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*  Taxine
There has been a recent discovery in a molecule derived from the yew: paclitaxel. It has been proved that it functions as an ... paclitaxel, isotaxine B, taxine A), glycosides (taxicatine) and taxane derivates (taxol A, taxol B). There have been a lot of ...
*  Epothilone
Like paclitaxel, epothilone B binds to the αβ-tubulin heterodimer subunit. Once bound, the rate of αβ-tubulin dissociation ... Epothilone B possess the same biological effects as paclitaxel both in vitro and in cultured cells. This is because they share ... Ganguly A, Yang H, Cabral F (November 2010). "Paclitaxel-dependent cell lines reveal a novel drug activity". Mol. Cancer Ther. ... Due to their better water solubility, cremophors (solubilizing agents used for paclitaxel which can affect cardiac function and ...
*  Paclitaxel total synthesis
... in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol ... "Synthesis of Paclitaxel. 1. Synthesis of the ABC Ring of Paclitaxel by SmI2-Mediated Cyclization" Organic Letters 17 (11), 2570 ... but it also opens the way to paclitaxel derivatives not found in nature but with greater potential. The paclitaxel molecule ... Paclitaxel Total Syntheses @ SynArchive.com Taxolog for Taxol research, founded by Holto The complete Taxol story from Chemical ...
*  Metastatic breast cancer
This has a higher response rate than solvent-based paclitaxel (15% vs 8%). Abraxane can also deliver a 49% higher dose of ... medication than solvent-based paclitaxel; however, the side effects are severe and include chemotherapy-induced peripheral ...
*  Paclitaxel
Albumin-bound paclitaxel (trade name Abraxane, also called nab-paclitaxel) is an alternative formulation where paclitaxel is ... Space-filling model of paclitaxel Rotating paclitaxel molecule model Crystal structure of paclitaxel Total charge surface of ... Moreover, Paclitaxel has been used in vitro to inhibit insulin fibrillation; in a molar ratio of 10:1 (insulin:paclitaxel), it ... Paclitaxel is one of several cytoskeletal drugs that target tubulin. Paclitaxel-treated cells have defects in mitotic spindle ...
*  DHA-paclitaxel
The advantage of DHA-paclitaxel over paclitaxel is DHA-paclitaxel's ability to carry much higher concentrations of paclitaxel ... DHA-paclitaxel (or Taxoprexin) is an investigational drug (from Protarga Inc) made by linking paclitaxel to docosahexaenoic ... With increased activity, DHA-paclitaxel, also known as Taxoprexin, may have a more successful response in cancer patients than ... "A phase II open-label study of DHA-paclitaxel (Taxoprexin) by 2-h intravenous infusion in previously untreated patients with ...
*  Protein-bound paclitaxel
... , also known as nanoparticle albumin-bound paclitaxel or nab-paclitaxel, is an injectable formulation ... Stinchcombe, Thomas E (2007). "Nanoparticle albumin-bound paclitaxel: a novel Cremphor-EL®-free formulation of paclitaxel". ... In this formulation, paclitaxel is bonded to albumin as a delivery vehicle. It is manufactured and sold in the United States by ... "Paclitaxel (Abraxane)". U.S. Food and Drug Administration. 11 October 2012. Retrieved 10 December 2012. Resolution 9190, ...
*  DMOZ - Health: Pharmacy: Drugs and Medications: P: Paclitaxel
Paclitaxel was approved by the FDA in 1992 for use in the treatment of ovarian cancer and in 1994 for use in the treatment of ... Paclitaxel is a chemotherapeutic drug originally developed from the bark of the Pacific Yew tree. Given the relative scarcity ... Paclitaxel was approved by the FDA in 1992 for use in the treatment of ovarian cancer and in 1994 for use in the treatment of ... Paclitaxel is a chemotherapeutic drug originally developed from the bark of the Pacific Yew tree. Given the relative scarcity ...
*  Natural product
Paclitaxel, in contrast, is a tubulin polymerization stabilizer and is used as a chemotherapeutic drug. Paclitaxel is based on ... Sneader W (2005). "Paclitaxel (taxol)". Drug Discovery: A History (Rev. and updated ed.). Chichester: Wiley. pp. 112-113. ISBN ... An example of this is paclitaxel, which can be manufactured by extracting 10-deacetylbaccatin III from T. brevifolia needles, ... Clinically useful examples include the anticancer agents paclitaxel and omacetaxine mepesuccinate (from Taxus brevifolia and ...
*  Nanomedicine
FDA (October 2012). "Highlights of Prescribing Information, Abraxane for Injectable Suspension" (PDF). "Paclitaxel (Abraxane ... is the nanoparticle albumin bound paclitaxel. Doxil was originally approved by the FDA for the use on HIV-related Kaposi's ...
