Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL (July 2010). "Aryl hydrocarbon receptor and NF-E2-related factor 2 are key ... Hosgood HD, Menashe I, He X, Chanock S, Lan Q (December 2009). "PTEN identified as important risk factor of chronic obstructive ... 99 (7): 1965-1973.e2. doi:10.1016/j.fertnstert.2013.01.146. PMID 23472950. Guey LT, García-Closas M, Murta-Nascimento C, ... Saito A, Kawamoto M, Kamatani N (June 2009). "Association study between single-nucleotide polymorphisms in 199 drug-related ...
Moi P, Chan K, Asunis I, Cao A, Kan YW (October 1994). "Isolation of NF-E2-related factor 2 (NRF2), a NF-E2-like basic leucine ... January 2011). "NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport ... and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor- ... "Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization". Human ...
NF-E2)-related factor 2) transcription factor: Dimethyl fumarate (Tecfidera), Diroximel fumarate (Vumerity), approved by the ... but also injury-related) changes in olegodendrocytes, making OPCs respond to differentiation factors. Because of the side ... Related to this, MS patients have been reported to have low levels of uric acid, which is a natural antioxidant, and has been ... hydralazine: Due to its ability to damage myelin nerve sheaths, acrolein may be a factor in the development of multiple ...
... and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) ... Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene. Polyamine-modulated factor 1 has been ... "Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) ... Wang Y, Devereux W, Stewart TM, Casero RA (August 2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a ...
"Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice". Genes to Cells. 19 (8): 650-65. doi:10.1111/ ... Chan JY, Han XL, Kan YW (Dec 1993). "Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast". ... "The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome- ... "Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and ...
... family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 ... "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/ ... In T cells, BACH2 is recruited by the transcription factor Vitamin D receptor (VDR) both in vitro and in vivo (for example, in ... Mendelian BACH2-related immunodeficiency and autoimmunity (BRIDA) syndrome in humans is caused by haploinsufficiency of this ...
In 1989, the first CNC transcription factor NFE2L2 was identified. Subsequently, several related proteins were identified, ... similar to the clustering of p45 NF-E2, NFE2L1, and NFE2L2 near HOXC, HOXB, and HOXD genes respectively. This implies that all ... like factor 3, also known as NFE2L3 or 'NRF3', is a transcription factor that in humans is encoded by the Nfe2l3 gene. Nrf3 is ... diverging to give rise to four closely related transcription factors. The human Nfe2l3 gene encodes a 694 amino acid residue ...
This further influences several genes involved in regulation of the NF-κB-related pathway network. MicroRNA Cicatiello L, ... Intracellular miR-618 levels can be regulated by E2 via the ER2 receptor. This points towards a possible of this miRNA, amongst ... "Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors ... Decreased levels of miR-618 have been observed in estradiol(E2)-stimulated MCF-7 breast cancer cells following hormone ...
... transcription factors to the NEDD9 promoter. Prostaglandin E2 induces NEDD9 transcription. The Fox transcription factor ... the NEDD9 promoter also has potential binding sites for a number of additional transcription factors, including STAT5A and NF- ... In response to integrin activation, FAK or the related kinase RAFTK recruits NEDD9 into a focal adhesion site, binds it via the ... NEDD9 is induced by Wnt signaling in colon cancer, based on binding to T-cell factor (TCF) factors in the promoter region. ...
Examples of such partners include Runx/PEBP2, AP2, C/EBP, c-Jun, Krox-20, Krox-24, MEF2B, NF-E2, Oct-4 and p73, which interact ... and Runt related transcription factors (RUNX1/)2). The proliferative functions of WWTR1 (TAZ) and its paralog, YAP, are ... Endogenous hormonal factors that are synthesized for normal physiological functions such as epinephrine and glucagon have also ... Dai C, Chen X, Li J, Comish P, Kang R, Tang D (September 2020). "Transcription factors in ferroptotic cell death". Cancer Gene ...
... family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 ... "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/ ... This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family ( ... Kanezaki R, Toki T, Yokoyama M, Yomogida K, Sugiyama K, Yamamoto M, Igarashi K, Ito E (Mar 2001). "Transcription factor BACH1 ...
