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*  Cocaine intoxication
Cocaine's acute effect in the central nervous system is to raise the amount of dopamine and serotonin in the nucleus accumbens ...
*  Nucleus accumbens
The nucleus accumbens (NAc or NAcc), also known as the accumbens nucleus, or formerly as the nucleus accumbens septi (Latin for ... The nucleus accumbens core (NAcc core) is the inner substructure of the nucleus accumbens. Location: The nucleus accumbens core ... The nucleus accumbens shell (NAcc shell) is a substructure of the nucleus accumbens. The shell and core together form the ... Each cerebral hemisphere has its own nucleus accumbens, which can be divided into two structures: the nucleus accumbens core ...
*  Euphoria
the caudate was more involved during the anticipation and the nucleus accumbens was more involved during the experience of peak ... Exercise is known to affect dopamine signaling in the nucleus accumbens, producing euphoria as a result, through increased ... Mavridis IN (March 2015). "Music and the nucleus accumbens". Surg Radiol Anat. 37 (2): 121-125. doi:10.1007/s00276-014-1360-0. ... may reflect opposing abnormalities in the nucleus accumbens, medial prefrontal cortex, amygdala, or other structures. ... ...
*  Desire
One of these so-called hedonic hotspots lies in a subregion of the nucleus accumbens called the medial shell. A second is found ... Studies have shown that dopamine signaling in the nucleus accumbens shell and endogenous opioid signaling in the ventral ... nucleus accumbens shell region), updates the value placed on different goals in light of this new experience (orbital ... these include the nucleus accumbens (NAc; the major component of the ventral striatum), the basal forebrain (components of ...
*  Reward system
... which works by increasing dopamine turnover in the nucleus accumbens. Nicotine infused directly into the nucleus accumbens also ... the nucleus accumbens and olfactory tubercle), dorsal striatum (i.e., the caudate nucleus and putamen), substantia nigra (i.e ... the orexinergic nucleus in the lateral hypothalamus), thalamus (multiple nuclei), subthalamic nucleus, globus pallidus (both ... One of these so-called hedonic hotspots lies in a subregion of the nucleus accumbens called the medial shell. A second is found ...
*  Gliotransmitter
... "mGluR5 stimulates gliotransmission in the nucleus accumbens". Proc Natl Acad Sci U S A. 104 (6): 1995-2000. doi:10.1073/pnas. ...
*  FOSB
ΔFosB overexpression in nucleus accumbens induces NFκB ... In contrast, the ability of ΔFosB to repress the c-Fos gene occurs ... In the nucleus accumbens, ΔFosB functions as a "sustained molecular switch" and "master control protein" in the development of ... Increases in nucleus accumbens ΔJunD expression (via viral vector-mediated gene transfer) or G9a expression (via ... ΔFosB expression in the nucleus accumbens shell increases resilience to stress and is induced in this region by acute exposure ...
*  Fusiform gyrus
Knutson, Brian; Gibbs, Sasha E. B. (2007-02-06). "Linking nucleus accumbens dopamine and blood oxygenation". Psychopharmacology ...
*  Hierarchical structure of the Big Five
... the nucleus accumbens connection revisited. Behavioural Brain Research, 88, 27-34. J.P. Rushton, P. Irwing / Personality and ...
*  Deep brain stimulation
... nucleus accumbens, ventral capsule/ventral striatum, inferior thalamic peduncle, and the lateral habenula. A recently proposed ... for Parkinson plus patients to two nuclei simultaneously, subthalamic nucleus and tegmental nucleus of pons, with the use of ... for OCD and depression to the nucleus accumbens; for incessant pain to the posterior thalamic region or periaqueductal gray; ... nucleus ventralis intermedius thalami (Vim) or the subthalamic nucleus and electric pulses are used therapeutically. The lead ...
*  Dextroamphetamine
ΔFosB overexpression in nucleus accumbens induces NFκB ... In contrast, the ability of ΔFosB to repress the c-Fos gene occurs ... Once nucleus accumbens ΔFosB is sufficiently overexpressed, it begins to increase the severity of addictive behavior (i.e., ... stimulants act not only on working memory function, but also on general levels of arousal and, within the nucleus accumbens, ... Dopamine acts in the nucleus accumbens to attach motivational significance to stimuli associated with reward. Wood S, Sage JR, ...
*  Epigenetics of cocaine addiction
In one set of experiments, it was found that a significant increase in ΔFosB in the nucleus accumbens led to ΔFosB binding to ... It should be noted that only in the nucleus accumbens do G9a levels matter for cocaine addiction. Studies have been done in ... Contrary to most studies focusing on the nucleus accumbens, Febo et al. suggested that the reward brain circuitry is not the ... focused on histone modification in the nucleus accumbens. They suggest that the H3K9me2 modification in this area of the brain ...
*  C-Fos
... nucleus accumbens). c-Fos repression by ΔFosB's AP-1 complex within the D1-type medium spiny neurons of the nucleus accumbens ... ΔFosB overexpression in nucleus accumbens induces NFκB ... In contrast, the ability of ΔFosB to repress the c-Fos gene occurs ... Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefrontal ... "Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization". Nat. Neurosci. 12 ...
*  Grey matter
... nucleus accumbens; septal nuclei), cerebellar (deep cerebellar nuclei - dentate nucleus, globose nucleus, emboliform nucleus, ... fastigial nucleus), brainstem (substantia nigra, red nucleus, olivary nuclei, cranial nerve nuclei). Grey matter in the spinal ...
