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*  Paxillin
MBInfo: Paxillin Paxillin Info with links in the Cell Migration Gateway Paxillin at the US National Library of Medicine Medical ... paxillin expression levels increased, suggesting a role for paxillin in both types of cardiomyopathy. Paxillin has been shown ... paxillin distribution was revamped coordinate with increased phosphorylation and cleavage of paxillin. Similarly, paxillin was ... Paxillin is a protein that in humans is encoded by the PXN gene. Paxillin is expressed at focal adhesions of non-striated cells ...
*  Keith Burridge
Deakin, NO; Turner, CE (2008). "Paxillin comes of age". Journal of Cell Science. 121 (Pt 15): 2435-44. doi:10.1242/jcs.018044. ... Turner CE, Glenney JR, Burridge K; Glenney Jr; Burridge (September 1990). "Paxillin: a new vinculin-binding protein present in ... His research on focal adhesions includes the discovery of many adhesion proteins including vinculin, talin and paxillin, and ... He then discovered other focal adhesion components including paxillin and contributed to the discovery of zyxin and palladin. ...
*  Focal adhesion
Actin TES (protein) Paxillin Chen, CS; Alonso, JL; Ostuni, E; Whitesides, GM; Ingber, DE (2003). "Cell shape provides global ... paxillin and tensin. Many of these focal complexes fail to mature and are disassembled as the lamellipodia withdraw. However, ...
*  PTPRT
PTPrho also dephosphorylates paxillin on tyrosine 88. Higher levels of tyrosine 88 phosphorylation of paxillin are observed in ... When colon cancer cells are engineered to express a mutant form of paxillin that is incapable of being tyrosine phosphorylated ... This suggests that PTPrho may function as a tumor suppressor protein by regulating paxillin phosphorylation. PTPrho has been ... 2010). "Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T". ...
*  PTPN12
Côté, J F; Turner C E; Tremblay M L (Jul 1999). "Intact LIM 3 and LIM 4 domains of paxillin are required for the association to ... Nishiya, N; Iwabuchi Y; Shibanuma M; Côté J F; Tremblay M L; Nose K (Apr 1999). "Hic-5, a paxillin homologue, binds to the ... 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain". J. ... PTPN12 has been shown to interact with BCAR1, Grb2, PSTPIP1, TGFB1I1, Paxillin and SHC1. GRCh38: Ensembl release 89: ...
*  CD49d
... has been shown to interact with LGALS8 and Paxillin. GRCh38: Ensembl release 89: ENSG00000115232 - Ensembl, May 2017 ... "A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell ... "Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding". J. Biol. Chem. 276 (44): 40903-9. doi: ...
*  SORBS1
"Paxillin and ponsin interact in nascent costameres of muscle cells". Journal of Molecular Biology. 369 (3): 665-82. doi:10.1016 ...
*  PTK2
Mazaki Y, Hashimoto S, Sabe H (March 1997). "Monocyte cells and cancer cells express novel paxillin isoforms with different ... Schaller MD, Otey CA, Hildebrand JD, Parsons JT (September 1995). "Focal adhesion kinase and paxillin bind to peptides ... Brown MC, Perrotta JA, Turner CE (November 1996). "Identification of LIM3 as the principal determinant of paxillin focal ... Additional components of focal adhesions include actin, filamin, vinculin, talin, paxillin, tensin and RSU-1. FAK is ...
*  CRKL
Paxillin RAPGEF1, RICS, STAT5A, Syk, and WAS. Crk GRCh38: Ensembl release 89: ENSG00000099942 - Ensembl, May 2017 GRCm38: ... competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase". Molecular and Cellular Biology ... "CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells". The Journal of Biological Chemistry. 270 (49): ... "CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells". The Journal of Biological Chemistry. 270 (49): ...
*  Vinculin
The complex at the focal adhesions consists of several proteins such as vinculin, α-actin, paxillin, and talin, at the ... Turner CE, Miller JT (1994). "Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM ... Mazaki Y, Hashimoto S, Sabe H (March 1997). "Monocyte cells and cancer cells express novel paxillin isoforms with different ... Mazaki Y, Hashimoto S, Sabe H (1997). "Monocyte cells and cancer cells express novel paxillin isoforms with different binding ...
*  TGFB1I1
Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (Apr 1999). "Hic-5, a paxillin homologue, binds to the protein ... Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (Apr 1999). "Hic-5, a paxillin homologue, binds to the protein ... Liu S, Thomas SM, Woodside DG, Rose DM, Kiosses WB, Pfaff M, Ginsberg MH (Dec 1999). "Binding of paxillin to alpha4 integrins ... "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling ...
*  LPXN
2000). "Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses". Nature. 402 (6762): 676-81. ... paxillin. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. ...
*  GIT1
Nishiya N, Shirai T, Suzuki W, Nose K (2003). "Hic-5 interacts with GIT1 with a different binding mode from paxillin". J. ...
*  BCAR1
Panetti TS (2002). "Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration". Front. ...
*  TLN1
Mazaki Y, Hashimoto S, Sabe H (Mar 1997). "Monocyte cells and cancer cells express novel paxillin isoforms with different ... "Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL". The Journal of Biological ...
*  BCR (gene)
"Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL". J. Biol. Chem. 270 (10): 5039-47 ...
*  PAK1
Paxillin-S258, and Paxillin-S273. PAK1 and/or PAK1-dependent signals modulate the expression of its genomic targets, including ... Nayal A, Webb DJ, Brown CM, Schaefer EM, Vicente-Manzanares M, Horwitz AR (May 2006). "Paxillin phosphorylation at Ser273 ... paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases". Molecular Cell. 49 (4): 668-79. doi:10.1016/j ...
*  PTK2B
Paxillin, RAS p21 protein activator 1, RB1CC1, SORBS2, Src, and TGFB1I1, VE-PTP Tyrosine kinase GRCh38: Ensembl release 89: ... that shares extensive homology with paxillin". J. Cell Sci. 112 (2): 181-90. PMID 9858471. Avraham S, Avraham H (1997). " ... kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin". J ...
*  Mary Beckerle
PLoS Genet 9(3):e1003406.[LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain.Smith MA, ... 2013) LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PLoS One. 8(8):e69378. Pronovost ... 2013) LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PLoS One. 8(8):e69378.[2] ... Blankman E, Deakin NO, Hoffman LM, Jensen CC, Turner CE, Beckerle MC (2013). LIM domains target actin regulators paxillin and ...
*  Megakaryocyte-associated tyrosine kinase
Grgurevich S, Mikhael A, McVicar DW (1999). "The Csk homologous kinase, Chk, binds tyrosine phosphorylated paxillin in human ...
*  Alpha-tubulin 3C
"Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton". The ...
*  PPP2R5C
"A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal. 19 (4 ... "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal. 19 (4 ...
*  PAK2
... paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases". Molecular Cell. 49 (4): 668-79. doi:10.1016/j ... Paxillin phosphorylation at S272 and S274 activates ADAM10 protease, and STAT5 phosphorylation at S779 modulates BCL-ABL- ...
*  PARVA
Nikolopoulos SN, Turner CE (2002). "Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their ... a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion". J. Cell Biol. 151 (7): 1435- ...
*  TUBG2
2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton". J ...