... is a protein that in humans is encoded by the PGA3 gene. This gene encodes a protein ... "Entrez Gene: Pepsinogen 3, group I (pepsinogen A)". Retrieved 2017-08-25. Shiotani A, Iishi H, Uedo N, Kumamoto M, Nakae Y, ... pepsinogen I and pepsinogen II levels in patients with duodenal ulcer". J. Gastroenterol. Hepatol. 23 (11): 1666-71. doi: ... Kamangar F, Diaw L, Wei WQ, Abnet CC, Wang GQ, Roth MJ, Liu B, Lu N, Giffen C, Qiao YL, Dawsey SM (2009). "Serum pepsinogens ...

... also known as pepsinogen C or pepsinogen II is a pepsinogen precursor of the enzyme gastricsin that in humans is ... Pepsinogen Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K (January 1988). "Primary structure of human pepsinogen ... Pals G, Azuma T, Mohandas TK, Bell GI, Bacon J, Samloff IM, Walz DA, Barr PJ, Taggart RT (February 1989). "Human pepsinogen C ( ... 1997). "Purification of pepsinogens from human urine and electrophoretic analysis by caseogram print". Biochem. Mol. Biol. Int ...

It is produced by the stomach cells called "chief cells" in its inactive form pepsinogen, which is a zymogen. Pepsinogen is ... Gastric chief cells: Produce pepsinogen. Chief cells are mainly found in the body of stomach, which is the middle or superior ... and also to activate pepsinogen into pepsin. Intrinsic factor (IF): Intrinsic factor is produced by the parietal cells of the ...

"Entrez Gene: PGA5 pepsinogen 5, group I (pepsinogen A)". Ichinose M, Miki K, Wong RN, et al. (1991). "Methylation and ... Pepsinogen A is a protein that in humans is encoded by the PGA5 gene. GRCh38: Ensembl release 89: ENSG00000256713 - Ensembl, ... 1987). "Molecular cloning of a pair of human pepsinogen A genes which differ by a Glu----Lys mutation in the activation peptide ... 1989). "The renal metabolism of pepsinogen A and C in man". Clin. Nephrol. 31 (2): 103-6. PMID 2920466. Evers MP, Zelle B, ...

Ong, E. B. & Perlmann, G. E. (1968). "The amino-terminal sequence of porcine pepsinogen". J. Biol. Chem. 243 (23): 6104-6109. ... particularly her discoveries on the biology phosphoproteins and the structure and action of pepsin and pepsinogen. Perlmann was ...

Conversely, inhibition of CCKB receptors in the gut produces similar inhibition of secretion of gastric acid and pepsinogen ... "CCK1 and CCK2 receptors regulate gastric pepsinogen secretion". European Journal of Pharmacology. 373 (1): 71-84. doi:10.1016/ ...

Pepsin in its secreted form is inactive (pepsinogen). However, once it reaches the gastric lumen it becomes activated into ...

In birds, the gastric glands of the proventriculus secrete both the HCl and pepsinogen. Since pepsinogen is a zymogen, it is ... It contains glands that secrete HCL and pepsinogen. The gastric glands of birds only have one type of cell that produces both ... The primary function of the proventriculus is to secrete hydrochloric acid (HCl) and pepsinogen into the digestive compartments ... while chief cells secrete the pepsinogen into the lumen. ... HCL and pepsinogen, unlike mammals which have different cell ...

... chief cells that secrete pepsinogen (this is a precursor to pepsin- the highly acidic environment converts the pepsinogen to ... Highly stomach-specific proteins include GKN1, expressed in the mucosa; pepsinogen PGC and the lipase LIPF, expressed in chief ... Gastric juice in the stomach also contains pepsinogen. Hydrochloric acid activates this inactive form of enzyme into the active ...

McPhie, P. (2 December 1975). "The origin of the alkaline inactivation of pepsinogen". Biochemistry. 14 (24): 5253-5256. doi: ...

In pepsinogen A, the first 11 residues of the mature pepsin sequence are displaced by residues of the propeptide. The ... Sielecki AR, Fujinaga M, Read RJ, James MN (June 1991). "Refined structure of porcine pepsinogen at 1.8 A resolution". Journal ... Hartsuck JA, Koelsch G, Remington SJ (May 1992). "The high-resolution crystal structure of porcine pepsinogen". Proteins. 13 (1 ... hydrogen bond stabilises the propeptide conformation and is probably responsible for triggering the conversion of pepsinogen to ...