Hirotsu, Y (2012). "NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of ... Lee, CS (2011). "Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression ... Similar results were also observed in p45 NF-E2 knockout mice. The p45 NF-E2-sMaf heterodimer regulates genes responsible for ... p45 NF-E2 (NFE2), Nrf1 (NFE2L1), Nrf2 (NFE2L2), and Nrf3 (NFE2L3) - not to be confused with Nuclear Respiratory factors) and ...
NFE2 (NF-E2 p45) RELA (NF-κB p65) SREBP STAT1 TCF3 (E2A) TP53 (p53) YY1 Yeast proteins: Gal4p Gcn4 Pdr1 Pdr3 Oaf1 Viral ... a KIX domain or KIX-related domain that interacts with the transactivation domain of many different transcription factors. The ... Goto NK, Zor T, Martinez-Yamout M, Dyson HJ, Wright PE (November 2002). "Cooperativity in transcription factor binding to the ... of interactions between transactivation domain 1 of the p65 subunit of NF-κB and transcription regulatory factors". Nucleic ...
... although there is not universal agreement on the Big Five theory and the related Five-Factor Model (FFM). The following ... He maps these temperaments to the Myers-Briggs groupings SP, SJ, NF, and NT. He also gives each of the 16 MBTI types a name, as ... factor (which parallels, though not perfectly measuring, the NEO-PI factor of neuroticism). This factor's scales indicate a ... One factor-analytic study based on (N=1291) college-aged students found six different factors instead of the four purported ...
... nf-e2 transcription factor, p45 subunit MeSH D12.776.930.155.200.100 - core binding factor alpha 1 subunit MeSH D12.776.930.155 ... This list covers transcription factors. For other protein-related codes, see List of MeSH codes (D12.776). Codes before these ... nf-e2 transcription factor, p45 subunit MeSH D12.776.930.323.500.500 - hepatocyte nuclear factor 1-alpha MeSH D12.776.930.323. ... hepatocyte nuclear factor 3-beta MeSH D12.776.930.977.249.875 - hepatocyte nuclear factor 3-gamma The list continues at List of ...
Transcription factor NF-kB in unstimulated cells is inactivated by IkBa inhibitor protein binding. The activation of NF-kB is ... Finally, SUMO is transferred to an E2 cysteine, forming another thioester bond. Ubiquitin tag has a well understood role of ... SAE2 has been shown to interact with SAE1, Small ubiquitin-related modifier 1, and UBE2I. GRCh38: Ensembl release 89: ... This may be a mechanism for cell to regulate the number of NF-kB available for transcriptional activation. Transcription factor ...
"Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB ... Vatsyayan J, Qing G, Xiao G, Hu J (Sep 2008). "SUMO1 modification of NF-kappaB2/p100 is essential for stimuli-induced p100 ... Semplici F, Meggio F, Pinna LA, Oliviero S (Jun 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme ... In response to mitogens, PDCD4, an inhibitor of the translation initiation factor eIF4A, is rapidly degraded in a βTrCP- and ...
Yoon JB, Li G, Roeder RG (Mar 1994). "Characterization of a family of related cellular transcription factors which can modulate ... maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene". Genomics. 30 (2): 398-9. PMID 8586452. Romerio F, ... "Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4". Molecular and Cellular Biology. 20 (20): ... a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors". The Journal of ...
Small ubiquitin-related modifier 1 is a protein that in humans is encoded by the SUMO1 gene. This gene encodes a protein that ... Calcium is an essential factor for the development of cardiac myocyte contraction and relaxation. Thus, the management of ... Desterro JM, Rodriguez MS, Hay RT (August 1998). "SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation". Molecular ... E1 and E2". Biochemical and Biophysical Research Communications. 254 (3): 693-8. doi:10.1006/bbrc.1998.9995. PMID 9920803. Liou ...
... a member of the NF-E2 family of transcription factors, as a substrate for caspase-3(-like) proteases". Cell Death and ... Shu HB, Halpin DR, Goeddel DV (June 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751- ... Wikimedia Commons has media related to Caspase 3. The MEROPS online database for peptidases and their inhibitors: C14.003 ... "Entrez Gene: CASP3 caspase 3, apoptosis-related cysteine peptidase". Harrington HA, Ho KL, Ghosh S, Tung KC (2008). " ...
