Loading...
*  2,5-Diketopiperazine
"Diketopiperazines as neuroprotective agents". Mini reviews in medicinal chemistry. 12 (1): 2-12. doi:10.2174/138955712798868959 ... Derivatives of cyclo(L-His-L-Pro) have been studied extensively to develop therapeutic agents for neurodegeneration. The 2,5- ... The unsaturated derivatives are illustrated by phenylahistin the anti-cancer microtubule binding agent, and the mycotoxin ... an antibacterial agent used as food additives to prevent diarrhea in animals while the thio derivatives such as the cytotoxic ...
*  Artificial enzyme
"Carboxyfullerenes as neuroprotective agents". Proceedings of the National Academy of Sciences. 94 (17): 9434-9439. Bibcode: ...
*  Gavestinel
... a neuroprotective agent. CNS Drug Reviews, 6(2), 135-152. Dyker, A. G., & Lees, K. R. (1999). Safety and tolerability of ... April 04, 2001 GAIN Americas trial again shows no benefit from neuroprotectant agent in stroke Chopra B, Chazot PL, Stephenson ...
*  Amitriptyline
Neuroprotective Agents and Antidepressant Therapy. Springer. pp. 374-. ISBN 978-81-322-2803-5. Andres Martin; Lawrence Scahill ... Alternative agents, SSRIs and SNRIs, are safer in overdose, though they are no more efficacious than TCAs. English folk singer ... Amitriptyline is the most widely researched agent for prevention of frequent tension headaches. Eating disorders: The few ... 281-. ISBN 978-0-8155-1856-3. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: ...
*  NMDA receptor antagonist
Maas, AI (2001). "Neuroprotective agents in traumatic brain injury". Expert Opinion on Investigational Drugs. 10 (4): 753-767. ... Farber N, Hanslick J, Kirby C, McWilliams L, Olney J (1998). "Serotonergic agents that activate 5HT2A receptors prevent NMDA ... Delucemine: also a SSRI with neuroprotective properties. 8A-PDHQ: a high affinity PCP structural analogue. Aptiganel (Cerestat ... Hargreaves R, Hill R, Iversen L (1994). "Neuroprotective NMDA antagonists: the controversy over their potential for adverse ...
*  Neuroprotection
Potentially neuroprotective trophic factors include CNTF, IGF-1, VEGF, and BDNF Anti protein aggregation agents: Protein ... Dodd S, Maes M, Anderson G, Dean OM, Moylan S, Berk M (2013). "Putative neuroprotective agents in neuropsychiatric disorders". ... Dodd S, Maes M, Anderson G, Dean OM, Moylan S, Berk M (2013). "Putative neuroprotective agents in neuropsychiatric disorders" ( ... Seidl SE, Potashkin JA (2011). "The promise of neuroprotective agents in Parkinson's disease". Front Neurol. 2: 68. doi:10.3389 ...
*  FP-C
Neuroprotective agents, vasoactive agents, loop diuretics, etc. Indications, limitations, and contraindications Signs and ...
*  Humanin
Xu, X; Chua, CC; Gao, J; Hamdy, RC; Chua, BH (Oct 2006). "Humanin is a novel neuroprotective agent against stroke". Stroke: A ... Beyond the possible neuroprotective effects, humanin protects against oxidative stress, atherosclerotic plaque formation, and ... Humanin is proposed to have myriad neuroprotective and cytoprotective effects. Both studies in cells and rodents have both ... Experiments using cultured cells have demonstrated that humanin has both neuroprotective as well as cytoprotective effects and ...
*  Latrepirdine
"Mitochondria as a target for neurotoxins and neuroprotective agents". Annals of the New York Academy of Sciences. 993: 334-44; ... Research was conducted in both Russia and western nations into potential applications as a neuroprotective drug to treat ... "Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer". Annals of the New York Academy of Sciences. ... and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores, which are believed to play ...
*  Alzheimer's disease research
Other approaches are neuroprotective agents, like AL-108 (phase II completed); or metal-protein interaction attenuation, as is ... "Mitochondria as a Target for Neurotoxins and Neuroprotective Agents". Annals of the New York Academy of Sciences. 993: 334-344 ... Allopregnanolone has been identified as a potential drug agent. Levels of neurosteroids such as allopregnanolone decline in the ... is a gamma secretase modulator sometimes called a selective amyloid beta 42 lowering agent. It is believed to reduce the ...
*  Chrysin
Discovery and Development of Neuroprotective Agents from Natural Products. Elsevier Science. p. 32. doi:10.1016/B978-0-12- ... A Class of Promising Neuroprotective Agents for Parkinson Disease". In Brahmachari G. ... As of 2016, there is no evidence for chrysin in human clinical applications and its use for compounding of therapeutic agents ... Nabavi SF, Braidy N, Habtemariam S, Orhan IE, Daglia M, Manayi A, Gortzi O, Nabavi SM (2015). "Neuroprotective effects of ...
*  Glaucoma
Tsai JC, Song BJ, Wu L, Forbes M (September 2007). "Erythropoietin: a candidate neuroprotective agent in the treatment of ... The possible neuroprotective effects of various topical and systemic medications are also being investigated. Prostaglandin ... Vascular flow and neurodegenerative theories of glaucomatous optic neuropathy have prompted studies on various neuroprotective ... involves the use of a novel group of medications known as anti-VEGF agents. These injectable medications can lead to a dramatic ...
