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*  Cycling probe technology
1999). "Detection of nucleic acids by cycling probe technology on magnetic particles: high sensitivity and ease of separation ...
*  Nucleic acid test
A nucleic acid test (NAT) or nucleic acid amplification test (NAAT) is a molecular technique used to detect a particular ... It does so by detecting and amplifying the RNA or DNA of the pathogen, that is, making extra copies of its nucleic acids. This ... Highly sensitive and specific for viral nucleic acid. There are multiple methods that fall in this group, including: Methods ... In 1999, new screening methods involving nucleic acid amplification and that protocol approved by FDA. Detects low levels of ...
*  Transfer-messenger RNA
Sharkady SM, Williams KP (2004). "A third lineage with two-piece tmRNA". Nucleic Acids Res. 32 (15): 4531-8. doi:10.1093/nar/ ... Williams KP (January 2002). "The tmRNA Website: invasion by an intron". Nucleic Acids Res. 30 (1): 179-82. doi:10.1093/nar/30.1 ... Zwieb C, Wower I, Wower J (1999). "Comparative sequence analysis of tmRNA". Nucleic Acids Res. 27 (10): 2063-71. doi:10.1093/ ... Eddy, S.; Durbin, R. (1994). "RNA sequence analysis using covariance models". Nucleic Acids Res. 22 (11): 2079-2088. doi: ...
*  Nicking enzyme amplification reaction
NICKING AND EXTENSION AMPLIFICATION REACTION FOR THE EXPONENTIAL AMPLIFICATION OF NUCLEIC ACIDS.. ...
*  L-Ribonucleic acid aptamer
Nucleic acid aptamers, including L-RNA aptamers, contain adenosine monophosphate, guanosine monophosphate, cytidine ... as L-nucleic acids are not amenable to enzymatic methods, such as polymerase chain reaction (PCR), used in SELEX. Therefore, ... An L-ribonucleic acid aptamer (L-RNA aptamer, trade name Spiegelmer - from German Spiegel "mirror" - by Noxxon Pharma) is an ... an enantiomer is made using synthetic D-amino acids. If the target is a larger protein molecule, beyond synthetic abilities, ...
*  Protein primary structure
Protein sequencing Nucleic acid primary structure Translation Pseudo amino acid composition SANGER F (1952). "The arrangement ... as well as mixtures or ambiguous amino acids (similar to nucleic acid notation). Peptides can be directly sequenced, or ... Functionally, however, the acetylation of lysine residues is used to regulate the binding of proteins to nucleic acids. The ... Arginine residues interact with the nucleic acid phosphate backbone and commonly form hydrogen bonds with the base residues, ...
*  Anti-thrombin aptamers
Nucleic Acids Research 34, 6653-6662, doi:10.1093/nar/gkl915 (2006) Tsiang, M. et al. Functional mapping of the surface ... Nucleic Acids Research 39, 7858-7867, doi:10.1093/nar/gkr522 (2011). Trapaidze, A. et al. Binding modes of thrombin binding ... Nucleic Acids Research 40, 8119-8128, doi:10.1093/nar/gks512 (2012). Nagatoishi, S. et al., Circular dichroism spectra ...
*  Touchdown polymerase chain reaction
Nucleic Acids Res. 19 (14): 4008. doi:10.1093/nar/19.14.4008. PMC 328507 . PMID 1861999. Hecker K, Roux K (1996). "High and low ...
*  Nucleic Acids Research
... is an open-access peer-reviewed scientific journal published by Oxford University Press. It covers ... "Nucleic Acids Research". 2014 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2015. Official website. ... research on nucleic acids, such as DNA and RNA, and related work. According to the Journal Citation Reports, the journal's 2016 ...
*  Nucleic acid
... and include peptide nucleic acid, morpholino- and locked nucleic acid, glycol nucleic acid, and threose nucleic acid. Each of ... Nucleic Acids Research journal Nucleic Acids Book (free online book on the chemistry and biology of nucleic acids) Molecular ... acid methods Nucleic acid structure Nucleic acid thermodynamics Oligonucleotide synthesis Quantification of nucleic acids He ... This gives nucleic acids directionality, and the ends of nucleic acid molecules are referred to as 5'-end and 3'-end. The ...
