"The Oval Portrait: 16 Case Studies of the Grattan Osteoclast - Artist in Residence Capstone Exhibition". 14 December 2015. " ...

Trihydroxyflavone inhibits osteoclast formation and bone resorption in vitro and in vivo". Phytotherapy Research. 33 (11): 2948 ...

By signalling through RANKL and RANK, they eventually trigger osteoclast production, which degrades bone tissue.[page needed] ...

"Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation". ...

"Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner". Blood. 109 (8): ...

"Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells". Blood. ...

This process in turn activates osteoclasts which begin to destroy bone, and it activates matrix metalloproteinases that destroy ...

Calcitonin decreases the release of calcium from bone, by decreasing the activity of osteoclasts, cells which break down bone. ... Bone is constantly reabsorbed by osteoclasts and created by osteoblasts, so calcitonin effectively stimulates movement of ...

An osteoid osteoma is a benign (non-cancerous) bone tumor that arises from osteoblasts and some components of osteoclasts. It ...

... are FDA-approved bisphosphonates used to reduce bone reabsorption by inhibiting osteoclasts. They are most commonly used for ...

Loss of carbonic anhydrase activity in bones impairs the ability of osteoclasts to promote bone resorption, leading to ...

Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis". ...

... is expressed by microglia and osteoclasts, and is involved in development and/or maintenance of brain and bone. In mice, ... TREM2 is expressed on macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia, which are immune ...

Although osteoclasts are active during the natural formation of healthy bone the term "osteolysis" specifically refers to a ... Osteolysis is an active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification. ...

Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known ... and novel pathways for osteoclast biology" (PDF). Lab. Invest. 94 (3): 275-285. doi:10.1038/labinvest.2013.140. PMID 24336069. ...

It is also reported that JDP2 plays an important role in the RANK-mediated osteoclast differentiation. Further, JDP2 is ... April 2003). "Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast ... December 2012). "The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast ...

"Nirogacestat suppresses RANKL-Induced osteoclast formation in vitro and attenuates LPS-Induced bone resorption in vivo". ...

It works by blocking the activity of osteoclast cells and thus decreases the breakdown of bone. Zoledronic acid was patented in ...

Wu H, Xu G, Li YP (May 2009). "Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates ... It is part of proton pumps in the plasma membranes of osteoclasts and aids with extracellular acidification in bone resorption ...

Osteoclasts also sense the increased inflammation of the mandible and maxilla and are further activated to break down bone ... The overactive protein likely causes inflammation in the jaw bones and triggers the production of osteoclasts, which are cells ... Cherubism is displayed with genetic conformation and when excessive osteoclasts are found in the affected areas of the mandible ...

Cells called osteoclasts secrete enzymes that dissolve old bone, allowing another type of cells called osteoblasts to form new ... Gorham and others speculated that such a change in the bone chemistry might cause an imbalance in the rate of osteoclast to ... The apparent contradiction concerning the presence or absence or the number of osteoclasts, may be explained by the different ... stimulated hyperactive osteoclasts. The resorbed bone is replaced by a markedly vascularized fibrous tissue. ...

Osteoclast, with bone below it, showing typical distinguishing characteristics: a large cell with multiple nuclei and a "foamy ... Subsequent to appropriate signaling, osteoclasts move to resorb the surface of the bone, followed by deposition of bone by ... Two main types of cells are responsible for bone metabolism: osteoblasts (which secrete new bone), and osteoclasts (which break ...

... in human osteoblasts and osteoclasts". Brain Res. 878 (1-2): 204-9. doi:10.1016/S0006-8993(00)02700-1. PMID 10996153. S2CID ...

The vATPase is also involved in acidifying the extracellular area of "bone resorbing osteoclasts," and "epithelial cells in the ...

In most cases, the bone at the base is destroyed by osteoclasts and the antlers fall off at some point. As a result of their ...

"Spatial Distribution of Biomaterial Microenvironment pH and Its Modulatory Effect on Osteoclasts at the Early Stage of Bone ...

Possibilities include impaired function of osteoclasts, cells which regulate bone growth, or disruption of the bone ...

Osteoclasts are gathered from circulating monocytes which are chemically drawn to the location where bone resorption takes ... The eruption will happen when differentiation of osteoclasts is allowed due to local administration of the colony-stimulating ... With the lack of colony-stimulating factor 1, a factor that encourages differentiation of osteoclasts, in osteopetrotic animals ... In the apex of the dental follicle, osteoprotegerin prevents osteoclast formation, and its expression is down-regulated. ...

Li YP, Chen W, Stashenko P (January 1996). "Molecular cloning and characterization of a putative novel human osteoclast- ... which in turn affects the acidification of the bone-osteoclast interface, resulting in infantile malignant osteopetrosis. T ...

In response to endotoxin derived from periodontal pathogens, several osteoclast-related mediators target the destruction of ... Major drivers of this aggressive tissue destruction are matrix metalloproteinases (MMPs), cathepsins, and other osteoclast- ...