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*  Bone resorption
Osteoclasts are generally present on the outer layer of bone, just beneath the periosteum. Attachment of the osteoclast to the ... Calcitonin decreases osteoclast activity, and decreases the formation of new osteoclasts, resulting in decreased resorption. ... The osteoclast then induces an infolding of its cell membrane and secretes collagenase and other enzymes important in the ... Osteoclasts are prominent in the tissue destruction found in psoriatic arthritis and rheumatology disorders. The human body is ...
*  Osteoclast
An osteoclast is a large multinucleated cell and human osteoclasts on bone typically have five nuclei and are about 150-200 µm ... In bone, osteoclasts are found in pits in the bone surface which are called resorption bays, or Howship's lacunae. Osteoclasts ... Once activated, osteoclasts move to areas of microfracture in the bone by chemotaxis. Osteoclasts lie in a small cavity called ... When osteoclast-inducing cytokines are used to convert macrophages to osteoclasts, very large cells that may reach 100 µm in ...
*  V-ATPase
They are thought to play a role in coupling of proton transport and ATP hydrolysis and aid the regulation of osteoclast fusion ... V-ATPases in the osteoclast plasma membrane pump protons onto the bone surface, which is necessary for bone resorption. In the ... osteoclasts (bone resorbing cells), macrophages, neutrophils, sperm, midgut cells of insects, and certain tumor cells. Plasma ... found in osteoclasts, that result in the bone disease autosomal recessive osteopetrosis {Frattini, 2000; Kornak, 2000; Sobacchi ...
*  RANKL
Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. Deficient mice, with an ... Yogo K, Ishida-Kitagawa N, Takeya T (2007). "Negative autoregulation of RANKL and c-Src signaling in osteoclasts". J. Bone ... The additional RANKL-mediated osteoclast frequency and activity will in turn increase secretion of growth factors, or matrix ... RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and ...
*  Acid phosphatase
Tartrate-resistant acid phosphatase may be used as a biochemical marker of osteoclast function during the process of bone ... Minkin, Cedrick (1982). "Bone Acid Phosphatase: Tartrate-resistant Acid Phosphatase as a Marker of Osteoclast Function". ...
*  Osteoclast stimulatory transmembrane protein
... is a protein that in humans is encoded by the OCSTAMP gene. GRCh38: Ensembl ...
*  ACP2
Chappard D, Alexandre C, Riffat G (1983). "Histochemical identification of osteoclasts. Review of current methods and ...
*  Host modulatory therapy
PGE2 upregulates bone resorption by osteoclasts and their levels are higher in patients with periodontal disease than in ... "Osteoclasts - Wheeless' Textbook of Orthopaedics". Wheelessonline.com. 2012-06-01. Retrieved 2015-05-06. "Subantimicrobial Dose ... This dosage of doxycycline has cytokine and osteoclasts inhibitory action rather than being antimicrobial. Enamel Matrix ...
*  Calcitonin receptor
CT works by activating the G-proteins Gs and Gq often found on osteoclasts, on cells in the kidney, and on cells in a number of ... Nishikawa T, Ishikawa H, Yamamoto S, Koshihara Y (September 1999). "A novel calcitonin receptor gene in human osteoclasts from ... Chambers TJ, Magnus CJ (January 1982). "Calcitonin alters behaviour of isolated osteoclasts". The Journal of Pathology. 136 (1 ... "Regulation of calcitonin receptor by glucocorticoid in human osteoclast-like cells prepared in vitro using receptor activator ...
*  Multiple myeloma
RANKL activates osteoclasts, which resorb bone. The resultant bone lesions are lytic (cause breakdown) in nature, and are best ... Additional findings may include: a raised calcium (when osteoclasts are breaking down bone, releasing calcium into the ...
*  Eldecalcitol
In contrast, osteoclasts break down bone tissue to increase blood calcium levels if they are low. This activity is performed ... In animals, eldecalcitol inhibits the activity of osteoclasts for the function to reduce bone degradation for calcium, while ... Matsuo, K; Irie, N (2008). "Osteoclast-osteoblast communication". Archives of Biochemistry and Biophysics. 473 (2): 201-209. ... where the body constantly maintains this calcium homeostasis through osteoblast and osteoclast activity. Osteoblast activity ...