*  Management of Parkinson's disease
Currently, no proven neuroprotective agents or treatments are available for PD. While still theoretical, neuroprotective ... and neuroprotective agents. The tragedy of a group of drug addicts in California in the early 1980s who consumed a contaminated ... Accordingly, neuroprotective therapy seeks to delay the introduction of levodopa. Several molecules have been proposed as ... In such cases, specific measures include the use of thickening agents for liquid intake, special postures when eating, and ...
*  GABAA receptor
He, Y.; Benz, A.; Fu, T.; Wang, M.; Covey, D.F.; Zorumski, C.F.; Mennerick, S. "Neuroprotective agent riluzole potentiates ... "Regulation of GABAA Receptor Subunit Expression by Pharmacological Agents". Pharmacological Reviews. 62 (1): 97-135. doi: ...
*  Julio Licinio
They also showed that interleukin 1 receptor antagonist is an endogenous neuroprotective agent. They have shown that the ... "Endogenous interleukin-1 receptor antagonist is neuroprotective". Biochemical and Biophysical Research Communications. 234 (1 ...
*  Gacyclidine
doi:10.1016/S0223-5234(99)80046-4. Hirbec H, Gaviria M, Vignon J (2001). "Gacyclidine: a new neuroprotective agent acting at ...
*  Huperzine A
Tun MK, Wüstmann D, Herzon SB (2011). "A robust and scalable synthesis of the potent neuroprotective agent (−)-huperzine A". ... Bai DL, Tang XC, He XC (2000). "Huperzine A, A Potential Therapeutic Agent for Treatment of Alzheimer's Disease". Current ... Zangara A (2003). "The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties ... possible additive cholinergic effects if huperzine A is taken with other acetylcholinesterase inhibitors or cholinergic agents ...
*  Spinal cord injury research
Other potentially neuroprotective agents under investigation in clinical trials include cethrin, erythropoietin, and ... Iron from blood damages the spinal cord through oxidative stress, so one option is to use a chelation agent to bind the iron; ...
*  Parkinson's disease clinical research
Agents currently under investigation as neuroprotective agents include anti-apoptotic drugs (omigapil, CEP-1347), ... Researchers are attempting to develop neuroprotective agents for Parkinson's disease, as well as other neurodegenerative brain ... Exercise may be neuroprotective. Animal studies show exercise may protect against dopaminergic neurotoxins, and research ... Several molecules have been proposed as potential neuroprotective treatments. However none of them has been conclusively ...
*  Sandra Rees
She was also involved in trialing neuroprotective agents to ameliorate injury in the developing brain. For her contribution to ...
*  Phosphodiesterase inhibitor
Recent studies have shown Quinazoline type PDE7 inhibitor to be potent anti-inflammatory and neuroprotective agents. Papaverine ... Jan 2012). "Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental ... The potential for selective phosphodiesterase inhibitors as therapeutic agents was predicted as early as 1977 by Weiss and Hait ... Weiss B.; Hait W.N. (1977). "Selective cyclic nucleotide phosphodiesterase inhibitors as potential therapeutic agents". Annu. ...
*  Alzheimer's disease
Other approaches are neuroprotective agents, such as AL-108, and metal-protein interaction attenuation agents, such as PBT2. A ... The imaging agent can help to detect Alzheimer's brain plaques, but will require additional clinical research before it can be ... Nehlig A. The neuroprotective effects of cocoa flavanol and its influence on cognitive performance. British Journal of Clinical ... Another similar agent is bapineuzumab, an antibody designed as identical to the naturally induced anti-amyloid antibody. ...
*  Spinal cord injury
Several potentially neuroprotective agents that target pathways like these are under investigation in human clinical trials. ... Neuroprotective drugs target secondary injury effects including inflammation, damage by free radicals, excitotoxicity (neuronal ...
*  Arachidonyl trifluoromethyl ketone
Specifically it inhibits the 85 kDa cystolic PLA2 (cPLA2). It has been studied as a neuroprotective agent after spinal cord ... "Arachidonyl trifluoromethyl ketone is neuroprotective after spinal cord injury". Journal of Neurotrauma: 110306202455053. doi: ...
*  Gene therapy in Parkinson's disease
Secondly, some genes have been identified which can modulate the neuron phenotype or act as neuroprotective agents. Also, the ... dopaminergic in relation to Parkinson disease system have shown that GNDF and NTN are very potential neuroprotective agents. ...
*  Effects of cannabis
Some clinical studies have proposed that CBD acts as a balancing force to regulate the strength of the psychoactive agent THC. ... THC and cannabidiol are also neuroprotective antioxidants. Research in rats has indicated that THC prevented hydroperoxide- ... Marijuana smoke was listed as a cancer agent in California in 2009. A study by the British Lung Foundation published in 2012 ... Mechoulam, R. (1984). Cannabinoids as therapeutic agents. Boca Raton, FL: CRC Press. ISBN 0-8493-5772-1. [page needed] Ad Hoc ...