... also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene. The CRK protein ... Proteins+c-crk at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Oncogene+Protein+v-crk at the U.S. ... Mayer BJ, Hanafusa H (1990). "Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein ... Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This ...

"The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins". Leukemia. 11 (3): 376-85 ... Crk-like protein is a protein that in humans is encoded by the CRKL gene. v-CRK avian sarcoma virus CT10-homolog-like contains ... Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase ... related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". ...

"Networks of interaction of p120cbl and p130cas with Crk and Grb2 adaptor proteins". Oncogene. 12 (12): 2491-8. PMID 8700507. ... of adaptor proteins which is characterized by the presence of multiple conserved motifs for protein-protein interactions, and ... Breast cancer anti-estrogen resistance protein 1 is a protein that in humans is encoded by the BCAR1 gene. BCAR1 is localized ... This acts as a protein-interaction motif, similar to those found in other adhesion-related proteins such as focal adhesion ...

1996). "Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk". Oncogene. 13 (7): 1379-85 ... The protein Abl gene is also known as abelson murine leukemia viral oncogene homolog 1 and is a protein that is encoded by the ... 1998). "Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor". ... Wang B, Kruh GD (1996). "Subcellular localization of the Arg protein tyrosine kinase". Oncogene. 13 (1): 193-7. PMID 8700546. ...

"The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins". Leukemia. 11 (3): 376-85 ... The protein encoded by this gene is a human guanine nucleotide releasing protein for Ras protein. It belongs to the adaptor- ... "Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins". Oncogene ... a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G". The Journal of Biological Chemistry. ...

... related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". ... Oncogene. 17 (15): 1893-901. doi:10.1038/sj.onc.1202108. PMID 9788432. Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, ... Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is ... "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N- ...

... related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". ... SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ... a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ...

Shi CS, Tuscano J, Kehrl JH (2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR ... Shi CS, Tuscano JM, Witte ON, Kehrl JH (1999). "GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase ... "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation". ... related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". ...

... oncogene protein v-cbl MeSH D12.776.624.664.520.750.846 - oncogene protein v-crk MeSH D12.776.624.664.520.750.860 - oncogene ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... oncogene protein v-maf MeSH D12.776.964.775.750.875 - oncogene proteins v-abl MeSH D12.776.964.775.750.882 - oncogene proteins ... oncogene proteins v-fos MeSH D12.776.964.700.750.900 - oncogene proteins v-mos MeSH D12.776.964.700.750.903 - oncogene proteins ...

Oncogene. 13 (3): 633-41. PMID 8760305. Menegon A, Leoni C, Benfenati F, Valtorta F (September 1997). "Tat protein from HIV-1 ... regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Molecular and ... SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene. SHC3 has been shown to interact with RICS ... Oncogene. 13 (6): 1111-21. PMID 8808684. "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3". ...

FAK is a highly conserved, non-receptor tyrosine kinase originally identified as a substrate for the oncogene protein tyrosine ... a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes". The ... PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by ... The encoded protein is a member of the FAK subfamily of protein tyrosine kinases that included PYK2, but lacks significant ...

Koval, A P; Karas M; Zick Y; LeRoith D (Jun 1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like ... IRS4 has been shown to interact with CRK and NISCH. GRCh38: Ensembl release 89: ENSG00000133124 - Ensembl, May 2017 "Human ... Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth ... Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains ...

... including FES proto-oncogene (FES) and CRK proto-oncogene (CRK). It also has suspected interactions with other proteins such as ... The protein has a molecular weight of 39.0 kilodaltons (kD) and a pI of 6.678. The main feature of the protein is the SH2 (Src ... "STRING: Protein-Protein Interaction Network". "TNK2 tyrosine kinase non receptor 2". "IL2 Interleukin 2". Clark, Peter (2012 ... Hematopoietic SH2 Domain Containing (HSH2D) protein is a protein encoded by the hematopoietic SH2 domain containing (HSH2D) ...

Oncogene. 21 (15): 2425-32. doi:10.1038/sj.onc.1205306. PMID 11948427. Nakazawa T, Watabe AM, Tezuka T, Yoshida Y, Yokoyama K, ... regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Molecular and ... Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of ... Signaling proteins like RhoA, regulate polymerization of actin. Due to differences proteins exhibited between normal and ...

14-3-3 proteins MeSH D12.644.360.024.318 - proto-oncogene proteins c-crk MeSH D12.644.360.024.326 - proto-oncogene proteins c- ... ras proteins MeSH D12.644.360.525.500.300 - oncogene protein p21(ras) MeSH D12.644.360.525.500.600 - proto-oncogene proteins ... proto-oncogene proteins c-mos MeSH D12.644.360.400.842 - raf kinases MeSH D12.644.360.400.842.249 - oncogene proteins v-raf ... proto-oncogene proteins b-raf MeSH D12.644.360.400.842.500 - proto-oncogene proteins c-raf MeSH D12.644.360.440 - mitogen- ...

