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*  PAX7
... is a transcription factor that plays a role in myogenesis through regulation of muscle precursor cells proliferation. It ... Paired box protein Pax-7 is a protein that in humans is encoded by the PAX7 gene. Pax-7 plays a role in neural crest ... PAX7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) PAX7 human gene location in the UCSC ... However, PAX7 is not required for spermatogenesis, as mice without PAX7+ spermatogonia show no deficits in fertility. PAX7 may ...
*  Neural plate
... border specifiers are induced as a set of transcription factors. Distalless-5, PAX3 and PAX7 prevent the border ... These induce a second set of transcription factors called neural crest specifiers, which cause cells to become neural crest ... Bone morphogenetic protein 4, or BMP4, is a transforming growth factor that causes the cells of the ectoderm to differentiate ...
*  PAX3
... of ARMS cases is associated with less common fusions of PAX7 to FOXO1 or rare fusions of PAX3 to other transcription factors, ... PAX3 and FOXO1 encode transcription factors, and the translocation results in a fusion transcription factor containing the N- ... Interaction of PAX3 with other transcription factors (such as SOX10) or chromatin factors (such as PAX3/7BP) enables ... PAX3 encodes a transcription factor with an N-terminal DNA binding domain consisting of a paired box (PD) encoded by exons 2, 3 ...
*  Myosatellite cell
Greater activation also results in increased expression of myogenic basic helix-loop-helix transcription factors MyoD, myogenin ... greater activation results in the progressive loss of Pax7 expression as they enter the proliferative stage. However, Pax7 is ... Myocyte nuclear factor (MNF), and c-met proto-oncogene (receptor for hepatocyte growth factor (HGF)) are less commonly used ... It is thought that HGF activates satellite cells, while insulin growth factor-I (IGF-1) and fibroblast growth factor (FGF) ...
*  Alveolar rhabdomyosarcoma
There is an age determination on which PAX proteins fuse together with the FOXO1 transcription factor. PAX3-FOXO1 positive ... The PAX7-FOXO1 fusion is often amplified in tumors (about 70 percent of all PAX7-FOXO1 fusion positive tumors) and the PAX3- ... Two fusion proteins can be associated with ARMS, but are not necessary, PAX3-FKHR (now known as FOXO1). and PAX7-FKHR. In ... Both fusion genes are composed of either the PAX3 or PAX7 DNA binding domains and the FOXO1 transactivation domain. This fusion ...
*  Pax genes
A Review of the Highly Conserved PAX6 Gene in Eye Development Regulation Paired domain in PROSITE Pax Transcription Factors at ... PAX7 has been possibly associated with myogenesis. It transcribes a protein of 520 amino acids from 8 exons and 2,260bps in ... genes are a family of genes coding for tissue specific transcription factors containing a paired domain and usually a partial, ... PAX7 directs postnatal renewal and propagation of myogenic satellite cells but not for the specification. PAX8 has been ...
*  MyoD
... is a transcription factor and can also direct chromatin remodelling through binding to a DNA motif known as the E-box. ... competent tissues that receive these wnt signals to actively express Pax3 and Pax7 in addition to myogenic regulatory factors, ... NFATc1 is a transcription factor that regulates composition of fiber type and the fast-to-slow twitch transition resulting from ... MyoD expression is a key transcription factor in fast twitch fibers which is inhibited by NFATc1 in oxidative fiber types. ...
*  Myogenesis
... proteins transcription factor family. Cells that make myogenic bHLH transcription factors (including MyoD or Myf5) are ... Associated Genetic Factors: PAX7 Mutations in Pax7 will prevent the formation of satellite cells and, in turn, prevent ... Sim2, a BHLH-Pas transcription factor, inhibits transcription by active repression and displays enhanced expression in ventral ... PAX3 is needed for the transcription of c-Met. Associated Genetic Factors: PAX3, c-Met, Mox2, MSX1, Six, Myf5, and MyoD Mox2 ( ...
*  Homeobox
Homeoprotein transcription factors typically switch on cascades of other genes. The homeodomain binds DNA in a sequence- ... PAX7; PDX1; PHOX2A; PHOX2B; PITX1; PITX2; PITX3; PROP1; PRRX1; PRRX2 RAX; RAX2; RHOXF1; RHOXF2 SATB1; SATB2; SEBOX; SHOX; SHOX2 ... Boudreau NJ, Varner JA (Feb 2004). "The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and ... These genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure ...
*  Mir-1 microRNA precursor family
... for the role of miR-1-2 as a modulator in acute myeloid leukemia via its transcription by the zinc-finger transcription factor ... "microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7". J ... Townley-Tilson WH, Callis TE, Wang D (2010). "MicroRNAs 1, 133, and 206: critical factors of skeletal and cardiac muscle ... that the control of smooth muscle cell differentiation by MiR-1 may be mediated by the down regulation of Kruppel-like factor 4 ...