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*  Dihydrochandonium
... is an aminosteroid non-depolarizing neuromuscular blocking agent. Fitzal, S; Ilias, W; Kalina, K; Schwarz, S ... Foldes, FF; Steinbereithner, K (1982). "Neuromuscular and cardiovascular effects of Duador, a new short-acting nondepolarizing ...
*  Alcuronium chloride
Hughes R, Chapple DJ (1976). "Effects of Non-Depolarizing Neuromuscular Blocking Agents on Peripheral Autonomic Mechanisms in ... Alcuronium is a neuromuscular blocking (NMB) agent, alternatively referred to as a skeletal muscle relaxant. It is a semi- ... a very long acting neuromuscular blocking agent For a formal definition of the durations of actions associated with NMB agents ... "The Mode of Action of Quaternary Ammonium Type Neuromuscular Blocking Agents". Br. J. Anaesth. 26 (6): 394-398. doi:10.1093/bja ...
*  Lethal injection
... non-depolarizing neuromuscular blocking agents like pancuronium stop this binding from taking place. The typical dose for ... is a non-depolarizing muscle relaxant (a paralytic agent) that blocks the action of acetylcholine at the motor end-plate of the ... The combination of a barbiturate induction agent and a nondepolarizing paralytic agent is used in thousands of anesthetics ... A neuromuscular blocking drug may then be given to cause paralysis which facilitates intubation, although this is not always ...
*  Tubocurarine chloride
In this sense, tubocurarine is the prototypical adjunctive neuromuscular non-depolarizing agent. However, others before ... hypnotic and neuromuscular blocking agents, and tracheal intubation, as well as monitoring techniques that were nonexistent in ... a long-acting neuromuscular blocking agent". The Journal of Pharmacology and Experimental Therapeutics. 118. Curare - History, ... now a recognized hallmark of the tetrahydroisioquinolinium class of neuromuscular blocking agents. Histamine release is ...
*  Sugammadex
... is used to reverse neuromuscular blockade after administration of non-depolarizing neuromuscular-blocking agents ... Sugammadex (Org 25969, tradename Bridion) is an agent for reversal of neuromuscular blockade by the agent rocuronium in general ... Recurarisation', a phenomenon of recurrence of neuromuscular block, may occur where the reversal agents wear off before a ... Sugammadex has been shown to have affinity for two other aminosteroid neuromuscular blocking agents, vecuronium and pancuronium ...
*  Pyrantel
... pamoate acts as a depolarizing neuromuscular blocking agent, thereby causing sudden contraction, followed by paralysis ... Spastic (tetanic) paralyzing agents, in particular pyrantel pamoate, may induce complete intestinal obstruction in a heavy worm ...
*  Butyrylcholinesterase
Of these, its most clinically important substrate is the depolarizing neuromuscular blocking agent, succinylcholine, which the ... Butyrylcholinesterase is a prophylactic countermeasure against organophosphate nerve agents. It binds nerve agent in the ... Because it is a biological scavenger (and universal target), it is currently the only therapeutic agent effective in providing ... The remaining 5-10% of the succinylcholine dose acts as an acetylcholine receptor agonist at the neuromuscular junction, ...
*  Decamethonium
... (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to ... In the process of binding, decamethonium activates (depolarizes) the motor endplate - but since the decamethonium itself is not ... degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release. Decamethonium does not produce ...
*  Doxacurium chloride
... and it is classified as a long-duration non-depolarizing neuromuscular blocking agent in a class of compounds commonly and most ... potent non-depolarizing agents with pharmacophoric elements derived from cross-combinations of the non-depolarizing agent, ... d-tubocurarine and the depolarizing agent, decamethonium. In the 1950s and 1960s, the present-day concept of a neuromuscular ... is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, ...
*  Ascaricide
Pyrantel pamoate (Antiminth, Pin-Rid, Pin-X), depolarizes ganglionic block of nicotinic neuromuscular transmission, resulting ... Spastic (tetanic) paralyzing agents, in particular pyrantel pamoate, may induce complete intestinal obstruction in a heavy worm ... Piperazine, a flaccid paralyzing agent that causes a blocking response of ascaris muscle to acetylcholine. The narcotizing ... Albendazole, a broad-spectrum antihelminthic agent that decreases ATP production in the worm, causing energy depletion, ...
*  Gantacurium chloride
... is a new experimental neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular ... The clinical arena of neuromuscular blocking agents is a minefield of jargonistic language, and some definitions below help to ... In this sense, gantacurium is a first in its class non-depolarizing neuromuscular blocking drug to arguably challenge the ... With the exception of one other clinically tested agent, BW785U77, no other clinically administered neuromuscular blocking drug ...
*  List of MeSH codes (D16)
... neuromuscular blocking agents MeSH D27.505.696.663.700.710.550 --- neuromuscular depolarizing agents MeSH D27.505.696.663. ... 700.710.575 --- neuromuscular nondepolarizing agents MeSH D27.505.696.663.850 --- sensory system agents MeSH D27.505.696.663. ... anti-allergic agents MeSH D27.505.954.122 --- anti-infective agents MeSH D27.505.954.122.085 --- anti-bacterial agents MeSH ... antiviral agents MeSH D27.505.954.122.388.077 --- anti-retroviral agents MeSH D27.505.954.122.388.077.088 --- anti-hiv agents ...
*  Rocuronium bromide
... (brand names Zemuron, Esmeron) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant ... Neostigmine can also be used as a reversal agent of rocuronium but is not as effective as sugammadex. Neostigmine is often ... non-depolarizing neuromuscular blocking drugs). The γ-cyclodextrin derivative sugammadex (trade name Bridion) has been recently ... It was designed to be a weaker antagonist at the neuromuscular junction than pancuronium; hence its monoquaternary structure ...
