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*  PEPD
Expression of the mutant enzyme in NIH 3T3 cells". The Journal of Clinical Investigation. 86 (1): 351-5. doi:10.1172/JCI114708 ... Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID ... Cell. 154 (2): 452-64. doi:10.1016/j.cell.2013.06.022. PMC 3717207 . PMID 23870131. "Infection and Immunity Immunophenotyping ( ... Surazyński A, Pałka J (2002). "FAK-independent regulation of prolidase activity and collagen biosynthesis in MCF-7 cells". ...
*  ERBB4
Cohen BD, Green JM, Foy L, Fell HP (Mar 1996). "HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence ... Cell. 127 (1): 185-97. doi:10.1016/j.cell.2006.07.037. PMID 17018285. "Entrez Gene: ERBB4 v-erb-a erythroblastic leukemia viral ... Culouscou JM, Plowman GD, Carlton GW, Green JM, Shoyab M (Sep 1993). "Characterization of a breast cancer cell differentiation ... Carpenter G (Mar 2003). "ErbB-4: mechanism of action and biology". Experimental Cell Research. 284 (1): 66-77. doi:10.1016/ ...
*  Mouse embryonic fibroblast
These cells developed into a commonly used cell line NIH 3T3. MEFs treated by mitomycin or gamma rays (such treatment makes MEF ... Finally digest the remains by enzymes to obtain single isolated cells and culture the cells in a tissue culture dishes. MEF ... Cell Biol. 17: 299-313. PMC 2106200 . PMID 13985244. Regad T, Sayers T, Rees R, eds. (2015). Principles of Stem Cell Biology ... which is remarkable in the development of stem cell biology. Fibroblast Embryonic stem cell Jian-ming Xu (2005). "Preparation, ...
*  Cyclin D1
"Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells". Nature. 313 (5999): 241-3. ... Cyclin D1 is expressed in all adult human tissues with the exception of cells derived from bone marrow stem cell lines (both ... Amplification of the CCND1 gene is present in: non-small cell lung cancers (30-46%) head and neck squamous cell carcinomas (30- ... Chromosomal translocation around the cyclin D1 gene locus is often seen in B mantle cell lymphoma. In mantle cell lymphoma, ...
*  Ravi Iyengar
Ram, P. T.; Horvath, C. M.; Iyengar, R (2000). "Stat3-mediated transformation of NIH-3T3 cells by the constitutively active ... "Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein". Science. 287 (5450): 142-4 ... His laboratory focuses on how cell signals are routed and processed through cellular signaling networks within cells to ... Cell. 133 (4): 666-80. doi:10.1016/j.cell.2008.04.025. PMC 2728678 . PMID 18485874. Bhalla, U. S.; Iyengar, R (1999). "Emergent ...
*  ABI1
"Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells". J. Cell Sci. 113 (21): ... Cell. Neurosci. 16 (3): 244-57. doi:10.1006/mcne.2000.0865. PMID 10995551. Fan PD, Goff SP (2000). "Abl Interactor 1 Binds to ... Cell. Biol. 20 (20): 7591-601. doi:10.1128/MCB.20.20.7591-7601.2000. PMC 86315 . PMID 11003655. Xu J, Ziemnicka D, Merz GS, ... Cell. 15 (1): 91-8. doi:10.1091/mbc.E03-06-0427. PMC 307530 . PMID 14565974. Lanzetti L, Rybin V, Malabarba MG, Christoforidis ...
*  Muscarinic acetylcholine receptor M1
"Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein ... Cell. Biol. 14 (4): 2343-51. doi:10.1128/mcb.14.4.2343. PMC 358601 . PMID 8139539. Offermanns S, Wieland T, Homann D, Sandmann ... Burford NT, Nahorski SR (1996). "Muscarinic m1 receptor-stimulated adenylate cyclase activity in Chinese hamster ovary cells is ... Ashkenazi A, Ramachandran J, Capon DJ (1989). "Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via ...
*  Phosphatidylinositol-3-phosphatase
"The discovery of a 3-phosphomonoesterase that hydrolyzes phosphatidylinositol 3-phosphate in NIH 3T3 cells". J. Biol. Chem. 264 ...
*  Muscarinic acetylcholine receptor M3
"Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein ... cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo". Cell ... These receptors are highly expressed on pancreatic beta cells and are critical regulators of glucose homoestasis by modulating ... However, with respect to vasculature, activation of M3 on vascular endothelial cells causes increased synthesis of nitric oxide ...
*  C-Met
Kochhar KS, Johnson ME, Volpert O, Iyer AP (1995). "Evidence for autocrine basis of transformation in NIH-3T3 cells transfected ... Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate ... phagocytes and NK cells), thus forming a bridge between an effector and a target cells. This induces the effector cell ... However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of ...
*  Hepatocyte growth factor
Kochhar KS, Johnson ME, Volpert O, Iyer AP (1995). "Evidence for autocrine basis of transformation in NIH-3T3 cells transfected ... It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts ... As well as the well-characterised effects of HGF on epithelial cells, endothelial cells and haemopoietic progenitor cells, HGF ... Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial ...
*  PPP1R12A
Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to ... Cell Biol. 3 (4): 346-52. doi:10.1038/35070019. PMID 11283607. Murányi A, Zhang R, Liu F, et al. (2001). "Myotonic dystrophy ... PPP1R12A Info with links in the Cell Migration Gateway. ... muscle and interaction of actin and myosin in nonmuscle cells. ...
