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*  Lamin
Nuclear lamins interact with membrane-associated proteins to form the nuclear lamina on the interior of the nuclear envelope. ... Intermediate filament Nuclear lamina Laminopathies Inner nuclear membrane proteins Dechat, Thomas; Adam, Stephen A.; Taimen, ... Some studies have demonstrated that lamins A and C are not required for the formation of the nuclear lamina, yet disruptions in ... This allows chromatin to separate from the nuclear lamina in order to be condensed. As apoptosis continues, cell structures ...
*  Nuclear lamina
... they mediate the attachment of the nuclear lamina to the nuclear envelope. The nuclear lamina is assembled by interactions of ... Journal of Structural Biology 129, 313-323 Media related to Nuclear lamina at Wikimedia Commons Nuclear Lamina at the US ... a functional nuclear lamina requires only B-type lamins. Various experiments show that the nuclear lamina plays a part in the ... the nuclear lamina and the nuclear pore complexes. This nuclear breakdown is necessary to allow the mitotic spindle to interact ...
*  LMNA-related congenital muscular dystrophy
LMNA-laminA/C (Spanish) Laminopathies. Nuclear lamina disases. (Spanish). ... They play an important role in the organization of chromatin and nuclear membrane. Unlike most muscular dystrophies, lamin A/C ...
*  MAP1LC3B
Nuclear LC3 interacts with lamin B1, and participates in the degradation of nuclear lamina. LC3 is also enriched in nucleoli ... "Autophagy mediates degradation of nuclear lamina". Nature. 527 (7576): 105-9. doi:10.1038/nature15548. PMC 4824414 . PMID ... The importance of the nuclear functions of autophagy proteins should not be underestimated. A large pool of LC3 is present in ... In response to starvation, nuclear LC3 is deacetylated and trafficked out of the nucleus into the cytoplasm where it functions ...
*  Cell nucleus
Towards the end of the cell cycle, the nuclear membrane is reformed, and around the same time, the nuclear lamina are ... Because the nuclear membrane is impermeable to large molecules, nuclear pores are required to regulate nuclear transport of ... and the nuclear matrix (which includes the nuclear lamina), a network within the nucleus that adds mechanical support, much ... The nuclear lamina is composed mostly of lamin proteins. Like all proteins, lamins are synthesized in the cytoplasm and later ...
*  Cytoskeleton
Nuclear lamina exist in all animals and all tissues. Some animals like the fruit fly do not have any cytoplasmic intermediate ... anchoring organelles and serving as structural components of the nuclear lamina. They also participate in some cell-cell and ... made of lamin, giving structural support to the nuclear envelope. made of desmin, play an important role in structural and ... Biology portal Molecular and cellular biology portal Cell (biology) Organelle Nuclear matrix Microfilament Hardin, Jeff; ...
*  Progeria
... and therefore does not become part of the nuclear lamina. Without lamin A, the nuclear lamina is unable to provide the nuclear ... Lamin A is a major component of a protein scaffold on the inner edge of the nucleus called the nuclear lamina that helps ... link) Korf B (2008). "Hutchinson-Gilford progeria syndrome, aging, and the nuclear lamina". N. Engl. J. Med. 358 (6): 552-5. ... Since the support that the nuclear lamina normally provides is necessary for the organizing of chromatin during mitosis, ...
*  Barrier to autointegration factor 1
Goldberg M, Harel A, Gruenbaum Y (2000). "The nuclear lamina: molecular organization and interaction with chromatin". Crit. Rev ... a component of the nuclear lamina. It also associates with the LEM Domain containing proteins LAP2, Emerin, and MAN1. Barrier ... This protein binds to DNA in a non-specific manner and studies in rodents suggest that it also binds to lamina-associated ... 2002). "BAF is required for emerin assembly into the reforming nuclear envelope". J. Cell Sci. 114 (Pt 24): 4575-85. PMID ...
*  Nuclear organization
Furthermore, CTCF is often found at self-interacting domain boundaries, and can anchor the chromatin to the nuclear lamina. ... nuclear transport, and alteration of nuclear structure. Controlled changes in nuclear organization are essential for proper ... For example, large, gene-poor chromosomes are commonly located on the periphery near the nuclear lamina while smaller, gene- ... October 2015). "The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear ...
*  CTCF
... also occurs frequently at the boundaries of sections of DNA bound to the nuclear lamina. Using chromatin immuno- ... and anchors DNA to cellular structures like the nuclear lamina. It also defines the boundaries between active and ... "Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions". Nature. 453 (7197): 948-51. doi: ...
*  Lamin B receptor
It localizes to the inner membrane of the nuclear envelope and anchors the lamina and the heterochromatin to the membrane. It ... "Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing". Science. 354 (6311): 468-472. doi: ... "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics". Journal of Cell Science. 113 Pt 21 ... Worman HJ, Yuan J, Blobel G, Georgatos SD (November 1988). "A lamin B receptor in the nuclear envelope". Proceedings of the ...
*  Cyclin B1
Heald R, McKeon F (May 1990). "Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis ... The nuclear envelope is a membranous structure containing large protein complexes supported by a network of nuclear lamins. ... compromising the structural integrity of the nuclear envelope so that it breaks down. The destruction of the nuclear envelope ... Nuclear-dominant expression of cyclin B1 leads to poorer prognosis due to its weak activity compared to cytoplasmic cyclin B1. ...
