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*  Neuregulin 1
NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. Neuregulin 1 is produced in ... Neuregulin and ErbB4 Mutant Mice Reveal Myelin and Synaptic Deficits - 2 May 2007. Functional Neuregulin Variant Linked to ... Neuregulin, ErbB4 Drive Developmental Cell Fates Neuregulin Partner ErbB4 Spices Up Genetic Associations - 17 February 2005 ... Neuregulin 1 is thought to play a role in synaptic plasticity. It has been shown that a loss of Neuregulin 1 within cortical ...
*  Neuregulin
... -2 (NRG2); Neuregulin-3 (NRG3); Neuregulin-4 (NRG4); In mammals, neuregulin family members are the products of 4 ... The neuregulin family includes: Neuregulin-1 (NRG1), with numerous discovered isoforms stemming from alternative splicing: Type ... Neuregulins or neuroregulins are a family of four structurally related proteins that are part of the EGF family of proteins. ... A study done on mice in early 2009 has indicated that when neuregulin-1\ErbB signalling is disrupted, the dendritic spines of ...
*  ERBB3
Binding of neuregulin to the ligand binding subdomains (I and III) induces a conformational change in ErbB3 that causes the ... Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C (1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor ... 1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature. 387 (6632): 512-6. doi:10.1038/387512a0. ... Interestingly, while this function of ErbB3 depends of neuregulin, it does not seem to require ErbB2, which is not expressed in ...
*  DeCODE genetics
January 2003). "Association of neuregulin 1 with schizophrenia confirmed in a Scottish population". Am. J. Hum. Genet. 72 (1): ...
*  IKZF4
2005). "Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos". Nat. Neurosci. 7 (11): 1250-8. doi: ... 447 (1): 76-80. doi:10.1016/S0014-5793(99)00265-3. ISSN 0014-5793. PMID 10218586. Kimura K, Wakamatsu A, Suzuki Y, et al. (2006 ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Perdomo J, Crossley M (2003). "The Ikaros family protein Eos associates with C ... 16 (1): 55-65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560. Bao J, Lin H, Ouyang Y, et al. ( ...
*  Gerald Fischbach
However, when wild-type neuregulin was added to homozygous mutant neuregulin explants (isolated tissue cell cultures) nine days ... His research on Neuregulin-1 revealed a possible function in CNS neurogenesis since the neuregulins were labeled throughout ... This indicated that neuregulin is not necessary for the proliferation of oligodendrocyte multipotent precursor cells. ... While at the NINDS, Fischbach researched the effects of neuregulin, which is a family of proteins including heregulin, neu ...
*  Beta-secretase 1
Cheret, Cecil; Michael Willem; Florence R Fricker; Hagen Wende (June 2013). "Bace1 and Neuregulin-1 cooperate to control ... Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 ... 1 (4-5): 168-74. doi:10.1159/000080982. PMID 16908986. Zacchetti D, Chieregatti E, Bettegazzi B, Mihailovich M, Sousa VL, ... 4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a ...
*  Kári Stefánsson
This has led to the discovery of the neuregulin-1 gene's association with schizophrenia. Kári Stefánsson was born in 1949 in ... This has led to the discovery of the neuregulin-1 gene's association with schizophrenia, a condition that Stefánsson's brother ... Executive Profile from BusinessWeek magazine [1] McKie, Robin (16 May 2004). "Icelandic DNA project hit by privacy storm". The ...
*  Autocrine signalling
Wilson, Timothy R.; Lee, Diana Y.; Berry, Leanne; Shames, David S.; Settleman, Jeff (2011). "Neuregulin-1-Mediated Autocrine ... have also demonstrated clinical efficacy in HER2 overexpressing breast cancers by disrupting a neuregulin-1 (NRG1)-mediated ... When interleukin-1 is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that ... 75 (1): 196-207. doi:10.1124/mol.108.049544. PMC 2669785 . PMID 18849352. Yi, Eun Hee; Lee, Chang Seok; Lee, Jin-Ku; Lee, Young ...
*  Schwann cell
It is thought that SOX10 might influence early glial precursors to respond to Neuregulin 1 (see below). Neuregulin 1 (NRG1) ... 1998). "The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1 are essential for development of the sympathetic nervous ... 2000). "Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses". Neuron. 25 ... 1 (7): 535-543. doi:10.1016/0896-6273(88)90103-1. Geise, K.; Martini, R.; Lemke, G; Soriano, P.; Schachner, M. (1992). "Mouse ...