*  Nucleosides, Nucleotides & Nucleic Acids
... is a monthly academic journal published by Taylor & Francis since 2000, continuing the ...
*  Bridged nucleic acid
C-ethylene-bridged nucleic acids (ENA) with nuclease-resistance and high affinity for RNA". Nucleic Acids Research. Supplement ... Bridged nucleic acids (BNAs) are modified RNA nucleotides. They are sometimes also referred to as constrained or inaccessible ... Saenger, W. (1984) Principles of Nucleic Acid Structure, Springer-Verlag, New York, ISBN 3-540-90761-0. Obika, S.; Nanbu, D.; ... Obika, Satoshi; Hari, Yoshiyuki; Sekiguchi, Mitsuaki; Imanishi, Takeshi (2001). "A 2′,4′-Bridged Nucleic Acid Containing 2- ...
*  Threose nucleic acid
Oligonucleotide synthesis Abiogenesis Glycol nucleic acid Peptide nucleic acid Yu, Hanyang; Zhang, Su; Chaput, John C. (10 ... Threose nucleic acid (TNA) is an artificial genetic polymer invented by Albert Eschenmoser. TNA has a backbone structure ... Was simple TNA the first nucleic acid on Earth to carry a genetic code?, New Scientist (behind paywall) ORIGIN OF LIFE: A ... Schoning, K; Scholz P; Guntha S; Wu X; Krishnamurthy R; Eschenmoser A (November 2000). "Chemical etiology of nucleic acid ...
*  Nucleic acid methods
... are the techniques used to study nucleic acids: DNA and RNA. Phenol-chloroform extraction Minicolumn ... spectroscopic nucleic acid quantitation Absolute abundance in number: real-time polymerase chain reaction (quantitative PCR) ... "A universal molecular translator for non-nucleic acid targets that enables dynamic DNA assemblies and logic operations". Chem. ... sequencing DNA sequencing Expression cloning Fluorescence in situ hybridization Lab-on-a-chip Comparison of nucleic acid ...
*  Peptide nucleic acid
Peptide synthesis Oligonucleotide synthesis Glycol nucleic acid Threose nucleic acid Clicked peptide polymer Nielsen PE, Egholm ... Peptide nucleic acid (PNA) is an artificially synthesized polymer similar to DNA or RNA. It was invented by Peter E. Nielsen ( ... June 2006). "Peptide Nucleic Acid (PNA): A Review". Journal of Chemical Technology and Biotechnology. An overview of the PNA ... Synthetic peptide nucleic acid oligomers have been used in recent years in molecular biology procedures, diagnostic assays, and ...
*  Nucleic acid structure
DNA supercoil Gene structure Non-helical models of DNA structure Nucleic acid design Nucleic acid double helix Nucleic acid ... Nucleic acid structure refers to the structure of nucleic acids such as DNA and RNA. Chemically speaking, DNA and RNA are very ... Nucleic acid structure prediction (computational) Nucleic acid thermodynamics Protein structure Krieger M, Scott MP, Matsudaira ... Structure of Nucleic Acids". Molecular cell biology. New York: W.H. Freeman and CO. ISBN 0-7167-4366-3. "Structure of Nucleic ...
*  Locked nucleic acid
A locked nucleic acid (LNA), often referred to as inaccessible RNA, is a modified RNA nucleotide. The ribose moiety of an LNA ... Locked Nucleic Acid Technology Bonetta, Laura (2005). "Prime time for real-time PCR". Nat. Methods. 2 (4): 305-312. doi:10.1038 ... Custom Locked Nucleic Acid (LNA™) oligonucleotides LNA Oligo Tools and Design Guidelines LNA Oligo melting temperature ... Owczarzy R.; You Y.; Groth C.L.; Tataurov A.V. (2011). "Stability and mismatch discrimination of locked nucleic acid-DNA ...
*  Nucleic acid metabolism
... is the process by which nucleic acids (DNA and RNA) are synthesized and degraded. Nucleic acids are ... Nucleic Acids Book (free online book on the chemistry and biology of nucleic acids) Interactive overview of nucleic acid ... Destruction of nucleic acid is a catabolic reaction. Additionally, parts of the nucleotides or nucleobases can be salvaged to ... Nucleic acid RNA DNA Carbohydrate metabolism Protein metabolism Voet, Donald; Voet, Judith; Pratt, Charlotte (2008). ...