*  Ced-3
These proteins are found in the nucleus, nuclear lamina, cytoskeleton, endoplasmic reticulum, and cytosol. The action of ... elegans nuclear-membrane protein NPP-14". Nature Structural & Molecular Biology. 23 (11): 958-964. doi:10.1038/nsmb.3308. PMID ...
*  LEM domain-containing protein 3
... an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin". The Journal of ... "The MAN antigens are non-lamin constituents of the nuclear lamina in vertebrate cells". Chromosoma. 104 (5): 367-379. doi: ... Inner nuclear membrane proteins Worman, H. J.; Fong, L. G.; Muchir, A.; Young, S. G. (2009). "Laminopathies and the long ... LEM domain-containing protein 3 (LEMD3), also known as MAN1, is an integral protein in the inner nuclear membrane (INM) of the ...
*  C8orf48
... is a nuclear protein specifically predicted to be located in the nuclear lamina. C8orf48 has been found to interact ... The C8orf48 protein is predicted to be a nuclear protein particularly located in the nuclear lamina. This protein does not ... The prediction is that C8orf48 is most likely nuclear and potentially cytoplasmic. When comparing orthologs of C8orf48 we see ... C8orf48 protein has two predicted nuclear localization signals one spanning from 135-149 amino acids and the other from 204-221 ...
*  Maturation promoting factor
This leads to depolymerisation of the nuclear lamina & breakdown of nuclear envelope into small vesicles. Causes ... The three lamins present in the nuclear lamina, lamin A, B & C, are phosphorylated by MPF at serine amino residues. ... This result demonstrated that mitotic entry was controlled by a diffusible cytoplasmic factor and not by a "nuclear clock." MPF ... Masui Y, Markert CL (1971), Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes. J Exp Zool 177:2 ...
*  Nuclear prelamin A recognition factor
The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited ... Nuclear prelamin A recognition factor, also known as NARF, is a protein which in humans is encoded by the NARF gene. Several ... The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is ... Barton RM, Worman HJ (Oct 1999). "Prenylated prelamin A interacts with Narf, a novel nuclear protein". The Journal of ...
*  CBX3
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded ... This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding ... Ye, Q; Worman H J (June 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human ... 1997). "Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR". J. Biol. ...
*  David M. Knipe
They further showed that the viral genome associated with the nuclear lamina for immediate-early transcription. This work ... Orzalli, M. H.; DeLuca, N. A.; Knipe, D. M. (2012). "Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection ... Orzalli, M. H.; Conwell, S. E.; Berrios, C.; DeCaprio, J. A.; Knipe, D. M. (2013). "Nuclear interferon-inducible protein 16 ...
*  GZMA
"Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis". Proc. Natl. Acad. ...
*  Laminopathy
Lamins are intermediate filament proteins that form the nuclear lamina scaffold underneath the nuclear envelope in animal cells ... The nuclear lamina appears to be an adaptation to mobility in animals as sessile organisms such as plants or fungi do not have ... Houben F, Ramaekers FC, Snoeckx LH, Broers JL (May 2007). "Role of nuclear lamina-cytoskeleton interactions in the maintenance ... They are attached to the nuclear envelope membrane via farnesyl anchors and interaction with inner nuclear membrane proteins ...
*  DNA damage theory of aging
"Methods to Monitor DNA Repair Defects and Genomic Instability in the Context of a Disrupted Nuclear Lamina". Methods Mol. Biol ... Although both mitochondrial and nuclear DNA damage can contribute to aging, nuclear DNA is the main subject of this analysis. ... Nuclear DNA damage can contribute to aging either indirectly (by increasing apoptosis or cellular senescence) or directly (by ... "Nuclear DNA damage as a direct cause of aging" (PDF). Rejuvenation Research. 12 (3): 199-208. doi:10.1089/rej.2009.0847. PMID ...
*  DNA repair-deficiency disorder
"Methods to Monitor DNA Repair Defects and Genomic Instability in the Context of a Disrupted Nuclear Lamina". Methods Mol. Biol ... Best, BP (2009). "Nuclear DNA damage as a direct cause of aging" (PDF). Rejuvenation Research. 12 (3): 199-208. doi:10.1089/rej ...
*  Nucleoporin 155
Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005). "Vertebrate Nup53 Interacts with the Nuclear Lamina and Is Required for the ... Nucleoporins are the main components of the nuclear pore complex (NPC) of eukaryotic cells. They are involved in the ... 2004). "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155". Mol. Cell. Proteomics. 3 (2 ... "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155". Mol. Cell. Proteomics. United States ...
*  LMNA
The nuclear lamina consist of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family ... Depolymerization of the nuclear lamins leads to disintegration of the nuclear envelope. Transfection experiments demonstrate ... Lamin A is targeted to the nuclear membrane by an isoprenyl group but it is cleaved shortly after arriving at the membrane. It ... During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are ...
*  Caspase-activated DNase
What is more, combining C3's amino acids leads to 5 α helices, 4 β lamina and a loop at the catalytic C-terminal which interact ... Targeting of p21 promoter is responsible for inducing cell differentiation, which is promoted by modifying the DNA nuclear ... caspase cleavage and nuclear fragmentation". Cell Death and Differentiation. 9 (11): 1172-84. doi:10.1038/sj.cdd.4401094. PMID ... and Inhibitor of Caspase-activated DNase to the Nuclear Phenotype and DNA Degradation during Apoptosis". The Journal of ...