... to stabilize essential compounds like amino acids, nucleic acids and lipids to target age-related diseases. Cantor held ... Cantor co-authored Biophysical Chemistry with Paul Schimmel, which was published in three volumes: Part 1, The Conformation of ... Cantor, C. R.; Katz, L. (1971). "Nucleic Acids". Annual Review of Physical Chemistry. 22: 25-46. Bibcode:1971ARPC...22...25C. ... Cantor's reviews include one on the physical chemistry of nucleic acids. ...

... acid design is the process of generating a set of nucleic acid base sequences that will associate into a desired conformation. ... Thus, in nucleic acids the sequence determines the pattern of binding and thus the overall structure. Nucleic acid design is ... Nucleic acid design encompasses all levels of nucleic acid structure: Primary structure-the raw sequence of nucleobases of each ... Nucleic acid design can be considered the inverse of nucleic acid structure prediction. In structure prediction, the structure ...

Nucleic Acids Research. 45 (D1): D145-D150. doi:10.1093/nar/gkw1007. PMC 5210517. PMID 27789689. Xuan Lin QX, Sian S, An O, ... protein complex that occupies the promoter DNA and the amino acid sequence of the cofactor determine its spatial conformation. ... Nucleic Acids Research. 45 (D1): D1040-D1045. doi:10.1093/nar/gkw982. PMC 5210657. PMID 27924042. Schmeier S, Alam T, Essack M ... Nucleic Acids Research. 34 (Web Server issue): W529-33. doi:10.1093/nar/gkl212. PMC 1538886. PMID 16845064. Wenta N, Strauss H ...

Furthermore, different Zα domains bind to the Z conformation of nucleic acid differently providing important avenues for ... Nucleic Acids Research. 9 (20): 5443-5457. doi:10.1093/nar/9.20.5443. PMC 327531. PMID 7301594. Wang, A. H.; Quigley, G. J.; ... Nucleic Acids Research. 26 (15): 2669-2672. doi:10.1093/nar/26.15.3486. PMC 147729. PMID 9671809. Schwartz, T.; Rould, M. A.; ... Nucleic Acids Research. 32 (22): 6501-6510. doi:10.1093/nar/gkh988. PMC 545456. PMID 15598822. Wang, Andrew H.-J.; Quigley, ...

Progress in Nucleic Acid Research and Molecular Biology. Vol. 61. pp. 181-209. doi:10.1016/S0079-6603(08)60827-2. ISBN 978-0-12 ... Monovalent cations have been shown to activate IMPDH enzymes and may serve to stabilize the conformation of the active-site ... IMPDH has also been shown to bind nucleic acids, and this function can be impaired by mutations that are located in the ... Magasanik B, Moyed HS, Gehring LB (May 1957). "Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5'- ...

Nucleic Acids Research. 31 (18): 5449-5460. doi:10.1093/nar/gkg732. PMC 203317. PMID 12954782. Sternberg N, Hamilton D (Aug ... "Crystal structure of a wild-type Cre recombinase-loxP synapse reveals a novel spacer conformation suggesting an alternative ... The carboxy terminal domain of the enzyme consists of amino acids 132-341 and it harbours the active site of the enzyme. The ... Cre recombinase consists of 343 amino acids that form two distinct domains. The amino terminal domain encompasses residues 20- ...

Nucleic Acids Research. 27 (3): 795-802. doi:10.1093/nar/27.3.795. PMC 148249. PMID 9889275. Mathews DH, Sabina J, Zuker M, ... The upstream inhibitory -24/-15 stretch from the aforementioned inhibitory conformation is now sequestered in a hairpin P(-1) ... Nucleic Acids Research. 18 (23): 6821-6827. doi:10.1093/nar/18.23.6821. PMC 332737. PMID 2263447. Perrotta AT, Been MD (April ... Nucleic Acids Research. 32 (3): 39e-39. doi:10.1093/nar/gnh037. PMC 373431. PMID 14973333. Page for Hepatitis delta virus ...

This can be used to: detect if two labelled protein or nucleic acids come into contact or a doubly labelled single molecules is ... Fluorescence has been used to study the structure and conformations of DNA and proteins with techniques such as Fluorescence ... nucleic acids, lipids or small molecules can be "labelled" with an extrinsic fluorophore, a fluorescent dye which can be a ... DNA detection: the compound ethidium bromide, when free to change its conformation in solution, has very little fluorescence. ...

