... osteopontin-b, and osteopontin-c. Exon 5 is lacking from osteopontin-b, whereas osteopontin-c lacks exon 4. Osteopontin-c has ... AOM1, an anti-osteopontin monoclonal antibody drug developed by Pfizer, Inc. to inhibit osteopontin, showed promise at ... Synthesis of osteopontin is stimulated by calcitriol (1,25-dihydroxy-vitamin D3). Regulation of the osteopontin gene expression ... It is expressed as one of three splice variants in PDAC, with osteopontin-a expressed in nearly all PDAC, osteopontin-b ...

2013). "Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine ... "Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of ... "Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of ... 2000). "Osteopontin". Critical Reviews in Oral Biology and Medicine. 11 (3): 279-303. doi:10.1177/10454411000110030101. PMID ...

Park EK, Thomas PS, Johnson AR, Yates DH (2009). "Osteopontin levels in an asbestos-exposed population". Clinical Cancer ... Several tumour biomarkers (soluble mesothelin-related protein (SMRP), osteopontin and fibulin3) have been evaluated for ...

Haylock DN, Nilsson SK (September 2006). "Osteopontin: a bridge between bone and blood". British Journal of Haematology. 134 (5 ... The Ras/RAF/MEK/ERK pathway is also implicated in overexpression of osteopontin (OPN), which is important for maintenance of ...

In addition to its ability to promote proliferation and metastasis, the interaction of this protein with osteopontin hastens ... Rangaswami, H; Bulbule, A; Kundu, GC (2006). "Osteopontin: role in cell signaling and cancer progression". Trends in Cell ...

Jain, S; Chakraborty, G; Kundu, GC (2006). "The Crucial Role of cyclooxygenase-2 in osteopontin-induced PKCα/c-Src/IKKα/β ... Behera, R; Kumar, V; Lohite, K; Karnik, S; Kundu, GC (2010). "Activation of JAK2/STAT3 signaling by osteopontin promotes tumor ... Kumar, V; Behera, R; Lohite, K; Karnik, S; Kundu, GC (2010). "p38 Kinase is Crucial for Osteopontin-induced Furin Expression ... Raja, R; Kale, S; Thorat, D; Gowrishankar, S; Lohite, K; Mane, A; Karnik, S; Kundu, GC (2013). "Hypoxia driven osteopontin ...

An inhibitor of the osteopontin protein was modeled. The Africa Rainfall Project (launched October 2019) will use the computing ...

2010). "Predictive significance of bone sialoprotein and osteopontin for bone metastases in resected Chinese non-small-cell ... 2003). "Differential expression of osteopontin and bone sialoprotein in bone metastasis of breast and prostate carcinoma". Clin ... and osteopontin". Biochem. Biophys. Res. Commun. 280 (2): 460-5. doi:10.1006/bbrc.2000.4146. PMID 11162539. Tye CE, Rattray KR ...

Thurner PJ, Chen CG, Ionova-Martin S, Sun L, Harman A, Porter A, Ager JW, Ritchie RO, Alliston T (June 2010). "Osteopontin ... However, in mice where expression of osteocalcin or osteopontin was eliminated by targeted disruption of the respective genes ( ... Minor, but important, amounts of small proteins, including osteocalcin and osteopontin, are secreted in bone's organic matrix. ... including osteocalcin and osteopontin, which compose the organic matrix of bone. In organized groups of disconnected cells, ...

Important uterine milk proteins are glycodelin-A, and osteopontin. Some secretory components from the uterine glands are taken ...

Ahmed, M., Sottnik, J., Dancik, G., Sahu, D., Handel, D., Theodorescu, D., Schwartz, M. (2016). "An Osteopontin/CD44 Axis in ...

Rittling, Susan R.; Denhardt, David T. (1999). "Osteopontin Function in Pathology: Lessons from Osteopontin-Deficient Mice". ... The following are categorized as SIBLING proteins: osteopontin (OPN) bone sialoprotein (BSP) dentin matrix protein 1 (DMP1) ...

