A re-examination of the organ specificity of lens antigens. Exp Eye Res. 1968 Jan;7(1):11-29. PubMed PMID 4966535 Clayton RM, ...

Pancreatic engineering is a testament to the molecular specificity of organs. Scientists have not yet been able to produce an ... ranging from end organ failure to cosmetic surgery. One of the greatest limitations to organ transplantation derives from organ ... which can be used in artificial organ and tissue regeneration. Organ and tissue transplantation treat a variety of medical ... Complete organ reconstruction is still in the early levels of development. Researchers are able to take the tissue from a donor ...

These encompass two (gastric and enterohepatic) groups, showing different organ specificity. Importantly, some species, such as ...

Organ-specific lymphocyte homing is important for antigen-specificity and in avoiding autoimmune cross-reactions. Lymphocyte ... High endothelial venules (HEVs) are cells found in secondary lymphoid organs that express large quantities of cell adhesion ... This happens so that the full repertoire of antigenic specificities of lymphocytes is continuously represented throughout the ... Lymphocyte homing receptor control of organ-specific lymphocyte trafficking is thought to prevent autoreactivity in immune ...

These organs are in direct contact with the urinary tract. As a result, urine samples contain cfDNA derived from apoptotic ... Both sensitivity and specificity levels are higher than 80% in most of the past clinical trials. In some papers, the ... Sensitivity and specificity of some ucfDNA applications are comparable to other standards in liquid biopsy. However, clinical ... However, the detection of cffDNA in maternal urine has a low sensitivity and specificity due to the short length and half-life ...

The specificity of a particular virus for a specific tissue is known as its tropism. Viruses in tracer studies are all ... neurotropic (capable of infecting neurons). The viral tracer may be introduced in peripheral organs, such as a muscle or gland ... Ugolini G (1995). "Specificity of rabies virus as a transneuronal tracer of motor networks: transfer from hypoglossal ...

The sensitivity and the specificity of these criteria for differentiating AIP from neoplasia are unknown. In cases of systemic ... other organ involvement with IgG4-related disease, pancreatic histology and response to steroid therapy. In 2002, the Japanese ... other organ involvement, and response to steroid therapy. Computed tomography (CT) findings in AIP include a diffusely enlarged ... "Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations". Arthritis & ...

August 2012). "Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns ...

Boswell HD, Dräger B, McLauchlan WR, Portsteffen A, Robins DJ, Robins RJ, Walton NJ (November 1999). "Specificities of the ... Plant Cell Tissue Organ Cult. 38 (2-3): 241-247. doi:10.1007/bf00033883. S2CID 21524758. ... O-acylpseudotropine This enzyme exhibits absolute specificity for the exo/3beta configuration found in pseudotropine as tropine ...

Boswell HD, Dräger B, McLauchlan WR, Portsteffen A, Robins DJ, Robins RJ, Walton NJ (November 1999). "Specificities of the ... Plant Cell Tissue Organ Cult. 38 (2-3): 241-247. doi:10.1007/bf00033883. S2CID 21524758. ...

Boswell HD, Dräger B, McLauchlan WR, Portsteffen A, Robins DJ, Robins RJ, Walton NJ (November 1999). "Specificities of the ... Plant Cell Tissue Organ Cult. 38: 241-247. doi:10.1007/bf00033883. ... O-acyltropine This enzyme exhibits absolute specificity for the endo/3alpha configuration found in tropine as pseudotropine. ...

... causes those affected to fear a specific disease and is unlikely to transfer to a different disease or organ. In ... One way nosophobia differs from hypochondriasis is in specificity. ...

... s may also occur elsewhere: very rarely in solid organs (most notably the heart and liver) and hollow organs (such as ... In this condition, the teratomas may contain B cells with NMDA-receptor specificities. After surgery, a risk exists of regrowth ... Both forms may contain or appear to contain complete organ systems, even major body parts such as a torso or limbs. Fetus in ... Beyond the newborn period, symptoms of a teratoma depend on its location and organ of origin. Ovarian teratomas often present ...

