Preliminary tests have shown it to be an effective neuraminidase inhibitor against the influenza A virus subtype H1N1. Huang, ... neuraminidase inhibitors from Vitis amurensis". Food Chemistry. 124 (2): 437-443. doi:10.1016/j.foodchem.2010.06.049. ISSN 0308 ...
... is a neuraminidase inhibitor isolated from the fungus Phellinus linteus. Yeom, JH; Lee, IK; Ki, DW; Lee, MS; Seok ... SJ; Yun, BS (2012). "Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus". Mycobiology. 40 (2): 142-4. doi: ...
... is a neuraminidase inhibitor, a competitive inhibitor of influenza's neuraminidase enzyme. The enzyme cleaves the ... May 2016). "Neuraminidase inhibitors for influenza: a systematic review and meta-analysis of regulatory and mortality data". ... Wang K, Shun-Shin M, Gill P, Perera R, Harnden A (April 2012). Harnden A (ed.). "Neuraminidase inhibitors for preventing and ... April 2014). "Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children". The Cochrane ...
Interview with Vincent Racaniello on his career in virology, from early work on neuraminidases to universal influenza virus ... "Anti-Influenza B Virus neuraminidase antibodies and uses thereof". Justia Patents. "US Patent Application for INFLUENZA VIRUS ... defined the mechanism of neuraminidase inhibitors (which are now FDA-approved antivirals) and "pioneered the field of reverse ...
... is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby ... Thorlund K, Awad T, Boivin G, Thabane L (May 2011). "Systematic review of influenza resistance to the neuraminidase inhibitors ... McKimm-Breschkin JL (January 2013). "Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance". ... a S247N neuraminidase mutation) giving some resistance to oseltamivir and zanamivir, but no significant reduction in ...
It attaches to CD46 using a dead neuraminidase domain. Pan CH, Jimenez GS, Nair N, et al. (August 2008). "Use of Vaxfectin ...
Bardeletti G, Kessler N, Aymard-Henry M (1975). "Morphology, biochemical analysis and neuraminidase activity of rubella virus ...
NA codes for neuraminidase, an antigenic glycosylated enzyme found on the surface of the influenza viruses. It facilitates the ... N1 stands for the first of several known types of the protein neuraminidase. Other examples include: A/duck/Hong Kong/308/78( ... The hemagglutinin (HA) and neuraminidase (NA) RNA strands specify the structure of proteins that are most medically relevant as ... and Consensus Screening of Avian Influenza H5N1 Wild-Type Neuraminidase and of the Oseltamivir-Resistant H274Y Variant". J. ...
Laborda, Pedro; Wang, Su-Yan; Voglmeir, Josef (2016-11-11). "Influenza Neuraminidase Inhibitors: Synthetic Approaches, ... synthesis of the anti-influenza neuraminidase inhibitor oseltamivir phosphate (Tamiflu)". J. Org. Chem. 66 (6): 2044-51. doi: ...
Wagner R, Matrosovich M, Klenk HD (May 2002). "Functional balance between haemagglutinin and neuraminidase in influenza virus ...
Hemagglutinin-neuraminidase (HN) is a single protein that induces hemagglutination and possesses neuraminidase (sialidase) ... Most likely, viral hemagglutinin-neuraminidase protein, highly contributes to the effect (see "Neuraminidase (NA) removal of ... Neuraminidase (NA), a subunit of the HN protein, binds to and cleaves sialic acid from the cell surface. NA also promotes cell ... Neuraminidase (NA) is a sialidase that cleaves and removes sialic acid from the surface of a host cell. This cleavage promotes ...
In particular, he designed and carried out critical studies evaluating the value of the neuraminidase inhibitors now in use for ... Monto, Arnold (2006). "Neuraminidase inhibitor susceptibility network position statement: antiviral resistance in influenza A/ ... How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?". mBio. 9 (2). doi:10.1128/mBio.02332-17. ... 2009 Co-chair Neuraminidase Inhibitor Susceptibility Network, 2006-2013 Co-chair, Infectious Disease Society of America ...
HN (Hemagglutinin-neuraminidase) attachment proteins occur in respiroviruses, rubulaviruses and avulaviruses. These possess ... Attachment proteins with neither haemagglutination nor neuraminidase activity are designated G (glycoprotein). These occur in ... both haemagglutination and neuraminidase activity, which cleaves sialic acid on the cell surface, preventing viral particles ...
