It is a nitrogen mustard β-chloro-nitrosourea compound used as an alkylating agent. Carmustine is an orange-yellow solid ... It is a nitrogen mustard β-chloro-nitrosourea compound. As an alkylating agent, carmustine can form interstrand crosslinks in ...

"Clinical Pharmacology and Toxicology of Mustard Compounds". Basic and Clinical Toxicology of Mustard Compounds. Springer. p. 64 ... Nitrogen mustards are nonspecific DNA alkylating agents. Nitrogen mustards are not related to the mustard plant or its pungent ... the nitrogen mustard known as "HN2" became the first chemotherapy drug mustine. The nitrogen mustard drug mustine (HN2), is no ... Nitrogen mustards are cytotoxic organic compounds with the chloroethylamine ((ClC2H4)2NR) functional group. Although originally ...

... compounds with nitrogen-mustard-like activity". Cancer. 6 (1): 142-148. doi:10.1002/1097-0142(195301)6:1. 3.0.CO;2-W. Kim KM, ... Thiotepa is an organophosphorus compound with the formula (C2H4N)3PS. It is an analog of N,N′,N″-triethylenephosphoramide (TEPA ...

They exchanged a nitrogen molecule for sulfur and had a more stable compound in nitrogen mustard. A year into the start of ... The era of cancer chemotherapy began in the 1940s with the first use of nitrogen mustards and folic acid antagonist drugs. The ... Such concerns led to the discovery of nitrogen mustard, a chemical warfare agent, as an effective treatment for cancer. Two ... Goodman LS; Wintrobe MM; Dameshek W; Goodman MJ; Gilman A; McLennan MT (1946). "Nitrogen mustard therapy. Use of methyl-bis( ...

The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, platinum compounds, and ... TNF or the effects of TNF are also suppressed by various natural compounds, including curcumin (an ingredient in turmeric) and ... Cyclophosphamide (Baxter's Cytoxan) is probably the most potent immunosuppressive compound. In small doses, it is very ...

Some organochlorine compounds, such as sulfur mustards, nitrogen mustards, and Lewisite, are even used as chemical weapons due ... Organochlorine chemistry is concerned with the properties of organochlorine compounds, or organochlorides, organic compounds ... transforming an electrophilic compound into a nucleophilic compound. The Wurtz reaction reductively couples two alkyl halides ... These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. They have higher ...

A similar family of compounds known as nitrogen mustards were studied further during World War II at the Yale School of ... Nitrogen mustards include mechlorethamine, cyclophosphamide, melphalan, chlorambucil, ifosfamide and busulfan. Nitrosoureas ... The subtypes of alkylating agents are the nitrogen mustards, nitrosoureas, tetrazines, aziridines, cisplatins and derivatives, ... Originally derived from mustard gas used in World War I, there are now many types of alkylating agents in use. They are so ...

Tris(2-chloroethyl)amine is the organic compound with the formula N(CH2CH2Cl)3. Often abbreviated HN3 or HN-3, it is a powerful ... Nitrogen mustard NITROGEN MUSTARD HN-3. Emergency Response Safety and Health Database. National Institute for Occupational ... blister agent and a nitrogen mustard used for chemical warfare. HN3 was the last of the nitrogen mustard agents developed. It ... Nitrogen mustards react via an initial cyclization to the corresponding quaternary aziridine salt. The rate of this reaction is ...

Bis(2-chloroethyl)ethylamine is the organic compound with the formula C2H5N(CH2CH2Cl)2. Often abbreviated HN1, it is a powerful ... Nitrogen mustard The Emergency Response Safety and Health Database: NITROGEN MUSTARD HN-1. National Institute for Occupational ... nitrogen mustard can burn the GI tract and cause nausea, vomiting, hemorrhagic diarrhea, and abdominal pain. Nitrogen mustard ... Nitrogen mustards react via an initial cyclization to the corresponding aziridinium salt. The rate of this reaction is pH ...

... can refer to: Sulfur mustard (mustard gas) Nitrogen mustard This set index article lists chemical compounds ...

... with the derivation of the drug Mustine from nitrogen mustard compounds. U.K. Labour Minister Ernest Bevin announced that one ... that patients exposed to the sulfur mustard gas had reduced white blood cell counts; with the substitution of nitrogen for ... the American merchant marine ship SS John Harvey had been carrying a cargo of 2,000 M-47A1 mustard gas bombs. The ship was one ... sulfur, the first compound that could fight cancer cells with minimal harm to healthy cells was created, ...

Nitrogen mustard vesicants, Chloroethyl compounds, Orphan drugs). ... but with nitrogen substituting for sulfur was discovered-the "nitrogen mustards" were born. The particular nitrogen mustard ... Einhorn, J. (1985). "Nitrogen mustard: the origin of chemotherapy for cancer". Int J Radiat Oncol Biol Phys. 11 (7): 1375-1378 ... Jacobson L.O., Spurr C.L., Barron E., Smith T., Lushbaugh C., Dick G.F. (1946). "Nitrogen Mustard Therapy: Studies on the ...

Nitrogen mustard vesicants, Chloroethyl compounds, Isopropylamino compounds, All stub articles, Amine stubs). ... TL-301 is a nitrogen mustard vesicant. HN1 (nitrogen mustard) HN2 (nitrogen mustard) HN3 (nitrogen mustard) "Chemical Warfare ...

