*  EEF2
Peptide Elongation Factor 2 at the US National Library of Medicine Medical Subject Headings (MeSH). ... This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for ... Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. ... Kaneda Y, Yoshida MC, Kohno K, Uchida T, Okada Y (Jul 1984). "Chromosomal assignment of the gene for human elongation factor 2 ...
*  Prokaryotic elongation factors
Elongation factor Eukaryotic elongation factor PDB Molecule of the Month Elongation factors - September 2006 Peptide Elongation ... Factor G at the US National Library of Medicine Medical Subject Headings (MeSH) Peptide Elongation Factor Tu at the US National ... In prokaryotes, four elongation factors are required for translation: EF-Tu, EF-Ts, EF-G and EF-P. EF-Tu mediates the entry of ... EF-Ts serves as the guanine nucleotide exchange factor for EF-Tu, catalyzing the release of GDP from EF-Tu. EF-G catalyzes the ...
*  EF-G
Peptide Elongation Factor G at the US National Library of Medicine Medical Subject Headings (MeSH). ... EF-G or elongation factor G (historically known as translocase) is a prokaryotic elongation factor and a GTPase responsible for ... G C Atkinson; S L Baldauf (2011). "Evolution of elongation factor G and the origins of mitochondrial and chloroplast forms". ... "Dual use of GTP hydrolysis by elongation factor G on the ribosome". Translation. 1: e24315. doi:10.4161/trla.24315. Zavialov AV ...
*  EF-Tu
Peptide Elongation Factor Tu at the US National Library of Medicine Medical Subject Headings (MeSH). ... EF-Tu (elongation factor thermo unstable) is a prokaryotic elongation factor responsible for catalyzing the binding of an ... "Inhibitory mechanisms of antibiotics targeting elongation factor Tu". Current Protein & Peptide Science. 3 (1): 121-131. doi: ... EF-Ts (elongation factor thermo stable) EF-G eEF-1 EEF-2 EFR (EF-Tu receptor) PDB Molecule of the Month EF-Tu Weijland, A.; ...
*  EEF-1
Biol., 9: 39, doi:10.1186/1471-2148-9-39, PMC 2652445 , PMID 19216746 Peptide Elongation Factor 1 at the US National Library of ... eEF-1 is a eukaryotic elongation factor. Its α and βγ subunits act as counterparts to EF-Tu and EF-Ts, respectively Genes ... elongation factor-like). Although its function has not been studied in depth, it appears to be similar to EF-1α. Only two ... "Gain and loss of elongation factor genes in green algae", BMC Evol. ...
*  Pattern recognition receptor
... bacterial peptides (flagellin, microtubule elongation factors), peptidoglycans and lipoteichoic acids (from Gram-positive ... Since that time two other plants PRRs, Arabidopsis FLS2 (flagellin) and EFR (elongation factor Tu receptor)have been isolated. ... Mutations in NOD2 in cooperation with environmental factors lead to development of chronic inflammation in the intestine. ... and single stranded RNA which recruit factors via twin N-terminal CARD domains to activate antiviral gene programs, which may ...
*  Eukaryotic translation elongation factor 1 alpha 1
"Protein kinase C delta-specific phosphorylation of the elongation factor eEF-alpha and an eEF-1 alpha peptide at threonine 431 ... an elongation factor protein, a GTPase, and an actin bundling protein. As an elongation factor, it is known to mediate the ... EEF1A1 eukaryotic translation elongation factor 1 alpha 1". Becker M, Kuhse J, Kirsch J (Dec 2013). "Effects of two elongation ... Elongation factor 1-alpha 1 (eEF1a1) is a protein that in humans is encoded by the EEF1A1 gene. This gene encodes an isoform of ...
*  List of MeSH codes (D08)
... peptide elongation factor g MeSH D08.811.277.040.330.300.100.700 --- peptide elongation factor tu MeSH D08.811.277.040.330.300. ... peptide elongation factor 1 MeSH D08.811.277.040.330.300.100.850 --- peptide elongation factor 2 MeSH D08.811.277.040.330.300. ... factor ixa MeSH D08.811.277.656.300.760.315 --- factor xa MeSH D08.811.277.656.300.760.320 --- factor xia MeSH D08.811.277.656. ... gtp phosphohydrolase-linked elongation factors MeSH D08.811.277.040.330.300.100.200 --- ...
