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*  NCK1
Ger M, Zitkus Z, Valius M (October 2011). "Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (September 2003). "GC-GAP, a Rho family GTPase-activating protein ... The WASp binds to the SH3 domains within the N-terminus of the protein and after Nck1 has been activated by the signal from the ...
*  MLLT4
... and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6". The Journal of Biological Chemistry. 274 ... "The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal ... Afadin is a protein that in humans is encoded by the MLLT4 gene. AF6 is a Ras (see HRAS; MIM 190020) target that regulates cell ... Yamamoto T, Harada N, Kawano Y, Taya S, Kaibuchi K (May 1999). "In vivo interaction of AF-6 with activated Ras and ZO-1". ...
*  MRAS
... and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6". The Journal of Biological Chemistry. 274 ... and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6". The Journal of Biological Chemistry. 274 ... M-Ras is involved in many biological processes by activating a wide variety of proteins. For instance, it is activated by Ras ... Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the ...
*  List of MeSH codes (D12.776)
... p120 gtpase activating protein MeSH D12.776.402.300.700.500 - ras-GRF1 MeSH D12.776.402.300.700.700 - son of sevenless proteins ... groel protein MeSH D12.776.602.500.500.100 - fusion proteins, bcr-abl MeSH D12.776.602.500.500.320 - fusion proteins, gag-onc ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... fusion proteins, gag-pol MeSH D12.776.964.775.350.400 - hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, ...
*  RAS p21 protein activator 1
Ger M, Zitkus Z, Valius M (October 2011). "Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates ... RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human ... "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck ... RASA1 RAS p21 protein activator (GTPase activating protein) 1". Chow A, Gawler D (October 1999). "Mapping the site of ...
*  List of MeSH codes (D12.776.476)
... p120 gtpase activating protein MeSH D12.776.476.325.150.750 -- rgs proteins MeSH D12.776.476.325.300.200 -- eukaryotic ... mitogen-activated protein kinase 1 MeSH D12.776.476.450.169.750 -- mitogen-activated protein kinase 3 MeSH D12.776.476.450. ... 169.875 -- mitogen-activated protein kinase 6 MeSH D12.776.476.450.169.937 -- mitogen-activated protein kinase 7 MeSH D12.776. ... 476.450.340.500 -- mitogen-activated protein kinase 8 MeSH D12.776.476.450.340.750 -- mitogen-activated protein kinase 9 MeSH ...
*  ARHGAP5
Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene. Rho GTPase activating protein 5 ... Kulkarni SV, Gish G, van der Geer P, Henkemeyer M, Pawson T (2000). "Role of p120 Ras-GAP in directed cell movement". J. Cell ... Chakravarty G, Roy D, Gonzales M, Gay J, Contreras A, Rosen JM (2000). "P190-B, a Rho-GTPase-activating protein, is ... Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM (2006). "P190-B Rho GTPase-activating protein overexpression ...
*  List of MeSH codes (D12.644)
... p120 gtpase activating protein MeSH D12.644.360.325.150.750 --- rgs proteins MeSH D12.644.360.325.225 --- guanine nucleotide ... gtpase-activating proteins MeSH D12.644.360.325.150.100 --- chimerin proteins MeSH D12.644.360.325.150.100.200 --- chimerin 1 ... jnk mitogen-activated protein kinases MeSH D12.644.360.450.340.500 --- mitogen-activated protein kinase 8 MeSH D12.644.360.450. ... mitogen-activated protein kinase 1 MeSH D12.644.360.450.169.750 --- mitogen-activated protein kinase 3 MeSH D12.644.360.450. ...
*  Cadherin-catenin complex in learning and memory
Internalization is dependent on protein synthesis, and p120 catenin proteins (p120ctn) are implicated in the turnover, ... Rac (GTPase) inhibition remediates a reduction of spine density in p120ctn deficiency. E-cadherin binding to p120ctn may ... p120ctn signals through guanine nucleotide exchange factors (GEFs) and GAPs to activate the Rho family of GTPases. RhoA must be ... P120 ctn proteins are thought to either inhibit endocytosis of neural cadherins, or act at the cell surface to control cadherin ...