... each level in the hierarchy may reflect a variable degree of specificity or "granularity" from one System Organ Class to ... according to the level of specificity required. The Lowest Level Term (LLT) level provides maximum specificity. The terminology ... The 27 System Organ Classes (SOCs) represent parallel axes that are not mutually exclusive. This characteristic, called "multi- ... The highest or broadest level is System Organ Class (SOC), further divided into High-Level Group Terms (HLGT), High-Level Terms ...

There has been much conjecture to explain such apparently striking tissue specificity. Major determinants of where BRCA1- and ... An innate genomic deficit impairs normal responses and exacerbates the susceptibility to disease in organ targets. This theory ... and reproductive organs; and bone marrow suppression (reduced blood cell production that leads to anemia). Women having ... BRCA2-associated hereditary cancers occur are related to tissue specificity of the cancer pathogen, the agent that causes ...

Blood flow, blood transit time, and organ blood volume, can all be calculated with reasonable sensitivity and specificity. This ... "Radiation - Effects on organs of the body (somatic effects)". Encyclopedia Britannica. Retrieved 2021-03-21. Simpson G (2009 ... Individualize the examination and adjust the radiation dose to the body type and body organ examined. Different body types and ... New software allows the reconstruction of data in non-orthogonal (oblique) planes, which help in the visualization of organs ...

This activation occurs in secondary lymphoid organs such as the spleen and the lymph nodes. In short, the theory is an ... The differentiated effector cells derived from an activated lymphocyte bear receptors of identical specificity as the parent ... Each lymphocyte bears a single type of receptor with a unique specificity (generated by V(D)J recombination). Receptor ... explanation of the mechanism for the generation of diversity of antibody specificity. The first experimental evidence came in ...

An organ called the thymus is responsible for ensuring that any T-cells that attack self proteins are not allowed to live. In ... In this arrangement there were cells that were 'blank' or had new specificities, these new antigens were called "W" antigens, ... In organ transplant the goal was to explain graft rejection for recipients, and of course, to prevent future rejection. From ... But the naming of these antigens is not borne out of function but the need to match organ donors with recipients. In the early ...

... salivary gland and other organs. Like other mollicutes, they show a high host specificity. In the first taxonomy of Mollicutes ...

In fact, different organs in the body - even between different species - are known to utilize a similar sets of paracrine ... Specificity of signaling can be controlled if only some cells can respond to a particular hormone. Endocrine signaling involves ... regulating distant target organs. In vertebrates, the hypothalamus is the neural control center for all endocrine systems. In ...

A high organ specificity is important because the injected activity should accumulate in the organ under investigation, as ... the image of the target organ can be obscured. Also, high organ specificity allows for the reduction of the injected activity, ... Radiopharmaceuticals containing 99m Tc are currently being applied in the determining morphology of organs, testing of organ ... there should be a high activity ratio of the target organ to nontarget organs. If there is a high activity in organs adjacent ...

Ultrasound imaging, like MRI, does not use radiation and is safe for examination of the pelvis and female reproductive organs. ... Overall, it is estimated that MRI has a sensitivity of 74% and specificity of 91% for the detection of adenomyosis. Diagnosis ... Overall, it is estimated that transvaginal ultrasonography has a sensitivity of 79% and specificity of 85% for the detection of ...

Female midges most likely detect their hosts using a specialized organ called a Johnston's organ, a collection of sensory cells ... There is evidence of host specificity and selection of particular biting sites for some species. Corethrella species have been ...

... theme in biological systems is that increasing complexity in specialized tissues and organs allows for greater specificity of ... The liver is the major organ that metabolizes ethanol due to its high concentration of these enzymes. The average human ...

The specificity of drugs cannot be talked about without mentioning the affinity of the drugs. The affinity is a measure of how ... The same receptor can be located on different organs, and even on different types of tissues. There are also different subtypes ... It is this phenomenon that gives rise to drug specificity. Of course, drugs do not only act on receptors: they also act on ion ...

The specificity theory, which states that pain is "a specific sensation, with its own sensory apparatus independent of touch ... The British psychologist, Edward Titchener, pronounced in his 1896 textbook, "excessive stimulation of any sense organ or ... Moritz Schiff was first to definitively formulate the specificity theory of pain when, in 1858, he demonstrated that touch and ... but rather implicated the heart as the central organ for the sensation of pain. He was the principal advocate of the cardio- ...