*  Colloidal gold
Gibson, Jacob D. (2007). "Paclitaxel-Functionalized Gold Nanoparticles". Journal of the American Chemical Society. 129: 11653- ... Gold nanoparticles are being investigated as carriers for drugs such as Paclitaxel. The administration of hydrophobic drugs ...
*  Timeline of cancer treatment development
". "Paclitaxel, Protein-Bound Suspension". Paclitaxel, Protein-Bound Suspension. Cancer.Org. January 6, 2015. Retrieved January ...
*  Specific rotation
"The Merck Index Online: Paclitaxel". Royal Society of Chemistry. Retrieved 30 June 2014. "The Merck Index Online: Penicillin V ...
*  Boston Scientific
"FDA approves Taxus paclitaxel-eluting stent". www.medscape.com/. Retrieved 20 Feb 2015. "Boston Scientific Closes Cameron ...
*  Nicholas Kounis
Everolimus-eluting versus paclitaxel-eluting stents. Kounis NG, Goudevenos JA. Lancet 2010;375:1160-3. Kounis NG. Kounis ...
*  Taxane
Paclitaxel was originally derived from the Pacific yew tree. Taxanes are difficult to synthesize because of their numerous ... Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. Cabazitaxel was FDA approved to treat ... Hoffman, Angela M; Shahidi, Fereidoon (January 2009). "Paclitaxel and other taxanes in hazel". Journal of Functional Foods. 1 ( ... and the international nonproprietary name of the compound is paclitaxel. Taxine Hagiwara, H.; Sunada, Y. (2004). "Mechanism of ...
*  Sonidegib
"LDE225 and Paclitaxel in Solid Tumors". ClinicalTrials.gov. National Institutes of Health. 13 February 2014. Retrieved 16 ... "Gemcitabine + Nab-paclitaxel With LDE-225 (Hedgehog Inhibitor) as Neoadjuvant Therapy for Pancreatic Adenocarcinoma". ...
*  Taxus chinensis
Paclitaxel or Taxol can be produced. The tree can also be used in many other ways and is under special protection of national ...
*  ANG1005
Paclitaxel is generally prevented from reaching its target in the cell due to the presence of the efflux pump P-glycoprotein (P ... ANG1005 is a paclitaxel-Angiopep-2 conjugate. Various Angiopep vectors have been composed and differ by their anti-cancer ... This has then been shown to be a prospective cancer therapy drug that can not only be conjugated to paclitaxel but also ... Therefore, paclitaxel binds at the site of β-tubulin and induces polymerization, thus protecting the microtubule from ...
*  Kaposi's sarcoma
... or paclitaxel. With the decrease in the death rate among people with HIV/AIDS receiving new treatments in the 1990s, the rates ... "Paclitaxel is safe and effective in the treatment of advanced AIDS-related Kaposi's sarcoma". Journal of Clinical Oncology. 17 ... "Mechanism of Paclitaxel Activity in Kaposi's Sarcoma". The Journal of Immunology. 165 (1): 509-17. doi:10.4049/jimmunol.165.1. ...
*  Body surface area
Average BSA Sparreboom A, Verweij J (15 Jul 2003). "Paclitaxel Pharmacokinetics, Threshold Models, and Dosing Strategies". ...
*  Evofosfamide
... evofosfamide and protein-bound paclitaxel (nab-paclitaxel) have been investigated in combination with gemcitabine in patients ... The study CA046 compares gemcitabine with gemcitabine plus nab-paclitaxel. Gemcitabine is a generic product sold by many ... The indirect comparison of both studies shows comparable efficacy profiles of evofosfamide and nab-paclitaxel in combination ... Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine. New England Journal of Medicine 369, 1691-1703 ( ...
*  Robert Yarchoan
He led the first clinical studies showing that paclitaxel was an effective therapy for Kaposi's sarcoma and that thalidomide ... Treatment of HIV-associated Kaposi's sarcoma with paclitaxel. Lancet 346:26-28. Yarchoan Amherst Honorary Degree Description ...
*  Castor oil
Paclitaxel, a mitotic inhibitor used in cancer chemotherapy; Sandimmune (cyclosporine injection, USP), an immunosuppressant ...
*  Mitotic inhibitor
Paclitaxel-used to treat lung cancer, ovarian cancer, breast cancer, and advanced forms of Kaposi's sarcoma. Docetaxel-used to ... Examples of mitotic inhibitors frequently used in the treatment of cancer include paclitaxel, docetaxel, vinblastine, ... "Treatment of HIV-associated Kaposi's sarcoma with paclitaxel". Lancet. 346 (8966): 26-28. doi:10.1016/S0140-6736(95)92654-2. ...