*  Nucleic acid inhibitor
A nucleic acid inhibitor is a type of antibacterial that acts by inhibiting the production of nucleic acids. There are two ... Antifolates act primarily as inhibitors of both RNA and DNA, and are often grouped with nucleic acid inhibitors in textbooks. ... because tetrahydrofolate is also involved in the synthesis of amino acids serine and methionine), so they are sometimes ...
*  Nucleic acid thermodynamics
... is the study of how temperature affects the nucleic acid structure of double-stranded DNA (dsDNA). ... occurs when half of the double-stranded nucleic acid has dissociated. If no additional nucleic acids are present, then [A], [B ... elegantly describe the thermodynamic parameters for forming double-stranded nucleic acid AB from single-stranded nucleic acids ... In general, the free energy of forming a nucleic acid duplex is Δ G 37 ∘ ( t o t a l ) = Δ G 37 ∘ ( i n i t i a t i o n s ...
*  Glycol nucleic acid
Oligonucleotide synthesis Abiogenesis Threose nucleic acid Peptide nucleic acid Locked nucleic acid Zhang Lilu; Peritz Adam; ... Glycol nucleic acid (GNA) is a polymer similar to DNA or RNA but differing in the composition of its "backbone". GNA is not ... It is possibly the simplest of the nucleic acids, so making it a hypothetical precursor to RNA. ... "A simple glycol nucleic acid". J Am Chem Soc. 127 (12): 4174-5. doi:10.1021/ja042564z. PMID 15783191. Seita, Tooru; Yamauchi, ...
*  Nucleic acid notation
One example of an Ambigraphic nucleic acid notation is AmbiScript, a rationally designed nucleic acid notations that combined ... "The practical and pedagogical advantages of an ambigraphic nucleic acid notation". Nucleosides, Nucleotides & Nucleic Acids. 25 ... The nucleic acid notation currently in use was first formalized by the International Union of Pure and Applied Chemistry (IUPAC ... An ambigraphic nucleic acid notation also makes it easy to identify genetic palindromes, such as endonuclease restriction sites ...
*  Nucleic acid design
... is the process of generating a set of nucleic acid base sequences that will associate into a desired ... Thus, in nucleic acids the sequence determines the pattern of binding and thus the overall structure. Nucleic acid design is ... Nucleic acid design encompasses all levels of nucleic acid structure: Primary structure-the raw sequence of nucleobases of each ... Nucleic acid design can be considered the inverse of nucleic acid structure prediction. In structure prediction, the structure ...
*  Nucleic acid analogue
Artificial nucleic acids include peptide nucleic acid (PNA), Morpholino and locked nucleic acid (LNA), as well as glycol ... locked nucleic acid (LNA) or bridged nucleic acid (BNA), morpholino, and peptide nucleic acid (PNA). Although these ... RNA may be too complex to be the first nucleic acid, so before the RNA world several simpler nucleic acids that differ in the ... 2009). "Nucleic acid base analog FRET-pair facilitating detailed structural measurements in nucleic acid containing systems". J ...
*  Nucleic acid nomenclature
Molecular biologists use several shorthand terms when referring to nucleic acid molecules, such as DNA and RNA, collectively ... the positions of the carbons in the ribose sugar that forms the backbone of the nucleic acid chain are numbered, and are used ... referred to as nucleic acid nomenclature. The most common is the representation of the base pairs as letters-an adenine ... to indicate the direction of nucleic acids (5'->3' versus 3'->5'). This is referred to as directionality. In addition to the ...
*  Ariosa v. Sequenom
... inherited nucleic acid from the serum or plasma sample and detecting the presence of a paternally inherited nucleic acid of ... Claim 1 is illustrative: 1. A method for detecting a paternally inherited nucleic acid of fetal origin performed on a maternal ...
*  Nucleic acid sequence
The sequence of nucleobases on a nucleic acid strand is translated by cell machinery into a sequence of amino acids making up a ... Biological deoxyribonucleic acid represents the information which directs the functions of a living thing. Nucleic acids also ... A nucleic acid sequence is a succession of letters that indicate the order of nucleotides within a DNA (using GACT) or RNA ( ... Once a nucleic acid sequence has been obtained from an organism, it is stored in silico in digital format. Digital genetic ...