"The origin of the alkaline inactivation of pepsinogen". Biochemistry. 14 (24): 5253-5256. doi:10.1021/bi00695a003. ISSN 0006- ...

Specificity for B chain of insulin is more restricted than that of pepsin A This enzyme is formed from pig pepsinogen B. Pepsin ... Ryle AP (1970). Perlmann GE, Lorand, L (eds.). The porcine pepsins and pepsinogens. Methods in Enzymology. Vol. 19. pp. 316-336 ...

Pepsin Lee D, Ryle AP (September 1967). "Pepsinogen D. A fourth proteolytic zymogen from pig gastric mucosa". The Biochemical ... James MN, Sielecki AR (1986). "Molecular structure of an aspartic proteinase zymogen, porcine pepsinogen, at 1.8 A resolution ...

"Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression". Journal of Cancer Research and Clinical ...

Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with hydrochloric acid produced by gastric ... The gastric chief cell (also known as a zymogenic cell or peptic cell) is a cell in the stomach that releases pepsinogen and ... Leptin has been found in the pepsinogen granules of chief cells. Gastric pit cells are replaced every 2-4 days. This high rate ...

He also crystallized Porcine Pepsinogen and published a paper on crystallization. From 1969-1973, Rao worked as a junior ...

Consequences of the damage done to the gastric gland by O. ostertagi include: Pepsinogen is not activated to its active form, ... Affected glands lack differentiated acid-producing parietal and pepsinogen producing chief cells. Type I and type II disease is ... The analysis of sera for increased plasma pepsinogen levels is a useful diagnostic aid. Generally, increased levels of ... body weight and reproductive measures Blood pepsinogen concentration, which increases with abomasal mucosa injury has also been ...

It also has the function of stimulating pepsinogen secretion by chief cells. VIP seems to be an important neuropeptide during ... Sanders MJ, Amirian DA, Ayalon A, Soll AH (November 1983). "Regulation of pepsinogen release from canine chief cells in primary ...

Hydrochloric acid is secreted by parietal cells, pepsinogen is secreted by gastric chief cells and mucus is secreted by mucus ... Gastric juice contains hydrochloric acid, pepsinogen and mucus in a healthy adult. ...

... pepsinogen A (also called pepsinogen I), pepsinogen B, progastricsin (also called pepsinogen II and pepsinogen C), prochymosin ... Pepsinogen+A at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Pepsinogen+C at the U.S. National Library ... Pepsin cleaves the 44 amino acids from pepsinogen to create more pepsin. Pepsinogens are mainly grouped in 5 different groups ... Pepsin's proenzyme, pepsinogen, is released by the gastric chief cells in the stomach wall, and upon mixing with the ...

Another partially inactivated pepsinogen completes the activation by removing the peptide, turning the pepsinogen into pepsin. ... Enzymes like pepsin are created in the form of pepsinogen, an inactive zymogen. Pepsinogen is activated when chief cells ... Examples of zymogens: Trypsinogen Chymotrypsinogen Pepsinogen Most proteins in the coagulation system (examples, prothrombin, ...

Xie G, Raufman JP (2001). "Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief ...

Northrop also isolated and crystallized pepsinogen (the precursor to pepsin), trypsin, chymotrypsin, and carboxypeptidase. For ...

Gastric chief cells produce pepsinogen, which is activated by the acid to form pepsin. Pepsin is a protease that can digest and ...

Causes chief cells to secrete pepsinogen, the zymogen (inactive) form of the digestive enzyme pepsin. Increases antral muscle ...

... and pepsinogen-producing cells in the abomasum of sheep". Anatomia, Histologia, Embryologia. 30 (4): 231-5. doi:10.1046/j.1439- ...

A gastric chief cell (or peptic cell, or gastric zymogenic cell) is a type of gastric gland cell that releases pepsinogen and ... It works in conjunction with the parietal cell, which releases gastric acid, converting the pepsinogen into pepsin. The terms ... Chief cells release the zymogen (enzyme precursor) pepsinogen when stimulated by a variety of factors including cholinergic ... and pepsinogen-producing cells in the abomasum of sheep". Anatomia, Histologia, Embryologia. 30 (4): 231-235. doi:10.1046/j. ...

... to pepsinogen: a journey through time in quest for the stomach's secretion". Annals of Gastroenterology. 25 (2): 119-122. PMC ...

This is in contrast to the gastric glands of the stomach where chief cells secrete pepsinogen. Also, new epithelium is formed ...