Neuromuscular junction disease
... is a medical condition where the normal conduction through the neuromuscular junction fails to ... Neuromuscular junction diseases can also be referred to as end plate diseases or disorders.[citation needed] Among ... Immune-mediated diseases include a variety of diseases not only affecting the neuromuscular junction. Immune-mediated disorders ... Toxic diseases are a result of a form of poison that effects neuromuscular junction functioning. Most commonly animal venom or ...
Neuromuscular junction
... diseases can be of genetic and autoimmune origin. Genetic disorders, such as Congenital myasthenic ... crayfish and fruit flies have a glutamatergic neuromuscular junction. AChRs at the skeletal neuromuscular junction form ... Finsterer J, Papić L, Auer-Grumbach M (October 2011). "Motor neuron, nerve, and neuromuscular junction disease". Curr. Opin. ... A neuromuscular junction (or myoneural junction) is a chemical synapse between a motor neuron and a muscle fiber. It allows the ...
Action potential
Hirsch NP (July 2007). "Neuromuscular junction in health and disease". British Journal of Anaesthesia. 99 (1): 132-8. doi: ... A special case of a chemical synapse is the neuromuscular junction, in which the axon of a motor neuron terminates on a muscle ... Muscle action potentials are provoked by the arrival of a pre-synaptic neuronal action potential at the neuromuscular junction ... Hughes BW, Kusner LL, Kaminski HJ (April 2006). "Molecular architecture of the neuromuscular junction". Muscle & Nerve. 33 (4 ...
Polyneuropathy in dogs and cats
"Diseases of the Peripheral Nerve and Neuromuscular Junction: Degenerative Diseases". The Merck Veterinary Manual. 2006. ... "Diseases of the Peripheral Nerve and Neuromuscular Junction: Metabolic Disorders". The Merck Veterinary Manual. 2006. Retrieved ... "Diseases of the Peripheral Nerve and Neuromuscular Junction: Inflammatory Disorders". The Merck Veterinary Manual. 2006. ... 159-160, ISBN 978-1-4051-2814-8. (CS1 maint: location, Use dmy dates from March 2014, Dog diseases, Cat diseases). ...
Chronaxie
Electromyography is used to diagnose neuropathies, myopathies, and neuromuscular junction diseases. Chronaxie is increased in ...
Electromyoneurography
"Interpretation of electroneuromyographic studies in diseases of neuromuscular junction and myopathies". Neurology India. 56 (3 ... One example of its use is to detect neuropathy due to diseases like diabetes mellitus. It can also be used to detect muscle ... use proves to be clinically relevant by allowing for both the source and location of a particular neuromuscular disease to be ... A decreased amplitude or duration may indicate nerve damage due to a muscle diseases, whereas an increase in these demonstrates ...
Bienfang's test
Myasthenia gravis is an autoimmune disease involving the neuromuscular junction leading to skeletal muscle weakness and ... Ocular myasthenia Myasthenia gravis Cogan, DG (1965). "Myasthenia gravis: a review of the disease and a description of lid ... whereas the CLT test may only be positive in individuals with more pronounced disease. ...
Ambenonium chloride
Ambenonium is used to treat muscle weakness due to disease or defect of the neuromuscular junction (myasthenia gravis). ... This, in turn, facilitates transmission of impulses across the myoneural junction and effectively treats the disease. ... and thus inhibits signal transmission across the neuromuscular junction. Ambenonium reversibly binds acetylcholinesterase, ...
List of neuromuscular disorders
Myoneural junction and neuromuscular diseases). ... GSD type II (Pompe disease) GSD type V (McArdle disease) GSD ... van Adel, BA; Tarnopolsky, MA (March 2009). "Metabolic myopathies: update 2009". Journal of Clinical Neuromuscular Disease. 10 ... mtDNA deletion Glycogen storage diseases (GSD) are a group of diseases caused by mutations related to glycogen metabolism. ... Mitochondrial myopathies are diseases caused by mutations related to mitochondria, and thus are generally inherited from the ...
Myasthenia gravis
Autoimmune diseases, Myoneural junction and neuromuscular diseases, Wikipedia neurology articles ready to translate, Wikipedia ... Myasthenia gravis is an autoimmune disease of the neuro-muscular junction which results from antibodies that block or destroy ... Myasthenia gravis (MG) is a long-term neuromuscular junction disease that leads to varying degrees of skeletal muscle weakness ... Neuromuscular junction: 1. Axon 2. Muscle cell membrane 3. Synaptic vesicle 4. Nicotinic acetylcholine receptor 5. ...