The C-terminus of DOCK proteins interacts with another adaptor protein, Crk. Dock4 undergoes RhoG/ELMO-dependent recruitment to ... Oncogene. 27 (44): 5845-5855. doi:10.1038/onc.2008.202. PMC 4774646. PMID 18641688. Côté JF, Vuori K (December 2002). " ... DOCK family proteins contribute to cell signalling by activating G proteins of the Rho family, such as Rac and Cdc42. Dock4 has ... Dedicator of cytokinesis protein 4 (Dock4), is a large (~190 kDa) protein encoded in the human by the DOCK4 gene, involved in ...

... a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G". J. Biol. Chem. 273 (11): 6446-51. doi: ... a novel mechanism of protein tyrosine phosphatase substrate recognition". Oncogene. 15 (8): 877-85. doi:10.1038/sj.onc.1201279 ... novel SH2-containing protein family), and other proteins such as the Id family of helix-loop-helix proteins. In terms of post- ... CRK-associated substrate-related protein (CAS-L), and Cas scaffolding protein family member 2 (CASS2). An important paralog of ...

"The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68". Oncogene. 14 (2): 223 ... Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... "The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68". Oncogene. 14 (2): 223 ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ...

Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene ... Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell ... Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL ...

Crk-II and Grb2". Oncogene. 14 (19): 2331-8. doi:10.1038/sj.onc.1201074. PMID 9178909. Erdreich-Epstein A, Liu M, Kant AM, ... is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ... "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1-3): ... "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ...

... and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c ... role of PTP-PEST and adaptor proteins p130cas and Crk". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H710-21. doi:10.1152/ ... The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling ... This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, ...

SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ... Epidermal growth factor receptor has been shown to interact with: AR, ARF4, CAV1, CAV3, CBL, CBLB, CBLC, CD44, CDC25A, CRK, ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... a new mammalian cbl family protein". Oncogene. 18 (22): 3365-75. doi:10.1038/sj.onc.1202753. PMID 10362357. Wang Z, Wang M, ...

SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ... Donaldson JC, Dempsey PJ, Reddy S, Bouton AH, Coffey RJ, Hanks SK (April 2000). "Crk-associated substrate p130(Cas) interacts ... Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded ... Changes in its DNA sequence transform it into an oncogene that leads to the formation of a different protein with implications ...

B-Raf proto-oncogene, casein kinase 2-interacting protein 1, and filamin A. Functions of PAK1 are regulated by its ability to ... "PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells ... ARG-binding protein 2γ, hepatitis B virus X protein, STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl ... These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of ...

"Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins". J. Biol. Chem. 271 (24): 14468-72. ... Oncogene. 9 (4): 1039-45. PMID 8134107. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" ... This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in ... a novel protein-protein interaction module". Genes Dev. 11 (17): 2239-49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539 ...

Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 ( ... KIT has been shown to interact with: APS, BCR, CD63, CD81, CD9, CRK, CRKL, DOK1, FES, GRB10, Grb2, KITLG, LNK, LYN, MATK, MPDZ ... Proto-Oncogene+Proteins+c-kit at the U.S. National Library of Medicine Medical Subject Headings (MeSH) C-kit receptor entry in ... KIT is a proto-oncogene, meaning that overexpression or mutations of this protein can lead to cancer. Seminomas, a subtype of ...

Crk, and Crk-L adaptors". J. Biol. Chem. 271 (15): 8564-9. doi:10.1074/jbc.271.15.8564. PMID 8621483. Tamma SM, Chirmule N, ... "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): ... "Entrez Gene: VAV2 vav 2 oncogene". Doody, G M; Billadeau D D; Clayton E; Hutchings A; Berland R; McAdam S; Leibson P J; Turner ... Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene. VAV2 is the second member of ...

The hybrid gene product ABL/BCR is an oncogene which could lead several types of leukemia including BAL. ABL/BCR could active ... It has been shown that associates with Host cell factor C1, CREB binding protein, WDR5, CTBP, MEN1, etc. The rearrangement of ... Some focal adhesion complex (PAXILLIN, FAK0 could be activated by BCR/ABL with adaptor molecule CRK-L. BCR/ABL could inactivate ...

The development is signaled locally by proteins known as fibroblast growth factors that include FGF10. The shoulder girdle in ... "A New Kinosternoid from the Late Cretaceous Hell Creek Formation of North Dakota and Montana and the Origin of the Dermatemys ... Analyses of c-Jun and DJ-1 Proto-oncogenes". Cytogenetic and Genome Research. 127 (2-4): 79-93. doi:10.1159/000297715. PMID ... "Sister Group Relationship of Turtles to the Bird-Crocodilian Clade Revealed by Nuclear DNA-coded Proteins". Molecular Biology ...

Mazon Creek' Lagerstätte further clarifies lysorophian origins". Zoological Journal of the Linnean Society. 187 (2): 506-517. ... Analyses of c-Jun and DJ-1 proto-oncogenes". Cytogenetic and Genome Research. 127 (2-4): 79-93. doi:10.1159/000297715. PMID ... "Sister group relationship of turtles to the bird-crocodilian clade revealed by nuclear DNA-coded proteins". Molecular Biology ...