*  Muscarinic acetylcholine receptor M5
1994). "Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a ... Cell. Biochem. 228 (1-2): 57-72. doi:10.1023/A:1013368509855. PMID 11855742. Strausberg RL, Feingold EA, Grouse LH, et al. ( ... 1996). "Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to ... receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell ...
*  ELK1
"Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro". Science. 257 (5075): 1404-7. ... Cell. Biol. 16 (3): 1094-102. PMC 231092 . PMID 8622654. Zinck R, Hipskind RA, Pingoud V, Nordheim A (June 1993). "c-fos ... Given its role as a transcription factor, Elk1 is expressed in the nuclei of non-neuronal cells. The protein is present in the ... Cell. Biol. 13 (8): 4539-48. PMC 360070 . PMID 8393135. Moodie SA, Willumsen BM, Weber MJ, Wolfman A (June 1993). "Complexes of ...
*  MAP3K12
"Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells". J. Histochem. Cytochem. 47 (10 ... Cell. 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. Molecular and Cellular Biology portal. ... Cell. Biol. 19 (10): 7245-54. doi:10.1128/mcb.19.10.7245. PMC 84717 . PMID 10490659. Merritt SE, Mata M, Nihalani D, Zhu C, Hu ... This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of ...
*  ERBB3
Zhang K, Sun J, Liu N, Wen D, Chang D, Thomason A, Yoshinaga SK (1996). "Transformation of NIH 3T3 cells by HER3 or HER4 ... kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells". Cancer Res ... amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells". Clin. Cancer Res. ... Cell. Biol. 16 (10): 5276-87. PMC 231527 . PMID 8816440. Citri A, Skaria KB, Yarden Y (2003). "The deaf and the dumb: the ...
*  Hexadimethrine bromide
Polybrene in combination with DMSO shock is used to transfect some cell types such as NIH-3T3 and CHO. It has other uses, ... is a cationic polymer used to increase the efficiency of transduction of certain cells with retrovirus in cell culture. ... Hexadimethrine bromide acts by neutralizing the charge repulsion between virions and sialic acid on the cell surface. Use of ... "Polybrene increases retrovirus gene transfer efficiency by enhancing receptor-independent virus adsorption on the target cell ...
*  EBF1
"Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and ... "Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of ... EBF1 stands for Early B-Cell Factor 1. EBF1 controls the expression of key proteins required for B cell differentiation, signal ... "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica ...
*  Fasudil
... mitogen-activated protein kinase activation triggers p27Kip1 degradation independently of CDK2/cyclin E in NIH 3T3 cells". The ... Human pulmonary arterial smooth muscle cells treated with fasudil showed a decrease in cell proliferation in a dose-dependent ... Cell Physiology. 278 (1): C57-65. doi:10.1152/ajpcell.2000.278.1.c57. PMID 10644512. Ocaranza MP, Rivera P, Novoa U, Pinto M, ... Fouty BW, Rodman DM (Mar 2003). "Mevastatin can cause G1 arrest and induce apoptosis in pulmonary artery smooth muscle cells ...
*  5-HT1A receptor
Varrault A, Bockaert J, Waeber C (1992). "Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and ... Cell. 3 (9): 961-9. doi:10.1091/mbc.3.9.961. PMC 275657 . PMID 1330092. Levy FO, Gudermann T, Perez-Reyes E, Birnbaumer M, ... Aune TM, McGrath KM, Sarr T, Bombara MP, Kelley KA (1993). "Expression of 5HT1a receptors on activated human T cells. ... 5-HT1A receptors can be located on the cell body, dendrites, axons, and both presynaptically and postsynaptically in nerve ...
*  S100A13
"S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells". ... "S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells". Journal of Cell Science. 115 (Pt 15): 3149-58 ... In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting ... S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a ...
*  Fbx15
It became active in NIH 3T3 cells when Oct3/4 and Sox2 were coexpressed and cooperatively bind to the enhancer sequence. ... After the process of iPS Cells the right cells have to be chosen, so this gene Fbx15 can be used. This gene is a selection ... "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors." Cell 126.4 (2006): ... In mice having a beta-galactosidase gene knocked into the Fbx15 locus, stain was detected in ES cells, early embryos (from two- ...
*  Alpha-1B adrenergic receptor
... which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal ... 2003). "alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP- ... 2004). "Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration ... 2004). "Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic ...
*  Dock11
... is expressed at lower levels in NIH-3T3 fibroblasts, C2C12 myoblasts and Neuro-2A neuroblastoma cells. Dock11 mRNA has ... Côté JF, Vuori K (August 2007). "GEF what? Dock180 and related proteins help Rac to polarize cells in new ways". Trends in Cell ... Meller N, Merlot S, Guda C (November 2005). "CZH proteins: a new family of Rho-GEFs". Journal of Cell Science. 118 (Pt 21): ... Cell Cycle. 6 (6): 750-7. doi:10.4161/cc.6.6.3986. PMC 2040307 . PMID 17361101. Lin Q, Yang W, Baird D, Feng Q, Cerione RA ( ...
*  C-Raf
Kolch W, Heidecker G, Lloyd P, Rapp UR (January 1991). "Raf-1 protein kinase is required for growth of induced NIH/3T3 cells". ... Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by ... cell migration, inhibition of apoptosis, and cell differentiation. Hereditary gain-of-function mutations of c-Raf are ... "X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility". Nat. Cell Biol. 10 (12): 1447-55. doi: ...
*  NOL1
"Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense ... Overexpression of p120 leads to malignant transformation of 3T3 cells while treatment with antisense p120 mRNA causes the ... "A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation". Cancer ... Cell Biol. 4 (7): 529-33. doi:10.1038/ncb814. PMID 12080348. Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B (2002). " ...