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*  Automated patch clamp
"Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches". Pflügers ... Automated patch clamping is beginning to replace manual patch clamping as a method to measure the electrical activity of ... Book chapter on planar patch clamping Center for Automated In-Vivo Patch Clamp Recording. ... Different techniques are used to automate patch clamp recordings from cells in cell culture and in vivo. This work has been ...
*  Action potential
"Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches". Pflugers Arch ... Neher E (1992). "The patch clamp technique". Scientific American. 266 (3): 44-51. doi:10.1038/scientificamerican0392-44. PMID ... who developed the technique of patch clamping to examine the conductance states of individual ion channels. In the 21st century ... Patch-clamping verified that ionic channels have discrete states of conductance, such as open, closed and inactivated. Optical ...
*  Erwin Neher
Neher E (September 1988). "The use of the patch clamp technique to study second messenger-mediated cellular events". ... Neher E, Sakmann B (March 1992). "The patch clamp technique". Scientific American. 266 (3): 44-51. doi:10.1038/ ... through their development of the patch-clamp technique, a project Neher began as a postdoctoral research associate in the ... Neher E, Sakmann B, Steinbach JH (July 1978). "The extracellular patch clamp: a method for resolving currents through ...
*  Channelome
Jurkat-Rott, K.; Lehmann-Horn, F. (2004). "The Patch Clamp Technique in Ion Channel Research". Current Pharmaceutical ... It can be performed by a variety of techniques, including patch clamp electrophysiology, PCR, and immunohistochemistry. ... conventional and automated patch clamp analysis". Pharmacological research : the official journal of the Italian ...
*  Patch clamp
Patch clamping can be performed using the voltage clamp technique. In this case, the voltage across the cell membrane is ... The patch clamp technique is a laboratory technique in electrophysiology used to study ionic currents in individual isolated ... patch clamp recording over sharp electrode technique recording is that the larger opening at the tip of the patch clamp ... The inside-out and outside-out techniques are called "excised patch" techniques, because the patch is excised (removed) from ...
*  Charles F. Stevens
This work paved the way for Nobel laureate Erwin Neher's patch clamping techniques. Neher was a postdoctoral associate with ...
*  Large-conductance mechanosensitive channel
MscL was first discovered on the surface of giant Escherichia coli spheroplasts using patch-clamp technique. Subsequently, the ... showed that both Ec-MscS and Ec-MscL are capable of adaptive behavior under constant pressure stimuli in excised membrane patch ...
*  Bert Sakmann
"Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches". Pflügers ... and invention of the patch clamp. Bert Sakmann was Professor at Heidelberg University and is an Emeritus Scientific Member of ...
*  Argiotoxin
In this case, the analysis was made of the stomach muscles and using the patch clamp technique. The research findings were ... Then, the observation was based on routine voltage clamp technique. Electrical measurements were obtained from the evaluation ...
*  Calcium channel blocker
Perforated patch clamp technique was used having intracellular fluid inside the pipette and extracellular fluid in the bath ... VGCCs were isolated and calcium current was recorded using patch clamp technique having ethanol as a treatment. Recordings were ... Voltage clamp recordings have been done on the aplysia neuron. ... at a voltage clamp of +30 mV. Results showed calcium current ...
*  Viral neuronal tracing
This is a useful method if you wish to label a cell after performing the patch clamp technique. Once the tracer is introduced ...
*  Hyperpolarization (biology)
Hyperpolarization is a change in membrane potential, neuroscientists measure it using a technique known as patch clamping. ... This is done using a glass micropipette, also called a patch pipette, with a 1 micrometer diameter. There is a small patch that ... Using an amplifier and a voltage clamp, which is an electronic feedback circuit, allows the experimenter to maintain the ... membrane potential at a fixed point and the voltage clamp then measures tiny changes in current flow. The membrane currents ...
*  Flame polishing
... is essential to creation of the glass pipettes used for the patch clamp technique of voltage clamping. Fire ...
*  Pflügers Archiv: European Journal of Physiology
In 1978, Erwin Neher and Bert Sakmann published the first description of the patch clamp technique in Pflügers Archiv. Pflügers ... "The Extracellular Patch Clamp: A Method for Resolving Currents Through Individual Open Channels in Biological Membranes", ... From the First Action Potential to Patch Clamp", Pflügers Archiv: European Journal of Physiology, 447 (3): 267-271, doi:10.1007 ...
*  Stuart Cull-Candy
He has been a keen advocate of patch-clamp recording techniques combined with molecular methods for investigating central ...
*  Stimulus (physiology)
Patch clamp techniques allow for the manipulation of the intracellular or extracellular ionic or lipid concentration while ...
*  Multielectrode array
This non-invasive electrophysiology laboratory technique can be more efficient than the patch clamp method. Microelectrode ... Furthermore, in vitro arrays are non-invasive when compared to patch clamping because they do not require breaching of the cell ... In general, the major strengths of in vitro arrays when compared to more traditional methods such as patch clamping include: ... Animat Artificial pacemaker Deep brain stimulation Patch clamp Bioelectronics Boven K-H, Fejtl M, Möller A, Nisch W, Stett A. ...
*  UCL Neuroscience
He went on to directly measure singe ion channel currents by developing the now ubiquitously used patch-clamp technique with ... To achieve this, they developed a voltage-clamp technique to demonstrate that impulse transmission relied upon the selective ...
*  Soliton model in neuroscience
citation needed) Single channel currents The patch clamp technique isolates a microscopic patch of membrane on the tip of a ... Ionic currents under voltage clamp The voltage clamp, used by Hodgkin and Huxley (1952) (Hodgkin-Huxley Model) to ... accurately predict the properties of the macroscopic currents measured under conventional voltage clamp. (citation needed) ... action potentials is a routinely observed phenomenon in neuroscience laboratories and are the basis of a standard technique for ...
*  Harvey Prize
"Breakthrough achievements in developing the patch clamp technique which revolutionized modern electrophysiology by enabling ... "Research and techniques in the improvement of cereal grains, which have inspired scientists seeking to provide adequate food ... "Contribution to science and technology through his development of nuclear magnetic resonance techniques for generating images ... of many previously intractable problems and has made linear programming into one of the most frequently used techniques of ...
*  Neurophysics
Examples of techniques developed and used in neurophysics are patch clamp, tomography and two-photon excitation microscopy. ...
*  Voltage sensitive phosphatase
Because membrane potential can be controlled using patch clamp techniques, placing VSPs in a membrane allows for experimenters ...
*  Two-pore channel
... s were analyzed by using cell biological methods, endolysosomal patch clamp techniques, and a variety of other ... especially the patch clamp technique. In order to clearly visualize the plant vacuoles, scientists have relied on fluorescent ... Using these techniques, scientists have been able to collect significant qualitative data in order to make conclusions about ...
*  Alexander G. Petrov
Curvature electric effects in artificial and natural membranes studied using patch clamp techniques, A. G. Petrov, R. L. Ramsey ...
*  Vesicle (biology and chemistry)
While transport can be more easily investigated with patch clamp techniques, vesicles can also be isolated from objects for ... which a patch clamp is not applicable. Phospholipid vesicles have also been studied in biochemistry. For such studies, a ...
*  Plastic welding
The alternative is a patch, except that the patch can not be sanded flush with the original surrounding plastic to the same ... This technique requires one part to be transmissive to a laser beam and either the other part absorptive or a coating at the ... The friction caused by the motion combined with the clamping pressure between the two parts creates the heat which begins to ... A number of techniques are used for welding of semi-finished plastic products as given below: Hot gas welding, also known as ...