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*  2-Oxazolidone
... is a heterocyclic organic compound containing both nitrogen and oxygen in a 5-membered ring. Oxazolidinones are a ... Oxazolidinones are mainly used as antimicrobials. The antibacterial effect of oxazolidinones is by working as protein synthesis ... An oxazolidinone derivative used for other purposes is rivaroxaban, which is approved by the FDA for venous thromboembolism ... Substituents at the 4 and 5 position of the oxazolidinone direct any aldol reaction to the alpha position of the carbonyl of ...
*  Clindamycin
"Lincosamides, Oxazolidinones, and Streptogramins". Merck Manual of Diagnosis and Therapy. Merck & Co. November 2005. Archived ... overlapping with the binding sites of the oxazolidinone, pleuromutilin, and macrolide antibiotics, among others. The X-ray ...
*  Benzoyl peroxide/clindamycin
"Lincosamides, Oxazolidinones, and Streptogramins". Merck Manual of Diagnosis and Therapy. Merck & Co. November 2005. Retrieved ...
*  Linezolid
November 1987). "Oxazolidinones, a new class of synthetic antibacterial agents: in vitro and in vivo activities of DuP 105 and ... The oxazolidinones have been known as monoamine oxidase inhibitors since the late 1950s. Their antimicrobial properties were ... The oxazolidinone pharmacophore-the chemical "template" essential for antimicrobial activity-consists of a 1,3-oxazolidin-2-one ... Linezolid is a member of the oxazolidinone class of medications. When given for short periods, linezolid is a relatively safe ...
*  Eperezolid
... is an oxazolidinone antibiotic. Linezolid Brickner, S. J.; Hutchinson, D. K.; Barbachyn, M. R.; Manninen, P. R.; ... Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections". ...
*  Reaction progress kinetic analysis
"Are Oxazolidinones Really Unproductive, Parasitic Species in Proline Catalysis? - Thoughts and Experiments Pointing to an ...
*  Streptogramin A
KEGG COMPOUND Mukhtar, T. A.; Wright, G.D. (2005). "Streptogramins, Oxazolidinones, and Other Inhibitors of Bacterial Protein ...
*  Hajos-Parrish-Eder-Sauer-Wiechert reaction
The view of oxazolidinones as a parasitic species is contested by Seebach and Eschenmoser who in 2007 published an article in ... One of the things they did was reacting an oxazolidinone with the activated aldehyde chloral in an aldol addition: In 2008, ... Are Oxazolidinones Really Unproductive, Parasitic Species in Proline Catalysis? - Thoughts and Experiments Pointing to an ... Blackmond in 2004 also found oxazolidinones as intermediates (NMR) in a related proline-catalysed α-aminooxylation of propanal ...
*  Streptogramin B
Mukhtar, T.A.; Wright, G.D. (2005). "Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis". Chem ...
*  Ranbezolid
... (RBx7644) is an oxazolidinone antibacterial. It competitively inhibits monoamine oxidase-A (MAO-A). European Journal ...
*  Chiral auxiliary
Oxazolidinones can be prepared from amino acids or readily available amino alcohols. A large number of oxazolidinones are ... Acylation of a chiral oxazolidinone with propanoyl chloride. Deprotonation at the α-carbon of an oxazolidinone imide with a ... Some of the commercially available oxazolidinone chiral auxiliaries. Acylation of the oxazolidinone is achieved by ... The chiral oxazolidinone in the Michael acceptor controlled the stereochemistry of one of two stereocenters in the molecule. ...
*  Oxazolidine
... dione, which has two in-cycle keto groups (a carbamate and a lactam). Oxazolidinone, which has an in-cycle carbamate ...
