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*  CRKL
"The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins". Leukemia. 11 (3): 376-85 ... Crk-like protein is a protein that in humans is encoded by the CRKL gene. v-CRK avian sarcoma virus CT10-homolog-like contains ... Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase ... Oncogene. 8 (9): 2469-74. PMID 8361759. Senechal K, Halpern J, Sawyers CL (September 1996). "The CRKL adaptor protein ...
*  Proto-oncogene tyrosine-protein kinase Src
... , also known as proto-oncogene c-Src or simply c-Src , is a non-receptor tyrosine ... This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this ... This protein phosphorylates specific tyrosine residues in other proteins. An elevated level of activity of c-Src tyrosine ... Eventually this normal gene mutated into an abnormally functioning oncogene within the Rous sarcoma virus. Once the oncogene is ...
*  Gag-onc fusion protein
... the protein is called a "transforming protein". Note that since the viral oncogenes originated from a host genome, the ... "Oncogene Protein p65(gag-jun) - MeSH - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-07-11. Principles of Virology, 3rd edition, ... Rous sarcoma virus Fusion protein Fusion gene Fusion transcript Chimeric gene Bcr-abl fusion protein Oncovirus Retrovirus ... is a general term for a fusion protein formed from a group-specific antigen ('gag') gene and that of an oncogene ('onc'), a ...
*  DEK (gene)
Alexiadis V, Waldmann T, Andersen J, Mann M, Knippers R, Gruss C (2000). "The protein encoded by the proto-oncogene DEK changes ... The human DEK gene encodes the DEK protein. This gene encodes a protein with one SAP domain. The protein binds to cruciform and ... Kappes F, Burger K, Baack M, Fackelmayer FO, Gruss C (2001). "Subcellular localization of the human proto-oncogene protein DEK ... Forero L, Zwirner NW, Fink CW, Fernández-Viña MA, Stastny P (1998). "Juvenile arthritis, HLA-A2 and binding of DEK oncogene- ...
*  Metencephalon
Wnt1 is a proto-oncogene protein (Wingless-type MMTV integration site family, member 1). This gene was originally thought to ... Fgf8 is also known as Fibroblast Growth Factor 8. It is a protein that is widely thought to be the most important organizing ...
*  MYB (gene)
Myb proto-oncogene protein also known as transcriptional activator Myb is a protein that in humans is encoded by the MYB gene. ... Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three ... MYB protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Drosophila Myb oncogene-like - The ... Favier D, Gonda TJ (1994). "Detection of proteins that bind to the leucine zipper motif of c-Myb". Oncogene. 9 (1): 305-11. ...
*  Targeted therapy
Drebin JA, Link VC, Stern DF, Weinberg RA, Greene MI (July 1985). "Down-modulation of an oncogene protein product and reversion ... Perantoni AO, Rice JM, Reed CD, Watatani M, Wenk ML (September 1987). "Activated neu oncogene sequences in primary tumors of ... The most successful targeted therapies are chemical entities that target or preferentially target a protein or enzyme that ... Other examples of molecular targeted therapeutics targeting mutated oncogenes, include PLX27892 which targets mutant B-raf in ...
*  RAS-associated autoimmune leukoproliferative disorder
1988). "Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21". Science. 239 (888-893): 888 ... "NEUROBLASTOMA RAS VIRAL ONCOGENE HOMOLOG; NRAS". OMIM. Retrieved 8 April 2014. de Vos AM; Tong L; Milburn MV; et al. ( ... The reduced GTPase activity locks the cells in an activated state and degrades the pro-apoptotic BIM protein, thus making the ...
*  WNT1
Proto-oncogene protein Wnt-1 is a protein that in humans is encoded by the WNT1 gene. The WNT gene family consists of ... It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein ... These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate ... The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene ...
*  WNT3
Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene. The WNT gene family consists of ... It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene ... These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate ... Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". ...
*  Protein-S-isoprenylcysteine O-methyltransferase
"Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl ... Ota IM, Clarke S (1989). "Enzymatic methylation of 23-29-kDa bovine retinal rod outer segment membrane proteins. Evidence for ... The enzyme catalyzes the chemical reaction S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine ⇌ {\displaystyle ... Stephenson RC, Clarke S (1990). "Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes ...
*  Adapter molecule crk
"Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity". Proc Natl Acad ... Adapter molecule crk also known as proto-oncogene c-Crk or p38 is a protein that in humans is encoded by the CRK gene. The CRK ... Crk Info with links in the Cell Migration Gateway Proto-Oncogene Proteins c-crk at the US National Library of Medicine Medical ... Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth ...
*  IRS4
Koval, A P; Karas M; Zick Y; LeRoith D (Jun 1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like ... Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth ... The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. IRS4 has been shown to ... Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains ...
*  Lipocalin
72:797-806(1994)] Flower DR, Attwood TK, North AC (1991). "Mouse oncogene protein 24p3 is a member of the lipocalin protein ... Proteins known to belong to this family include alpha-1-microglobulin (protein HC); major urinary proteins; alpha-1-acid ... Von Ebner's gland protein (VEGP); and lizard epididymal secretory protein IV (LESP IV). Human proteins that contain lipocalin ... Major urinary proteins, a lipocalin subfamily, are found in mouse and rat urine and may act as protein pheromones themselves. ...
