotensinogen. Renin cleaves the peptide at the Leu10-Val11 ... Ferrario, C. M.; Iyer, S. N. (1998). "angiotensin-(1-7): A bioactive fragment of the renin-angiotensin system". Regulatory ... This generation consists of two groups of compounds, either peptide analogues of the prosegment of renin or peptide analogues ... Non-peptide substances were known to be able to solve the problems of poor pharmacokinetic properties and low specificity. This ...
β-Lipotropin can be cleaved into smaller peptides. In humans, γ-lipotropin, β-MSH, and β-endorphin, are all possible fragments ... γ-lipotropin is the amino-terminal peptide fragment of β-lipotropin. In humans, it has 56 amino acids. Gamma lipotropin is ... Peptides Direct information page, accessed 26 August 2013 Le Grand C (2016). The straight dope : the inside story of sport's ... Birdsall and Hulme demonstrated that the C-fragment of lipotropin (β-endorphin) has a high affinity for opiate receptors in the ...
September 1999). "Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin". Bioorganic & ... a multireceptor opioid peptide". The Journal of Peptide Research. 59 (3): 123-33. doi:10.1034/j.1399-3011.2002.01967.x. PMID ... Biphalin is a dimeric enkephalin endogenous peptide (Tyr-D-Ala-Gly-Phe-NH)2 composed of two tetrapeptides derived from ... March 1998). "Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide". ...
Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M (July 2015). "Peptide Fragments ...
Martoglio B, Graf R, Dobberstein B (November 1997). "Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with ... "Identification of a calmodulin-binding and inhibitory peptide domain in the HIV-1 transmembrane glycoprotein". AIDS Research ...
Peptides and fragments. Not a true class Peptides [58231] (121): peptides and fragments. Not a true class. Designed proteins [ ... Folds consisting of two or more domains belonging to different classes membrane and cell surface proteins and peptides [56835 ...
Cholecystokinin tetrapeptide (CCK-4, tetragastrin, Trp-Met-Asp-Phe-NH2) is a peptide fragment derived from the larger peptide ... Since it is a peptide, CCK-4 must be administered by injection, and is rapidly broken down once inside the body so has only a ... García-López MT, González-Muñiz R, Martín-Martínez M, Herranz R (2007). "Strategies for design of non peptide CCK1R agonist/ ... Kalindjian SB, McDonald IM (2007). "Strategies for the design of non-peptide CCK2 receptor agonist and antagonist ligand". ...
"Peptide fragments derived from the beta-chain of hemoglobin (hemorphins) are centrally active in vivo". Peptides. 10 (4): 747- ... Casomorphin Brantl V, Gramsch C, Lottspeich F, Mertz R, Jaeger KH, Herz A (June 1986). "Novel opioid peptides derived from ... Hemorphin-4 is an endogenous opioid peptide of the hemorphin family which possesses antinociceptive properties and is derived ... Peptides. 13 (4): 623-31. doi:10.1016/0196-9781(92)90165-Y. PMID 1359507. S2CID 32330624. Lantz I, Glämsta EL, Talbäck L, ...
"Peptide fragments derived from the beta-chain of hemoglobin (hemorphins) are centrally active in vivo". Peptides. 10 (4): 747- ... Casomorphin Brantl V, Gramsch C, Lottspeich F, Mertz R, Jaeger KH, Herz A (June 1986). "Novel opioid peptides derived from ... Hemorphins are a class of naturally occurring, endogenous opioid peptides which are found in the bloodstream, and are derived ... Articles with short description, Short description matches Wikidata, Opioid peptides). ...
Individual peptides are then analyzed for overall deuteration of each peptide fragment. Using this technique the resolution of ... Bache N, Rand KD, Roepstorff P, Jørgensen TJ (August 2008). "Gas-phase fragmentation of peptides by MALDI in-source decay with ... In this regard, the conclusions have been mixed, while it is possible to obtain UVPD fragments which has not undergone ... For example, the location and relative amount of deuterium exchange along the peptide backbone can be determined roughly by ...
A peptide fragment of ChgA located in the Vasostatin-1, namely ChgA29-42 has been identified as the antigenic epitope ... Chromogranin A is cleaved by an endogenous prohormone convertase to produce several peptide fragments. See chromogranin A ... These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). ... April 2011). "Cutting edge: vasostatin-1-derived peptide ChgA29-42 is an antigenic epitope of diabetogenic BDC2.5 T cells in ...
"Antimicrobial Peptide Designing and Optimization Employing Large-Scale Flexibility Analysis of Protein-Peptide Fragments". ACS ... In particular, one such program used to model peptides as the specific ligand bonding to the protein is DockThor. Peptides are ... Ciemny M, Kurcinski M, Kamel K, Kolinski A, Alam N, Schueler-Furman O, Kmiecik S (August 2018). "Protein-peptide docking: ... Coarse-grained models are often implemented in the case of protein-peptide docking, as they frequently involve large-scale ...
In some brain areas, amidorphin is extensively further reduced into smaller fragments, such as the non-opioid peptide ... Opioid peptide Seizinger BR; Liebisch DC; Gramsch C; et al. (1985). "Isolation and structure of a novel C-terminally amidated ... The 26-residue peptide named amidorphin is found in several species including bovine (Bos taurus), sheep (Ovis aries), and pig ... Amidorphin is an endogenous, C-terminally amidated, opioid peptide generated as a cleavage product of proenkephalin A in some ...
Isemura S, Saitoh E, Sanada K (April 1980). "The amino acid sequence of a salivary proline-rich peptide, P-C, and its relation ... Schlesinger DH, Hay DI (January 1981). "Primary structure of the active tryptic fragments of human and monkey salivary anionic ... International Journal of Peptide and Protein Research. 27 (4): 373-9. doi:10.1111/j.1399-3011.1986.tb01030.x. PMID 3710693. ... proline-rich proteins". International Journal of Peptide and Protein Research. 17 (1): 34-41. doi:10.1111/j.1399-3011.1981. ...
... a fragmented peptide sample is loaded onto a matrix and ionized through the use of a high energy laser. The fragmented ions are ... In bio-informatics, a peptide-mass fingerprint or peptide-mass map is a mass spectrum of a mixture of peptides that comes from ... This spectrum shows the masses and relative abundances of the peptide fragments present in the sample. In reading a spectrum ... Cottrell, J. S. (1994-06-01). "Protein identification by peptide mass fingerprinting". Peptide Research. 7 (3): 115-124. ISSN ...
November 2000). "Amyloid fibril formation by Aβ16-22, a seven-residue fragment of the Alzheimer's β-amyloid peptide, and ... August 2002). "Assembling amyloid fibrils from designed structures containing a significant amyloid β-peptide fragment". The ... although only for simplified peptides having a length remarkably shorter than that of peptides or proteins involved in disease ... Other polypeptides and proteins such as amylin and the β amyloid peptide do not have a simple consensus sequence and are ...
Alternatively, peptides can be fragmented with MS/MS to more definitively identify them. MS is also the preferred method for ... It is the process of assigning amino acids from peptide fragment masses of a protein. De novo sequencing has proven successful ... Collision-induced dissociation is used in mainstream applications to generate a set of fragments from a specific peptide ion. ... An intermediate "middle-down" approach in which larger peptide fragments are analyzed may also sometimes be used. The ...