*  CRKL
Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N (December 2002). "Grit, a GTPase-activating protein ... Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T ... to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". The Journal of Biological Chemistry ... Crk-like protein is a protein that in humans is encoded by the CRKL gene. v-CRK avian sarcoma virus CT10-homolog-like contains ...
*  PTK2B
This protein has been shown to bind a CRK-associated substrate, a nephrocystin, a GTPase regulator associated with FAK, and the ... The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or ... and the p120(GAP) C2 domain". FEBS Lett. 469 (1): 88-92. doi:10.1016/s0014-5793(00)01252-7. PMID 10708762. Zrihan-Licht S, Fu Y ... The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to ...
*  HCK
"The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck ... Howlett CJ, Bisson SA, Resek ME, Tigley AW, Robbins SM (Apr 1999). "The proto-oncogene p120(Cbl) is a downstream substrate of ... "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck ... Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene. The protein encoded by this gene is a ...
*  PTPRM
Inhibition of the Rho GTPase Rac1 permitted neurite outgrowth on PTPmu from neurons in the temporal retina. The proteins PLCĪ³1 ... PTPmu tyrosine phosphatase activity is activated by shear stress. Caveolin 1 is a scaffolding protein enriched in endothelial ... a protein that is also localized to adherens junctions. Although p120 catenin is a potential substrate of PTPmu, others have ... The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases ...
*  SOS1
... and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). The first exchange factor to be identified for RAS ... "Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)". J. Biol ... the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated ... Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by ...
*  PIK3R1
A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919-30. doi:10.1016/S0092- ... Gesbert F, Garbay C, Bertoglio J (1998). "Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and ... kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells". Cancer Res ... Protein Pept. Sci. 5 (1): 1-8. doi:10.2174/1389203043486955. PMID 14965316. Joseph AM, Kumar M, Mitra D (2005). "Nef: " ...
*  PTPRT
2012). "Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT". J Cell Sci. 125 (Pt ... p120 catenin, desmoglein, E-cadherin, N-cadherin, and VE-cadherin. Purified wild-type PTPrho GST fusion protein was able to ... The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling ... This suggests that these proteins are PTPrho substrates. PTPrho also dephosphorylates BCR protein. The ability of PTPrho to ...
*  DOK1
... effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)- ... Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. DOK1 has ... Docking protein 1 is a protein that in humans is encoded by the DOK1 gene. Docking protein 1 is constitutively tyrosine ... It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 ...
*  Adapter molecule crk
Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (2003). "GC-GAP, a Rho family GTPase-activating protein that ... Gesbert F, Garbay C, Bertoglio J (1998). "Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and ... Moon SY, Zang H, Zheng Y (2003). "Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP". J. Biol. ... "Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades". J. Biol. Chem ...
*  NEDD9
NSP proteins are also multidomain scaffolds, which bind activated RTKs in response to extracellular stimuli and recruit both ... In cancer cells, NEDD9 can drive mesenchymal-type movement by activating RAC1 GTPase and WAVE in complex with its GEF DOCK3, ... "Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)". J. Biol ... novel SH2-containing protein family), and other proteins such as the Id family of helix-loop-helix proteins. In terms of post- ...
*  BRD8
2006). "SMAP2, a Novel ARF GTPase-activating Protein, Interacts with Clathrin and Clathrin Assembly Protein and Functions on ... 1999). "p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated ... Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene. The protein encoded by this gene ... 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs ...
*  CD117
... receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein". ... and p120(CBL)". J. Biol. Chem. 272 (15): 10248-53. doi:10.1074/jbc.272.15.10248. PMID 9092574. Liang X, Wisniewski D, Strife A ... it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal ... Proto-Oncogene Proteins c-kit at the US National Library of Medicine Medical Subject Headings (MeSH) C-kit receptor entry in ...
*  GRB2
"Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... Gesbert F, Garbay C, Bertoglio J (Feb 1998). "Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL ... Linker of activated T cells, Lymphocyte cytosolic protein 2, MAP2, MAP3K1 MAP4K1, MED28, MST1R, MUC1, Mitogen-activated protein ... Hildebrand JD, Taylor JM, Parsons JT (Jun 1996). "An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 ...