... has been shown to interact with Low affinity nerve growth factor receptor. GRCh38: Ensembl release 89: ENSG00000187601 ...

"Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". Journal of Neurovirology. 8 ... First of all, it has been proved that the Cdk5 antagonist, after a long time of using it, works as an inhibitor of the growth ... This is due to those 2 factors upregulating p35 which activates the production of the Cdk5 protein. It has also been ... The result of the formation of this complex is the apoptosis of nerve cells and neuroinflammation. This discovery could be used ...

"Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". J. Neurovirol. 8 Suppl 2 (2 ... Ruscica M, Dozio E, Motta M, Magni P (2007), "Modulatory Actions of Neuropeptide y on Prostate Cancer Growth: Role of MAP ... activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. 272 (5): ... "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene. 12 (4): 863-73. PMID 8632909. Peruzzi F, ...

"Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". J. Neurovirol. 8 Suppl 2 (2 ...

"Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". J. Neurovirol. 8 Suppl 2 (2 ... "Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates ... Dinerstein-Cali H, Ferrag F, Kayser C, Kelly PA, Postel-Vinay M (August 2000). "Growth hormone (GH) induces the formation of ... "Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human ...

Nerve growth factor (NGF) plays the major role in the regulation of peripherin. It is both a transcriptional inducer and post- ... The 5' flanking regions and regulatory sequences were also very similar and a nerve growth factor negative regulatory element, ... As the nerve cell matures, these type III IFs are replaced by more complex type IV neurofilaments expanding the diameter of ... In nerve cells, for example, the expressions of different types of IFs relates to the change in shape during development. Early ...

Persons with keratoconjunctivitis sicca have elevated levels of tear nerve growth factor (NGF). It is possible that this eye's ... Sendecka M, Baryluk A, Polz-Dacewicz M (2004). "[Prevalence and risk factors of dry eye syndrome]" [Prevalence and risk factors ... Liu NN, Liu L, Li J, Sun YZ (2014). "Prevalence of and risk factors for dry eye symptom in mainland china: a systematic review ... The connection between a loss in nerve sensitivity and tear production is also the subject of current research. Dry eye also ...

November 1999). "Nerve growth factor (NGF) supports tooth morphogenesis in mouse first branchial arch explants". Developmental ... Mitsiadis TA, Dicou E, Joffre A, Magloire H (January 1992). "Immunohistochemical localization of nerve growth factor (NGF) and ... "Immunocytochemical demonstration of nerve growth factor receptor (NGF-R) in developing human fetal teeth". Anatomy and ... Once there, the nerves develop around the tooth bud and enter the dental papilla when dentin formation has begun. Nerves never ...

Glial Growth Factor and nerve-dependent proliferation in the regeneration blastema of urodele amphibians. Cell 45, 301-306 ( ... This led to the identification of Glial Growth Factor, an early member of the Neuregulin family of growth factors that are key ... Identification and purification of glial growth factor. Journal of Neuroscience 4, 75-83 (1984) Brockes JP, Kintner CR. ... Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate.Science 330, 485-490 (2007). Yun MH, ...

May 2010). "Nerve growth factor and artemin are paracrine mediators of pancreatic neuropathy in pancreatic adenocarcinoma". ... December 1999). "Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting ... However, during target innervation, sympathetic neurons become dependent on neural growth factor for survival support. Unlike ... to support the survival neurons in later stages of development and can enhance neuron growth better than neural growth factor ...

Fukuoka M, Sakurai K, Ohta T, Kiyoki M, Katayama I (2001). "Tacalcitol, an active vitamin D3, induces nerve growth factor ... 24R-dihydroxyvitamin D3 on the growth of human keratinocytes". The Journal of Dermatology. 17 (2): 97-103. doi:10.1111/j.1346- ...

Marchetti D, Menter D, Jin L, Nakajima M, Nicolson GL (October 1993). "Nerve growth factor effects on human and mouse melanoma ... a receptor for fibroblast growth factors. Perlecan binds to growth factors involved in growth plate development. Perlecan ... Perlecan can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. ... Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding element". J. Biol. Chem. 272 (8): ...

Further research dealt with nerve growth factors, in particular brain-derived neurotrophic factor (BDNF); the functional ... "Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor". Proc Natl Acad Sci U S A. 92 ... in particular brain-derived neurotrophic factor, play an important role in synaptic plasticity (Korte et al., PNAS 1995 & 1996 ... "Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor ...

October 2002). "M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation". Biochemical and ...

Studies have shown that nicergoline also increases nerve growth factor in the aged brain. In addition to the α1A-adrenergic ... "Repeated injections of nicergoline increase the nerve growth factor level in the aged rat brain". Japanese Journal of ...

Isolates from the genus, called Scabronines, may increase nerve growth factor synthesis in vitro. Sarcodon species have yellow ... "Stimulation of neurotrophic factor secretion from 1321N1 human astrocytoma cells by novel diterpenoids, scabronines A and G". ...

