Nucleoside-diphosphate kinases (NDPKs, also NDP kinase, (poly)nucleotide kinases and nucleoside diphosphokinases) are enzymes ... Nucleoside Nucleotide Nucleoside monophosphate Nucleoside triphosphate Thymidine kinase Thymidylate kinase Thymidine kinase in ... Nucleoside diphosphate kinase activity involves the transfer of the γ-phosphate of nucleoside triphosphate (NTP) to nucleoside ... NDK possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate ...

... a diphosphate-purine nucleoside kinase (EC 2.7.1.143) is an enzyme that catalyzes the chemical reaction diphosphate + a purine ... purine nucleoside phosphotransferase. This enzyme is also called pyrophosphate-purine nucleoside kinase. Tryon VV, Pollack D ( ... Tryon VV, Pollack JD (1985). "Distinctions in Mollicutes purine metabolism: pyrophosphate-dependent nucleoside kinase and ... the two substrates of this enzyme are diphosphate and purine nucleoside, whereas its two products are phosphate and purine ...

Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene. It is thought to be a metastasis ... Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) ... Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H (1998). "Association of nucleoside diphosphate kinase nm23-H2 with human ... Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H (February 1998). "Association of nucleoside diphosphate kinase nm23-H2 with ...

ADK complements nucleoside diphosphate kinase deficiency. Nucleoside diphosphate (NDP) kinase catalyzes in vivo ATP-dependent ... In mutated Escherichia coli that had a disrupted nucleoside diphosphate kinase, adenylate kinase performed dual enzymatic ... In mutated Escherichia coli that had a disrupted nucleoside diphosphate kinase, adenylate kinase performed dual enzymatic ... Lu Q, Inouye M (June 1996). "Adenylate kinase complements nucleoside diphosphate kinase deficiency in nucleotide metabolism". ...

Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene. Nucleoside diphosphate kinase (NDK) ... Moréra S, Lacombe ML, Xu Y, LeBras G, Janin J (1995). "X-ray structure of human nucleoside diphosphate kinase B complexed with ... Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H (1998). "Association of nucleoside diphosphate kinase nm23-H2 with human ... Webb PA, Perisic O, Mendola CE, Backer JM, Williams RL (1995). "The crystal structure of a human nucleoside diphosphate kinase ...

Lacombe ML, Milon L, Munier A, Mehus JG, Lambeth DO (Jun 2000). "The human Nm23/nucleoside diphosphate kinases". Journal of ... This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) ... "Molecular cloning and characterization of a thioredoxin/nucleoside diphosphate kinase related dynein intermediate chain from ... a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ ...

Nucleoside-diphosphate kinase Guanine nucleotide exchange factor Buday, L; Downward J (1993). "Epidermal growth factor ... Nucleotide exchange factors actively assist in the exchange of depleted nucleoside diphosphates for fresh nucleoside ... of nucleoside diphosphates for nucleoside triphosphates bound to other proteins. Many cellular proteins cleave (hydrolyze) ... nucleoside triphosphates-adenosine triphosphate (ATP) or guanosine triphosphate (GTP)-to their diphosphate forms (ADP and GDP) ...

Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H (1998). "Association of nucleoside diphosphate kinase nm23-H2 with human ... Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H (February 1998). "Association of nucleoside diphosphate kinase nm23-H2 with ... nucleoside diphosphate kinase).In conclusion, as mentioned above, the telomeric repeat-binding factor 1 protein has most of its ... Chi NW, Lodish HF (Dec 2000). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with ...

... a modulator of nucleoside diphosphate kinase activity in mycobacteria". Molecular Microbiology. 74 (5): 1187-1197. doi:10.1111/ ... Sureka, Kamakshi; Sanyal, Sourav; Basu, Joyoti; Kundu, Manikuntala (1 December 2009). "Polyphosphate kinase 2: ... and Stress-Activated Protein Kinase 1-Triggered Phosphorylation Events Are Central to Helicobacter pylori Peptidyl Prolyl cis ... and Stress-Activated Protein Kinase 1-Triggered Phosphorylation Events Are Central to Helicobacter pylori Peptidyl Prolyl cis ...

The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a ... a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13". Human Genetics. 99 ... "The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase". The Journal of Biological Chemistry. 275 (19 ... "Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell ...