*  Bone
... is constantly remodelled by the resorption of osteoclasts and created by osteoblasts. Osteoclasts are large cells with ... and can bind to receptors on osteoclasts to directly inhibit osteoclast activity. Osteoprotegerin is secreted by osteoblasts ... Osteoclasts are very large multinucleate cells that are responsible for the breakdown of bones by the process of bone ... Because the osteoclasts are derived from a monocyte stem-cell lineage, they are equipped with phagocytic-like mechanisms ...
*  Calcitriol
For instance, PTH also indirectly stimulates osteoclasts. However, the main effect of PTH is to increase the rate at which the ... which in turn activates osteoclasts. Calcitriol acts in concert with parathyroid hormone (PTH) in all three of these roles. ... intestinal uptake causes bone to take up more calcium than it loses by hormonal stimulation of osteoclasts. Only when there are ...
*  Tamoxifen
Therefore, by inhibiting osteoclasts, it prevents osteoporosis. When tamoxifen was launched as a drug, it was thought that ... "Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts". Cell. 130 (5): 811-23. doi ... "Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival". The EMBO Journal. 27 (3): 535-45 ...
*  Calcitonin
... lowers blood calcium and phosphorus mainly through its inhibition of osteoclasts. Osteoblasts do not have calcitonin ... found on osteoclasts, and in the kidney and regions of the brain, is a G protein-coupled receptor, which is coupled by Gs to ... Inhibits osteoclast activity in bones Minor effect: Inhibits renal tubular cell reabsorption of Ca2+ and phosphate, allowing ... "Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization". The Journal of ...
*  Osteopontin
Osteoclast Fujisawa R (2002). "[Recent advances in research on bone matrix proteins]". Nippon Rinsho. 60. Suppl 3: 72-8. PMID ... Specifically, research suggests it plays a role in anchoring osteoclasts to the mineral matrix of bones. The organic part of ... OPN serves to initiate the process by which osteoclasts develop their ruffled borders to begin bone resorption. It is also ... Reinholt FP, Hultenby K, Oldberg A, Heinegård D (June 1990). "Osteopontin--a possible anchor of osteoclasts to bone". Proc. ...
*  Tartrate-resistant acid phosphatase
TRAP is associated with osteoclast migration to bone resorption sites, and, once there, TRAP is believed to initiate osteoclast ... In osteoclasts, ROS are generated at the ruffled border and seem to be required for resorption and degradation to occur. In the ... Modulation of osteoclast adhesion in vitro". J. Biol. Chem. 269 (21): 14853-6. PMID 8195113. Darden AG, Ries WL, Wolf WC, ... In osteoclasts, TRAP is localized within the ruffled border area, the lysosomes, the Golgi cisternae and vesicles. Mammalian ...
*  Hajdu-Cheney syndrome
NOTCH2 is also shown to regulate RANK-L osteoclastogenesis, which is the production of functional osteoclasts. Osteoclasts are ...
*  Lil Bub
Vibrations from travel also break down the osteoclasts. She was recorded running at the Strand Bookstore after her book signing ...
*  Nikos Athanasou
1996) Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis. Ann Rheum ... With TJ Chambers he developed the osteoclast lacunar bone resorption assay system. His work was the first to show that the ... His work on hip and knee implants focused on the importance of biomaterial wear particles on promoting osteoclast formation, ... 1984). Resorption of bone by isolated rabbit osteoclasts. J Cell Science 66: 383 - 399 PMID 6746762 Athanasou NA, Quinn J. ( ...
*  Ccaat-enhancer-binding proteins
MafB gene activation suppresses the formation of osteoclasts. Thus, upregulation of LAP diminishes the number of osteoclasts, ... Inhibition of the expression of mTOR can stop osteoclast activity. Miller M, Shuman JD, Sebastian T, Dauter Z, Johnson PF (Apr ...
*  Dental braces
Bones are made of cells called osteoclasts and osteoblasts. Two different kinds of bone resorption are possible: direct ...
*  Diphenidine
"Active NMDA glutamate receptors are expressed by mammalian osteoclasts". The Journal of Physiology. 518 (1): 47-53. doi:10.1111 ...
*  Giant cell
Macrophage fusion : the making of osteoclasts and giant cells. ...
*  TREM2
Cella M, Buonsanti C, Strader C, Kondo T, Salmaggi A, Colonna M (2003). "Impaired differentiation of osteoclasts in TREM-2- ... "DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features". J. Exp. Med. 198 (4): 669-75 ...