*  PLCB4
2006). "Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia". Nat. Med. 12 (7): 824 ... 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 is an enzyme that in humans is encoded by the PLCB4 gene. The ... 29 (1): 53-61. doi:10.1006/geno.1995.1214. PMID 8530101. "Entrez Gene: PLCB4 phospholipase C, beta 4". Cefai D, Debre P, ... 303 (1): 174-80. doi:10.1006/viro.2002.1676. PMID 12482669. Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing ...
*  Glutamate hypothesis of schizophrenia
Neuregulin 1 deficits may also be involved in glutaminergic hypofunction as NRG1 hypofunction leads to schizophrenia-pattern ...
*  Animal model of schizophrenia
The gene NRG1 codes for neuregulin 1, a growth factor which is crucial to the development of the nervous system, and to ... One such mouse model is the heterozygous removal of the EGF-like domain on neuregulin 1, these models are called Nrg1(ΔEGF)+/− ... Other neuregulin 1 models include the heterozygous removal of the transmembrane domain (Nrg1(ΔTM)+/− mice) and the ... NRG1 and the gene for the receptor to which neuregulin 1 binds, ERBB4, have been tested as possible animal models of ...
*  Trastuzumab
... downregulates neuregulin-1 (NRG-1), which is essential for the activation of cell survival pathways in ... NRG-1 activates the MAPK pathway and the PI3K/AKT pathway as well as focal adhesion kinases (FAK). These are all significant ... 4 (1): 87-95. doi:10.4161/cc.4.1.1360. PMID 15611642. Kute, T; Lack CM; Willingham M; Bishwokama B; Williams H; Barrett K; ... 90 (1): 126-32. doi:10.1038/clpt.2011.74. PMID 21633346. Zeglinski, M., Ludke, A., Jassal, D. S. & Singal, P. K. Trastuzumab- ...
*  Neuregulin 2
... , also known as NRG2, is a protein which in humans is encoded by the NRG2 gene. Neuregulin 2 (NRG2) is a novel ... 1999). "The human neuregulin-2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of ... Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C (May 1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4- ... 1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature. 387 (6632): 512-6. doi:10.1038/387512a0. ...
*  List of MeSH codes (D12.776)
... neuregulin-1 MeSH D12.776.503.280.249.500 - mannose-binding lectin MeSH D12.776.503.280.249.600 - pulmonary surfactant- ... cofilin 1 MeSH D12.776.220.525.212.750 - cofilin 2 MeSH D12.776.220.525.212.875 - destrin MeSH D12.776.220.525.246.500 - actin- ... hiv-1 reverse transcriptase MeSH D12.776.964.970.880.325 - gene products, env MeSH D12.776.964.970.880.325.330 - hiv envelope ... neurofibromin 1 MeSH D12.776.402.150.500.500 - p120 gtpase activating protein MeSH D12.776.402.300.700.500 - ras-GRF1 MeSH ...
*  Epidermal growth factor
... neuregulin-2 (NRG2) neuregulin-3 (NRG3) neuregulin-4 (NRG4). All family members contain one or more repeats of the conserved ... 284 (1): 2-13. doi:10.1016/S0014-4827(02)00105-2. PMID 12648462. Stortelers C, Souriau C, van Liempt E, van de Poll ML, van ... 15 (1): 11-15. doi:10.1590/s1555-79602013000100004. PMID 23396236. Yang, S; Geng, Z; Ma, K; Sun, X; Fu, X (June 2016). " ... 186 (1): 38-53. doi:10.1016/j.atherosclerosis.2005.06.038. PMID 16076471. Harris RC, Chung E, Coffey RJ (2003). "EGF receptor ...
*  Pharmaceutical industry in China
Based on the innovative theory, Zensun has successfully developed two drugs: Recombinant Human Neuregulin-1 injection, an anti- ... clinical trials and commercialization process of Recombinant Human Neuregulin-1 (Neucardin), an exciting and novel treatment ... Three potential Category 1 drugs are also under development: an anti-Hepatitis B drug, a new immuno-enhancer drug and ... 1 Western medicine and dyeing provider. Eli Lilly and Company opened its first overseas representative office in Shanghai in ...
*  Growth factor
Neuregulin 2 (NRG2) Neuregulin 3 (NRG3) Neuregulin 4 (NRG4) Neurotrophins Brain-derived neurotrophic factor (BDNF) Nerve growth ... Stimulates IL-1 synthesis. Activates B-cells and NK cells. IL-3 - Stimulates production of all non-lymphoid cells. IL-4 - ... IGF-1) Insulin-like growth factor-2 (IGF-2) Interleukins IL-1- Cofactor for IL-3 and IL-6. Activates T cells. IL-2 - T-cell ... IGF-1, EGF, and TGF-β which begin healing of wounds by attracting and activating macrophages, fibroblasts, and endothelial ...
