Genome-wide CRISPR-Cas9 knockout screens
Toulmé JJ, Hélène C (December 1988). "Antimessenger oligodeoxyribonucleotides: an alternative to antisense RNA for artificial ... Ecker JR, Davis RW (August 1986). "Inhibition of gene expression in plant cells by expression of antisense RNA". Proceedings of ... and antisense technologies. By the year 2000, RNA interference (RNAi) technology had emerged as a fast, simple, and inexpensive ...
Polypharmacology
"A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for ... "The concept of multiple-target anti-miRNA antisense oligonucleotide technology". MicroRNA and Cancer. Methods in Molecular ...
Anti-miRNA oligonucleotides
"A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for ... Davis, S.; Lollo, B; Freier, S; Esau, C (28 April 2006). "Improved targeting of miRNA with antisense oligonucleotides". Nucleic ... Wang, Zhiguo (28 August 2010). "The Concept of Multiple-Target Anti-miRNA Antisense Oligonucleotide Technology". MicroRNA and ...
Oligonucleotide
1997). Antisense Oligodeoxynucleotides and Antisense RNA : Novel Pharmacological and Therapeutic Agents. Boca Raton, Florida: ... Oligonucleotides are composed of 2'-deoxyribonucleotides (oligodeoxyribonucleotides), which can be modified at the backbone or ... Antisense oligonucleotides (ASO) are single strands of DNA or RNA that are complementary to a chosen sequence. In the case of ... Antisense oligonucleotides can be used to target a specific, complementary (coding or non-coding) RNA. If binding takes place ...
Computational gene
Undoubtedly, progress on antisense biotechnology will also result in a direct benefit to the model of computational genes.[ ... and stereochemistry of phosphorothioate analogs of oligodeoxyribonucleotides". Journal of the American Chemical Society. 106 ( ... In vivo applications of antisense oligonucleotides showed that toxicity is largely due to impurities in the oligonucleotide ... Brysch, Wolfgang; Schlingensiepen, Karl-Hermann (1994). "Design and application of antisense oligonucleotides in cell culture, ...
List of MeSH codes (D27)
... antisense MeSH D27.720.470.530.600.150.640.640 - oligodeoxyribonucleotides, antisense MeSH D27.720.470.530.600.150.640.645 - ... antisense MeSH D27.720.470.530.600.150.200.640 - oligodeoxyribonucleotides, antisense MeSH D27.720.470.530.600.150.640 - ... antisense MeSH D27.720.470.530.600.150.760.645 - oligoribonucleotides, antisense MeSH D27.720.470.530.600.223 - DNA probes MeSH ... antisense elements (genetics) MeSH D27.720.470.530.600.150.200 - DNA, ...
Oblimersen
... is an antisense oligodeoxyribonucleotide being studied as a possible treatment for several types of cancer, including chronic ... The antisense oligonucleotide drug oblimersen was developed by Genta Incorporated to target Bcl-2. An antisense DNA or RNA ... Dias N, Stein CA (November 2002). "Potential roles of antisense oligonucleotides in cancer therapy. The example of Bcl-2 ... Oblimersen (INN, trade name Genasense; also known as Augmerosen and bcl-2 antisense oligodeoxynucleotide G3139) ...
List of MeSH codes (D13)
MeSH D13.150.200.640 - oligodeoxyribonucleotides, antisense MeSH D13.150.480.640 - oligodeoxyribonucleotides, antisense MeSH ... antisense MeSH D13.444.308.150.640 - oligodeoxyribonucleotides, antisense MeSH D13.444.308.180 - DNA, archaeal MeSH D13.444. ... antisense MeSH D13.444.600.150.200.640 - oligodeoxyribonucleotides, antisense MeSH D13.444.600.150.640 - oligonucleotides, ... oligodeoxyribonucleotides, antisense MeSH D13.444.600.150.640.645 - oligoribonucleotides, antisense MeSH D13.444.600.150.760 - ...
Oligonucleotide synthesis
This property determines the use of OPS as antisense oligonucleotides in in vitro and in vivo applications where the extensive ... Chemical synthesis of oligodeoxyribonucleotides by the hydrogenphosphonate approach". Tetrahedron Lett. 27 (34): 4051. doi: ... They are most commonly used as antisense oligonucleotides, small interfering RNA, primers for DNA sequencing and amplification ... Letsinger, R. L.; Mahadevan, V. (1966). "Stepwise synthesis of oligodeoxyribonucleotides on an insoluble polymer support". J. ...
RNA therapeutics
Antisense drugs are based on the fact that antisense RNA hybridizes with and inactivates mRNA. These drugs are short sequences ... October 2003). "Innate immune responses induced by CpG oligodeoxyribonucleotide stimulation of ovine blood mononuclear cells". ... Antisense RNA is used for treating cancer and inhibition of metastasis and vectors for antisense sequestration. Particularly ... US 2017283805, Bonci D, De Maria R, "Antisense RNA for Treating Cancer and Inhibition of Metastasis and Vectors for Antisense ...
U7 small nuclear RNA
Cotten M, Schaffner G, Birnstiel ML (1989). "Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ... O-ethyl oligoribonucleotides and phosphorothioate oligodeoxyribonucleotides as inhibitors of the in vitro U7 snRNP-dependent ... Madocsai C, Lim SR, Geib T, Lam BJ, Hertel KJ (2005). "Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs ... Liu S, Asparuhova M, Brondani V, Ziekau I, Klimkait T, Schümperli D (2004). "Inhibition of HIV-1 multiplication by antisense U7 ...
Index of molecular biology articles
... anti-sense strand - antibiotic resistance - antibody - antisense - antisense strand - AP-1 site - apo-beta-carotenoid-14',13'- ... oligodeoxyribonucleotide - oligonucleotide - oligosaccharide-transporting ATPase - oncogene - oncovirus - open reading frame - ...
Polymerase chain reaction
The oligonucleotides alternate between sense and antisense directions, and the overlapping segments determine the order of the ... "Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides". Gene. 164 (1): 49-53. doi: ... ends of each of the sense and anti-sense strands of the DNA target (DNA polymerase can only bind to and elongate from a double- ...