Nucleic Acids Research. 33 (Web Server issue): W690-2. doi:10.1093/nar/gki445. PMC 1160206. PMID 15980564. Chang TH, Huang HD, ... RNA thermometer - Another class of mRNA regulatory segments which change conformation in response to temperature fluctuations, ... Nucleic Acids Research. 35 (14): 4809-4819. doi:10.1093/nar/gkm487. PMC 1950547. PMID 17621584. Weinberg Z, Wang JX, Bogue J, ... Nucleic Acids Research. 36 (18): 5955-5969. doi:10.1093/nar/gkn601. PMC 2566862. PMID 18812398. Loh E, Dussurget O, Gripenland ...

Coaxial stacking is the tendency of nucleic acid blunt ends to bind to each other, by interactions between the exposed bases. ... a perpendicular stacked conformation at moderate concentrations, and rotate into a parallel stacked conformation at low ... A Holliday junction is a branched nucleic acid structure that contains four double-stranded arms joined. These arms may adopt ... In the 1990s, crystallography and nucleic acid NMR methods became available, as well as computational molecular modelling tools ...

Folding, including the secondary and tertiary structure of biopolymers (nucleic acids and proteins). Akamptisomerism - due to ... the anti-conformation (left-most, below) and the gauche conformation (right-most, below). Both conformations are free of ... Ring conformation Cyclohexane conformations, including with chair and boat conformations among others. Cycloalkane ... The staggered conformation is more stable by 12.5 kJ/mol than the eclipsed conformation, which is the energy maximum for ethane ...

Heo, L; Park, H; Seok, C (2013). "GalaxyRefine: Protein structure refinement driven by side-chain repacking". Nucleic Acids ... and standard deviations of the discrete conformations (known as rotamers) of the amino acid side chains in proteins as a ... Nucleic Acids Research. 46 (W1): W296-W303. doi:10.1093/nar/gky427. PMC 6030848. PMID 29788355. Studer, G; Tauriello, G; ... "Potential energy function and parameters for simulations of the molecular dynamics of proteins and nucleic acids in solution". ...

Nucleic Acids Res. 29 (16): 3424-32. doi:10.1093/nar/29.16.3424. PMC 55847. PMID 11504880. Stehlin C, Wurtz JM, Steinmetz A, ... "X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation". EMBO J. 20 (21): 5822 ... "All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta". Nat. Struct. Biol. 10 (10): 820-5. doi:10.1038/ ...

A second goal is to uncover structural details of nucleic acid structural transitions, such as those involving different DNA ... her research aims to understand the influence of chemical architecture on the conformation, properties, and interactions of ... Wilma Olson was involved in setting up the nucleic acid database, in collaboration with Helen M. Berman. Olson's studies DNA as ... nucleic acids. Olson received her bachelor's degree in chemistry at the University of Delaware in 1967, with honors and ...

His research seeks to understand the structural basis for macromolecular reactions, from the role of nucleic acids as targets ... This model challenged Richard Dickerson's long-standing non-electrostatic DNA conformation model by suggesting that the peaks ... they have shown that ferrous iron is an effective cofactor for the ribosome and other nucleic acid processing enzymes. Williams ... Subsequent studies have confirmed the direct role of cations in nucleic acid chemistry. Since 2008, Williams' research group ...

Thomas J, Lea K, Zucker-Aprison E, Blumenthal T (May 1990). "The spliceosomal snRNAs of Caenorhabditis elegans". Nucleic Acids ... "Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre". The EMBO Journal. 31 (6 ... Zwieb C (January 1997). "The uRNA database". Nucleic Acids Research. 25 (1): 102-3. doi:10.1093/nar/25.1.102. PMC 146409. PMID ...

She is a member of the editorial board of Nucleic Acids Research. Yiliang Ding received several awards and recognitions since ... the single-molecule RNA structure profiling method that is capable of dissecting individual RNA structure conformation in ... Her group's research on nucleic acid chemistry and RNA biology focuses on understanding the dynamics of RNA structure in living ... "Abscisic Acid Coordinates Nod Factor and Cytokinin Signaling during the Regulation of Nodulation in Medicago truncatula". ...

Nucleic acid and protein NMR spectroscopy are similar but differences exist. Nucleic acids have a smaller percentage of ... It is now a common tool for the determination of Conformation Activity Relationships where the structure before and after ... Nucleic acid NMR is the use of NMR spectroscopy to obtain information about the structure and dynamics of polynucleic acids, ... The types of NMR usually done with nucleic acids are 1H or proton NMR, 13C NMR, 15N NMR, and 31P NMR. Two-dimensional NMR ...

... particularly protein and nucleic acids such as DNA and RNA. In fact, the double-helical structure of DNA was deduced from ... X-ray crystallography is the primary method for determining the molecular conformations of biological macromolecules, ...