*  Limbic system
Olds and Milner found that rats with metal electrodes implanted into their nucleus accumbens, as well as their septal nuclei, ... Nucleus accumbens: involved in reward, pleasure, and addiction. Diencephalic structures: Hypothalamus: a center for the limbic ... It is highly interconnected with the nucleus accumbens, which plays a role in sexual arousal and the "high" derived from ... particularly the mammillary bodies and septal nuclei Subcortical areas: Septal nuclei, a set of structures that lie in front of ...
*  Behavioral epigenetics
ΔFosB overexpression in nucleus accumbens induces NFκB ... In contrast, the ability of ΔFosB to repress the c-Fos gene occurs ... Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefrontal ... in the nucleus accumbens). Hence, a cycle emerges whereby changes in the pleasure-reward areas contribute to the long-lasting ...
*  Methamphetamine
ΔFosB overexpression in nucleus accumbens induces NFκB ... In contrast, the ability of ΔFosB to repress the c-Fos gene occurs ... A large body of literature has demonstrated that such ΔFosB induction in D1-type [nucleus accumbens] neurons increases an ... In simpler terms, this necessary and sufficient relationship means that ΔFosB overexpression in the nucleus accumbens and ... Drugs of abuse induce neuroplasticity in the natural reward pathway, specifically the nucleus accumbens (NAc), thereby causing ...
*  Hippocampus
Goto Y, Grace AA (Nov 2008). "Limbic and cortical information processing in the nucleus accumbens". Trends in Neurosciences. 31 ... Different thalamic nuclei, (from the anterior and midline groups), the medial septal nucleus, the supramamillary nucleus of the ... Its projecting pathways include the medial septal nucleus and supramammillary nucleus. The dorsal hippocampus also has more ... and from the nucleus reuniens of the thalamus to field CA1. A very important projection comes from the medial septal nucleus, ...
*  Dual systems model
"Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents". NeuroImage. 25 (4): ... namely the nucleus accumbens). The striatum has been linked to reward processing, learning, and motivation. Neuroimaging ... the pathway connecting the ventral tegmental area to the nucleus accumbens and olfactory tubercle, plays a critical role in the ... "Encoding of Aversion by Dopamine and the Nucleus Accumbens". Frontiers in Neuroscience. 6. doi:10.3389/fnins.2012.00137. ISSN ...
*  Dopamine receptor
When this occurs, particularly in the nucleus accumbens, increased D1 and decreased D2 receptor signaling mediates the " ... Cocaine upregulates D3 receptors in the nucleus accumbens, possibly contributing to drug seeking behavior. Certain stimulants ... within the nucleus accumbens, improve the saliency of tasks. Thus, stimulants improve performance on effortful but tedious ... Maximum expression of dopamine D3 receptors is noted in the islands of Calleja and nucleus accumbens. D4 is encoded by the ...
*  Eric J. Nestler
... and associated epigenetic remodeling in the medium spiny neurons of the nucleus accumbens. Nestler is the author (with Dennis S ... "Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens". Genome Biol. 15 (4): R65. doi:10.1186/gb-2014-15-4- ...
*  MIAT (gene)
MIAT is upregulated in the nucleus accumbens of cocaine and heroin users. The nucleus accumbens is a region involved in ... the nucleus accumbens shell connection". Neuropharmacology. Frontiers in Addiction Research: Celebrating the 30th Anniversary ... altered expression in the nucleus accumbens of heroin abusers". Journal of Neurochemistry. 116 (3): 459-66. doi:10.1111/j.1471- ... "Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse". ...
*  Addiction-related structural neuroplasticity
The nucleus accumbens plays an integral role in addiction. Almost every addictive drug of abuse induces the release of dopamine ... The nucleus accumbens (NAc) plays an essential part in the formation of addiction. Almost every drug with addictive potential ... The effects of drugs of abuse on the ventral tegmental area (VTA) and the nucleus accumbens (NAc) have been studied extensively ... 3.3.co;2-t. Robinson, T.E. (1999). "Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens ...
*  Cholecystokinin B receptor
Lanza M, Makovec F (Jan 2000). "Cholecystokinin (CCK) increases GABA release in the rat anterior nucleus accumbens via CCK(B) ... Activation enhances GABA release in rat anterior nucleus accumbens. CCK-B receptors modulate dopamine release, and influence ...
*  NACC
Nucleus accumbens, a brain structure National Anti-Corruption Commission Thailand. ...
*  Huntingtin-associated protein 1
... nucleus accumbens, dentate gyrus, septal nuclei, bed nucleus of the stria terminalis, and hypothalamus. They also identified ... especially in both of the pedunculopontine nuclei, the supraoptic nucleus, and the olfactory bulb. The possible significance of ... Furthermore, Page and colleagues identified HAP1 mRNA in the following forebrain limbic nuclei: the amygdala, ...
*  Pain and pleasure
Well known hedonic hotspots involved in the processing of pleasure include the nucleus accumbens, posterior ventral pallidum, ... and the nucleus accumbens. Not only have Leknes and Tracey, two leading neuroscientists in the study of pain and pleasure, ... The Functional Connectivity of the Nucleus Accumbens". Journal of Neuropsychiatry and Clinical Neurosciences. 23 (2): 30-30. ... Other brainstem sites, such as the parabrachial nucleus, the dorsal raphe, locus coeruleus, and the medullary reticular ...