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*  P21-activated kinases
... activated kinase 2". "Entrez Gene: PAK3 p21 (CDKN1A)-activated kinase 3". "Entrez Gene: PAK4 p21(CDKN1A)-activated kinase 4". ... p21-Activated Kinases at the US National Library of Medicine Medical Subject Headings (MeSH) "Entrez Gene: PAK1 p21/Cdc42/Rac1- ... p21 activated kinases (PAKs) are members of a family of enzymes. They serve as targets for the small GTP binding proteins CDC42 ... activated kinase 1 (STE20 homolog, yeast)". "Entrez Gene: PAK2 p21 (CDKN1A)- ...
*  PAK1
Shin YJ, Kim YB, Kim JH (September 2013). "Protein kinase CK2 phosphorylates and activates p21-activated kinase 1". Molecular ... "Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases". The ... "LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain". The Journal of ... "Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and ...
*  PAK4
"P21-activated kinase 4 regulates the cyclin-dependent kinase inhibitor p57(kip2) in human breast cancer". Anatomical Record. ... "Protein kinase D-mediated phosphorylation at Ser99 regulates localization of p21-activated kinase 4". The Biochemical Journal. ... "Protein kinase D regulates cofilin activity through p21-activated kinase 4". The Journal of Biological Chemistry. 286 (39): ... "Entrez Gene: PAK4 p21(CDKN1A)-activated kinase 4". Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A ( ...
*  PAK3
Liu RX, Wang WQ, Ye L, Bi YF, Fang H, Cui B, Zhou WW, Dai M, Zhang J, Li XY, Ning G (August 2010). "p21-activated kinase 3 is ... PAK3 (p21-activated kinase 2, beta-PAK) is one of three members of Group I PAK family of evolutionary conserved serine/ ... Bagrodia S, Taylor SJ, Jordon KA, Van Aelst L, Cerione RA (September 1998). "A novel regulator of p21-activated kinases". The ... Holderness Parker N, Donninger H, Birrer MJ, Leaner VD (2013). "p21-activated kinase 3 (PAK3) is an AP-1 regulated gene ...
*  ARHGEF7
Brown MC, West KA, Turner CE (2002). "Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal ... Koh CG, Tan EJ, Manser E, Lim L (2002). "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of ... Bagrodia S, Taylor SJ, Jordon KA, Van Aelst L, Cerione RA (Oct 1998). "A novel regulator of p21-activated kinases". J Biol Chem ... "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1-3): ...
*  ABI gene family member 3
This may be accomplished through interaction with p21-activated kinases. GRCh38: Ensembl release 89: ENSG00000108798 - Ensembl ...
*  Androgen receptor
"AR and ER interaction with a p21-activated kinase (PAK6)". Molecular Endocrinology. 16 (1): 85-99. doi:10.1210/mend.16.1.0753. ... Fix C, Jordan C, Cano P, Walker WH (July 2004). "Testosterone activates mitogen-activated protein kinase and the cAMP response ... "Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6". The Journal of Biological Chemistry. 276 (18 ... Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator". The Journal of ...
*  PAK6
"Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase". The Journal of Biological Chemistry. 280 (5): ... "Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain". Journal ... "Entrez Gene: PAK6 p21(CDKN1A)-activated kinase 6". Lee SR, Ramos SM, Ko A, Masiello D, Swanson KD, Lu ML, Balk SP (January 2002 ... The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein ...
*  PAK5
He S, Feng M, Liu M, Yang S, Yan S, Zhang W, Wang Z, Hu C, Xu Q, Chen L, Zhu H, Xu N (1 December 2014). "P21-activated kinase 7 ... Han K, Zhou Y, Gan ZH, Qi WX, Zhang JJ, Fen T, Meng W, Jiang L, Shen Z, Min DL (December 2014). "p21-activated kinase 7 is an ... "Entrez Gene: PAK7 p21(CDKN1A)-activated kinase 7". Dan C, Nath N, Liberto M, Minden A (January 2002). "PAK5, a new brain- ... Wang X, Gong W, Qing H, Geng Y, Wang X, Zhang Y, Peng L, Zhang H, Jiang B (December 2010). "p21-activated kinase 5 inhibits ...
*  PAK2
"Entrez Gene: PAK2 p21 (CDKN1A)-activated kinase 2". "Entrez Gene: PAK2 p21 (CDKN1A)-activated kinase 2". Wilkes MC, Murphy SJ, ... Roig J, Traugh JA (October 1999). "p21-activated protein kinase gamma-PAK is activated by ionizing radiation and other DNA- ... The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear ... The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear ...