*  P-site
... elongation factor P) stimulated synthesis of peptide bonds, and EF-G-mediated translocation of initiator-tRNA into the P-site. ... Rodnina, MV; Savelsbergh, A; Katunin, VI; Wintermeyer, W (2 January 1997). "Hydrolysis of GTP by elongation factor G drives ... catalyzed by elongation factor EF-G. The ribosomal P-site plays a vital role in all phases of translation. Initiation involves ... Prior to peptide bond formation, an aminoacyl-tRNA is bound in the A-site, a peptidyl-tRNA is bound in the P-site, and a ...
*  Elongation factor P
In molecular biology, elongation factor P is a prokaryotic protein translation factor required for efficient peptide bond ... Elongation factor P consists of three domains: An N-terminal KOW-like domain A central OB domain, which forms an ... "Crystal structure of elongation factor P from Thermus thermophilus HB8". Proc. Natl. Acad. Sci. U.S.A. 101 (26): 9595-600. doi: ... Leaps in Translational Elongation Science (2009) 326, 677. This article incorporates text from the public domain Pfam and ...
*  Protein-synthesizing GTPase
... s (EC 3.6.5.3, elongation factor (EF), initiation factor (IF), peptide-release or termination factor ... They usually include translation initiation factors such as IF-2 and translation elongation factors such as EF-Tu. Kurzchalia, ... Rodnina, M.V.; Savelsberg, A.; Katunin, V.I.; Wintermeyer, W. (1997). "Hydrolysis of GTP by elongation factor G drives tRNA ... Freistroffer, D.V.; Pavlov, M.Y.; MacDougall, J.; Buckingham, R.H.; Ehrenberg, M. (1997). "Release factor RF3 in E. coli ...
*  GTP-binding elongation factor family, EF-Tu/EF-1A subfamily
The GTP-binding protein synthesis factor family also includes the eukaryotic peptide chain release factor GTP-binding subunits ... In molecular biology, the GTP-binding elongation factor family, EF-Tu/EF-1A subfamily is a family of elongation factors, which ... "A conserved amino acid sequence around Arg-68 of Artemia elongation factor 1 alpha is involved in the binding of guanine ... and the prokaryotic selenocysteine-specific elongation factor selB. Domain 2 adopts a beta-barrel structure, and is involved in ...
*  Negative elongation factor
It is unknown whether or not NELF-C and NELF-D are peptides resulting from the same mRNA with different translation initiation ... P-TEFb (positive transcription elongation factor b) inhibits the effect of NELF and DSIF on Pol II elongation, via its ... In molecular biology, NELF (negative elongation factor) is a four-subunit protein (NELF-A, NELF-B, NELF-C/NELF-D, and NELF-E) ... "Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active ...
*  Aminoacyltransferase
The aminoacyl-tRNA molecule has close relationships with elongation factors like EF-Tu. Peptidyl transferases are also a type ... of aminoacyltransferase that catalyze the formation of peptide bonds, as well as the hydrolytic step that leads to the release ...
*  EF1 guanine nucleotide exchange domain
Elongation factor EF1B (also known as EF-Ts or EF-1beta/gamma/delta) is a nucleotide exchange factor that is required to ... found in the C-terminal region of the peptides. Their N-terminal regions may be involved in interactions with the gamma chain ( ... the EF1 guanine nucleotide exchange domain is a protein domain found in the beta and delta chains of elongation factors from ... "Structural studies of eukaryotic elongation factors". Cold Spring Harb. Symp. Quant. Biol. 66: 425-37. doi:10.1101/sqb.2001.66. ...
*  Leucine-rich repeat receptor like protein kinase PEPR1
They sense PAMPs such as chitin from fungal cell wall, flagellin elongation factors etc. In addition to PAMPs, PRRs also ... AtPEP 1, a 23-amino acids precursor peptide encoded by c-terminal of PROPEP 1 gene, is considered to be a DAMP associated ... Ryan, Clarence A.; Pearce, Gregory (2003-11-25). "Systemins: A functionally defined family of peptide signals that regulate ... Huffaker, Alisa; Pearce, Gregory; Ryan, Clarence A. (2006-06-27). "An endogenous peptide signal in Arabidopsis activates ...
*  Prokaryotic large ribosomal subunit
... provides a binding site for the G-protein factors (assists initiation, elongation, and termination), and helps protein folding ... The N3 (nitrogen) of A2486 (2451) is closest to the peptide bond being synthesized and may function as a general base to ... After initiation, elongation, and termination, there is a fourth step of the disassembly of the post-termination complex of ... 2. Nissen P, Hansen J, Ban N, Moore P, Steitz T (2000). "The structural basis of ribosome activity in peptide bond synthesis". ...