*  Hirschsprung's disease
Common and rare DNA variations in the neuregulin 1 (NRG1) and NRG3 (NRG3) were first shown to be associated with the disease in ... 123A (1): 100-6. doi:10.1002/ajmg.a.20491. PMC 1201564 . PMID 14556255. Flori E, Girodon E, Samama B, Becmeur F, Viville B, ... 15-. ISBN 978-1-901346-67-1. Retrieved 2010-11-12. Martucciello G, Pini Prato A, Puri P, Holschneider AM, Meier-Ruge W, Jasonni ... 27: 1-7. Worman S, Ganiats TG (1995). "Hirschsprung's disease: a cause of chronic constipation in children". Am Fam Physician. ...
*  Adult neurogenesis
... and neuregulin 1 receptor (ERBB4), as being possibly responsible for this deficit in the normal regeneration of neurons. ... 581 (1): 156-160. doi:10.1016/0006-8993(92)90356-E. Aimone J. B.; Li Y.; Lee S. W.; Clemenson G. D.; Deng W.; Gage F. H. (2014 ... 495 (1): 70-83. doi:10.1002/cne.20840. PMID 16432899. Jin, K; Peel, A. L.; Mao, X. O.; Xie, L; Cottrell, B. A.; Henshall, D. C ... In addition, IGF-1 alters c-fos expression in the hippocampus. When IGF-1 is blocked, exercise no longer induces neurogenesis. ...
*  Ragavendra R. Baliga
Neuregulin Cell Signaling in Cardiac Myocyte-Am J Physiol. 1999 Nov;277(5 Pt 2):H2026-37 Post-Prandial Hemodynamics in ... 2008 Jan;4(1):ix-xiii. Review. PMID 18313619. Baliga RR, Young JB. Never too late to drink from the fountain of youth. Heart ... 2010 Jan;6(1):xi-xiii. PMID 19945053. Baliga RR, Narula J. Salt never calls itself sweet. Indian J Med Res. 2009 May;129(5):472 ... 2009 Jan;5(1):xi-xiv. PMID 19026378. Baliga RR, Young JB. "Stiff central arteries" syndrome: does a weak heart really stiff the ...
*  Neuroepithelial cell
... cytokines or neuregulin 1 (NRG1) - that can determine whether the cells will differentiate into either neurons or glia. On a ... As part of this polarity, neuroepithelial cells express prominin-1 in the apical plasma membrane as well as tight junctions to ... ISBN 1-932594-10-8. Retrieved 7 December 2011. Zolessi, F. R. (2009). "Vertebrate Neurogenesis: Cell Polarity". Encyclopedia of ... Retrieved 1 November 2011. Chin, L. S.; Jayarao, M. "Colloid Cysts". Medscape. Retrieved 7 December 2011. "Oligodendroglioma". ...
*  List of MeSH codes (D12.776.641)
... neuregulin-1 MeSH D12.776.641.650.070.075 -- angiotensin i MeSH D12.776.641.650.070.078 -- angiotensin ii MeSH D12.776.641.650. ...
*  List of MeSH codes (D12.644)
... neuregulins MeSH D12.644.276.937.750 --- neuregulin-1 MeSH D12.644.276.952 --- parathyroid hormone-related protein MeSH D12.644 ... map kinase kinase 1 MeSH D12.644.360.440.200 --- map kinase kinase 2 MeSH D12.644.360.440.300 --- map kinase kinase 3 MeSH ... ADP-ribosylation factor 1 MeSH D12.644.360.525.400 --- rab gtp-binding proteins MeSH D12.644.360.525.400.025 --- rab1 gtp- ... interleukin-1 MeSH D12.644.276.174.500.800 --- tumor necrosis factor-alpha MeSH D12.644.276.174.750 --- tumor necrosis factors ...
*  Endogenous regeneration
... neuregulins (NRGs), vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) induce formation of ... Type 1 cells in the hippocampus are multipotent in vitro. However, although there is evidence that both new neurons and glia ... 18 (1): 108-115. doi:10.1016/j.conb.2008.04.001. Altman J. (1966). "Autoradiographic and histological studies of postnatal ... In the dentate gyrus, putative stem cells, called type 1 cells, proliferate into type 2 and type 3 cells, which are transiently ...