*  Laudexium metilsulfate
Neuromuscular blocking agents at the US National Library of Medicine Medical Subject Headings (MeSH). ... As with all clinically established (as well as experimental agents) with a non-depolarizing mechanism of action, its ... Laudexium metilsulfate is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing ... Taylor EP (1952). "Synthetic neuromuscular blocking agents. Part II. Bis(quaternary ammonium salts) derived from laudanosine". ...
*  Rapacuronium bromide
As a non-depolarizing agent it did not cause initial stimulation of muscles before weakening them. Due to risk of fatal ... Rapacuronium bromide (brand name Raplon) is a rapidly acting, non-depolarizing aminosteroid neuromuscular blocker formerly used ...
*  Mivacurium chloride
... to synthesize potent non-depolarizing agents with pharmacophores derived from cross-combinations of the non-depolarizing agent ... non-depolarizing neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular- ... From the 1950s through to the 1970s, the present-day concept of a neuromuscular blocking agent with a rapid onset and an ultra- ... Like other non-depolarizing neuromuscular blockers, the pharmacological action of mivacurium is antagonism to nicotinic ...
*  Candocuronium iodide
... as part of the search for a non-depolarizing replacement for the most popular clinically used depolarizing agent, suxamethonium ... is an aminosteroid neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular- ... The discovery program initiated by Singh initially led to the synthesis of the bis-quaternary non-depolarizing agent HS-342 (4, ... Neuromuscular blocking agents at the US National Library of Medicine Medical Subject Headings (MeSH). ...
*  Atracurium besilate
Neuromuscular-blocking agents can be classified in accordance to their duration of pharmacological action, defined as follows: ... Atracurium is in the neuromuscular-blocker family of medications and is of the non-depolarizing type. It works by blocking the ... Neuromuscular blocking agents at the US National Library of Medicine Medical Subject Headings (MeSH) Pharmacy and pharmacology ... Stenlake JB, Waigh RD, Urwin J, Dewar GH, Hughes R, Chapple DJ (1981). "Biodegradable neuromuscular blocking agents. Part 3. ...
*  Voluntary euthanasia
Then a triple intravenous dose of a non-depolarizing neuromuscular muscle relaxant is given, such as 20 mg pancuronium bromide ... Only for pancuronium bromide (Pavulon) are there substantial indications that the agent may also be given intramuscularly in a ... "Administration and Compounding Of Euthanasic Agents". Lundin, Leigh (April 2009). Fairstein, Linda, ed. The Prosecution Rests. ...
*  Muscle relaxant
Alternatively, depolarizing agents, such as succinylcholine, are nicotinic receptor agonists which mimic Ach, block muscle ... Neuromuscular blockers act by interfering with transmission at the neuromuscular end plate and have no central nervous system ( ... Most neuromuscular blockers function by blocking transmission at the end plate of the neuromuscular junction. Normally, a nerve ... By 1943, neuromuscular blocking drugs became established as muscle relaxants in the practice of anesthesia and surgery. The U.S ...
*  Sodium thiopental
... a triple dose of a non-depolarizing neuromuscular blocking drug is given, such as 20 mg pancuronium bromide (Pavulon) or 20 mg ... Its use has been largely replaced with that of propofol, but retains popularity as an induction agent for rapid sequence ... Royal Dutch Society for the Advancement of Pharmacy (1994). "Administration and Compounding of Euthanasic Agents". The Hague. ... Instead, anesthesia is usually maintained with an inhaled anesthetic (gas) agent. Inhaled anesthetics are eliminated relatively ...
*  Anesthetic
... helps reverse the effects of non-depolarizing muscle relaxants Sugammadex, new agent that is designed to bind Rocuronium ... neuromuscular disease and paralyzed (quadraplegic, paraplegic) patients. The mechanism is reported to be through upregulation ... No anaesthetic agent currently in use meets all these requirements, nor can any anaesthetic agent be considered safe. There are ... Halothane, an agent introduced in the 1950s, has been almost completely replaced in modern anesthesia practice by newer agents ...
*  Repetitive nerve stimulation
These agents make more ACH available to bind at the ACHRs and may potentially diminished CMAP decrement, resulting in a normal ... The acetylcholine binds to nicotinic receptors on the muscle fiber, which open sodium channels and depolarizes the muscle cell ... Repetitive nerve stimulation is used to diagnose neuromuscular junction (NMJ) disorders, the most common of which is myasthenia ... a physician can assess for the presence of a neuromuscular junction disease, and differentiate between presynaptic and ...
*  Suxamethonium chloride
Mivacurium, a non-depolarizing neuromuscular blocking drug, is also metabolized via the same route with a similar clinical ... Lee, C; Katz R. (2009). "Clinical implications of new neuromuscular concepts and agents: So long, neostigmine! So long, sux!". ... Suxamethonium is in the neuromuscular blocker family of medications and is of the depolarizing type. It works by blocking the ... In people with neuromuscular disease or burns, an injection of suxamethonium can lead to a large release of potassium from ...
*  Nicotinic agonist
Agonists, e.g. nicotine, can however act as depolarizing agents when encountered to nAChRs for some time (seconds or minutes, ... "Synthesis and Structure-Activity Relationships of Neuromuscular Blocking Agents", Current Medicinal Chemistry, 9: 1507-1536, ... nAChR are found in the neuromuscular junction on skeletal muscles. Two different receptors have been found, one of which has ... Among nAChR antagonists designed specifically for the neuromuscular system are nerve gases and other poisons designed for quick ...