*  ERGIC2
It has been shown to interact with a number of proteins, such as beta-amyloid, protein elongation factor 1alpha, and otoferlin ... Nelson TJ, Alkon DL (2007). "Protection against beta-amyloid-induced apoptosis by peptides interacting with beta-amyloid". J ... "The possible interaction of CDA14 and protein elongation factor 1alpha". Biochim Biophys Acta. 1784 (2): 312-8. doi:10.1016/j. ...
*  Prokaryotic translation
Prokaryotic initiation factors Prokaryotic elongation factors Prokaryotic factors Farabaugh, Philip J. (1978-08-24). "Sequence ... And the E site which is the exit site of the now uncharged tRNA after it gives its amino acid to the growing peptide chain. The ... Once the nascent protein is released in termination, Ribosome Recycling Factor and Elongation Factor G (EF-G) function to ... This process is catalyzed by elongation factor G (EF-G). The deacylated tRNA at the E site is released from the ribosome during ...
*  Elongation factor
In the ribosome, they facilitate translational elongation, from the formation of the first peptide bond to the formation of the ... Eukaryotic elongation factors GTP-binding elongation factor family, EF-Tu/EF-1A subfamily Prokaryotic elongation factors ... Elongation factors are a set of proteins that are used in protein synthesis in the process of cell cycle and elongation in some ... Elongation factors play a role in orchestrating the events of this process, and in ensuring the 99.99% accuracy of translation ...
*  Thiostrepton
"Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu". J. Am. Chem. Soc. 131 (16): 5946-55. doi: ... The precursor of thiostrepton contains 58 amino acids in the peptide chain, which includes 41-aa leading peptide (LP) and 17-aa ... Bycroft, Barrie W.; Gowland, Maxim S. (1978). "The structures of the highly modified peptide antibiotics micrococcin P1 and P2 ... Thiostrepton is a natural product of the ribosomally synthesized and post-translationally modified peptide (RiPP) class. ...
*  Protein synthesis inhibitor
Fusidic acid prevents the turnover of elongation factor G (EF-G) from the ribosome. Ricin inhibits elongation by enzymatically ... Thus, it binds to the ribosomal A site and participates in peptide bond formation, producing peptidyl-puromycin. However, it ... Quinupristin binds to a nearby site on the 50S ribosomal subunit and prevents elongation of the polypeptide, as well as causing ... Chloramphenicol blocks the peptidyl transfer step of elongation on the 50S ribosomal subunit in both bacteria and mitochondria ...
*  Post-translational modification
1989). "Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine- ... a frog opioid peptide of methionine in deltorphin, also a frog opioid peptide protein splicing, self-catalytic removal of ... beta-Lysine addition on a conserved lysine of the elongation factor P (EFP) in most bacteria. EFP is an homolog to eIF5A ( ... "The tRNA synthetase paralog PoxA modifies elongation factor-P with (R)-β-lysine". Nat Chem Biol. 7: 667-9. doi:10.1038/nchembio ...
*  Central dogma of molecular biology
Complexes of initiation factors and elongation factors bring aminoacylated transfer RNAs (tRNAs) into the ribosome-mRNA complex ... The biopolymers that comprise DNA, RNA and (poly)peptides are linear polymers (i.e.: each monomer is connected to at most two ... Some proteins then excise internal segments from their own peptide chains, splicing the free ends that border the gap; in such ... As the amino acids get linked into the growing peptide chain, the chain begins folding into the correct conformation. ...
*  EEF1G
Elongation factor 1-gamma is a protein that in humans is encoded by the EEF1G gene. This gene encodes a subunit of the ... "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. ... "Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli. Subunit interactions, elongation activity ... Kim JE, Kim KH, Lee SW, Seol W, Shiba K, Kim S (2000). "An elongation factor-associating domain is inserted into human ...
*  Enterobacteria phage T4
The rate of DNA replication in a living cell was measured as the rate of phage T4 DNA elongation in phage-infected E. coli. ... and late sigma factor (gp55) interaction". J Mol Biol. 319 (2): 289-304. doi:10.1016/S0022-2836(02)00298-X. PMID 12051907. (T4 ... "A bipartite bacteriophage T4 SOC and HOC randomized peptide display library: detection and analysis of phage T4 terminase (gp17 ... McCarthy D, Minner C, Bernstein H, Bernstein C (1976). "DNA elongation rates and growing point distributions of wild-type phage ...