Nitrogen mustards, Chloroethyl compounds, All stub articles, Neurotoxin stubs). ... Jaim-Etcheverry G, Mari'a Zieher L (1980). "DSP-4: A novel compound with neurotoxic effects on noradrenergic neurons of adult ...

... a nitrogen mustard compound, for treatment of cancer 1949 - Oncolytic viruses began human clinical trials 1951 - Dr. Jane C. ... nitrogen mustard, vincristine, procarbazine, and prednisone 1965 - MOMP regimen combination therapy, consisting of: ... anti-cancer compound, isolated from the yew plant 1967 - Camptothecin, anti-cancer compound, isolated from the Camptotheca ...

Nitrogen mustards, Phosphorodiamidates, Chloroethyl compounds). ... is in the class of oxazaphosphorine compounds, and is the main ... phosphoramide mustard and acrolein. Ludeman SM (August 1999). "The chemistry of the metabolites of cyclophosphamide". Current ...

Nitrogen mustards, Phosphorodiamidates, Chloroethyl compounds, All stub articles, Organic compound stubs). ...

Nitrogen mustards, Phosphorodiamidates, Chloroethyl compounds, World Health Organization essential medicines, Wikipedia ... Ifosfamide is in the alkylating agent and nitrogen mustard family of medications. It works by disrupting the duplication of DNA ...

Nitrogen mustards, Chloroethyl compounds, Withdrawn drugs, 2-Naphthyl compounds). ... Due to the undesirable side effects of nitrogen mustard, chlornaphazine, another member of the nitrogen mustard series with a ... nitrogen mustards such as chlornaphazine could be administered. In patients with Hodgkin's disease treated with nitrogen ... Chlornaphazine is a nitrogen mustard that was predominantly used in Scandinavia as a treatment for polycythemia and Hodgkin's ...

Nitrogen mustards, Chloroethyl compounds, World Health Organization essential medicines, Wikipedia medicine articles ready to ... leading to the nitrogen mustards. With an acceptable therapeutic index in humans, nitrogen mustards were first introduced in ... When heated to decomposition it emits very toxic fumes of hydrogen chloride and nitrogen oxides Nitrogen mustards arose from ... aromatic mustards like chlorambucil were introduced as less toxic alkylating agents than the aliphatic nitrogen mustards, ...

Nitrogen mustards, Organochlorides, Chloroethyl compounds, All stub articles, Antineoplastic and immunomodulating drug stubs). ... Normustine, also known as bis(2-chloroethyl)carbamic acid, is a nitrogen mustard and alkylating antineoplastic agent (i.e., ...

Nitrogen mustards, Chloroethyl compounds, All stub articles, Antineoplastic and immunomodulating drug stubs). ... Trofosfamide (INN) is a nitrogen mustard alkylating agent. It is sometimes abbreviated "TRO". It has been used in trials to ...

Nitrogen mustards, Chloroethyl compounds, World Health Organization essential medicines, Wikipedia medicine articles ready to ... It was originally made from nitrogen mustard. Bendamustine has been used both as sole therapy and in combination with other ... Common adverse reactions are typical for the class of nitrogen mustards, and include nausea, fatigue, vomiting, diarrhea, fever ...

Nitrogen mustards, Chloroethyl compounds, Cyclopropyl compounds, All stub articles, Analgesic stubs). ... Its alkylating group is a bis(chloroalkyl)amino-residue similar to that of the nitrogen mustards. Chloroxymorphamine, an ...

Nitrogen mustards, Organochlorides, Chloroethyl compounds, All stub articles, Antineoplastic and immunomodulating drug stubs). ...

Chloroethyl compounds, Imidazolines, Nitrogen mustards, Organochlorides, All stub articles, Cardiovascular system drug stubs). ...

Nitrogen mustards, Chloroethyl compounds). ... Mannomustine (INN), also known as mannitol nitrogen mustard, ... tradename Degranol is an old alkylating antineoplastic agent from the group of nitrogen mustards. It was first synthesized and ...

Nitrogen mustards, Thiazoles, Amides, Phenyl compounds, Ethers, Transient receptor potential channel agonists). ... JT-010 is a chemical compound which acts as a potent, selective activator of the TRPA1 channel, and has been used to study the ...

Chloroethyl compounds, Estradiol esters, Nitrogen mustards, Synthetic estrogens, All stub articles, Steroid stubs, Genito- ... steroidal estrogen and cytostatic antineoplastic agent and a chlorphenacyl nitrogen mustard-coupled estrogen ester that was ... Estradiol mustard, also known as chlorphenacyl estradiol diester, as well as estradiol 3,17β-bis(4-(bis(2-chloroethyl)amino) ... mustard and other cytostatic-linked estrogens like estramustine phosphate have reduced toxicity relative to non-linked nitrogen ...

Nitrogen mustards, Organochlorides, Oxazaphosphinans, Phosphorodiamidates, Prodrugs, Chloroethyl compounds, World Health ... It was postulated that the presence of the phosphate bond to the nitrogen atom could inactivate the nitrogen mustard moiety, ... Cyclophosphamide is in the alkylating agent and nitrogen mustard family of medications. It is believed to work by interfering ... They converted the base nitrogen mustard into a nontoxic "transport form". This transport form was a prodrug, subsequently ...