The sensitivity of RF for established rheumatoid arthritis is only 60-70% with a specificity of 78%. Rheumatoid factor is part ... such as that associated with tissue or organ rejection. In such instances, RF may serve as one of several serological markers ... Falkenburg, W.J.J. (November 2015). "IgG Subclass Specificity Discriminates Restricted IgM Rheumatoid Factor Responses From ...

... s are any of various convergently evolved inoculum-retention and -cultivation organs in a wide range of insect ... Batra, Lekh Raj (1966-07-08). "Ambrosia Fungi: Extent of Specificity to Ambrosia Beetles". Science. American Association for ... Mayers, Chase (Apr 29, 2021). Chase Mayers: How selective fungus-growing organs define fungus farming in ambrosia beetles. ...

... is expressed in a total of seventy-four organs. In a study of ninety-five individuals, twenty-seven different tissues ... had RNA sequencing completed to determine the tissue-specificity of the protein-coding genes. C11orf42 is expressed in a ...

Because any medication that could reduce the inflammation of CPPD bears a risk of causing organ damage, treatment is not ... However, even this method has poor sensitivity, specificity, and inter-operator agreement. These two modalities currently ...

Most commonly accepted theory of the specificity is based on Dscam gene. Dscam gene also known as Down syndrome cell adhesive ... In an adult animal, the peripheral lymphoid organs contain a mixture of B and T cells in at least three stages of ... Those traits are immune memory and specificity. Although the hallmarks are present the mechanisms are different from those in ... These include expansion of natural killer (NK) cells with so-far unexplained specificity for antigens, expansion of NK cells ...

... ting allows one to observe a particular gene's expression pattern between tissues, organs, developmental stages, ... Experimental conditions that can affect the efficiency and specificity of hybridization include ionic strength, viscosity, ... as well as the gene expression in the rejection of transplanted organs.[18] If an upregulated gene is observed by an abundance ... but it also has a high specificity, which is important to reduce false positive results.[11] ...

Evolutionary psychology has proposed several explanations for love. Monkey infants and children are for a very long time dependent on parental help. Love has therefore been seen as a mechanism to promote mutual parental support of children for an extended time period. Another is that sexually transmitted diseases may cause, among other effects, permanently reduced fertility, injury to the fetus, and increase risks during childbirth. This would favor exclusive long-term relationships reducing the risk of contracting an STD.[1] From the perspective of evolutionary psychology the experiences and behaviors associated with love can be investigated in terms of how they have been shaped by human evolution.[2] For example, it has been suggested that human language has been selected during evolution as a type of "mating signal" that allows potential mates to judge reproductive fitness.[3] Miller described evolutionary psychology as a starting place for further research: "Cognitive neuroscience could try ...

Reichert, Edward Tyson (1913). The Differentiation and Specificity of Starches in Relation to Genera, Species, Etc: ... Bionanocomposites have been used in tissue engineering to replace, support, or regenerate the cells, organs, or parts of human ... engineering aims to generate functional constructs which could replace or improve damaged or infected tissues or whole organs. ...

... "intertentacular organ" in the base of a pair of tentacles. Others' are fertilized internally, in the intertentacular organ or ... "Specificity of cues inducing defensive spines in the bryozoan Membranipora membranacea". Marine Ecology Progress Series. 225 ... which holds the organs. Zooids have no special excretory organs, and autozooids' polypides are scrapped when they become ... all of the larva's internal organs are destroyed during the metamorphosis to the adult form and the adult's organs are built ...

ex vivo part of an organ (e.g. a segment of an intestine). ... analytic specificity, positive, negative predictive values, ... ex vivo organ (e.g. heart of a dog). * ...

Organ development. Main article: ABC model of flower development. The ABC model is a simple model that describes the genes ... "Pollinator specificity, floral odour chemistry and the phylogeny of Australian sexually deceptive Chiloglottis orchids: ... Each of these parts or floral organs is arranged in a spiral called a whorl.[5] The four main whorls (starting from the base of ... The primary purpose of the flower is reproduction.[39] Since the flowers are the reproductive organs of the plant, they mediate ...

