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*  Anti-neutrophil cytoplasmic antibody
... expressed by bacteria and other microorganisms that have the power to stimulate a strong immune response by activation of T- ... 1990). "Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro". ... Furthermore, neutrophils release chemoattractive signalling molecules that recruit more neutrophils to the endothelium, acting ... Immunofluorescence (IF) on ethanol-fixed neutrophils is used to detect ANCA, although formalin-fixed neutrophils may be used to ...
*  Neutrophil extracellular traps
NETs allow neutrophils to kill extracellular pathogens while minimizing damage to the host cells. Upon in vitro activation with ... Neutrophil extracellular traps (NETs) are networks of extracellular fibers, primarily composed of DNA from neutrophils, which ... sites where platelets bind neutrophils). NET activation and release, or NETosis, is a dynamic process that can come in two ... The full NETosis activation pathway is still under investigation but a few key proteins have been identified and slowly a full ...
*  Formyl peptide receptor 1
"Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between ... Thomas KM, Pyun HY, Navarro J (Nov 1990). "Molecular cloning of the fMet-Leu-Phe receptor from neutrophils". The Journal of ... Furthermore, bacteria-induced complement activation also causes the formation of complement component 3a (C3a) by cleavage from ... FPR1 is widely expressed by circulating blood neutrophils, eosinophils, basophils, monocytes, and platelets; tissue-bound ...
*  Alpha defensin
Prieto, JA; Panyutich, AV; Heine, RP (January 1997). "Neutrophil activation in preeclampsia. Are defensins and lactoferrin ... Initially human alpha defensin peptides were isolated from the neutrophils and are thus called human neutrophil peptides. Human ... Human neutrophil peptides are found in human atherosclerotic arteries, inhibit LDL metabolism and fibrinolysis and promote Lp(a ... Human neutrophil-derived alpha-defensins (HNPs) are capable of enhancing phagocytosis by mouse macrophages. HNP1-3 have been ...
*  Neutrophil
2004). "Neutrophil activation in vitro". Tsitologiia. 46 (2): 155-158. PMID 15174354. Gerasimov I.G., Ignatov D.Yu. (2005). " ... Neutrophils may be subdivided into segmented neutrophils and banded neutrophils (or bands). They form part of the ... Neutrophils from women exhibit a small additional X chromosome structure, known as a "neutrophil drumstick". Neutrophils will ... In 2004, Brinkmann and colleagues described a striking observation that activation of neutrophils causes the release of web- ...
*  Phagocyte
CS1 maint: Multiple names: authors list (link) Lee WL, Downey GP; Downey (February 2001). "Neutrophil activation and acute lung ... Neutrophils do not return to the blood; they turn into pus cells and die. Mature neutrophils are smaller than monocytes and ... Neutrophils also play a key role in the development of most forms of acute lung injury. Here, activated neutrophils release the ... Neutrophils do not normally exit the bone marrow until maturity but during an infection neutrophil precursors called myelocytes ...
*  Endothelin 2
Paulino EC, Steil AA, Jancar S (July 2006). "Effect of endothelins on human neutrophil activation by immune complexes". ...
*  Staphopain A (Staphylococcus aureus)
... of activation. It shows a duplex role in affecting chemotaxis; while inactivating neutrophil CXCR2 receptor, generates an ... Staphopain A was shown to inhibit activation of the complement system activation by cleaving components that are part of all ... "Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis". The EMBO Journal. 31 (17): ... Staphopain A is elastinolytic to a degree fairly equal to that of neutrophil elastase, and has a very broad specificity ...
*  Integrin alpha M
Schymeinsky J, Mócsai A, Walzog B (August 2007). "Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms ... chemotaxis and cellular activation. It is involved in the complement system due to its capacity to bind inactivated complement ...
*  List of Divers Alert Network publications
... neutrophil activation and intravascular bubbles following open-water scuba diving. Goldman, S (2013); An improved new class of ... neutrophil activation and intravascular bubbles following open-water scuba diving". Undersea and Hyperbaric Medicine : Journal ...
*  Neal W. Pollock
... neutrophil activation, and intravascular bubbles following open-water SCUBA diving". Journa. 112 (8): 1268-78. doi:10.1152/ ...
*  Felty's syndrome
Dwivedi, N., & Radic, M. (2012). Neutrophil activation and B-cell stimulation in the pathogenesis of Felty's syndrome. Polskie ... Neutropenia In Felty's syndrome, chronic activation of neutrophils progresses to neutropenia and unabated infections. ... Neutropenia is a decreased concentration of neutrophils in the blood. Neutrophils are the most abundant cells among white blood ... Inflammatory chemicals draw neutrophils to the area where they congregate and fight infection. A decrease in the number of ...