GTP is the equivalent of ATP and they can be interconverted by Nucleoside-diphosphate kinase. Konrad Bloch and Feodor Lynen ... Yu, H.; Rao, X.; Zhang, K. (2017). "Nucleoside diphosphate kinase (Ndk): A pleiotropic effector manipulating bacterial ... Pettit, Flora H.; Pelley, John W.; Reed, Lester J. (1975-07-22). "Regulation of pyruvate dehydrogenase kinase and phosphatase ... Allosteric regulator Acetyl-CoA serves as an allosteric regulator of pyruvate dehydrogenase kinase (PDK). It regulates through ...

NM23-2: NM23-2 is a nucleoside diphosphate kinase involved in organogenesis and differentiation. NM23-1: NM23-1 is the product ... "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR ... "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR ... Phosphorylation: Phosphorylation of RORα1, which inhibits its transcriptional activity, is induced by Protein Kinase C. ERK2: ...

Gemcitabine is metabolized by nucleoside kinases to Gemcitabine diphosphate and Gemcitabine triphosphate. Gemcitabine ... Gefitinib (Iressa; withdrawn from the U.S. market) is one such drug, which targets the tyrosine kinase domain of the epidermal ... Erlotinib (Tarceva), another EGFR tyrosine kinase inhibitor, increased survival in non-small cell lung cancer and was approved ... March 2007). "Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer: ...

... such as nucleoside-phosphate kinases and nucleoside-diphosphate kinases. Other small molecules that are substrates of kinases ... thymidylate kinase, can act upon dTMP to create the diphosphate form, dTDP. Nucleoside diphosphate kinase catalyzes production ... dependent protein kinase Cell signaling Cyclin-dependent kinase G protein-coupled receptor Nucleoside-diphosphate kinase ... Thymidine kinase is one of the many nucleoside kinases that are responsible for nucleoside phosphorylation. It phosphorylates ...

Fischbach MA, Settleman J. Specific biochemical inactivation of oncogenic Ras proteins by nucleoside diphosphate kinase. Cancer ...

Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene. NME3 has been shown to interact with ... Overview of all the structural information available in the PDB for UniProt: Q13232 (Nucleoside diphosphate kinase 3) at the ... "p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling". Proceedings of the National Academy of ...

Baillat G, Gaillard S, Castets F, Monneron A (May 2002). "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, ... Mps one binder kinase activator-like 3 is an enzyme that in humans is encoded by the MOBKL3 gene. This gene was identified ... "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex ...

Thymidine kinase Thymidylate kinase Nucleoside diphosphate kinase Thymidylate synthase Thymidine O'Neill KL, Buckwalter M, ... diphosphate by the enzyme thymidylate kinase and further to thymidine triphosphate by the enzyme nucleoside diphosphate kinase ... Thymidine kinase 1 is such a salvage enzyme, whereas thymidine kinase 2 is not cell cycle-dependent. Thymidine kinase is a ... Thymidine kinase is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, ...

UTP can be biosynthesized from UDP by Nucleoside Diphosphate Kinase after using the phosphate group from ATP. UDP + ATP ⇌ UTP ... Uridine-5′-triphosphate (UTP) is a pyrimidine nucleoside triphosphate, consisting of the organic base uracil linked to the 1′ ...

UMP/CMP kinase (EC 2.7.4.14) can phosphorylate UMP into uridine diphosphate, which nucleoside diphosphate kinase can ... UMP/CMP kinase can phosphorylate (d)CMP into cytidine diphosphate or deoxycytidine diphosphate, which nucleoside diphosphate ... Thymidylate kinase can phosphorylate TMP into thymidine diphosphate, which nucleoside diphosphate kinase can phosphorylate into ... Uridine kinase (aka uridine-cytidine kinase) can then phosphorylate the 5'-carbon of this nucleoside into uridine monophosphate ...

They are first reduced by RNR and then phosphorylated by nucleoside diphosphate kinases to dATP and dGTP. Ribonucleotide ... Ribonucleoside diphosphate (NDP) is reduced by thioredoxin to a deoxyribonucleoside diphosphate (dNTP). The general reaction is ... Ribonucleoside diphosphate + NADPH + H+ -> Deoxyribonucleoside diphosphate + NADP+ + H2O To illustrate this equation, dATP and ... Without the phosphate group, the composition of the nucleobase and sugar is known as a nucleoside. The interchangeable ...

"Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and ... "A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase". J. Biol. Chem. 270 (24): 14251-4. doi ...

"Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and ...

2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B ...

2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B ... 1996). "Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C." J. Biol. ...

2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B ...

2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B ...

2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B ... 1999). "KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation ...

2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B ... 2004). "A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium ... 1995). "A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase". J. Biol. Chem. 270 (24): ... 2000). "Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2". J. Biol. Chem ...

2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B ...