*  Autophosphorylation
"Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors". Journal of ... Wang J, Wu JW, Wang ZX (Dec 2011). "Structural insights into the autoactivation mechanism of p21-activated protein kinase". ... The Src-family kinases are examples of proteins that utilize autophosphorylation to sustain their activated states. Src kinases ... 3. Subsequent autophosphorylation of tyr-416 activates the kinase. 4. The constitutive activation of src kinase observed in ...
*  NCK1
"Interaction of the Nck adapter protein with p21-activated kinase (PAK1)". J. Biol. Chem. 271 (42): 25746-9. doi:10.1074/jbc. ... "Interaction of the Nck adapter protein with p21-activated kinase (PAK1)". J. Biol. Chem. 271 (42): 25746-9. doi:10.1074/jbc. ... Su YC, Han J, Xu S, Cobb M, Skolnik EY (March 1997). "NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates ... Su YC, Han J, Xu S, Cobb M, Skolnik EY (1997). "NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the ...
*  Regeneration (biology)
"Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice". Proceedings of the National Academy of ... Once wounded, their cells become activated and start to remodel tissues and organs back to the pre-existing state. The Caudata ... ROS production is essential to activate the Wnt signaling pathway, which has been associated with regeneration in other systems ... are activated as they were when the limb was formed in the embryo. The positional identity of the distal tip of the limb (i.e. ...
*  BCL2L11
... a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes". Cancer Cell. 5 (6): 575-85. doi:10.1016/j.ccr. ... 2002). "Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis". Mol. ...
*  Mir-7 microRNA precursor
Inhibits p21-Activated Kinase 1 and Regulates Its Functions". Cancer Research. 68 (20): 8195-200. doi:10.1158/0008-5472.CAN-08- ...
*  TBCB
2005). "p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B". Mol. Cell. Biol. 25 (9): ... 1997). "Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors". J. Cell ...
*  DYNLL1
... a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes". Cancer Cell. 5 (6): 575-85. doi:10.1016/j.ccr. ... "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V ... "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V ... "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Research. Molecular ...
*  Lim kinase
Lim Kinases are activated by PAK (p21-activated kinase). Recent work indicates that LIMK activity is also modulated by HIV-1 ... LIM kinase-1 (LIMK1) and LIM kinase-2 (LIMK2) are actin-binding kinases that phosphorylate members of the ADF/cofilin family of ... Lim kinases are activated by signaling through small GTPases of the Rho family. Upstream, LIMK1 is regulated by Pak1, and LIMK2 ... LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal ...
*  Chp (GTPase)
Chp was identified in 1998 as a GTPase interacting with the p21 activated kinase PAK2. RhoV/Chp delineates with RhoU/Wrch a Rho ... activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton". Curr Biol. 8 (20): 1125-8. doi:10.1016/ ...
*  Derlin-2
Rhee S, Grinnell F (2006). "P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction ...
*  ARPC1B
... "p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate". EMBO Reports. 5 (2): 154-60. doi: ... "p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate". EMBO Reports. 5 (2): 154-60. doi: ... "Structure of Arp2/3 complex in its activated state and in actin filament branch junctions". Science. 293 (5539): 2456-9. doi: ...
*  PAK1IP1
p21-activated protein kinase-interacting protein 1 is an enzyme that in humans is encoded by the PAK1IP1 gene. PAK1IP1 has been ... "Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1". Proc Natl Acad Sci U S A. 98 (11 ...
*  ARHGEF11
Barac A, Basile J, Vázquez-Prado J, Gao Y, Zheng Y, Gutkind JS (Feb 2004). "Direct interaction of p21-activated kinase 4 with ... Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (Oct 2002). "B plexins activate Rho through PDZ-RhoGEF". FEBS Letters. ...
*  CBL (gene)
"The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1-3): ... Melander F, Andersson T, Dib K (March 2003). "Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl- ... Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL (April 1999). "Cbl functions downstream of Src kinases in Fc ... Zhang S, Broxmeyer HE (January 1999). "p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2 ...
*  RAC3
2000). "Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway ... 2002). "Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". Int. J. Mol. Med. 9 (5): 451- ... and the activation of protein kinases. RAC3 has been shown to interact with CIB1 and HNF1A. GRCh38: Ensembl release 89: ...
*  Caspase-activated DNase
Besides, Caspase 3 induces DNA breaks in the promoter of the factor p21 and this strand breakup is related to p21 gene ... Some studies have shown that this differentiation is due to many CAD kinase substrates. Referring to the example of skeletal ... Caspase-activated DNase, and Inhibitor of Caspase-activated DNase to the Nuclear Phenotype and DNA Degradation during Apoptosis ... "Specific chaperone-like activity of inhibitor of caspase-activated DNase for caspase-activated DNase". The Journal of ...