Margaret Ransone Murray
Murray's later work examined the functional differentiation of neuro-muscular junctions, to understand degenerative diseases of ... Veneroni, Giorgio; Murray, Margaret R. (1969). "Formation de novo and development of neuromuscular junctions in vitro". Journal ... role of circulating demyelinating factors that contribute to neurological degeneration in multiple sclerosis and other diseases ...
Ocular myasthenia
... gravis (MG) is a disease of the neuromuscular junction resulting in hallmark variability in muscle weakness ... At the neuromuscular junction, this electrical message is converted into a chemical message as acetylcholine is released from ... but has been shown to be helpful in young MG patients with acute disease within 3 years of disease onset, in patients with ... and is likely associated with thyroid disease, thymomas (20% incidence), and other autoimmune diseases such as scleroderma, ...
Flightless fruit fly
Myoneural junction and neuromuscular diseases, Pet foods, Insect common names). ... Lloyd, T. E. and Taylor, J. P. (2010), Flightless flies: Drosophila models of neuromuscular disease. Annals of the New York ... Flightless fly models have been especially useful for the study of human neuromuscular diseases such as spinal muscular atrophy ... dystrophinopathies and other inherited neuromuscular diseases. Applications of flightless flies are extremely varied, even ...
Amikacin
... amikacin's paralytic effect on neuromuscular junctions can worsen muscle weakness. Side-effects of amikacin are similar to ... While the half-life of amikacin is normally two hours, it is 50 hours in those with end-stage renal disease. The majority (95 ... ISBN 978-0-12-411492-0. "FDA approves a new antibacterial drug to treat a serious lung disease using a novel pathway to spur ... Infectious Diseases. 10 (9): 621-629. doi:10.1016/S1473-3099(10)70139-0. PMID 20797644. Ahmad S, Mokaddas E (1 March 2014). " ...
Polyneuropathy
... molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease". Frontiers in ... Hereditary neuropathy with liability to pressure palsy Mononeuropathy Neuritis Neuromuscular disease Neuromuscular medicine ... one also needs to know what disorders are present within the family and what diseases the person may have. Although diseases ... It is the most common response of neurons to metabolic or toxic disturbances, and may be caused by metabolic diseases such as ...
Alpha motor neuron
Diseases that impair signaling between α-MNs and extrafusal muscle fibers, namely diseases of the neuromuscular junction have ... For example, myasthenia gravis is an autoimmune disease that prevents signaling across the neuromuscular junction, which ... The axon of an α-MN connects with its extrafusal muscle fiber via a neuromuscular junction, a specialized type of chemical ... while the neuromuscular junction uses acetylcholine exclusively. Acetylcholine is sensed by nicotinic acetylcholine receptors ...
Mitochondrial myopathy
Myoneural junction and neuromuscular diseases, Mitochondrial diseases). ... On biopsy, the muscle tissue of patients with these diseases usually demonstrate "ragged red" muscle fibers. These ragged-red ... Although no cure currently exists, there is hope in treatment for this class of hereditary diseases trials continue. Metabolic ... Mitochondrial myopathies are types of myopathies associated with mitochondrial disease. ...
Central core disease
Myoneural junction and neuromuscular diseases, Autosomal dominant disorders). ... Central core disease (CCD), also known as central core myopathy, is an autosomal dominant inherited muscle disorder present ... "central core disease" at Dorland's Medical Dictionary Talwalkar, SS; Parker, JR; Heffner, RR; Parker, JC (2006). "Adult central ... 2003). "Central core disease: clinical, pathological, and genetic features". Arch. Dis. Child. 88 (12): 1051-5. doi:10.1136/adc ...
Adrenergic release inhibitor
"Blockers of the Neuromuscular Junction as Antihypertensive Agents". Hypertensive Cardiovascular Disease: Pathophysiology and ...
Myotonic dystrophy
Myoneural junction and neuromuscular diseases, Trinucleotide repeat disorders, Wikipedia medicine articles ready to translate, ... "Myotonic dystrophy kinase is a component of neuromuscular junctions". Hum. Mol. Genet. 2 (11): 1889-94. doi:10.1093/hmg/2.11. ... "Exercise therapy and other types of physical therapy for patients with neuromuscular diseases: a systematic review". Arch Phys ... "Construction of a Quality of Life Questionnaire for slowly progressive neuromuscular disease". Qual Life Res. 24 (11): 2615-23 ...