The low specificity of mammography [49] and of MRI [50] result in a relatively high rate of false positive screenings, with ... Due to its relatively high conductivity, blood may be used for functional imaging of perfusion in tissues and organs ... The specificity was 39% for mammography, 47% for the T-Scan alone, and 51% for the two combined.[54] ... Note how lines are bent by the change in conductivity between different organs.[1] ...

In an animal different types of cells are distributed among different organs that have evolved different sensitivities to DNA ... "Mutational specificity of gamma-radiation-induced guanine-thymine and thymine-guanine intrastrand cross-links in mammalian ...

There are many mutations that fall under the category of by effect on function, but depending on the specificity of the change ... "Map positions and specificities of suppressor mutations in Escherichia coli K-12". Genetics. 52 (2): 319-340. doi:10.1093/ ... "Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice". Genetics. 154 (3): 1291-300 ...

Specificity designationsEdit. An antibody can be called monospecific if it has specificity for the same antigen or epitope,[54] ... Rejection of xenotransplantated organs is thought to be, in part, the result of natural antibodies circulating in the serum of ... The linker is rich in glycine, which gives it more flexibility, and serine/threonine, which gives it specificity. Two different ... and therefore antigen specificity, remain unchanged. Thus the progeny of a single B cell can produce antibodies, all specific ...

In addition to antibody fragments, non‐antibody‐based approaches have also been used to direct CAR specificity, usually taking ... something that could be utilized in organ transplantation or rheumatic diseases like lupus.[36][37] ... The anti-CD20/CD3 bispecific molecule shows high specificity to both malignant B cells and cancer cells in mice.[76] FITC is ... a mutated FK506-binding protein with high specificity to the small molecule rimiducid/AP1903, and a gene encoding a pro-domain- ...

TdT is expressed mostly in the primary lymphoid organs, like the thymus and bone marrow. Regulation of its expression occurs ... 2.7.12: protein-dual-specificity. *see serine/threonine-specific protein kinases. 2.7.13: protein-histidine. *Protein-histidine ... Although expression is typically found to be in the primary lymphoid organs, recent work has suggested that stimulation via ...

... but lack specificity and sensitivity. After infection, immunity to the same strain of the virus - the genotype - protects ... such as those with common variable immunodeficiency or with a suppressed immune system after organ transplantation. These ...

However, for both B and T cells in the primary lymphoid organs, clonal deletion is the most common form of negative selection. ... Each of these lymphocytes express specificity to a particular epitope, or the part of an antigen to which B cell and T cell ... B and T cells are presented with self antigen after developing receptors while they are still in the primary lymphoid organs. ... B and T lymphocytes are tested for their affinity for self MHC/peptide complexes before leaving the primary lymphoid organs and ...

However, the absence of these sex organs will lead to difficulties in gender identification. Inspection of the genitalia with ... lacks specificity and clarity; and therefore unhelpful in the diagnosis process. Hence, many support groups and advocates ... Retrieved 2021-04-01.{{cite web}}: CS1 maint: url-status (link) (CS1 maint: url-status, Sexuality, Sex organs, Diseases and ...

Although the exact mechanisms still remain unclear, tissue specificity and complexity of the pathway is known to dictate the ... studies done on female rats have shown that SARMs can be designed to have effects on female libido and reproductive organs. ...

Their prey is absorbed outside their mouths by forcing out their digestive organs from their stomach. Its prey include carrion ... Antokhina, Tatiana I.; Britayev, Temir A. (2020). "Host recognition behaviour and its specificity in pontoniine shrimp ...

Long-term damage to organs has also been observed after the onset of COVID-19. Multi-year studies are underway to further ... Due to overlap with other infections such as adenovirus, imaging without confirmation by rRT-PCR is of limited specificity in ... Some people continue to experience a range of effects (long COVID) for months after recovery, and damage to organs has been ... The virus also affects gastrointestinal organs as ACE2 is abundantly expressed in the glandular cells of gastric, duodenal and ...