NGF or nerve growth factor, a protein involved primarily in the growth, as well as the maintenance, proliferation, and survival ... "The Multiple Life of Nerve Growth Factor: Tribute to Rita Levi-Montalcini (1909-2012)". Balkan Medical Journal. 30 (1): 4-7. ... Ribatti, Domenico (2008). "Napoleone Ferrara and the saga of vascular endothelial growth factor". Endothelium: Journal of ... vascular endothelial growth factor' in 1989, while working at Genentech. He is credited with developing a whole new class of ...

Among these were the discovery of the receptors (TRK) of certain nerve growth factors. (Klein et al., Cell 1991a,b) the proof ... guide the growth direction of nerve cell axons via repulsion. (Henkemeyer et al., Cell 1996; Orioli et al., EMBO Journal 1996; ... Rüdiger Klein's scientific research is focused on the molecular mechanisms which allow nerve cells to communicate. Rüdiger ...

... for Nerve Growth Factor), BDNF (for Brain Derived Neurotrophic Factor), NT-4 (for Neurotrophin-4) and NT-3 (for Neurotrophin-3 ... Pflug BR, Dionne C, Kaplan DR, Lynch J, Djakiew D (January 1995). "Expression of a Trk high affinity nerve growth factor ... "low affinity nerve growth factor receptor"). As opposed to TrkC, the LNGFR plays a somewhat less clear role in NT-3 biology. ... "High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second ...

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003-2006. " ... Mammalian transcription factor LSF is a target of ERK signaling. J. Cell. Biochem. 89:733-746. Hartley, D. and Cooper, G.M. ... Identification of transcription factor binding sites upstream of human genes regulated by the phosphatidylinositol 3-kinase and ... His work includes cellular growth control, cancer, and signal transduction. More specifically, he focuses on "the roles of ...

... s A and B promote the synthesis of nerve growth factor in astroglial cells. The eudesmane skeleton upon which ...

... a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells". Neuroscience Letters. 273 (1): 53-56. doi: ...

"Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fate". Cytokine & Growth Factor ... scientists found a significant increase in TrkA and nerve growth factor in gastric mucosa. The increase of TrkA and nerve ... Shi H, Zhu S, Qin B, Wang L, Yang J, Lu G, Dai F (December 2019). "Nerve growth factor and Tropomyosin receptor kinase A are ... Ohmichi M, Decker SJ, Pang L, Saltiel AR (August 1991). "Nerve growth factor binds to the 140 kd trk proto-oncogene product and ...

The survival factors are neurotrophic factors, including molecules such as nerve growth factor (NGF). NGF interacts with ... The survival of some sensory neurons depends on axon terminals making contact with sources of survival factors that prevent ...

Cowan, WM (2001). "Viktor Hamburger and Rita Levi-Montalcini: the path to the discovery of nerve growth factor". Annual Review ... Nerve rootlets combine to form nerve roots. Likewise, sensory nerve rootlets form off right and left dorsal lateral sulci and ... It is made of 31 segments from which branch one pair of sensory nerve roots and one pair of motor nerve roots. The nerve roots ... As these nerves travel from their respective roots to their point of exit from the vertebral column, the nerves of the lower ...

Experiments that further supported this theory led to the identification of the first neurotrophic factor, nerve growth factor ... Cowan, WN (2001). "Viktor Hamburger and Rita Levi-Montalcini: the path to the discovery of nerve growth factor". Annual Review ... An atrophic factor is a force that causes a cell to die. Only natural forces on the cell are considered to be atrophic factors ... Programmed cell death in the CNS is not dependent on external growth factors but instead relies on intrinsically derived cues. ...

PC12 cells treated for 10-14 days with nerve growth factor had no release of vesicles from the cell body which indicates the ... Treatment of PC12 cells with nerve growth factor creates cells with long processes known as neurite varicosities, which contain ... PC12 cells stop dividing and terminally differentiate when treated with nerve growth factor or dexamethasone. This makes PC12 ... "Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor". ...

The discovery of nerve growth factor by Rita Levi-Montalcini in 1954, and epidermal growth factor by Stanley Cohen in 1962, led ... epidermal growth factor (EGF) binds the epidermal growth factor receptor (EGFR), which causes dimerization and ... Cowan WM (March 2001). "Viktor Hamburger and Rita Levi-Montalcini: the path to the discovery of nerve growth factor". Annual ... Three basic signals determine cellular growth: Stimulatory (growth factors) Transcription dependent response For example, ...

It has been demonstrated that doxycycline mimics nerve growth factor (NGF) signaling in PC12 cells. However, the involvement of ... This stops bacterial growth giving the immune system time to kill and remove the bacteria. The substance is almost completely ... Some studies suggest that doxycycline can also suppress the activation of the nuclear factor-kappa B (NF-κB) pathway, which is ... tumor necrosis factor-alpha (TNF-α), and matrix metalloproteinases (MMPs) while increasing the production of anti-inflammatory ...