*  CSNK2B
"The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites ...
*  CD18
Schymeinsky J, Mócsai A, Walzog B (August 2007). "Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms ... Gahmberg CG, Fagerholm S (August 2002). "Activation of leukocyte beta2-integrins". Vox Sanguinis. 83 Suppl 1: 355-8. doi: ...
*  Syk
Schymeinsky J, Mócsai A, Walzog B (August 2007). "Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms ... Several transforming viruses contain "Immunoreceptor Tyrosine Activation Motifs" (ITAMs) which lead to activation of Syk ... However, activation of SYK relies less on phosporylation by Src family kinases than Zap-70. While Syk and Zap-70 are primarily ... "Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor ...
*  Neutrophil cytosolic factor 1
"The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites ... Neutrophil cytosolic factor 1 has been shown to interact with: Moesin, Neutrophil cytosolic factor 4, and RELA. GRCh38: Ensembl ... Neutrophil cytosol factor 1, also known as p47phox, is a protein that in humans is encoded by the NCF1 gene. The protein ... Gu Y, Xu YC, Wu RF, Nwariaku FE, Souza RF, Flores SC, Terada LS (May 2003). "p47phox participates in activation of RelA in ...
*  Perlecan
... implications for neutrophil activation". J. Leukoc. Biol. 68 (2): 251-9. PMID 10947070. Snow AD, Sekiguchi R, Nochlin D, Fraser ... Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding element". J. Biol. Chem. 272 (8): ... The contention of this paper is that perlecan downregulation leads to a loss of FAK activation and thus less ERK signaling, ... The upstream 2.5 kilobases of the perlecan promoter region were studied by CAT activation in cell lines of various histological ...
*  EMR2
Upon neutrophil activation, EMR2 rapidly moves to membrane ruffles and the leading edge of the cell. Additionally, ligation of ... "Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and ... "Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function". FASEB Journal. 22 (3): 741-51. doi:10.1096/fj.07- ... EMR2 by antibody promotes neutrophil and macrophage effector functions suggesting a role in potentiating inflammatory responses ...
*  S100A8
... to plasma membrane correlates with human neutrophil activation". J. Biol. Chem. 267 (27): 19379-82. PMID 1326551. Schäfer T, ... Miyasaki KT, Bodeau AL, Murthy AR, Lehrer RI (1993). "In vitro antimicrobial activity of the human neutrophil cytosolic S-100 ...
*  Diabetic cardiomyopathy
Neutrophil activation can also lead to NAD(P)H oxidase production of free radicals further damaging the surrounding cells. ... Koya D, King GL (June 1998). "Protein kinase C activation and the development of diabetic complications". Diabetes. 47 (6): 859 ...
*  CD97
Upon lymphoid, myeloid cells and neutrophil activation, CD97 is upregulated to promote adhesion and migration to sites of ... Hamann J, Wishaupt JO, van Lier RA, Smeets TJ, Breedveld FC, Tak PP (Apr 1999). "Expression of the activation antigen CD97 and ... Hamann J, Wishaupt JO, van Lier RA, Smeets TJ, Breedveld FC, Tak PP (Apr 1999). "Expression of the activation antigen CD97 and ... Furthermore, ectopic CD97 expression facilitated RhoA activation through binding of Gα12/13 as well as induced Ki67 expression ...
*  FOXO4
Crossley LJ (2003). "Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of ... FOXO's activation of these pathways produces an increase in lifespan for worms, flies, mice; similar variants of FOXO3a have ...
*  FOXO3
Crossley LJ (Oct 2003). "Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, ...
*  CCRL2
... and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this ... 2004). "Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis". Arthritis ... This gene is expressed at high levels in primary neutrophils and primary monocytes, ...
*  Remote ischemic conditioning
Studies show that repeated daily RIC treatments lead to significant downregulation of neutrophil activation and proinflammatory ... "Interference of propofol with signal transducer and activator of transcription 5 activation and cardioprotection by remote ... "Remote ischemic preconditioning decreases adhesion and selectively modifies functional responses of human neutrophils". The ...
*  NOX4
... in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen ... H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF- ... "Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of ...
*  Histamine H2 receptor
Inhibition of neutrophil activation and chemotaxis H2-receptor antagonist GRCh38: Ensembl release 89: ENSG00000113749 - Ensembl ... It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. PKA functions to phosphorylate ... Esbenshade TA, Kang CH, Krueger KM, Miller TR, Witte DG, Roch JM, Masters JN, Hancock AA (Feb 2003). "Differential activation ... Vascular smooth muscle Neutrophils Mast cells Heart Uterus Central nervous system tissues Caudate-putamen Cerebral cortex ( ...