... releasing NF-κB. NF-κB is a heterodimeric transcription factor that translocates to the nucleus and mediates the transcription ... Both protein molecules tumor necrosis factor alpha and keratin 17 appear to be related in case of oral submucous fibrosis In ... On macrophages: stimulates phagocytosis, and production of IL-1 oxidants and the inflammatory lipid prostaglandin E2 (PGE2) On ... reported another cytotoxic factor produced by macrophages and named it tumor necrosis factor (TNF). Both factors were described ...
"The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf ... MafK was also identified as p18 NF-E2, a component of NF-E2 complex binding to a specific motif (NF-E2) in the regulatory ... Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH (Jun 1995). "Transcription factor NF-E2 ... recognized as antioxidant/electrophile response elements or NF-E2-binding motifs to which Nrf2-sMaf heterodimers and p45 NF-E2- ...
... nf-e2 transcription factor, p45 subunit MeSH D12.776.260.262.500.500 - hepatocyte nuclear factor 1-alpha MeSH D12.776.260.262. ... For other protein-related codes, see List of MeSH codes (D12.776). Codes before these are found at List of MeSH codes (D12.776 ... nf-e2 transcription factor, p45 subunit MeSH D12.776.260.235.750.750 - maf transcription factors, small MeSH D12.776.260.235. ... hepatocyte nuclear factor 3-beta MeSH D12.776.260.950.249.875 - hepatocyte nuclear factor 3-gamma The list continues at List of ...
Tumor necrosis factor-alpha (TNF-alpha) and its receptor are the molecules that seem to be responsible for the sensitization of ... TNF-alpha then binds to the TNF receptors expressed on nociceptors, activating the MAPK/NF-kappa B pathways. This leads to the ... The physiologic response to the binding is probably the production of prostaglandin E2 (PGE2) by cyclooxygenase 2 (COX-2). ... Landerholm, A. (2010). Neuropathic pain: Somatosensory Functions related to Spontaneous Ongoing Pain, Mechanical Allodynia and ...
Accumulation of oxidative DNA damage in osteoblastic and osteoclastic cells appears to be a key factor in age-related ... DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism. J Bone Miner Res. 2013;28(5):1214-1228. doi:10.1002/ ... 32 (1): 248-255.e2. doi:10.1016/j.cub.2021.10.065. ISSN 0960-9822. PMID 34813730. S2CID 244485732. Houssaye, Alexandra (10 ... These factors include insulin-like growth factors I and II, transforming growth factor-beta, fibroblast growth factor, platelet ...
NF-E2, NF-E2 p45 were found as the top transcription factor binding sites by QIAGEN in the TAS2R1 gene promoter. Several ... It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane ... Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the TAS2R1 gene. ... 149 (2): 181-197. doi:10.1085/jgp.201611637. ISSN 0022-1295. PMC 5299619. PMID 28053191. Deshpande, Deepak A; Wang, Wayne C H; ...
Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH (Jun 1995). "Transcription factor NF-E2 ... and its related sequences. Structural analyses have demonstrated that the basic region of a Maf factor recognizes the flanking ... recognized as antioxidant/electrophile response elements or NF-E2-binding motifs to which Nrf2-sMaf heterodimers and p45 NF-E2- ... "Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor". Molecular ...
June 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22 ... The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B ... June 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22 ... January 2000). "Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of ...
"Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB ... Vatsyayan J, Qing G, Xiao G, Hu J (September 2008). "SUMO1 modification of NF-kappaB2/p100 is essential for stimuli-induced ... Semplici F, Meggio F, Pinna LA, Oliviero S (June 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme ... In response to mitogens, PDCD4, an inhibitor of the translation initiation factor eIF4A, is rapidly degraded in a βTrCP- and ...
... and found it capable of activating the transcription factor NF-κB in mammalian cells. They speculated that TLR4 was a "pattern ... "Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal ... Official website Works on the topic Bruce Beutler at Wikisource Wikimedia Commons has media related to Bruce Beutler. Bruce A. ... "RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice". ...