Casaccia published a first-author Nature paper in 1996 showing that nerve growth factor highly specifically promotes the death ... Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature. 383: 716-9. PMID ... "Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75". Nature. 383 (6602): 716- ... Casaccia and her colleagues later found a critical transcription factor, Yin Yang 1, in the differentiation of OPCs. Casaccia ...

... receptors of neurotrophins like nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) - with high affinity ( ... "Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis". PLOS ... which fuel the growth of this cancer. The elimination half-life of DHEA-S is 7 to 10 hours, which is far longer than that of ...

... receptors for nerve growth factor (NGF) and other neurotrophins, as well as for DHEA and DHEA sulfate (DHEA-S). BNN-27 has ... "Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis". PLOS ... DHEA and DHEA-S were identified as important endogenous neurotrophic factors. These findings may explain the positive ...

Klein R, Jing SQ, Nanduri V, O'Rourke E, Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell ... "The TRK proto-oncogene encodes a receptor for nerve growth-factor." (1991). "trkC, a new member of the trk family of tyrosine ...

There are other neurotrophic factors structurally related to BDNF: NGF (for Nerve Growth Factor), NT-3 (for Neurotrophin-3) and ... "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor". Cell ... "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor". Cell ... "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor". Cell ...

Bose CK (Aug 2005). "Role of nerve growth factor and FSH receptor in epithelial ovarian cancer". Reproductive Biomedicine ... and other growth factors. The FSH receptor can also activate the extracellular signal-regulated kinases (ERK). In a feedback ... This synergistic activity of estrogen and FSH allows for follicle growth and development in the ovary.[citation needed] The ...

... receptors for the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), as well as for DHEA and ... "Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis". PLOS ... DHEA and DHEA-S were identified as important endogenous neurotrophic factors. These findings may explain the positive ...

Mendell's research within neurotrophins has focused specifically on nerve growth factors (NGF) and their role that they play ... For example, Mendell has conducted research which has shown the relationship between nerve growth factors and inflammatory pain ... "Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain". Anesthesiology: The Journal of the American Society ... was found by Mendell to be influenced by the introduction of nerve growth factor (NGF). It functions by interactions with ...

TrkA is a protein encoded by the NTRK1 gene and has the highest affinity to the binding nerve growth factor (NGF) After NGF is ... Aloe L, Rocco ML, Bianchi P, Manni L (November 2012). "Nerve growth factor: from the early discoveries to the potential ... TrkB has the highest affinity to the binding of brain-derived neurotrophic factor (BDNF) and NT-4. BDNF is a growth factor that ... The common ligands of trk receptors are neurotrophins, a family of growth factors critical to the functioning of the nervous ...

Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the ... Also as mentioned, there are other neurotrophic factors structurally related to NT-3: NGF (for "Nerve Growth Factor") BDNF (for ... NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived ... Jones KR, Reichardt LF (1990). "Molecular cloning of a human gene that is a member of the nerve growth factor family". Proc. ...

Emanuele, E; Politi, P; Bianchi, M; Minoretti, P; Bertona, M; Geroldi, D (April 2006). "Raised plasma nerve growth factor ... Other research has implicated nerve growth factor (NGF), a neurotrophin that is fundamental in the neuron survival and ...

Chaldakov GN, Stankulov IS, Fiore M, Ghenev PI, Aloe L (2001). "Nerve growth factor levels and mast cell distribution in human ... Concept of the neurotrophins NGF and BDNF as metabotrophic factors (metabotrophins) in cardiometabolic biology/diseases. ... and perivascular adipose tissue communicating through secreted factors (e.g. neurotrophins, adipokines, cytokines). In 1991, ...

Koch A, Mancini A, Stefan M, Niedenthal R, Niemann H, Tamura T (March 2000). "Direct interaction of nerve growth factor ... "Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor". J. Neurosci. Res. 59 (3): 356-64. doi: ... Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains". J. Biol. Chem. 272 (5): 2659 ... van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). "Stem cell factor induces ...

... stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus". Mycology. 1 (2): 92-8. doi:10.1080/ ...

... that promote nerve growth factor synthesis in vitro. Kawagishi, Hirokazu; Ando, Motoharu; Shinba, Kayoko; Sakamoto, Hideki; ... stimulators of nerve growth factor (NGF)-synthesis, from the mushroom Hericium erinaceum". Tetrahedron Letters. 32 (35): 4561- ... stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus". Mycology. 1 (2): 92-98. doi:10.1080/ ...

"Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". Journal of Neurovirology. 8 ... In the brain Pur-alpha plays a role in diseases involving glial cells, cells that support nerve cells, as well as diseases ... Following the identification of a Pur factor, which specifically bound a purine-rich sequence in the control region of the c- ... Bergemann AD, Johnson EM (March 1992). "The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene ...