RhoA also activates focal adhesion kinase activity. Together, these two pathways create the motile and invasive phenotype of ... stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility. These functions are activated by ... Increased expression of RhoA and ROCK1 in endothelial cell migration pathways can cause an increase in angiogenesis and ... and cell-cell and cell-matrix adhesion. In addition, ROCK kinases influence more distal cellular processes including gene ...

Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a ... Hafizi S, Ibraimi F, Dahlbäck B (2006). "C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits ...

Normal FAK is a tyrosine kinase that gets recruited to focal adhesion sites and plays a key role in directed cell movement. ... as cancer is the dysregulation of these normal pathways. Knowing which pathways involve Fyn will provide key insight for the ... This family also includes Abl, Src, focal adhesion kinase and Janus kinase.) Fyn is located downstream of several cell surface ... a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation ...

"Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway". Journal of Cell Science. 122 (Pt ...

It also participates in signalling pathways that lead to metastasis, and it regulates the cytoskeleton and focal adhesions. A ... Cdk5 also phosphorylates Focal adhesion kinase (FAK). This may stimulate nuclear translocation, which plays an important role ... It was demonstrated that a decrease in Cdk5 reduced the expression of TAZ, a component of the Hypothalamus pathway. As a result ... Recently Cdk5 has emerged as an essential kinase in sensory pathways. Recent reports by Pareek et al. suggest its necessity in ...

"Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase". Nature. Springer Science ... In particular, Schlaepfer is well known for his studies on focal adhesion kinase (FAK). Schlaepfer received his PhD in ... "Integrin α4β1 Promotes Focal Adhesion Kinase-Independent Cell Motility via α4 Cytoplasmic Domain-Specific Activation of c-Src ... focal adhesion formation, and cell motility". Journal of Cell Biology. Rockefeller University Press. 180 (1): 187-203. doi: ...

... paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway". Mol. ... and its localization in focal adhesion". Biochemical and Biophysical Research Communications. 235 (3): 794-798. doi:10.1006/ ... via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth". J. Biol. Chem. 277 (46 ... "Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion". J. Biol. Chem. 278 (52): 52116-23. doi ...

NRG-1 activates the MAPK pathway and the PI3K/AKT pathway as well as focal adhesion kinases (FAK). These are all significant ... The pathway initiates the MAP kinase pathway as well as the PI3 kinase/AKT pathway, which in turn activates the NF-κB pathway. ... These include the PI3K/Akt pathway and the MAPK pathway. Signals on these pathways promote cell proliferation and the growth of ... The EGF pathway includes the receptors HER1 (EGFR), HER2, HER3, and HER4; the binding of ligands (e.g. EGF etc.) to HER ...

Because inhibition of RhoA results in a decrease in both stress fibers and focal adhesion, cell motility is increased. P27 can ... Recent research has suggested that both miR-221 and miR-222 control p27 levels although the pathways are not well understood. ... Non-epithelial cancers use different pathways to inactivate p27. Many cancer cells also upregulate Skp2 which is known to play ... P27 is misplaced to the cytoplasm by the MAP2K, Ras, and Akt pathways although the mechanisms are not entirely understood. ...

Alternatively, LRP1 may regulate focal adhesion disassembly of cancer cells through the ERK and JNK pathways to aid invasion. ... Statin Pathway edit]] The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". Cluster of ... "Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly". The ... LRP1 mediates pathways that interact with astrocytes and pericytes, which are associated with the blood-brain barrier. In ...

Gordon JA, Sodek J, Hunter GK, Goldberg HA (2009). "Bone sialoprotein stimulates focal adhesion-related signaling pathways: ... delineation of the mineral-binding and cell adhesion domains and structural analysis of the RGD domain". J. Bone Miner. Res. 12 ...

Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM (July 1999). "PTEN interactions with focal adhesion kinase and ... This pathway is regulated in part by PTEN. Loss of PTEN allows the pathway to go into overdrive, leading to cancer. A drug that ... Haier J, Nicolson GL (February 2002). "PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of ... Sansal I, Sellers WR (July 2004). "The biology and clinical relevance of the PTEN tumor suppressor pathway". Journal of ...

Such signaling is mainly orchestrated in focal adhesions, regions where the integrin-bound actin cytoskeleton detects changes ... The three main pathways that lead to its activation are GPCR pathways, RTK pathways, and gated ion channels; it regulates ... This pathway is very complex and includes many protein components. In many cell types, activation of this pathway promotes cell ... MAPK/ERK pathway: A pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. ...

The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). ... Han DC, Shen TL, Guan JL (Sep 2000). "Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase ... Han DC, Guan JL (Aug 1999). "Association of focal adhesion kinase with Grb7 and its role in cell migration". The Journal of ... Han DC, Guan JL (Aug 1999). "Association of focal adhesion kinase with Grb7 and its role in cell migration". The Journal of ...

... such as focal adhesion kinase) and the Hippo signaling pathway are present in unicellular holozoans. Other signaling pathways ... possess genes that encode proteins involved in cell-cell adhesion and cell-matrix adhesion (e.g. cadherin and integrin, ... Adhesion proteins are necessary in allowing cells to stick to each other and to the extracellular matrix, forming layers and ... insights into the unicellular ancestor of animals are obtained from the analysis of shared genes and genetic pathways between ...