"Calcification of Vascular Smooth Muscle Cell Cultures Inhibition by Osteopontin". Circulation Research. 84 (2): 166-178. doi: ...

"Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of ... such as osteopontin and ASARM peptides), and small inhibitory molecules (such as pyrophosphate), can occur in the extracellular ... "Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia". Bone. 95: 151-161. doi:10.1016/j.bone.2016.11.019 ... "Abnormal osteopontin and matrix extracellular phosphoglycoprotein localization, and odontoblast differentiation, in X-linked ...

Cook AC, Chambers AF, Turley EA, Tuck AB (2006). "Osteopontin induction of hyaluronan synthase 2 expression promotes breast ...

Salih E, Zhou HY, Glimcher MJ (Jul 1996). "Phosphorylation of purified bovine bone sialoprotein and osteopontin by protein ...

... and osteopontin. The most straightforward treatment of crystallopathies would be dissolving the crystals. Crystal dissolvents ...

"Cooperative unfolding of compact conformations of the intrinsically disordered protein osteopontin". Biochemistry. 52 (31): ...

Furger KA, Menon RK, Tuck AB, Bramwell VH, Chambers AF (November 2001). "The functional and clinical roles of osteopontin in ... 2000). "Expression of bone sialoprotein and osteopontin in breast cancer bone metastases". Clin. Exp. Metastasis. 18 (3): 253- ...

It has been shown that osteopontin and bone sialoprotein, bone matrix phosphoproteins, are highly efficient in vitro TRAP ... From this effect, it has been hypothesized that TRAP is secreted from the ruffled border, dephosphorylates osteopontin and ... Ek-Rylander B, Flores M, Wendel M, Heinegård D, Andersson G (May 1994). "Dephosphorylation of osteopontin and bone sialoprotein ... Proposed functions of TRAP include osteopontin /bone sialoprotein dephosphorylation, the generation of reactive oxygen species ...

... including Spp1 that encodes osteopontin. The expression of osteopontin by eosinophils shapes the pathogenesis of pulmonary ... pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopontin". ...

Osteopontin is a pro-inflammatory cytokine that is secreted by the two main cells in the brain that HIV infects, namely T cells ... Brown focuses her research program on studying the role of osteopontin in HIV pathogenesis in the central nervous system. ... Brown found, in 2011, that osteopontin enhances HIV replication and is overall increased in the brains of HIV infected ... Further exploring its mechanisms of action, Brown discovered in 2020 that osteopontin may exert protective functions in the CNS ...

Molecular mechanisms such as: juvista, ribosomal s6 kinase (RSK), and osteopontin were investigated. In 2011, the scientific ... Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced ...

Kazanecki, CC; Uzwiak, DJ; Denhxxardt, DT (1 November 2007). "Control of osteopontin signaling and function by post- ...

Osteopontin, a protein also expressed in bones, hence the "osteo-" prefix, is a marker for alpha motor neurons. This in turn ... 2011) "Osteopontin is an alpha motor neuron marker in the mouse spinal cord." Journal of Neuroscience Research. 90:732-742. ... One study in particular made this conclusion based on the fact that osteopontin was present in larger cell bodies, indicating ...

Osteopontin is involved in mineralization in the extracellular matrices of bones and teeth. Metalloenzymes all have one feature ...

"Chimeric peptides of statherin and osteopontin that bind hydroxyapatite and mediate cell adhesion". J. Biol. Chem. 275 (21): ...

The interface is filled with non-collagenous proteins, mainly osteopontin (OPN) and osteocalcin (OC). The osteopontin and ...

Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. Journal of the ...

Post-treatment monitoring Osteopontin (OPN) is a promising tool for monitoring praziquantel efficacy and post-treatment ... "Praziquantel pharmacotherapy reduces systemic osteopontin levels and liver collagen content in murine schistosomiasis mansoni ...