Neuropathy (disambiguation)
Encephalopathy Myelopathy Radiculopathy Neuromuscular junction disease Myopathy See also Charcot-Marie-Tooth disease ...
Paramyotonia congenita
Myoneural junction and neuromuscular diseases, Rare diseases). ... This disease can also present as hyperkalemic periodic ... A European Neuromuscular Center Workshop held 4-6 October 1992, Ulm, Germany". Neuromuscul Disord. 3 (2): 161-8. doi:10.1016/ ... A European Neuromuscular Center Workshop held 4-6 October 1992, Ulm, Germany". Neuromuscul Disord. 3 (2): 161-8. doi:10.1016/ ... Paramyotonia congenita (PC) is a rare congenital autosomal dominant neuromuscular disorder characterized by "paradoxical" ...
Neuromyotonia
Rare diseases, Myoneural junction and neuromuscular diseases). ... usually caused by antibodies against the neuromuscular junction ... However, because NMT mimics some symptoms of motor neuron disease (ALS) and other more severe diseases, which may be fatal, ... Their causative role has been established in some of these diseases but not all. Neuromyotonia is considered to be one of these ... From there, a patient is likely to be referred to a neurologist or a neuromuscular specialist. The neurologist or specialist ...
Dysarthria
... or the neuromuscular junction (in diseases such as myasthenia gravis) which block the nervous system's ability to activate ... Lyme disease Stroke Tay-Sachs disease, and late-onset Tay-Sachs disease (LOTS) Transient ischemic attack, a 'mini stroke' ... Huntington's disease, Niemann-Pick disease, and Friedreich's ataxia.[citation needed] Toxic and metabolic conditions include: ... Lechtenberg, R.; Gilman, S. (1978). "Speech Disorders in Cerebellar Disease" (PDF). Ann. Neurol. 3 (4): 285-290. doi:10.1002/ ...
Muscular dystrophy
Myoneural junction and neuromuscular diseases, Wikipedia medicine articles ready to translate). ... Muscular dystrophies (MD) are a genetically and clinically heterogeneous group of rare neuromuscular diseases that cause ... Muscle and Neuromuscular Junction Disorders): 1916-1931. doi:10.1212/CON.0000000000000399. PMC 5898965. PMID 27922500. " ... Disability rights advocates, however, have criticized the telethon for portraying those living with the disease as deserving ...
Thyrotoxic myopathy
Myoneural junction and neuromuscular diseases). ... was observed within the neuromuscular junction. This decrease ... consider basic neuromuscular junction function. Under normal circumstances, muscle contraction occurs when electrical impulses ... Graves' disease is an autoimmune condition where the immune system chronically stimulates the TSH receptor in the thyroid and ... Neuromuscular Disorders 5:47-52 1995. Chiu WY, Yang CC, Huang IC, Huang TS. Dysphagia as a manifestation of thyrotoxicosis: ...
Periodic paralysis
Myoneural junction and neuromuscular diseases, Channelopathies, Rare diseases). ... These diseases are not the same as having a very low level of potassium (hypokalemia) or high potassium (hyperkalemia) and must ... This disease is unusually difficult to diagnose. Patients often report years of wrong diagnosis and treatments that made them ... Periodic paralysis is a group of rare genetic diseases that lead to weakness or paralysis from common triggers such as cold, ...
Ullrich congenital muscular dystrophy
Myoneural junction and neuromuscular diseases, Collagen disease, Diseases named for discoverer, Rare diseases). ... "Ullrich congenital muscular dystrophy , Disease , Treatment , Genetic and Rare Diseases Information Center (GARD) - an NCATS ... Kelly, Evelyn B. (2013-01-07). Encyclopedia of Human Genetics and Disease [2 volumes]. ABC-CLIO. ISBN 9780313387142. ... of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular and ...
X-linked myotubular myopathy
Myoneural junction and neuromuscular diseases, Rare diseases). ... It is one of the severest congenital muscle diseases and is ...
Zaspopathy
Rare diseases, Myoneural junction and neuromuscular diseases, All stub articles, Musculoskeletal disease stubs). ... The disease encompasses multiple forms of both distal and proximal myopathies, and is caused by mutations in the gene referred ...