The most common antivirals are neuraminidase inhibitors, which, if begun during the first 48 hours after symptoms appear, will ... de Jong JC, Beyer WE, Rimmelzwaan GF, Fouchier RA, Osterhaus AD (January 2004). "[Neuraminidase inhibitors oseltamivir and ...
Cohen, Miriam (2013). "Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase". Virology Journal. 10: ... analogs that interfere with release of newly generated viruses from infected cells by inhibiting the viral enzyme neuraminidase ...
It is caused by a mutation in the CTSA gene which leads to a deficiency of enzymes β-galactosidase and neuraminidase. This ... Neuraminidase deficiency with beta-galactosidase deficiency at NIH's Office of Rare Diseases (Articles with short description, ... This leads to a deficiency of beta-galactosidase (GLB1) and neuraminidase-1 (NEU1). As a result, the lysosome is unable to ... This gene encodes the enzyme cathepsin A, which forms a protein complex with neuraminidase-1 and beta-galactosidase to break ...
October 1999). "Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza". The New England Journal of ...
It shows antimalarial, anticancer, antibacterial and antiviral (specifically against influenza neuraminidase) properties in ... neuraminidase inhibitors from Glycyrrhiza inflata". Bioorganic & Medicinal Chemistry Letters. 21 (1): 294-8. doi:10.1016/j.bmcl ...
This enzyme is similar to the enzyme neuraminidase produced by Types A and B in that they both function in destroying the host ... Type A and B have two glycoproteins: hemagglutinin (HA) and neuraminidase (NA). Types C and D have only one glycoprotein: ...
NA codes for neuraminidase which is an antigenic glycoprotein enzyme found on the surface of the influenza viruses. It helps ... Flu drugs Tamiflu and Relenza work by inhibiting some strains of neuraminidase. They were developed based on N2 and N9. "In the ... The virus that most closely matched H5N1 for virulence was one with the hemagglutinin (HA), the neuraminidase (NA) and the PB1 ... The name H5N1 refers to the subtypes of surface antigens present on the virus: hemagglutinin type 5 and neuraminidase type 1. ...
"Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children". The Cochrane Database of ...
Rhinovirus receptors are insensitive to neuraminidase but are sensitive to proteolytic enzymes. Asthmatic subjects in 9 to 11 ...
2015). "Catechins Inhibit Influenza Neuraminidase and its Molecular Basis with Mass Spectrometry". J. Pharm. Biomed. Anal. 111 ...
Goto, Hideo; Wells, Krisna; Takada, Ayato; Kawaoka, Y. (2001-10-01). "Plasminogen-binding activity of neuraminidase determines ... "Amino Acids Responsible for the Absolute Sialidase Activity of the Influenza A Virus Neuraminidase: Relationship to Growth in ...
Hemagglutinin (HA) and neuraminidase (NA) are two virus surface antigens that are constantly changing. Antigenic drift or ... Its 500 or so surface projections are made of hemagglutinin and neuraminidase. The Influenza B virus genome is 14,548 ...
... and neuraminidase (NA). The primary natural reservoir for most influenza A subtypes are wild aquatic birds; however, through a ... "The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase". International Journal of ...
Neuraminidase is an antigenic glycoprotein enzyme found on the surface of the influenza viruses. It helps the release of ... Flu drugs Tamiflu and Relenza work by inhibiting some strains of neuraminidase. They were developed based on N2 and N9. "In the ... Known factors involve the surface antigen encoding gene segments H (hemagglutinin) and N (neuraminidase) genes (causing it to ... in the presence of neuraminidase inhibitors, the loop changed its conformation to one similar to that in the N2 and N9 proteins ...
In contrast, neuraminidase is an enzyme involved in the release of progeny virus from infected cells, by cleaving sugars that ... Hemagglutinin and neuraminidase molecules cluster into a bulge in the cell membrane. The vRNA and viral core proteins leave the ... The major glycoprotein (HA) spike is interposed irregularly by clusters of neuraminidase (NA) spikes, with a ratio of HA to NA ... The hemagglutinin (H) and neuraminidase (N) proteins are key targets for antibodies and antiviral drugs, and they are used to ...
This enzyme is similar to the enzyme neuraminidase produced by Types A and B in that they both function in destroying the host ... Type A and B have two glycoproteins: hemagglutinin (HA) and neuraminidase (NA). Types C and D have only one glycoprotein: ...
Neuraminidase inhibitors may be used to treat viral pneumonia caused by influenza viruses (influenza A and influenza B). No ... April 2014). "Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children". The Cochrane ...