The specificities were 95%, 72%, and 73% for PAMG-1, fFN and CL, respectively. The NPVs were 96%, 87%, and 89% for PAMG-1, fFN ... Tatarinov, Yu S.; Petrunina, Yu A.; Gryaznova, I. M.; Petrunin, D. D. (July 1976). "Immunochemical identification of organ- ... specificity for ≤7 and ≤14 days, respectively. A second peer-reviewed, published study by this same group of authors involved ... with respect to SP specificity and PPV positive predictive value (P < 0.01) provides evidence toward being able to ...

The DRE has a 50% specificity for benign prostatic hyperplasia. Vigorous examination of the prostate in suspected acute ... organ damage, anal bruising, and foreign objects in the rectal cavity; Even though 1 in 4 colorectal cancers (CRC) is located ... for the limited gynecological palpations of internal organs when you are unable to access the vaginal vault or it is too ...

The REM Sleep Behavior Disorder Single-Question Screen offers diagnostic sensitivity and specificity in the absence of ... the nerves dealing with the unconscious functions of organs such as the intestines, heart, and urinary tract). The first signs ...

They also have organs on the head which produce red light; they are the only terrestrial organisms to emit light of this color ... symbiont specificity and codivergence in bioluminescent symbioses". Cladistics. 23 (5): 507-532. doi:10.1111/j.1096-0031.2007. ... These light organs are usually separate from the tissue containing the bioluminescent bacteria. However, in one species, ... Pyrosomes are colonial tunicates and each zooid has a pair of luminescent organs on either side of the inlet siphon. When ...

Finally, an organ-specific immune response is not seen in any other kind of venous disease. Iron deposition as a cause of MS ... According to Zamboni, CCSVI had a high sensitivity and specificity differentiating healthy individuals from those with multiple ...

CT scan has a sensitivity of 94%, specificity of 95%. Ultrasonography had an overall sensitivity of 86%, a specificity of 81%. ... Some of these conditions include inflammation of lymph nodes near the appendix or pain originating from other pelvic organs ... Due to its low sensitivity and specificity, on its own, WBC is not seen as a good indicator of appendicitis. A urinalysis ... Although some concerns about interpretation are identified, a 2019 Cochrane review found that sensitivity and specificity of CT ...

The specificity of a receptor is determined by its spatial geometry and the way it binds to the ligand through non-covalent ... Wilson's disease is caused by a defect in copper metabolism which results in accumulation of copper metal in various organs of ... because the ligands used do not have high specificity relative to calcium. For example, EDTA may be administered as a calcium ... stomach ulcer drug cimetidine was developed as an H2 antagonist by chemically engineering the molecule for maximum specificity ...

The specificity of the amount of choice is important, as too little or too great a degree of choice may negatively influence ... It is the effect of the constitution and present state of our organs." Compatibilism often regards the agent free as virtue of ...

Eventually, the tumor may grow large enough to invade nearby organs such as the seminal vesicles or the rectum, or tumor cells ... PI-RADS version 2 scoring has shown a specificity and sensitivity of 73% and 95%, respectively, for detection of prostate ... Only those who have male reproductive organs are able to get prostate cancer. Most prostate cancers are slow growing. Cancerous ... The prostate is a zinc-accumulating, citrate-producing organ. Transport protein ZIP1 is responsible for the transport of zinc ...

Stuart, GR; Oda, Y; de Boer, JG; Glickman, BW (March 2000). "Mutation frequency and specificity with age in liver, bladder and ... At least 4 studies have shown that caloric restriction reduces 8-OHdG damages in various organs of rodents. One of these ... Chiba T, Marusawa H, Ushijima T (2012). "Inflammation-associated cancer development in digestive organs: mechanisms and roles ...

Multiple organ dysfunction syndrome (MODS): Caused by an elevated inflammatory response, multiple organ dysfunction is a severe ... Over 10 studies have confirmed that the sensitivity and specificity of this test is 97% and 93% respectively; however, there is ... Lorz W, Cottier C, Imhof E, Gyr N (1993). "Multiple organ failure and coma as initial presentation of pheochromocytoma in a ... Patients require immediate, life-saving treatment to prevent further damage to other organs and/or death. Myocardial Ischemia/ ...