*  Aldol reaction
A number of oxazolidinones are now readily available in both enantiomeric forms. These may cost roughly $10-$20 US dollars per ... A widely used method is the Evans' acyl oxazolidinone method. Developed in the late 1970s and 1980s by David A. Evans and ... In the case of the Evans' method, the chiral auxiliary appended is an oxazolidinone, and the resulting carbonyl compound is an ... However, enantiopure oxazolidinones are derived in 2 synthetic steps from comparatively inexpensive amino acids, which means ...
*  Electrophilic fluorination
For fluorinations of carbonyl compounds, chiral oxazolidinones have been used with success. Tandem conjugate addition ...
*  Discovery and development of direct Xa inhibitors
Next, a phosgene equivalent is added to form the 2-oxazolidone ring and the phthalimide is removed. The free amine can now be ... The first hydrogen bond is a strong interaction which comes from the carbonyl oxygen of the oxazolidinone core of rivaroxaban. ... Yuan, Jianyong; Liu, Kai; Li, Lun; Yuan, Yong; Liu, Xuelei; Li, Yanwu (2014-09-18). "A Novel Synthesis of the Oxazolidinone ... In a one-pot reaction the carbamate cyclisizes to a 2-oxazolidone ring under slightly basic conditions while simultaneously the ...
*  P-site
"Oxazolidinone Antibiotics Target the P Site on Escherichiacoli Ribosomes". Antimicrobial Agents and Chemotherapy. 46 (4): 1080- ...
*  Tedizolid
Patients on tedizolid are also at low risk of peripheral and optic neuropathy, similar to other members of the oxazolidinone ... Tedizolid is a second-generation oxazolidinone derivative that is 4-to-16-fold more potent against staphylococci and ... "Tedizolid (TR-701): a new oxazolidinone with enhanced potency". Accessed 2015-03-16. Schaadt, R; Sweeney, D; Shinabarger, D; ... Tedizolid (formerly torezolid, trade name Sivextro), is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ...
*  Pemoline
... is a stimulant drug of the 4-oxazolidinone class. It was first synthesized in 1913 but its activity was not discovered ...
*  Protein synthesis inhibitor
Swaney SM, Aoki H, Ganoza MC, Shinabarger DL (December 1998). "The Oxazolidinone Linezolid Inhibits Initiation of Protein ... October 2008). "Rχ-01, a New Family of Oxazolidinones That Overcome Ribosome-Based Linezolid Resistance". Antimicrobial Agents ... an oxazolidinone) Telithromycin Streptogramins Retapamulin Protein biosynthesis Prokaryotic translation "Definition: protein ...
*  Radezolid
Lawrence L, Danese P, DeVito J, Franceschi F, Sutcliffe J (May 2008). "In vitro activities of the Rχ-01 oxazolidinones against ... Radezolid (INN, codenamed RX-1741) is a novel oxazolidinone antibiotic being developed by Melinta Therapeutics, Inc. for the ... October 2008). "Rχ-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance". Antimicrob. Agents ...
*  Asymmetric hydrogenation
The oxazolidinone auxiliary is also conveniently cleaved under the hydrogenation conditions. Asymmetric hydrogenation of ... where asymmetry is generated from a chiral oxazolidinone bound to the C2 position of the pyridine. Hydrogenating such ...
*  Electrophilic amination
When chiral oxazolidinones are used in conjunction with azo compounds, enantioselectivity is observed (see above). BINAP can ... In general, for reactions of enolates substituted with Evans oxazolidinones, trifluoroacetic acid promotes diazo transfer while ...
*  Cadazolid
... is an experimental antibiotic of the oxazolidinone class made by Actelion Pharmaceuticals Ltd. which is effective ... The chemical structure of cadazolid combines the pharmacophores of oxazolidinone and fluoroquinolone. In a study published in ...
*  D. Srinivasa Reddy
... and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure". ACS Med. Chem. Lett. doi: ...
*  Trifluoromethylation
"A Simple Method for Asymmetric Trifluoromethylation of-Acyl Oxazolidinones via Ru-Catalyzed Radical Addition to Zirconium ...