*  MYCL1
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene. MYCL1 is a bHLH (basic helix-loop- ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-1178. doi:10.1038/ ... Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma ... MYCL1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...
*  Protein kinase B
Proto-Oncogene Proteins c-akt at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple ... Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that ... Akt possesses a protein domain known as a PH domain, or Pleckstrin Homology domain, named after Pleckstrin, the protein in ...
*  GNAI2
"Two G protein oncogenes in human endocrine tumors". Science. 249 (4969): 655-9. doi:10.1126/science.2116665. PMID 2116665. ... Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene. GNAI2 has ... Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and ... "Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2". Fan X, Brass LF, ...
*  PTK2
FAK is a highly conserved, non-receptor tyrosine kinase originally identified as a substrate for the oncogene protein tyrosine ... PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by ... The encoded protein is a member of the FAK subfamily of protein tyrosine kinases that included PYK2, but lacks significant ... Lineage for Protein: Focal adhesion kinase 1 Q00944 "Entrez Gene: PTK2 PTK2 protein tyrosine kinase 2". Guan JL, Shalloway D ( ...
*  FGF3
INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene. FGF-3 is a member of ... Represa J, León Y, Miner C, Giraldez F (1991). "The int-2 proto-oncogene is responsible for induction of the inner ear". Nature ... Antoine M, Reimers K, Wirz W, Gressner AM, Müller R, Kiefer P (2006). "Fibroblast growth factor 3, a protein with a dual ... The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary ...
*  MAS1 oncogene
The MAS1 oncogene is a G protein-coupled receptor which binds the angiotensin-II metabolite Angiotensin (1-7). The MAS1 ... IUPHAR GPCR Database - MAS1 IUPHAR GPCR Database - MAS1L proto-oncogene proteins c-mas-1 at the US National Library of Medicine ... "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". ... is an endogenous ligand for the G protein-coupled receptor Mas". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8258-63. doi:10.1073/ ...
*  Geoffrey M. Cooper
More specifically, he focuses on "the roles of proto-oncogene proteins as elements of signal transduction pathways that control ... Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. J. Biol. Chem. 274:36796-36800. Erhardt, ... Regulation of neuronal survival by the Ser/Thr protein kinase Akt. Science 275:661-665. Erhardt, P., Tomaselli, K.J., and ... Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein Tip. J. Biol. Chem. 275:16925- ...
*  Platelet-derived growth factor
Proto-Oncogene Proteins c-sis at the US National Library of Medicine Medical Subject Headings (MeSH) McKinnon RD, Matsui T, ... The "c-Sis" oncogene is derived from PDGF. Age related downregulation of the PDGF receptor on islet beta cells has been ... It has been shown that the sis oncogene is derived from the PDGF B-chain gene. PDGF-BB is the highest-affinity ligand for the ... Human genes encoding proteins that belong to the platelet-derived growth factor family include: FIGF PDGFA; PDGFB; PDGFC; PDGFD ...
*  Tim Hunt
Nebreda, A.R.; Hunt, T. (1993). "The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but ... Distinguished for his studies of the control of protein synthesis in animal cells and for the discovery of cyclin, a protein ... "The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2". EMBO ... Cyclins are proteins that play a key role in regulating the cell-division cycle. Hunt found that cyclins begin to be ...
*  List of MeSH codes (D12.776)
... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... oncogene protein v-maf MeSH D12.776.964.775.750.875 - oncogene proteins v-abl MeSH D12.776.964.775.750.882 - oncogene proteins ... oncogene proteins v-fos MeSH D12.776.964.700.750.900 - oncogene proteins v-mos MeSH D12.776.964.700.750.903 - oncogene proteins ... oncogene proteins v-raf MeSH D12.776.964.700.750.925 - oncogene proteins v-rel MeSH D12.776.964.700.750.935 - oncogene proteins ...
*  C-Met
Proto-Oncogene Proteins c-met at the US National Library of Medicine Medical Subject Headings (MeSH) UniProtKB/Swiss-Prot entry ... The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to ... c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is ... PTEN (phosphatase and tensin homolog) is a tumor suppressor gene encoding a protein PTEN, which possesses lipid and protein ...
*  MAPK8IP3
C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene. The protein ... Oncogene. England. 21 (42): 6488-97. doi:10.1038/sj.onc.1205840. ISSN 0950-9232. PMID 12226752. Bowman, A B; Kamal A; Ritchings ... "Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3". Matsuura, Hiroshi; Nishitoh Hideki; Takeda ... and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in ...
*  RET proto-oncogene
GeneReviews/NCBI/NIH/UW entry on Multiple Endocrine Neoplasia Type 2 ret Proto-Oncogene Proteins at the US National Library of ... 1993). "Characterization of the ret proto-oncogene products expressed in mouse L cells". Oncogene. 8 (11): 2925-2929. PMID ... "The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins". Oncogene. 9 (6): 1661-8. PMID ... resulting in the juxtaposition of the C-terminal region of the RET protein with an N-terminal portion of another protein, can ...