... and sugar pucker conformations. For large-scale structure, these local parameters must be supplemented with other structural ... Nucleic acid NMR uses similar techniques as protein NMR, but has several differences. Nucleic acids have a smaller percentage ... Nucleic acid NMR is the use of NMR spectroscopy to obtain information about the structure and dynamics of nucleic acid ... exploit the chemical properties of nucleic acids using specific reagents and conditions to assay the structure of nucleic acids ...

... and sugar pucker conformations. The presence or absence of imino proton resonances, or of coupling between 15N atoms across a ... Nucleic acid NMR uses techniques similar to those of protein NMR, but has several differences. Nucleic acids have a smaller ... Because nucleic acids have a relatively large number of protons which are solvent-exchangeable, nucleic acid NMR is generally ... Nucleic Acids. New York: Oxford University Press. ISBN 0-19-508467-5. (Nuclear magnetic resonance spectroscopy, Nucleic acids, ...

... the conformation and the modifications of DNA and RNA Nucleic acid thermodynamics Ansevin, A.T.; Vizard, D.L.; Brown, B.W.; ... Nucleic Acids Research, 39 (8): e52-e52, doi:10.1093/nar/gkr035, PMC 3082908, PMID 21297115. Ririe, KM; Rasmussen, RP; Wittwer ... 1997 Dec;43(12):2262-7 Wienken CJ, Baaske P, Duhr S, Braun D (2011), "Thermophoretic melting curves quantify the conformation ...

Nucleic Acids Research. 42 (22): 13736-13748. doi:10.1093/nar/gku1230. PMC 4267650. PMID 25428364. Rajendra E, Oestergaard VH, ... "The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome". Molecular Cell. ...

Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 38: 37-89. doi:10.1016/S0079-6603(08) ... Protein structure and conformations of the pure (Na+ +K+)-ATPase". Biochim. Biophys. Acta. 694 (1): 27-68. doi:10.1016/0304- ...

Z-DNA's zigzag backbone is due to the C sugar conformation compensating for G glycosidic bond conformation. The conformation of ... DNA supercoil Gene structure Non-helical models of DNA structure Nucleic acid design Nucleic acid double helix Nucleic acid ... Nucleic acid structure refers to the structure of nucleic acids such as DNA and RNA. Chemically speaking, DNA and RNA are very ... Nucleic acid structure prediction (computational) Nucleic acid thermodynamics Protein structure Satellite DNA Triple-stranded ...

Double-helical RNA adopts a conformation similar to the A-form structure. Other conformations are possible; in fact, only the ... Nucleic acid tertiary structure is the three-dimensional shape of a nucleic acid polymer. RNA and DNA molecules are capable of ... Watson JD, Crick FH (April 1953). "Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid" (PDF). ... Watson JD, Crick FH (April 1953). "Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid" (PDF). ...

Other conformations are possible; A-DNA, B-DNA, C-DNA, E-DNA, L-DNA (the enantiomeric form of D-DNA), P-DNA, S-DNA, Z-DNA, etc ... Dickerson RE (1989). "Definitions and nomenclature of nucleic acid structure components". Nucleic Acids Res. 17 (5): 1797-1803 ... nucleic acid simulation software DNA nanotechnology G-quadruplex Molecular models of DNA Molecular structure of Nucleic Acids ( ... Melting occurs preferentially at certain points in the nucleic acid. T and A rich regions are more easily melted than C and G ...

Conversely, for nucleic acids, the secondary structure consists of the hydrogen bonding between the nitrogenous bases. The ... often noted as extended conformations), or turns. The success of a prediction is determined by comparing it to the results of ... Secondary structure is the general three-dimensional form of local segments of biopolymers such as proteins and nucleic acids ( ... For each amino acid in the sequence, the neural network is fed with a window of 15 acids. Added information is attached, ...

... nucleic acids, and polysaccharides to fold into well-defined conformations, such as α-helices and β-sheets. The structure of a ... Secrist, John (2005). "Nucleosides as anticancer agents: from concept to the clinic". Nucleic Acids Symposium Series. 49 (49): ... β-peptides are composed of amino acids containing an additional CH 2 unit between the amine and carboxylic acid. They are more ... Using a heteroligopeptide consisting of α-amino acids and cis-β-aminocyclopropanecarboxulic acids (cis-β-ACCs) they found the ...

In its lifetime, NCp7 facilitates the unwinding of tRNA, acts as a primer for reverse transcription, chaperones nucleic acids ... They react with the cysteine residues on the zinc finger of the NCp7 and cause a covalent conformation change which ejects the ... Nucleic Acids Research. 34 (2): 472-484. doi:10.1093/nar/gkj442. PMC 1351370. PMID 16434700. Musah, Rabi Ann (2004). "The HIV-1 ... These motifs contain two peptide units of Cys-X2-Cys-X4-His-X4-Cys (CCHC), where the X represents a substituted amino acid, ...