"The Rho-mDia1 Pathway Regulates Cell Polarity and Focal Adhesion Turnover in Migrating Cells through Mobilizing Apc and c-Src ... which are connected at one of their ends to focal adhesions, where actin polymerization occurs. Stress fiber assembly at focal ... "Tension is required but not sufficient for focal adhesion maturation without a stress fiber template". The Journal of Cell ... filopodia and cell adhesions CLIP 170: Binds the FH2 domain and recruits mDia1 to sites of phagocytosis Gα12/13: Helps to ...

Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM (July 1999). "PTEN interactions with focal adhesion kinase and ... BDNF can promote protective pathways and inhibit damaging pathways in the NSCs and NPCs that contribute to the brain's ... Both of these pathways probably involve calcium-mediated phosphorylation of CREB at Ser133, thus allowing it to interact with ... The activation of the BDNF-TrkB pathway is important in the development of short-term memory and the growth of neurons.[ ...

2002). "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and ... "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine- ... 2006). "JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration". J. Biol. Chem ... 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of ...

... signal transduction pathways and hematpoiesis/Chronic myelogenous leukemia. He was the first to fully clone the focal adhesion ... "The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells". The Journal of Biological ... a focal adhesion protein phosphorylated by P210BCR/ABL". The Journal of Biological Chemistry. 270 (10): 5039-5047. doi:10.1074/ ... "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". ...

... is the best established signaling pathway for NEDD9. Integrins are transmembrane proteins that nucleate focal adhesions, ... Focal adhesion targeting (FAT) domain The FAT-like C-terminal domain is highly conserved in focal adhesion proteins, and ... Hayashi I, Vuori K, Liddington RC (2002). "The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix ... This cleavage is prevented by focal adhesion formation, which suggests NEDD9 as a sensor of altered adhesion states. ...

Signal transduction pathways regulated via RhoA link plasma membrane receptors to focal adhesion formation and the subsequent ... Inhibition of this pathway prevented and ameliorated pathologic changes in diabetic complications, indicating that RhoA pathway ... similar to the attachment and detachment process found in the focal adhesion mechanism. ... therefore inhibits the growth and repair of neural pathways and axons. Inhibition of this pathway by its various components ...

... extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion ... induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways". Brain Res. Bull. 71 (1-3): 116-26. doi:10.1016/j ... involvement of the ubiquitin proteosome pathway". Exp. Hematol. 27 (10): 1542-7. doi:10.1016/S0301-472X(99)00094-6. PMID ...

Focal adhesions are large molecular complexes, which are generated following interaction of integrins with ECM, then their ... The repertoire of integrins expressed on a particular cell can specify the signaling pathway due to the differential binding ... So the focal adhesions contain integrin ligand, integrin molecule, and associate plaque proteins. Binding is propelled by ... In a reverse direction, when a receptor tyrosine kinase is activated, integrins co-localise at focal adhesion with the receptor ...

As with CD44, RHAMM can promote focal adhesion turnover by controlling focal adhesion kinase (FAK) phosphorylation and ... Mechanistically, RHAMM has been shown to promote cell motility through a number of different pathways. ... Hall CL, Wang C, Lange LA, Turley EA (Jul 1994). "Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover ... Extracellularly, RHAMM associates with CD44, and upon binding to hyaluronan, activates intracellular signaling pathways, mainly ...

Desmosome Epidermolysis bullosa Focal adhesion Nguyen NM, Pulkkinen L, Schlueter JA, Meneguzzi G, Uitto J, Senior RM (2006). " ... Hemidesmosomes are also involved in signaling pathways, such as keratinocyte migration or carcinoma cell intrusion. ... Hemidesmosomes are also comparable to focal adhesions, as they both attach cells to the extracellular matrix. Instead of ...

"A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading". J. Cell ... which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells ... Velyvis A, Yang Y, Wu C, Qin J (2001). "Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization ... found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2 ...

... inhibits the activation of FAK (Focal Adhesion Kinase), Phosphoinositide 3-kinase (PI3-kinase), protein kinase B (PKB ... One study has been done to determine the exact pathway used by tumstatin to induce apoptosis. This revealed that the pathway ... Tumstatin interacts with the αvβ3 integrin found in the apoptosis pathway. There are two activation sites on the tumstatin ... Since the mechanisms of both of these pathways are not unique to cancer, tumstatin's regulation of angiogenesis and apoptosis ...

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein ... Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene ... Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N- ... Smolenski A, Poller W, Walter U, Lohmann SM (2000). "Regulation of human endothelial cell focal adhesion sites and migration by ...

... such as focal adhesion kinase (FAK), which is involved in cell adhesion and migration. Sarcospan has been implicated in the ... SSPN is also an essential regulator of Akt signaling pathways. Without SSPN, Akt signaling pathways will be hindered and muscle ... For example, studies have shown that targeting specific signaling pathways, such as the FAK pathway, which is regulated by ... Sarcospan also plays a role in signaling pathways that are involved in muscle growth and regeneration. Studies have shown that ...

... a reduction in focal adhesion tension by transferring cells to softer ECM or by inhibiting ROCK results in focal adhesion ... Though the precise pathway that connects ECM stiffness to ROCK activity is unknown, the observation of increased traction in ... The properties of focal adhesions - whether stable or tugging - are independent of their neighbors and as such, each focal ... focal adhesions are quite more than simple anchors - their proteins have many roles in signaling. These proteins, such as focal ...